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The map label for this gene is lrp [H]

Identifier: 15602119

GI number: 15602119

Start: 284783

End: 285262

Strand: Direct

Name: lrp [H]

Synonym: PM0254

Alternate gene names: 15602119

Gene position: 284783-285262 (Clockwise)

Preceding gene: 15602117

Following gene: 15602120

Centisome position: 12.62

GC content: 36.88

Gene sequence:

>480_bases
ATGGAAAAGAAACTAATGAAAGCCCTAGATAGTATTGATATCAAAATTCTCAATGAGTTACAACGCAATGGAAAAATTTC
CAATATCGATTTATCAAAAAAAGTCGGGCTTTCTCCCACACCTTGTTTAGAACGAGTAAAGCGCCTTGAAAAACAAGGTG
TGATTATGGGATATCGTGCTTTATTGAATCCTGAATTATTAGATTCCCCTTTATTGGTGATTGTGGAAATTACATTAATT
CGCGGTAAACCGGATGTGTTTGAAGAATTTAATGCCGCAGTACAACAATTAGATGAAATTCAAGAATGTCATCTTGTCTC
CGGTGATTTTGACTATTTATTAAAAACGCGCGTTGCGGATATGGCGGCATATCGTAAATTGCTCGGCACAACTTTACTAC
GTTTACCCGGTGTAAATGACACACGCACTTATGTCGTGATGGAAGAAGTCAAACAAACCAATTTTCTCCAACTGAAGTAA

Upstream 100 bases:

>100_bases
TAAGTATGATTTAAGACAAAGAAAAAAAATTAAATTTTGAAAAATGGTGTAAAATTAGTTAATCTCACTAACATATTGCC
TTTTTAACCGCAGAGGAGTT

Downstream 100 bases:

>100_bases
TACAATGATTAAACGAATTTCTGAAAAATTTACCCCTAAGCAGTATCTATTGGCATTTTTCTTTCTTGTGGGCATGCTGT
TTGGCGTGTATTTGATCGTT

Product: leucine-responsive transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MEKKLMKALDSIDIKILNELQRNGKISNIDLSKKVGLSPTPCLERVKRLEKQGVIMGYRALLNPELLDSPLLVIVEITLI
RGKPDVFEEFNAAVQQLDEIQECHLVSGDFDYLLKTRVADMAAYRKLLGTTLLRLPGVNDTRTYVVMEEVKQTNFLQLK

Sequences:

>Translated_159_residues
MEKKLMKALDSIDIKILNELQRNGKISNIDLSKKVGLSPTPCLERVKRLEKQGVIMGYRALLNPELLDSPLLVIVEITLI
RGKPDVFEEFNAAVQQLDEIQECHLVSGDFDYLLKTRVADMAAYRKLLGTTLLRLPGVNDTRTYVVMEEVKQTNFLQLK
>Mature_159_residues
MEKKLMKALDSIDIKILNELQRNGKISNIDLSKKVGLSPTPCLERVKRLEKQGVIMGYRALLNPELLDSPLLVIVEITLI
RGKPDVFEEFNAAVQQLDEIQECHLVSGDFDYLLKTRVADMAAYRKLLGTTLLRLPGVNDTRTYVVMEEVKQTNFLQLK

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=158, Percent_Identity=76.5822784810127, Blast_Score=248, Evalue=1e-67,
Organism=Escherichia coli, GI87081742, Length=151, Percent_Identity=33.112582781457, Blast_Score=91, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18086; Mature: 18086

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKLMKALDSIDIKILNELQRNGKISNIDLSKKVGLSPTPCLERVKRLEKQGVIMGYRA
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCHHHHHHHHHHHCCHHHHHHH
LLNPELLDSPLLVIVEITLIRGKPDVFEEFNAAVQQLDEIQECHLVSGDFDYLLKTRVAD
HCCHHHHCCCCEEEHEEEHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MAAYRKLLGTTLLRLPGVNDTRTYVVMEEVKQTNFLQLK
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEECC
>Mature Secondary Structure
MEKKLMKALDSIDIKILNELQRNGKISNIDLSKKVGLSPTPCLERVKRLEKQGVIMGYRA
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCHHHHHHHHHHHCCHHHHHHH
LLNPELLDSPLLVIVEITLIRGKPDVFEEFNAAVQQLDEIQECHLVSGDFDYLLKTRVAD
HCCHHHHCCCCEEEHEEEHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MAAYRKLLGTTLLRLPGVNDTRTYVVMEEVKQTNFLQLK
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]