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The map label for this gene is dinP

Identifier: 15602332

GI number: 15602332

Start: 550753

End: 551820

Strand: Direct

Name: dinP

Synonym: PM0467

Alternate gene names: 15602332

Gene position: 550753-551820 (Clockwise)

Preceding gene: 15602331

Following gene: 15602333

Centisome position: 24.4

GC content: 40.82

Gene sequence:

>1068_bases
ATTCGAAAGATCATTCATGTGGATATGGATTGTTTCTATGCTGCAATTGAGATGCGAGATAATCCAACTCTGATCGGAAA
ACCCATTGCCGTAGGAGGAGAGGCGAAACACCGTGGTGTTCTCGCCACTTGTAATTATGAGGCTCGCAAATTTGGCTTAC
ATAGTGCCATGTCAACAGCACAAGCCTTTAAATTATGTCCTAATTTAATCTTATTACCAGTGAATATGCCTTTATATAAA
CAAGTATCACAGCAGATTCACCAGATTTTTCGACGCTATACCGATGTGATTGAACCGCTATCTTTAGATGAAGCCTATCT
AGATGTGACAGATTCTACAGCCTGTTCAGGCTCAGCAACTTGGATAGCAACAGAAATTCGTCAGGCTATTTTTAATGAAC
TGGGTTTGACTGCATCTGCAGGCATTGCGCCATTAAAATTTTTGGCTAAAATTGCATCGGAACAGAATAAACCGAACGGT
CAATTTGTGATTAAACCAGAACAAATTGAGCATTTTATTGCCAACTTGCCACTAAAAAAAATCCCCGGAGTGGGTAAAGT
GACGGCACAGCGCTTAATGGCAATGGGGCTAAATACGTGTGCGGATATTCAGCACATGAATAAAGCGCGATTATTAGAAC
AATTTGGTAAACTTGGACAGCGGATTTGGGCTTTTAGTCATGGCGTTGATGAACGCCATGTTGAACCACATCGGATCTTG
AAGTCGGTCGGCGTTGAGCGAACATTACAGCACAACATTGATGAATTAGCGCAAGCTTATGTCATTTTGGCTGAACTTTA
TGCATTGCTGATTCAGCGTCTTAAAACCCATTGTCCAACATTGTCTTTTTCTATGTTGCATAAAGTTGGTGTGAAACTGA
AGTTTGCAGATTTTCATGTGACGACTTTAGAAAAACGTGGCATGCTGATTACACTTAACTCGTTTGAATTACTGCTTACA
CAAATTTGGCAACGTGCAGCGGGGAGAGAAATCCGTTTAATCGGTTTACATGTGAATTTGCCTGAAACAACGGAGTCTAA
GACACAAGTACAGATGAGTTTGTGGTAA

Upstream 100 bases:

>100_bases
AGCGCGAACGTAGCTGTTTATTTATACAGTATCTTGTGTTAAAGTGCGGTAAAATTTTAAGAAATTTAGCTGACTTGTGG
ATACGTTTGTTATGGCGCCG

Downstream 100 bases:

>100_bases
AATTTCTTCGGCTTGCTATTGAATTTAACGATTTTGTTACTATATTACAACACTGAATACTTAACCTAACGATAAGGATT
TTACTTATGATGCGAATTTT

Product: DNA polymerase IV

Products: NA

Alternate protein names: Pol IV

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MRKIIHVDMDCFYAAIEMRDNPTLIGKPIAVGGEAKHRGVLATCNYEARKFGLHSAMSTAQAFKLCPNLILLPVNMPLYK
QVSQQIHQIFRRYTDVIEPLSLDEAYLDVTDSTACSGSATWIATEIRQAIFNELGLTASAGIAPLKFLAKIASEQNKPNG
QFVIKPEQIEHFIANLPLKKIPGVGKVTAQRLMAMGLNTCADIQHMNKARLLEQFGKLGQRIWAFSHGVDERHVEPHRIL
KSVGVERTLQHNIDELAQAYVILAELYALLIQRLKTHCPTLSFSMLHKVGVKLKFADFHVTTLEKRGMLITLNSFELLLT
QIWQRAAGREIRLIGLHVNLPETTESKTQVQMSLW

Sequences:

>Translated_355_residues
MRKIIHVDMDCFYAAIEMRDNPTLIGKPIAVGGEAKHRGVLATCNYEARKFGLHSAMSTAQAFKLCPNLILLPVNMPLYK
QVSQQIHQIFRRYTDVIEPLSLDEAYLDVTDSTACSGSATWIATEIRQAIFNELGLTASAGIAPLKFLAKIASEQNKPNG
QFVIKPEQIEHFIANLPLKKIPGVGKVTAQRLMAMGLNTCADIQHMNKARLLEQFGKLGQRIWAFSHGVDERHVEPHRIL
KSVGVERTLQHNIDELAQAYVILAELYALLIQRLKTHCPTLSFSMLHKVGVKLKFADFHVTTLEKRGMLITLNSFELLLT
QIWQRAAGREIRLIGLHVNLPETTESKTQVQMSLW
>Mature_355_residues
MRKIIHVDMDCFYAAIEMRDNPTLIGKPIAVGGEAKHRGVLATCNYEARKFGLHSAMSTAQAFKLCPNLILLPVNMPLYK
QVSQQIHQIFRRYTDVIEPLSLDEAYLDVTDSTACSGSATWIATEIRQAIFNELGLTASAGIAPLKFLAKIASEQNKPNG
QFVIKPEQIEHFIANLPLKKIPGVGKVTAQRLMAMGLNTCADIQHMNKARLLEQFGKLGQRIWAFSHGVDERHVEPHRIL
KSVGVERTLQHNIDELAQAYVILAELYALLIQRLKTHCPTLSFSMLHKVGVKLKFADFHVTTLEKRGMLITLNSFELLLT
QIWQRAAGREIRLIGLHVNLPETTESKTQVQMSLW

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain

Homologues:

Organism=Homo sapiens, GI84043967, Length=434, Percent_Identity=28.5714285714286, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI7706681, Length=435, Percent_Identity=27.816091954023, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI154350220, Length=310, Percent_Identity=33.2258064516129, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI7705344, Length=107, Percent_Identity=49.5327102803738, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI5729982, Length=120, Percent_Identity=40.8333333333333, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1786425, Length=343, Percent_Identity=57.1428571428571, Blast_Score=381, Evalue=1e-107,
Organism=Escherichia coli, GI1787432, Length=209, Percent_Identity=27.2727272727273, Blast_Score=78, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI193205700, Length=418, Percent_Identity=29.6650717703349, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17537959, Length=239, Percent_Identity=30.5439330543933, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI193205702, Length=239, Percent_Identity=29.7071129707113, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI115534089, Length=127, Percent_Identity=33.8582677165354, Blast_Score=81, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6324921, Length=271, Percent_Identity=28.4132841328413, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19923006, Length=323, Percent_Identity=29.4117647058824, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI21355641, Length=283, Percent_Identity=31.095406360424, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24644984, Length=283, Percent_Identity=31.095406360424, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24668444, Length=125, Percent_Identity=32, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DPO4_PASMU (Q9CNG4)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245404.1
- ProteinModelPortal:   Q9CNG4
- SMR:   Q9CNG4
- PRIDE:   Q9CNG4
- GeneID:   1243814
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0467
- NMPDR:   fig|272843.1.peg.467
- HOGENOM:   HBG734504
- OMA:   HRIFRRY
- ProtClustDB:   PRK02406
- BioCyc:   PMUL272843:PM0467-MONOMER
- BRENDA:   2.7.7.7
- GO:   GO:0005737
- HAMAP:   MF_01113
- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880
- InterPro:   IPR003583
- Gene3D:   G3DSA:3.30.1490.100
- PANTHER:   PTHR11076
- SMART:   SM00278

Pfam domain/function: PF00817 IMS; SSF100879 DNA_pol_Y-fam_little_finger

EC number: =2.7.7.7

Molecular weight: Translated: 39911; Mature: 39911

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS50173 UMUC

Important sites: ACT_SITE 104-104

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIIHVDMDCFYAAIEMRDNPTLIGKPIAVGGEAKHRGVLATCNYEARKFGLHSAMSTA
CCCEEEECHHHHHHHEEECCCCCEECCCEEECCCCCCCCEEEECCCHHHHHHHHHHHHHH
QAFKLCPNLILLPVNMPLYKQVSQQIHQIFRRYTDVIEPLSLDEAYLDVTDSTACSGSAT
HHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEECCCCCCCCCCCH
WIATEIRQAIFNELGLTASAGIAPLKFLAKIASEQNKPNGQFVIKPEQIEHFIANLPLKK
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHCCHHH
IPGVGKVTAQRLMAMGLNTCADIQHMNKARLLEQFGKLGQRIWAFSHGVDERHVEPHRIL
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
KSVGVERTLQHNIDELAQAYVILAELYALLIQRLKTHCPTLSFSMLHKVGVKLKFADFHV
HHHCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEECEEE
TTLEKRGMLITLNSFELLLTQIWQRAAGREIRLIGLHVNLPETTESKTQVQMSLW
EEHHHCCEEEEECHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCHHEEEEECC
>Mature Secondary Structure
MRKIIHVDMDCFYAAIEMRDNPTLIGKPIAVGGEAKHRGVLATCNYEARKFGLHSAMSTA
CCCEEEECHHHHHHHEEECCCCCEECCCEEECCCCCCCCEEEECCCHHHHHHHHHHHHHH
QAFKLCPNLILLPVNMPLYKQVSQQIHQIFRRYTDVIEPLSLDEAYLDVTDSTACSGSAT
HHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEECCCCCCCCCCCH
WIATEIRQAIFNELGLTASAGIAPLKFLAKIASEQNKPNGQFVIKPEQIEHFIANLPLKK
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHCCHHH
IPGVGKVTAQRLMAMGLNTCADIQHMNKARLLEQFGKLGQRIWAFSHGVDERHVEPHRIL
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
KSVGVERTLQHNIDELAQAYVILAELYALLIQRLKTHCPTLSFSMLHKVGVKLKFADFHV
HHHCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEECEEE
TTLEKRGMLITLNSFELLLTQIWQRAAGREIRLIGLHVNLPETTESKTQVQMSLW
EEHHHCCEEEEECHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCHHEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100