Click here to switch to the map view.

The map label for this gene is htpX

Identifier: 15602333

GI number: 15602333

Start: 551907

End: 552767

Strand: Direct

Name: htpX

Synonym: PM0468

Alternate gene names: 15602333

Gene position: 551907-552767 (Clockwise)

Preceding gene: 15602332

Following gene: 15602334

Centisome position: 24.45

GC content: 42.28

Gene sequence:

>861_bases
ATGATGCGAATTTTGCTATTTCTTGCCACGAACATGGCAGTTTTAGTTGTTTTTAACATTATTTTAAGTTTGACGGGGAT
CCAAGCACAAGATGCGACAGGGCTATTGCTCATGGCGGCATTATTTGGTTTTTCTGGTTCTTTAATTTCTCTGTTTTTAT
CTAAAACCATGGCTCTACGCGCTGTGGGGGCGGAAGTGATCAAACAGCCACGTAATGACATGGAACGTTGGTTAGTGAAT
ACAGTTCGTTCGCAAGCTGAACGCGCGAATTTACCGATGCCTGATGTCGCGATTTATCACTCTGAAGATGTGAATGCGTT
TGCGACAGGACCAAGTAAAAATAATTCCTTAGTGGCCGTGAGTACTGGCTTATTACGTGCCATGACACAAGATGAAGCAG
AAGCAGTACTTGCGCATGAAGTGGCACATATTAAAAATGGTGATATGGTGACCATGACCTTATTACAAGGTGTATTGAAC
ACATTCGTGATTTTTGTGTCACGCATGATCGCGAAAGTCGTGTCAAGCAATCGAGATGGTGAAAGTAGCACAGGGATTTA
TTTTCTTGTGTCTATGGTCTTGGAAATCTTATTTGGTTTCTTAGCCAGCATGATCGCCATGTGGTTCTCTCGCTATCGAG
AATTTCGTGCGGATGCAGGGTCTGCAAAGTTAGTCGGTAAACACAAAATGATTGCCGCGTTACAACGTTTGCAACGTTTA
CATGAACCACAAGAGTTAGAAGGACAGCTTGCCGCTTTTGCGATTAACGGTAAACGTGGTGGTTTAGCGGCTTTATTTAT
GAGCCATCCGCCATTAGAAAAACGTATTGCGGCATTACAACAATTAGATAGTTTTAAATAA

Upstream 100 bases:

>100_bases
TGAGTTTGTGGTAAAATTTCTTCGGCTTGCTATTGAATTTAACGATTTTGTTACTATATTACAACACTGAATACTTAACC
TAACGATAAGGATTTTACTT

Downstream 100 bases:

>100_bases
CACTGGTAATTTATTGAAGAAAGAGGCATGATCTTGCCTCTTTTTCTTTTTTAAAGTGCGGTCGATTTTCAGAAACTTTT
CAATTAGGGTATCTATGGAA

Product: heat shock protein HtpX

Products: NA

Alternate protein names: Heat shock protein HtpX

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MMRILLFLATNMAVLVVFNIILSLTGIQAQDATGLLLMAALFGFSGSLISLFLSKTMALRAVGAEVIKQPRNDMERWLVN
TVRSQAERANLPMPDVAIYHSEDVNAFATGPSKNNSLVAVSTGLLRAMTQDEAEAVLAHEVAHIKNGDMVTMTLLQGVLN
TFVIFVSRMIAKVVSSNRDGESSTGIYFLVSMVLEILFGFLASMIAMWFSRYREFRADAGSAKLVGKHKMIAALQRLQRL
HEPQELEGQLAAFAINGKRGGLAALFMSHPPLEKRIAALQQLDSFK

Sequences:

>Translated_286_residues
MMRILLFLATNMAVLVVFNIILSLTGIQAQDATGLLLMAALFGFSGSLISLFLSKTMALRAVGAEVIKQPRNDMERWLVN
TVRSQAERANLPMPDVAIYHSEDVNAFATGPSKNNSLVAVSTGLLRAMTQDEAEAVLAHEVAHIKNGDMVTMTLLQGVLN
TFVIFVSRMIAKVVSSNRDGESSTGIYFLVSMVLEILFGFLASMIAMWFSRYREFRADAGSAKLVGKHKMIAALQRLQRL
HEPQELEGQLAAFAINGKRGGLAALFMSHPPLEKRIAALQQLDSFK
>Mature_286_residues
MMRILLFLATNMAVLVVFNIILSLTGIQAQDATGLLLMAALFGFSGSLISLFLSKTMALRAVGAEVIKQPRNDMERWLVN
TVRSQAERANLPMPDVAIYHSEDVNAFATGPSKNNSLVAVSTGLLRAMTQDEAEAVLAHEVAHIKNGDMVTMTLLQGVLN
TFVIFVSRMIAKVVSSNRDGESSTGIYFLVSMVLEILFGFLASMIAMWFSRYREFRADAGSAKLVGKHKMIAALQRLQRL
HEPQELEGQLAAFAINGKRGGLAALFMSHPPLEKRIAALQQLDSFK

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=294, Percent_Identity=63.265306122449, Blast_Score=372, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_PASMU (P57846)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245405.1
- ProteinModelPortal:   P57846
- SMR:   P57846
- MEROPS:   M48.002
- GeneID:   1243815
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0468
- NMPDR:   fig|272843.1.peg.468
- HOGENOM:   HBG739460
- OMA:   HEPQEME
- ProtClustDB:   PRK05457
- BioCyc:   PMUL272843:PM0468-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 31344; Mature: 31344

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 140-140

Signals:

None

Transmembrane regions:

HASH(0xc21f240)-; HASH(0xca5eab0)-; HASH(0xcd4dae8)-; HASH(0xc237580)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRILLFLATNMAVLVVFNIILSLTGIQAQDATGLLLMAALFGFSGSLISLFLSKTMALR
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AVGAEVIKQPRNDMERWLVNTVRSQAERANLPMPDVAIYHSEDVNAFATGPSKNNSLVAV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEECCCCCCCCEEEE
STGLLRAMTQDEAEAVLAHEVAHIKNGDMVTMTLLQGVLNTFVIFVSRMIAKVVSSNRDG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ESSTGIYFLVSMVLEILFGFLASMIAMWFSRYREFRADAGSAKLVGKHKMIAALQRLQRL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
HEPQELEGQLAAFAINGKRGGLAALFMSHPPLEKRIAALQQLDSFK
CCCHHHCCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHCCH
>Mature Secondary Structure
MMRILLFLATNMAVLVVFNIILSLTGIQAQDATGLLLMAALFGFSGSLISLFLSKTMALR
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AVGAEVIKQPRNDMERWLVNTVRSQAERANLPMPDVAIYHSEDVNAFATGPSKNNSLVAV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEECCCCCCCCEEEE
STGLLRAMTQDEAEAVLAHEVAHIKNGDMVTMTLLQGVLNTFVIFVSRMIAKVVSSNRDG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ESSTGIYFLVSMVLEILFGFLASMIAMWFSRYREFRADAGSAKLVGKHKMIAALQRLQRL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
HEPQELEGQLAAFAINGKRGGLAALFMSHPPLEKRIAALQQLDSFK
CCCHHHCCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11248100