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The map label for this gene is apt

Identifier: 15602228

GI number: 15602228

Start: 425016

End: 425558

Strand: Direct

Name: apt

Synonym: PM0363

Alternate gene names: 15602228

Gene position: 425016-425558 (Clockwise)

Preceding gene: 15602227

Following gene: 15602229

Centisome position: 18.83

GC content: 39.23

Gene sequence:

>543_bases
ATGAACGATAAACTTGCTTTGATTAAATCTTCCATTAAGTCTATTCCAAATCATCCCAAAGAAGGGATTATTTTTCGCGA
CATTACCAGTTTGTTAGAAGTTCCTGCTGCTTTTCAGACCGTGGTTGATCTTTTTGTGACACGTTATAAAGAAAAAGGGA
TCACCAAAGTGTTAGGAACAGAATCACGTGGTTTTATTTTTGGTGCACCTGTGGCTTTAGCATTAAATGTGCCTTTTGTA
CTGGTGAGAAAACCGGGCAAATTACCACGTGAAACTATTTCACAAACCTATCAGTTAGAGTATGGACAAGATACGCTTGA
AATCCATACTGATGCAATTCATGCACAAGATAAAGTTTTGATTATTGATGATTTGCTCGCCACAGGTGGTACCGTAGAAG
CCACGGTGAAATTAGTTCAACGTTTAGGCGGTGATGTGCAAGACGCTGCTTTTGTGATTAACTTGCCTGATTTAGGTGGG
GAAGCACGTTTAAATGCATTAGGTATTGATGCTTATACCTTAGTGGACTTTGCTGGGCATTAA

Upstream 100 bases:

>100_bases
ACGAGCAACATTTTGATTGTATTTTTGTGTAAATGGCTGGTGTTATCCATTTGAAATCACAAAATAATTTTTATTTTAAC
CGCACTTATTAGGCAAAAAA

Downstream 100 bases:

>100_bases
TCCGTATCTCTGAGTATTGAAGAAAGGAAAATAAATGAGTTATCAAGTCTTGGCACGAAAATGGCGACCAAAAACCTTTA
GTGACGTGGTTGGGCAAACC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MNDKLALIKSSIKSIPNHPKEGIIFRDITSLLEVPAAFQTVVDLFVTRYKEKGITKVLGTESRGFIFGAPVALALNVPFV
LVRKPGKLPRETISQTYQLEYGQDTLEIHTDAIHAQDKVLIIDDLLATGGTVEATVKLVQRLGGDVQDAAFVINLPDLGG
EARLNALGIDAYTLVDFAGH

Sequences:

>Translated_180_residues
MNDKLALIKSSIKSIPNHPKEGIIFRDITSLLEVPAAFQTVVDLFVTRYKEKGITKVLGTESRGFIFGAPVALALNVPFV
LVRKPGKLPRETISQTYQLEYGQDTLEIHTDAIHAQDKVLIIDDLLATGGTVEATVKLVQRLGGDVQDAAFVINLPDLGG
EARLNALGIDAYTLVDFAGH
>Mature_180_residues
MNDKLALIKSSIKSIPNHPKEGIIFRDITSLLEVPAAFQTVVDLFVTRYKEKGITKVLGTESRGFIFGAPVALALNVPFV
LVRKPGKLPRETISQTYQLEYGQDTLEIHTDAIHAQDKVLIIDDLLATGGTVEATVKLVQRLGGDVQDAAFVINLPDLGG
EARLNALGIDAYTLVDFAGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=166, Percent_Identity=39.1566265060241, Blast_Score=127, Evalue=5e-30,
Organism=Homo sapiens, GI71773201, Length=131, Percent_Identity=41.2213740458015, Blast_Score=108, Evalue=3e-24,
Organism=Escherichia coli, GI1786675, Length=177, Percent_Identity=68.9265536723164, Blast_Score=247, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI17509087, Length=162, Percent_Identity=45.0617283950617, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323619, Length=163, Percent_Identity=42.9447852760736, Blast_Score=120, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6320649, Length=163, Percent_Identity=36.8098159509202, Blast_Score=90, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136334, Length=167, Percent_Identity=41.9161676646707, Blast_Score=124, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_PASMU (P57841)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245300.1
- ProteinModelPortal:   P57841
- SMR:   P57841
- GeneID:   1243710
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0363
- NMPDR:   fig|272843.1.peg.363
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   PMUL272843:PM0363-MONOMER
- BRENDA:   2.4.2.7
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19537; Mature: 19537

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDKLALIKSSIKSIPNHPKEGIIFRDITSLLEVPAAFQTVVDLFVTRYKEKGITKVLGT
CCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHCC
ESRGFIFGAPVALALNVPFVLVRKPGKLPRETISQTYQLEYGQDTLEIHTDAIHAQDKVL
CCCCEEEECCEEEEECCCEEEEECCCCCCHHHHHHHEEEECCCCEEEEEHHEECCCCCEE
IIDDLLATGGTVEATVKLVQRLGGDVQDAAFVINLPDLGGEARLNALGIDAYTLVDFAGH
EEEHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEECCCCEEEEEECCC
>Mature Secondary Structure
MNDKLALIKSSIKSIPNHPKEGIIFRDITSLLEVPAAFQTVVDLFVTRYKEKGITKVLGT
CCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHCC
ESRGFIFGAPVALALNVPFVLVRKPGKLPRETISQTYQLEYGQDTLEIHTDAIHAQDKVL
CCCCEEEECCEEEEECCCEEEEECCCCCCHHHHHHHEEEECCCCEEEEEHHEECCCCCEE
IIDDLLATGGTVEATVKLVQRLGGDVQDAAFVINLPDLGGEARLNALGIDAYTLVDFAGH
EEEHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEECCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100