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The map label for this gene is map [H]

Identifier: 15602324

GI number: 15602324

Start: 533616

End: 534419

Strand: Direct

Name: map [H]

Synonym: PM0459

Alternate gene names: 15602324

Gene position: 533616-534419 (Clockwise)

Preceding gene: 15602320

Following gene: 15602325

Centisome position: 23.64

GC content: 42.04

Gene sequence:

>804_bases
ATGGCAATTCCATTAAGAACGGAAGACGAAATTGTGAAGTTACGTGAGGCATGTAAGTTAGCCTCAGATGTCTTAGTGAT
GATTGAACCTTATGTTAAAGCGGGCGTGAGTACAGGTGAGTTGGATCGTATTTGCCATGAGTATATGGTGAACGAACAAA
AAACTATTTCAGCTTGTTTAGGTTATCATGGCTTTCCAAAAGCGACCTGTATTTCTGTTAATGAAGTCGTTTGTCACGGC
ATTCCCAGTGACGACAAAATATTAAAGCATGGCGATATTGTCAATATTGATGTGACAGTGATTAAAGACGGTTATTTTGG
CGATAATTCGAAGATGTATATTGTAGGTGAAACCAATGTGCGTAGCCAAAAATTATGCGAAGCAGCACAAGAAGCTCTCT
ATGTCGGATTACGCACAGTAAAACCGGGGATCCGTTTAAATGAGATTGGTCGAGCAATACAAACATACACCGAAAATCAA
GGGTTTAGCGTAGTACGTGAATATTGTGGACATGGCATCGGCTCAGAATTCCACTGTGAGCCACAAGTGCTACATTACTA
CGCAGACGATGGCGGTGTCATTTTACAACCGGGTATGGTGTTTACGATTGAACCGATGATTAATGCGGGGAAAAAAGAAG
TGCGTTTAATGGGAGATGGCTGGACTGTTAAAACCAAAGATCGTAGCCATTCTGCGCAATATGAACATCAATTAGTCGTC
ACGGAAACGGGTTGTGAAGTGATGACCATTCGAGAAGAAGAAGTCGCCGCAGGACGCATTCAACGAATCATGGTGAATGT
CTAA

Upstream 100 bases:

>100_bases
ATCTAATAACCGACTAATTCGTTCAAGAATTTATCAAGGATTTTTATGTTGGATAATGTTATAATTCGCGAACGAATGCA
TTTTCTGGAGAAATTTTTTT

Downstream 100 bases:

>100_bases
TACAAATTAAATATGGCTGAATTTTTTCAGCCATTTTTTTATTGATATTGAGAGGGCATAATGCTTTTTCCTTATTTTCC
CTTAAGTGAGCTTGATGTCA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MAIPLRTEDEIVKLREACKLASDVLVMIEPYVKAGVSTGELDRICHEYMVNEQKTISACLGYHGFPKATCISVNEVVCHG
IPSDDKILKHGDIVNIDVTVIKDGYFGDNSKMYIVGETNVRSQKLCEAAQEALYVGLRTVKPGIRLNEIGRAIQTYTENQ
GFSVVREYCGHGIGSEFHCEPQVLHYYADDGGVILQPGMVFTIEPMINAGKKEVRLMGDGWTVKTKDRSHSAQYEHQLVV
TETGCEVMTIREEEVAAGRIQRIMVNV

Sequences:

>Translated_267_residues
MAIPLRTEDEIVKLREACKLASDVLVMIEPYVKAGVSTGELDRICHEYMVNEQKTISACLGYHGFPKATCISVNEVVCHG
IPSDDKILKHGDIVNIDVTVIKDGYFGDNSKMYIVGETNVRSQKLCEAAQEALYVGLRTVKPGIRLNEIGRAIQTYTENQ
GFSVVREYCGHGIGSEFHCEPQVLHYYADDGGVILQPGMVFTIEPMINAGKKEVRLMGDGWTVKTKDRSHSAQYEHQLVV
TETGCEVMTIREEEVAAGRIQRIMVNV
>Mature_266_residues
AIPLRTEDEIVKLREACKLASDVLVMIEPYVKAGVSTGELDRICHEYMVNEQKTISACLGYHGFPKATCISVNEVVCHGI
PSDDKILKHGDIVNIDVTVIKDGYFGDNSKMYIVGETNVRSQKLCEAAQEALYVGLRTVKPGIRLNEIGRAIQTYTENQG
FSVVREYCGHGIGSEFHCEPQVLHYYADDGGVILQPGMVFTIEPMINAGKKEVRLMGDGWTVKTKDRSHSAQYEHQLVVT
ETGCEVMTIREEEVAAGRIQRIMVNV

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=249, Percent_Identity=43.7751004016064, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI40385867, Length=248, Percent_Identity=39.9193548387097, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI1786364, Length=254, Percent_Identity=67.3228346456693, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI1788728, Length=209, Percent_Identity=24.8803827751196, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71996291, Length=251, Percent_Identity=43.4262948207171, Blast_Score=206, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6323273, Length=263, Percent_Identity=42.9657794676806, Blast_Score=223, Evalue=2e-59,
Organism=Drosophila melanogaster, GI21355531, Length=246, Percent_Identity=43.4959349593496, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24583427, Length=245, Percent_Identity=40.4081632653061, Blast_Score=199, Evalue=1e-51,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29683; Mature: 29552

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIPLRTEDEIVKLREACKLASDVLVMIEPYVKAGVSTGELDRICHEYMVNEQKTISACL
CCCCCCCHHHHHHHHHHHHHHHHHEEEEEHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHH
GYHGFPKATCISVNEVVCHGIPSDDKILKHGDIVNIDVTVIKDGYFGDNSKMYIVGETNV
CCCCCCCEEEEEHHHHEECCCCCCCCEEECCCEEEEEEEEEECCEECCCCEEEEEECCCC
RSQKLCEAAQEALYVGLRTVKPGIRLNEIGRAIQTYTENQGFSVVREYCGHGIGSEFHCE
CHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCC
PQVLHYYADDGGVILQPGMVFTIEPMINAGKKEVRLMGDGWTVKTKDRSHSAQYEHQLVV
CEEEEEEECCCCEEECCCEEEEEEHHHCCCCEEEEEEECCEEEEECCCCCCCCCCEEEEE
TETGCEVMTIREEEVAAGRIQRIMVNV
EECCCEEEEEEHHHHHHHHHHEEEECC
>Mature Secondary Structure 
AIPLRTEDEIVKLREACKLASDVLVMIEPYVKAGVSTGELDRICHEYMVNEQKTISACL
CCCCCCHHHHHHHHHHHHHHHHHEEEEEHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHH
GYHGFPKATCISVNEVVCHGIPSDDKILKHGDIVNIDVTVIKDGYFGDNSKMYIVGETNV
CCCCCCCEEEEEHHHHEECCCCCCCCEEECCCEEEEEEEEEECCEECCCCEEEEEECCCC
RSQKLCEAAQEALYVGLRTVKPGIRLNEIGRAIQTYTENQGFSVVREYCGHGIGSEFHCE
CHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCC
PQVLHYYADDGGVILQPGMVFTIEPMINAGKKEVRLMGDGWTVKTKDRSHSAQYEHQLVV
CEEEEEEECCCCEEECCCEEEEEEHHHCCCCEEEEEEECCEEEEECCCCCCCCCCEEEEE
TETGCEVMTIREEEVAAGRIQRIMVNV
EECCCEEEEEEHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]