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The map label for this gene is butB

Identifier: 30024012

GI number: 30024012

Start: 917431

End: 918501

Strand: Direct

Name: butB

Synonym: L117145

Alternate gene names: 30024012

Gene position: 917431-918501 (Clockwise)

Preceding gene: 15672878

Following gene: 15672880

Centisome position: 38.78

GC content: 40.06

Gene sequence:

>1071_bases
ATGCGCGCAGCACGTTTTTACGACCGCGGGGATATCCGCATTGATGAAATTAATGAACCAATAGTAAAAGCTGGCCAAGT
TGGCATTGATGTGGCTTGGTGTGGAATTTGTGGAACAGATCTCCATGAATTTTTAGATGGCCCAATTTTTTGTCCGTCAG
CAGAACATCCTAATCCAATTACTGGAGAAGTACCACCAGTCACTCTTGGACATGAAATGTCTGGGGTTGTAAATTTTATA
GGTGAAGGAGTAAGCGGACTTAAAGTAGGTGACCATGTCGTTGTCGAACCTTATATCGTTCCCGAAGGGACTGATACAAG
TGAAACTGGACATTATAACCTCTCAGAAGGCTCAAACTTTATTGGTTTGGGCGGAAATGGTGGAGGTTTGGCTGAAAAAA
TTTCTGTTGATGAACGTTGGGTTCACAAAATTCCTGATAACTTACCATTGGATGAAGCTGCTCTAATTGAGCCACTATCA
GTCGGCTATCACGCTGTTGAACGAGCAAATTTAAGTGAAAAGAGTACGGTATTAGTTGTTGGTGCTGGACCAATTGGACT
ATTAACTGCTGCCGTTGCAAAAGCGCAAGGACATACTGTTATCATCAGTGAACCTAGTGGACTTCGTCGTAAAAAAGCAC
AAGAAGCACAAGTTGCTGATTATTTCTTCAATCCAATTGAAGATGACATTCAAGCTAAAGTTCATGAAATTAATGAAAAA
GGAGTGGACGCAGCCTTTGAATGTACCTCTGTCCAACCGGGATTTGACGCTTGTCTAGATGCGATTCGTATGGGTGGAAC
AGTTGTCATTGTCGCAATTTGGGGCAAGCCTGCTAGTGTTGATATGGCAAAATTAGTAATCAAAGAAGCTAACCTTTTAG
GAACGATTGCTTATAATAACACTCATCCAAAAACAATTGATTTAGTATCAACAGGTAAAATAAAATTGGACCAATTCATC
ACAGCTAAAATCGGTTTGGATGATTTGATTGATAAAGGATTCGATACGCTGATTCATCATAATGAAACAGCTGTTAAAAT
TTTAGTTTCACCAACTGGTAAAGGTCTATAA

Upstream 100 bases:

>100_bases
TTAGAAATAATGATAGAATAAACTCGTGAGAGAAATCTCAAATACTAAATTTAATTGATTGCCTGAAACGACAACCATCC
TATATAGAGGAGGCGTTTTT

Downstream 100 bases:

>100_bases
AATAAATAAATAAAGGAGAAATAAGATGTCTAAAATTGCAGCAGTTACTGGAGCAGGTCAAGGAATAGGTTTTGCAATCG
CAAAACGTCTCTATAATGAT

Product: 2,3-butanediol dehydrogenase

Products: NA

Alternate protein names: Acetoin reductase/2,3-butanediol dehydrogenase; AR/BDH [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MRAARFYDRGDIRIDEINEPIVKAGQVGIDVAWCGICGTDLHEFLDGPIFCPSAEHPNPITGEVPPVTLGHEMSGVVNFI
GEGVSGLKVGDHVVVEPYIVPEGTDTSETGHYNLSEGSNFIGLGGNGGGLAEKISVDERWVHKIPDNLPLDEAALIEPLS
VGYHAVERANLSEKSTVLVVGAGPIGLLTAAVAKAQGHTVIISEPSGLRRKKAQEAQVADYFFNPIEDDIQAKVHEINEK
GVDAAFECTSVQPGFDACLDAIRMGGTVVIVAIWGKPASVDMAKLVIKEANLLGTIAYNNTHPKTIDLVSTGKIKLDQFI
TAKIGLDDLIDKGFDTLIHHNETAVKILVSPTGKGL

Sequences:

>Translated_356_residues
MRAARFYDRGDIRIDEINEPIVKAGQVGIDVAWCGICGTDLHEFLDGPIFCPSAEHPNPITGEVPPVTLGHEMSGVVNFI
GEGVSGLKVGDHVVVEPYIVPEGTDTSETGHYNLSEGSNFIGLGGNGGGLAEKISVDERWVHKIPDNLPLDEAALIEPLS
VGYHAVERANLSEKSTVLVVGAGPIGLLTAAVAKAQGHTVIISEPSGLRRKKAQEAQVADYFFNPIEDDIQAKVHEINEK
GVDAAFECTSVQPGFDACLDAIRMGGTVVIVAIWGKPASVDMAKLVIKEANLLGTIAYNNTHPKTIDLVSTGKIKLDQFI
TAKIGLDDLIDKGFDTLIHHNETAVKILVSPTGKGL
>Mature_356_residues
MRAARFYDRGDIRIDEINEPIVKAGQVGIDVAWCGICGTDLHEFLDGPIFCPSAEHPNPITGEVPPVTLGHEMSGVVNFI
GEGVSGLKVGDHVVVEPYIVPEGTDTSETGHYNLSEGSNFIGLGGNGGGLAEKISVDERWVHKIPDNLPLDEAALIEPLS
VGYHAVERANLSEKSTVLVVGAGPIGLLTAAVAKAQGHTVIISEPSGLRRKKAQEAQVADYFFNPIEDDIQAKVHEINEK
GVDAAFECTSVQPGFDACLDAIRMGGTVVIVAIWGKPASVDMAKLVIKEANLLGTIAYNNTHPKTIDLVSTGKIKLDQFI
TAKIGLDDLIDKGFDTLIHHNETAVKILVSPTGKGL

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=333, Percent_Identity=32.7327327327327, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI262073058, Length=376, Percent_Identity=27.1276595744681, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI71743840, Length=376, Percent_Identity=27.1276595744681, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1788073, Length=339, Percent_Identity=28.023598820059, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI226510992, Length=338, Percent_Identity=30.1775147928994, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1790045, Length=314, Percent_Identity=29.9363057324841, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1787863, Length=340, Percent_Identity=27.9411764705882, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1788407, Length=189, Percent_Identity=34.9206349206349, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788075, Length=374, Percent_Identity=25.4010695187166, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790718, Length=310, Percent_Identity=26.4516129032258, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082125, Length=347, Percent_Identity=25.0720461095101, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87081918, Length=312, Percent_Identity=26.6025641025641, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=331, Percent_Identity=32.02416918429, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17562878, Length=335, Percent_Identity=30.4477611940298, Blast_Score=140, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6319258, Length=385, Percent_Identity=35.3246753246753, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6319257, Length=382, Percent_Identity=33.5078534031414, Blast_Score=216, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6323099, Length=349, Percent_Identity=31.2320916905444, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6322619, Length=351, Percent_Identity=31.3390313390313, Blast_Score=143, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6319955, Length=351, Percent_Identity=31.3390313390313, Blast_Score=142, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6324486, Length=318, Percent_Identity=25.1572327044025, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319621, Length=330, Percent_Identity=25.7575757575758, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=325, Percent_Identity=26.1538461538462, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737897, Length=347, Percent_Identity=28.2420749279539, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17137530, Length=346, Percent_Identity=28.0346820809249, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI45550770, Length=355, Percent_Identity=23.0985915492958, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221457811, Length=355, Percent_Identity=23.0985915492958, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45551930, Length=348, Percent_Identity=22.7011494252874, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17737895, Length=370, Percent_Identity=25.4054054054054, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.4 [H]

Molecular weight: Translated: 37879; Mature: 37879

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAARFYDRGDIRIDEINEPIVKAGQVGIDVAWCGICGTDLHEFLDGPIFCPSAEHPNPI
CCCCCCCCCCCEEEECCCCCHHHCCCCCEEEEEECCCHHHHHHHHCCCEECCCCCCCCCC
TGEVPPVTLGHEMSGVVNFIGEGVSGLKVGDHVVVEPYIVPEGTDTSETGHYNLSEGSNF
CCCCCCEEECCHHHHHHHHHHCCCCCCEECCEEEEEEEEECCCCCCCCCCCEECCCCCCE
IGLGGNGGGLAEKISVDERWVHKIPDNLPLDEAALIEPLSVGYHAVERANLSEKSTVLVV
EEECCCCCCCCEEECCCHHHHHHCCCCCCCCHHHHHHHHHHCHHHHHHCCCCCCCEEEEE
GAGPIGLLTAAVAKAQGHTVIISEPSGLRRKKAQEAQVADYFFNPIEDDIQAKVHEINEK
ECCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
GVDAAFECTSVQPGFDACLDAIRMGGTVVIVAIWGKPASVDMAKLVIKEANLLGTIAYNN
CCCCEEEECCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHCCEEEEEEECC
THPKTIDLVSTGKIKLDQFITAKIGLDDLIDKGFDTLIHHNETAVKILVSPTGKGL
CCCCEEEEEECCCEEECCEEEECCCHHHHHHCCHHHHHCCCCEEEEEEEECCCCCC
>Mature Secondary Structure
MRAARFYDRGDIRIDEINEPIVKAGQVGIDVAWCGICGTDLHEFLDGPIFCPSAEHPNPI
CCCCCCCCCCCEEEECCCCCHHHCCCCCEEEEEECCCHHHHHHHHCCCEECCCCCCCCCC
TGEVPPVTLGHEMSGVVNFIGEGVSGLKVGDHVVVEPYIVPEGTDTSETGHYNLSEGSNF
CCCCCCEEECCHHHHHHHHHHCCCCCCEECCEEEEEEEEECCCCCCCCCCCEECCCCCCE
IGLGGNGGGLAEKISVDERWVHKIPDNLPLDEAALIEPLSVGYHAVERANLSEKSTVLVV
EEECCCCCCCCEEECCCHHHHHHCCCCCCCCHHHHHHHHHHCHHHHHHCCCCCCCEEEEE
GAGPIGLLTAAVAKAQGHTVIISEPSGLRRKKAQEAQVADYFFNPIEDDIQAKVHEINEK
ECCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
GVDAAFECTSVQPGFDACLDAIRMGGTVVIVAIWGKPASVDMAKLVIKEANLLGTIAYNN
CCCCEEEECCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHCCEEEEEEECC
THPKTIDLVSTGKIKLDQFITAKIGLDDLIDKGFDTLIHHNETAVKILVSPTGKGL
CCCCEEEEEECCCEEECCEEEECCCHHHHHHCCHHHHHCCCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377 [H]