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The map label for this gene is putP_1 [H]

Identifier: 15602206

GI number: 15602206

Start: 401467

End: 402981

Strand: Reverse

Name: putP_1 [H]

Synonym: PM0341

Alternate gene names: 15602206

Gene position: 402981-401467 (Counterclockwise)

Preceding gene: 15602210

Following gene: 15602205

Centisome position: 17.85

GC content: 42.51

Gene sequence:

>1515_bases
ATGTTTGGATTGGATCCAACACTTATTACATTTACGATTTATATTTTTGGCATGTTGCTGATTGGCTTATTCGCCTATCG
TTATACTAATAATTTATCAGATTACATTTTAGGGGGACGTCGTTTAGGCAGTTTTGTAACCGCCATGTCAGCCGGTGCCT
CCGATATGTCAGGCTGGCTGTTAATGGGTTTACCCGGTGCGATTTACCTGTCTGGCTTAATTGAAGGTTGGATAGCCATT
GGCTTAACTATCGGAGCTTATCTGAATTGGCTATTTGTGGCAGGACGTTTACGTATTTACACTGAATTTAACCAAAATGC
GCTGACTTTACCTGAATATTTTCACCACCGTTTCGGTACGTCACATAATCTCCTAAAAATTGTGTCCGCCAGTATCATTT
TGGTCTTCTTTACTATTTACTGTGCCTCAGGCGTCGTCGCAGGGGCAAAACTGTTCCAAAATCTCTTTTCTGTAGATTAT
GCGACTGCACTTTGGTACGGTGCTTTAGCCACCATTGCTTACACCTTTATTGGTGGCTTTTTAGCCGTGAGTTGGACAGA
CACTATTCAAGCCACATTAATGATTTTCGCCTTGATTCTAACACCCGTGTTTGTGTTAATTAGCCTAGAAGGATTAAGTC
AATTTAACGTGGTGCTCGCACAAGCGGAAAGCCAAGCTCATAAAGACTTTACCGATATTTTCACAGGTACTACTCCGCTA
GGTTTACTCAGTTTAGCGGCTTGGGGGTTAGGTTATTTTGGTCAACCGCACATTCTAGCGCGCTTTATGGCAGCGGATTC
GGTAAAATCCTTAAACAAAGCACGTAGAATCAGCATGACTTGGATGATTCTCTGTTTAGTCGGAGCAATGGGCATTGGCT
TTTTTGGTATTGCCTATTTCTATGCTAATCCCACCGTGGCAGGTTTAGTCAATAAAGAATCAGAACAAGTATTTATTGAA
TTAGCCAAATTACTCTTTAATCCGTGGATCGCGGGGATTTTACTGTCCGCCATTCTCGCGGCGGTGATGAGCACGCTAAG
TTGTCAATTATTGATTTCTTCCAGTGCGATTACCGAAGATTTTTATAAAGGTTTTATCCGTCCAACGGCGTCTGAAAAAG
AATTAGTCTGGTTAGGGCGTGCCATGGTGTTAGCAATTGCTGCGATTGCGATTTGGATTGCGCAAGATGAACACAGCAAA
GTACTCAAACTGGTGGAATTTGCGTGGGCAGGTTTTGGCAGTGCATTTGGTCCTGTTGTATTATTTTCTTTATTCTGGAA
ACGCATGACTTCTTCGGCAGCATTGCTCGGCATGCTAACTGGAGCTATCGTGGTCTTTGGTTGGAAAAGCTGGACACCAA
TCGGTTCTGAATTACACCAGTTGTATGAAATGATCCCCGGCTTTACTTTAGCAAGCTTGGTGATTATCACCACTTCATTG
CTCTCTGCCAAACCAGAAGCACAAATTGTTGACACTTTTGAACAAGCACAAAAGGCTTATAAAAACGCACTATGA

Upstream 100 bases:

>100_bases
GAAAAGGGAAATAGAATAATAGTGCTAAATAAGGTAAAATGTGAGCTTTCTCAAATTTTGGCTGAGAAAAATCATACTTT
TAGATGTTTGAGAGGTCATC

Downstream 100 bases:

>100_bases
TTGACTTTCGTCCTTTTTATCAACACATTGCCACCACTCATTTATCCGCGTGGCTTGAAACCCTTCCCCTGCAATTAAAA
CAGTGGGAAAAACAAACCCA

Product: hypothetical protein

Products: NA

Alternate protein names: Proline permease [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MFGLDPTLITFTIYIFGMLLIGLFAYRYTNNLSDYILGGRRLGSFVTAMSAGASDMSGWLLMGLPGAIYLSGLIEGWIAI
GLTIGAYLNWLFVAGRLRIYTEFNQNALTLPEYFHHRFGTSHNLLKIVSASIILVFFTIYCASGVVAGAKLFQNLFSVDY
ATALWYGALATIAYTFIGGFLAVSWTDTIQATLMIFALILTPVFVLISLEGLSQFNVVLAQAESQAHKDFTDIFTGTTPL
GLLSLAAWGLGYFGQPHILARFMAADSVKSLNKARRISMTWMILCLVGAMGIGFFGIAYFYANPTVAGLVNKESEQVFIE
LAKLLFNPWIAGILLSAILAAVMSTLSCQLLISSSAITEDFYKGFIRPTASEKELVWLGRAMVLAIAAIAIWIAQDEHSK
VLKLVEFAWAGFGSAFGPVVLFSLFWKRMTSSAALLGMLTGAIVVFGWKSWTPIGSELHQLYEMIPGFTLASLVIITTSL
LSAKPEAQIVDTFEQAQKAYKNAL

Sequences:

>Translated_504_residues
MFGLDPTLITFTIYIFGMLLIGLFAYRYTNNLSDYILGGRRLGSFVTAMSAGASDMSGWLLMGLPGAIYLSGLIEGWIAI
GLTIGAYLNWLFVAGRLRIYTEFNQNALTLPEYFHHRFGTSHNLLKIVSASIILVFFTIYCASGVVAGAKLFQNLFSVDY
ATALWYGALATIAYTFIGGFLAVSWTDTIQATLMIFALILTPVFVLISLEGLSQFNVVLAQAESQAHKDFTDIFTGTTPL
GLLSLAAWGLGYFGQPHILARFMAADSVKSLNKARRISMTWMILCLVGAMGIGFFGIAYFYANPTVAGLVNKESEQVFIE
LAKLLFNPWIAGILLSAILAAVMSTLSCQLLISSSAITEDFYKGFIRPTASEKELVWLGRAMVLAIAAIAIWIAQDEHSK
VLKLVEFAWAGFGSAFGPVVLFSLFWKRMTSSAALLGMLTGAIVVFGWKSWTPIGSELHQLYEMIPGFTLASLVIITTSL
LSAKPEAQIVDTFEQAQKAYKNAL
>Mature_504_residues
MFGLDPTLITFTIYIFGMLLIGLFAYRYTNNLSDYILGGRRLGSFVTAMSAGASDMSGWLLMGLPGAIYLSGLIEGWIAI
GLTIGAYLNWLFVAGRLRIYTEFNQNALTLPEYFHHRFGTSHNLLKIVSASIILVFFTIYCASGVVAGAKLFQNLFSVDY
ATALWYGALATIAYTFIGGFLAVSWTDTIQATLMIFALILTPVFVLISLEGLSQFNVVLAQAESQAHKDFTDIFTGTTPL
GLLSLAAWGLGYFGQPHILARFMAADSVKSLNKARRISMTWMILCLVGAMGIGFFGIAYFYANPTVAGLVNKESEQVFIE
LAKLLFNPWIAGILLSAILAAVMSTLSCQLLISSSAITEDFYKGFIRPTASEKELVWLGRAMVLAIAAIAIWIAQDEHSK
VLKLVEFAWAGFGSAFGPVVLFSLFWKRMTSSAALLGMLTGAIVVFGWKSWTPIGSELHQLYEMIPGFTLASLVIITTSL
LSAKPEAQIVDTFEQAQKAYKNAL

Specific function: Catalyzes the sodium-dependent uptake of extracellular L-proline [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=503, Percent_Identity=45.1292246520875, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI109659836, Length=461, Percent_Identity=24.0780911062907, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI4507031, Length=476, Percent_Identity=25.4201680672269, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI110835708, Length=540, Percent_Identity=22.962962962963, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4507035, Length=382, Percent_Identity=23.8219895287958, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI11141885, Length=409, Percent_Identity=25.4278728606357, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1787251, Length=498, Percent_Identity=62.6506024096386, Blast_Score=606, Evalue=1e-174,
Organism=Escherichia coli, GI1790503, Length=443, Percent_Identity=25.5079006772009, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI87082237, Length=445, Percent_Identity=26.7415730337079, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1790113, Length=516, Percent_Identity=22.093023255814, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115533094, Length=385, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI115533096, Length=251, Percent_Identity=30.6772908366534, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221459584, Length=371, Percent_Identity=25.3369272237197, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI221459588, Length=453, Percent_Identity=25.3863134657837, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24645928, Length=364, Percent_Identity=25, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221459586, Length=390, Percent_Identity=22.5641025641026, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24650192, Length=448, Percent_Identity=22.3214285714286, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24640370, Length=364, Percent_Identity=24.1758241758242, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI221459582, Length=375, Percent_Identity=22.9333333333333, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24651741, Length=458, Percent_Identity=23.7991266375546, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19920916, Length=382, Percent_Identity=22.5130890052356, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 55052; Mature: 55052

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure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HCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]