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The map label for this gene is dnaX [H]

Identifier: 15602229

GI number: 15602229

Start: 425593

End: 427737

Strand: Direct

Name: dnaX [H]

Synonym: PM0364

Alternate gene names: 15602229

Gene position: 425593-427737 (Clockwise)

Preceding gene: 15602228

Following gene: 15602232

Centisome position: 18.85

GC content: 42.14

Gene sequence:

>2145_bases
ATGAGTTATCAAGTCTTGGCACGAAAATGGCGACCAAAAACCTTTAGTGACGTGGTTGGGCAAACCCATATTTTAACCGC
GCTTTCTAATGGGTTGAAAGAAAATCGCCTGCATCATGCCTATCTCTTTTCTGGAACGCGTGGTGTAGGGAAAACGTCGA
TAGCTCGTTTATTTGCGAAAGGCTTAAATTGCGTTCATGGTGTGACAGCCGAACCTTGTGGTGAATGTGAACATTGTAAA
GCAATTGAACAGGGAAACTTTATTGATCTGATTGAAATTGACGCAGCATCACGTACGAAAGTCGAAGATACGCGTGAGTT
ATTGGATAATGTACAATACAAACCAGTACAAGGACGCTATAAGGTTTATCTAATCGACGAAGTCCATATGCTTTCCCGTC
ATTCGTTTAACGCTTTACTGAAAACCTTAGAAGAACCACCGGAGTATGTCAAATTCTTACTGGCAACCACTGATCCGCAA
AAACTGCCTATTACGATTTTATCCCGTTGTATGCAGTTTCATTTAAAGGCGTTGGAACAGCAACAAATCGCACAGCATCT
TGAATTTATTCTTACCCAAGAGAAAATCCCCTTTGAGTTTCTTGCGTTAGAAAAATTAGCCAAAGCTGCACAGGGCAGTA
TTCGTGATAGCTTAAGTTTAACGGATCAAGCGATTGCAATGAGTAATGGCAACATTACCTTAAATGTGGTGCATGAGATG
TTAGGCTTGCTTGATGATGATCAAGCTTTAGACATTATCCATGCTTTGCAACAAGGGCAGGGTGAGTCAGTGATGAAAGG
GGTACAAGCCGTTGCGGAAAAAGGGGGAGATTGGGACGAATTATTGCGTGATATCGGCGAGAATTTGCATAAAATTGCCA
TGCAACAGTTATTGCCTAGTTCACAGCTGGATGACACGAGTCGAATCGGTTTTCTAGCCAGTCATATTTCACCAGAAGAT
GTGCAGTTTTTCTATCAAGTTATGCTCACGGGACGTAAAGAACTGCCGTATGCGCCAAATCGTCGTATTGGGGTTGAAAT
GACGTTATTGCGGGCATTAGCCTTTCATCCTAAATTCGTTGCTGTGGCACCAACGCATGCAACGCTCGTCTCTGAGCAAG
ATATAGGCGGTTCATCAACGCGTCATATTGAAGTCCCGATCGTTTCACAAAATATAAAATCGCAATATAAAAGCCAAGTG
AAATCAACAGTCGCAGCACCGGCACAGGTTAGCCCTCCTGTTGAGGAAAAGGTGCACACACACACAGAAGAAACGGAAAC
GTATTCGCCTGCATTTGATGCTTTAGCTCAGATTGATAAATTAGATCATTTAACTATCACGCCACAGAAAGAAAAAAAAA
AGCATAGTTCATCAACAGAAGCGTTAGCACCACGGGTTTCCTTATCAAGTGATACCTCCTCTTCTACGTTAACATCATTA
CTGGTGATTGAAAGTAAACCGCGTGATACAAGTTTCATAAAAAATAAGGCTTCCGCTTTATCAACACTATCTGCGCCAGA
AACGGCGCTATCCTCAGCCTCTCCTTTAAATACGCCTGTATTACAAGCAACACAGCATACTGAACCTGAAGGAGAAGACG
AAGATGACATCATCGATGATACGCTTTTGGCGGAAACTTATCGTTGGGAATGGCGTAATCCAGAATTGGCTAAAACACAA
GAGGGGATTAAGCCTTCTGCTTTAAAACAGCGTTTAGAACAAGAAATTACGCCTGAATTGCGCGCGAAAGTGATTGATAT
CGCACGTAAACAAGATTTTTGGACAGATTGTGTAGAGTCACTTGATATCCAGAATTTAACCAAAGAATTAGCCTTAAACT
GTATTTTACTTTCACATGATGGGGAAGTGTTTCATCTTGGCGTGCGTGACAACAAAGCGCACTTACACACCACGAATGCA
CAACAGCAGTTACAGCAAGCATTGAGCCAATTACAACAGCAAGCTATGAATGTGCTGATCTCGCCGACGGACTCTGACAA
CTTGACACCAACAGAATGGTATCGGCAAACCTATAAAGCGTTGCGTGAAAAAGCGCAACAAGCGTTACAGCAAGATGAGA
AATTGCAGCTTTTTTTACATGAATTTAGTGCAGAAATCGAGCTTTCGACAGTAAAACCAATTTAA

Upstream 100 bases:

>100_bases
GGGGAAGCACGTTTAAATGCATTAGGTATTGATGCTTATACCTTAGTGGACTTTGCTGGGCATTAATCCGTATCTCTGAG
TATTGAAGAAAGGAAAATAA

Downstream 100 bases:

>100_bases
GTGCGGTCGATTTTACGAGAATTTTCACGCCCTCAATCTTGAGGGCGTATTTTTAGTCTTCAGAACTTGTCTTGTTCGGG
TGCAATCCGACATAACCTCG

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 714; Mature: 713

Protein sequence:

>714_residues
MSYQVLARKWRPKTFSDVVGQTHILTALSNGLKENRLHHAYLFSGTRGVGKTSIARLFAKGLNCVHGVTAEPCGECEHCK
AIEQGNFIDLIEIDAASRTKVEDTRELLDNVQYKPVQGRYKVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQ
KLPITILSRCMQFHLKALEQQQIAQHLEFILTQEKIPFEFLALEKLAKAAQGSIRDSLSLTDQAIAMSNGNITLNVVHEM
LGLLDDDQALDIIHALQQGQGESVMKGVQAVAEKGGDWDELLRDIGENLHKIAMQQLLPSSQLDDTSRIGFLASHISPED
VQFFYQVMLTGRKELPYAPNRRIGVEMTLLRALAFHPKFVAVAPTHATLVSEQDIGGSSTRHIEVPIVSQNIKSQYKSQV
KSTVAAPAQVSPPVEEKVHTHTEETETYSPAFDALAQIDKLDHLTITPQKEKKKHSSSTEALAPRVSLSSDTSSSTLTSL
LVIESKPRDTSFIKNKASALSTLSAPETALSSASPLNTPVLQATQHTEPEGEDEDDIIDDTLLAETYRWEWRNPELAKTQ
EGIKPSALKQRLEQEITPELRAKVIDIARKQDFWTDCVESLDIQNLTKELALNCILLSHDGEVFHLGVRDNKAHLHTTNA
QQQLQQALSQLQQQAMNVLISPTDSDNLTPTEWYRQTYKALREKAQQALQQDEKLQLFLHEFSAEIELSTVKPI

Sequences:

>Translated_714_residues
MSYQVLARKWRPKTFSDVVGQTHILTALSNGLKENRLHHAYLFSGTRGVGKTSIARLFAKGLNCVHGVTAEPCGECEHCK
AIEQGNFIDLIEIDAASRTKVEDTRELLDNVQYKPVQGRYKVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQ
KLPITILSRCMQFHLKALEQQQIAQHLEFILTQEKIPFEFLALEKLAKAAQGSIRDSLSLTDQAIAMSNGNITLNVVHEM
LGLLDDDQALDIIHALQQGQGESVMKGVQAVAEKGGDWDELLRDIGENLHKIAMQQLLPSSQLDDTSRIGFLASHISPED
VQFFYQVMLTGRKELPYAPNRRIGVEMTLLRALAFHPKFVAVAPTHATLVSEQDIGGSSTRHIEVPIVSQNIKSQYKSQV
KSTVAAPAQVSPPVEEKVHTHTEETETYSPAFDALAQIDKLDHLTITPQKEKKKHSSSTEALAPRVSLSSDTSSSTLTSL
LVIESKPRDTSFIKNKASALSTLSAPETALSSASPLNTPVLQATQHTEPEGEDEDDIIDDTLLAETYRWEWRNPELAKTQ
EGIKPSALKQRLEQEITPELRAKVIDIARKQDFWTDCVESLDIQNLTKELALNCILLSHDGEVFHLGVRDNKAHLHTTNA
QQQLQQALSQLQQQAMNVLISPTDSDNLTPTEWYRQTYKALREKAQQALQQDEKLQLFLHEFSAEIELSTVKPI
>Mature_713_residues
SYQVLARKWRPKTFSDVVGQTHILTALSNGLKENRLHHAYLFSGTRGVGKTSIARLFAKGLNCVHGVTAEPCGECEHCKA
IEQGNFIDLIEIDAASRTKVEDTRELLDNVQYKPVQGRYKVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQK
LPITILSRCMQFHLKALEQQQIAQHLEFILTQEKIPFEFLALEKLAKAAQGSIRDSLSLTDQAIAMSNGNITLNVVHEML
GLLDDDQALDIIHALQQGQGESVMKGVQAVAEKGGDWDELLRDIGENLHKIAMQQLLPSSQLDDTSRIGFLASHISPEDV
QFFYQVMLTGRKELPYAPNRRIGVEMTLLRALAFHPKFVAVAPTHATLVSEQDIGGSSTRHIEVPIVSQNIKSQYKSQVK
STVAAPAQVSPPVEEKVHTHTEETETYSPAFDALAQIDKLDHLTITPQKEKKKHSSSTEALAPRVSLSSDTSSSTLTSLL
VIESKPRDTSFIKNKASALSTLSAPETALSSASPLNTPVLQATQHTEPEGEDEDDIIDDTLLAETYRWEWRNPELAKTQE
GIKPSALKQRLEQEITPELRAKVIDIARKQDFWTDCVESLDIQNLTKELALNCILLSHDGEVFHLGVRDNKAHLHTTNAQ
QQLQQALSQLQQQAMNVLISPTDSDNLTPTEWYRQTYKALREKAQQALQQDEKLQLFLHEFSAEIELSTVKPI

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=236, Percent_Identity=24.5762711864407, Blast_Score=71, Evalue=5e-12,
Organism=Homo sapiens, GI194306571, Length=239, Percent_Identity=24.2677824267782, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI194306567, Length=239, Percent_Identity=24.2677824267782, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1786676, Length=381, Percent_Identity=65.0918635170604, Blast_Score=518, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI71986063, Length=293, Percent_Identity=23.5494880546075, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322528, Length=281, Percent_Identity=26.6903914590747, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324039, Length=241, Percent_Identity=25.3112033195021, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 79862; Mature: 79730

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQVLARKWRPKTFSDVVGQTHILTALSNGLKENRLHHAYLFSGTRGVGKTSIARLFAK
CCHHHHHHHCCCCCHHHHHCHHHHHHHHHHCHHHCCCEEEEEECCCCCCCHHHHHHHHHH
GLNCVHGVTAEPCGECEHCKAIEQGNFIDLIEIDAASRTKVEDTRELLDNVQYKPVQGRY
HHHHHCCCCCCCCCCCHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQKLPITILSRCMQFHLKALEQ
EEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
QQIAQHLEFILTQEKIPFEFLALEKLAKAAQGSIRDSLSLTDQAIAMSNGNITLNVVHEM
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCEEHHHHHHH
LGLLDDDQALDIIHALQQGQGESVMKGVQAVAEKGGDWDELLRDIGENLHKIAMQQLLPS
HCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
SQLDDTSRIGFLASHISPEDVQFFYQVMLTGRKELPYAPNRRIGVEMTLLRALAFHPKFV
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEE
AVAPTHATLVSEQDIGGSSTRHIEVPIVSQNIKSQYKSQVKSTVAAPAQVSPPVEEKVHT
EECCCHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHC
HTEETETYSPAFDALAQIDKLDHLTITPQKEKKKHSSSTEALAPRVSLSSDTSSSTLTSL
CCHHCCCCCHHHHHHHHHHHCCCEEECCCHHHHHCCCCHHHHCCCCCCCCCCCHHHHHEE
LVIESKPRDTSFIKNKASALSTLSAPETALSSASPLNTPVLQATQHTEPEGEDEDDIIDD
EEEECCCCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHCCCCCCCCCCCCCHHHHH
TLLAETYRWEWRNPELAKTQEGIKPSALKQRLEQEITPELRAKVIDIARKQDFWTDCVES
HHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LDIQNLTKELALNCILLSHDGEVFHLGVRDNKAHLHTTNAQQQLQQALSQLQQQAMNVLI
CCHHHHHHHHHHEEEEEECCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHEEE
SPTDSDNLTPTEWYRQTYKALREKAQQALQQDEKLQLFLHEFSAEIELSTVKPI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECCCC
>Mature Secondary Structure 
SYQVLARKWRPKTFSDVVGQTHILTALSNGLKENRLHHAYLFSGTRGVGKTSIARLFAK
CHHHHHHHCCCCCHHHHHCHHHHHHHHHHCHHHCCCEEEEEECCCCCCCHHHHHHHHHH
GLNCVHGVTAEPCGECEHCKAIEQGNFIDLIEIDAASRTKVEDTRELLDNVQYKPVQGRY
HHHHHCCCCCCCCCCCHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQKLPITILSRCMQFHLKALEQ
EEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
QQIAQHLEFILTQEKIPFEFLALEKLAKAAQGSIRDSLSLTDQAIAMSNGNITLNVVHEM
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCEEHHHHHHH
LGLLDDDQALDIIHALQQGQGESVMKGVQAVAEKGGDWDELLRDIGENLHKIAMQQLLPS
HCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
SQLDDTSRIGFLASHISPEDVQFFYQVMLTGRKELPYAPNRRIGVEMTLLRALAFHPKFV
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEE
AVAPTHATLVSEQDIGGSSTRHIEVPIVSQNIKSQYKSQVKSTVAAPAQVSPPVEEKVHT
EECCCHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHC
HTEETETYSPAFDALAQIDKLDHLTITPQKEKKKHSSSTEALAPRVSLSSDTSSSTLTSL
CCHHCCCCCHHHHHHHHHHHCCCEEECCCHHHHHCCCCHHHHCCCCCCCCCCCHHHHHEE
LVIESKPRDTSFIKNKASALSTLSAPETALSSASPLNTPVLQATQHTEPEGEDEDDIIDD
EEEECCCCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHCCCCCCCCCCCCCHHHHH
TLLAETYRWEWRNPELAKTQEGIKPSALKQRLEQEITPELRAKVIDIARKQDFWTDCVES
HHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LDIQNLTKELALNCILLSHDGEVFHLGVRDNKAHLHTTNAQQQLQQALSQLQQQAMNVLI
CCHHHHHHHHHHEEEEEECCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHEEE
SPTDSDNLTPTEWYRQTYKALREKAQQALQQDEKLQLFLHEFSAEIELSTVKPI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]