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The map label for this gene is thrC

Identifier: 15674085

GI number: 15674085

Start: 2172280

End: 2173770

Strand: Reverse

Name: thrC

Synonym: L0092

Alternate gene names: 15674085

Gene position: 2173770-2172280 (Counterclockwise)

Preceding gene: 15674086

Following gene: 15674084

Centisome position: 91.89

GC content: 34.54

Gene sequence:

>1491_bases
ATGGTAACTTTTTATCAGTCAACACGTGATAAATCAAATAAAAAAACAGCGTCGCAAGCTATTTTACAAGGTTTGGCAGA
AGATGGTGGACTTTTTGTTCCCGTTGACTTTCCAAAAGTTGATTTAGACTTTGAAAAATTAAAAAACGCTTCTTATCAAG
AAATTGCTGAACTTGTTTTGAAAGCATTTTTTGATGATTTTTCTGCTGACGAAATTAAATCAATGGTGACAAAAGCATAC
GGAGAAAAATTCGATAGTCCGGAAATTGCACCGCTTAAAAGACTTGGGAATCACTATATTCTTGAACTTTTTCATGGTGA
AACGATTGCTTTTAAAGACATGGCACTCTCTATCTTACCTCATTTAATGACCCAAGCGGCTAAGAAAAATGGTGTGACTA
ATGAAATTGTTATCTTGACTGCAACTTCTGGAGATACAGGGAAAGCCGCAATGGCCGGTTTTGCTGATGTGCCCCAAACA
AAAATTATTGTTTTTTATCCCAAAGGTGGTGTCAGCCATATTCAAGAGCAACAAATGCTGACTCAAAAAGGGGAAAATGT
TCATGTTGTTGGAATTGATGGAAACTTTGACCAAGCTCAAACAGCAGTAAAAGAAATGTTTAATAACAAAGTTTTACATG
ATCAACTTTTGAAAAATAATAAACAATTTTCGTCAGCAAATTCAATGAATATTGGACGTTTGATTCCCCAAGTTGCTTAT
TATATTTATGCTTACGCACAACTTGTCAAAACTGGTCAAATTACTGACGGAGAAGAAATTAATTTTTCAGTTCCAACAGG
GAATTTTGGAAATATCTTAGCGGCTTATTATGCTAAAAAATTGGGCTTGCCCGTTCATCAGCTCATCTGTGCTTCAAATA
AAAATAATGTACTGACAGACTTTTTCAAAACAGGACTTTATGATAAAAATCGTGAATTCTATGTAACAAGTTCACCTTCA
ATGGATATTTTGGTCTCTTCAAATCTTGAACGTTTAATTTTTGAATTAACTGACGAAAATGATAAAGTAACCTCAGATTT
ACTGACAGCCCTATCAGTAGAAGGGCATTATCAAATTTCTAAAGAAATGATTACTAAACTTCAGGGATTTGTGGCCGACT
GGGCATCAGAAGATGAAATTTCAAAAGAAATTCAAGAAACTTTTGAAAATGAAAAATATGTTCTGGACCCTCATACAGCA
GTAGCAAATTATGTCTATCATCAAATTCAACCCAAAGAAAAAACAGTTGTGGTCAGCACGGCAAGTCCTTATAAGTTTCC
AAAAGTTGTTTTAGAAGGGCTTGAAAATGATAAAACAGAGCTGTCAGTAAATAGAGACGATTTTGCTGCTGTTAAATCAC
TTGAAAAATTGAGTGGGATTCCATTACCAAAAGCAGTCATCGGACTTGAAGAAGCAGAAGTTCTACATCATACCGTTATT
CCAGCCGCTGAAATGCAAAAAGAAGTAGAAAAATATCTTGGCTTAAAATGA

Upstream 100 bases:

>100_bases
TAAGTATTATAATAAAAAAAGCCACGAGAATTCGTGGCTTTTTGCGAGTTTACAGAATATTTGTTATAATTATAAAAAAT
GTGATTGGGGAATAAATATC

Downstream 100 bases:

>100_bases
AAACAAATAGAGAAATATTAAAATTCGCATTTCCGGCGATTATTGAAAATTTCTTACAAATGCTTGTAGGGGTGAGTGAC
ACAATGATTGTTGCTCACCT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MVTFYQSTRDKSNKKTASQAILQGLAEDGGLFVPVDFPKVDLDFEKLKNASYQEIAELVLKAFFDDFSADEIKSMVTKAY
GEKFDSPEIAPLKRLGNHYILELFHGETIAFKDMALSILPHLMTQAAKKNGVTNEIVILTATSGDTGKAAMAGFADVPQT
KIIVFYPKGGVSHIQEQQMLTQKGENVHVVGIDGNFDQAQTAVKEMFNNKVLHDQLLKNNKQFSSANSMNIGRLIPQVAY
YIYAYAQLVKTGQITDGEEINFSVPTGNFGNILAAYYAKKLGLPVHQLICASNKNNVLTDFFKTGLYDKNREFYVTSSPS
MDILVSSNLERLIFELTDENDKVTSDLLTALSVEGHYQISKEMITKLQGFVADWASEDEISKEIQETFENEKYVLDPHTA
VANYVYHQIQPKEKTVVVSTASPYKFPKVVLEGLENDKTELSVNRDDFAAVKSLEKLSGIPLPKAVIGLEEAEVLHHTVI
PAAEMQKEVEKYLGLK

Sequences:

>Translated_496_residues
MVTFYQSTRDKSNKKTASQAILQGLAEDGGLFVPVDFPKVDLDFEKLKNASYQEIAELVLKAFFDDFSADEIKSMVTKAY
GEKFDSPEIAPLKRLGNHYILELFHGETIAFKDMALSILPHLMTQAAKKNGVTNEIVILTATSGDTGKAAMAGFADVPQT
KIIVFYPKGGVSHIQEQQMLTQKGENVHVVGIDGNFDQAQTAVKEMFNNKVLHDQLLKNNKQFSSANSMNIGRLIPQVAY
YIYAYAQLVKTGQITDGEEINFSVPTGNFGNILAAYYAKKLGLPVHQLICASNKNNVLTDFFKTGLYDKNREFYVTSSPS
MDILVSSNLERLIFELTDENDKVTSDLLTALSVEGHYQISKEMITKLQGFVADWASEDEISKEIQETFENEKYVLDPHTA
VANYVYHQIQPKEKTVVVSTASPYKFPKVVLEGLENDKTELSVNRDDFAAVKSLEKLSGIPLPKAVIGLEEAEVLHHTVI
PAAEMQKEVEKYLGLK
>Mature_496_residues
MVTFYQSTRDKSNKKTASQAILQGLAEDGGLFVPVDFPKVDLDFEKLKNASYQEIAELVLKAFFDDFSADEIKSMVTKAY
GEKFDSPEIAPLKRLGNHYILELFHGETIAFKDMALSILPHLMTQAAKKNGVTNEIVILTATSGDTGKAAMAGFADVPQT
KIIVFYPKGGVSHIQEQQMLTQKGENVHVVGIDGNFDQAQTAVKEMFNNKVLHDQLLKNNKQFSSANSMNIGRLIPQVAY
YIYAYAQLVKTGQITDGEEINFSVPTGNFGNILAAYYAKKLGLPVHQLICASNKNNVLTDFFKTGLYDKNREFYVTSSPS
MDILVSSNLERLIFELTDENDKVTSDLLTALSVEGHYQISKEMITKLQGFVADWASEDEISKEIQETFENEKYVLDPHTA
VANYVYHQIQPKEKTVVVSTASPYKFPKVVLEGLENDKTELSVNRDDFAAVKSLEKLSGIPLPKAVIGLEEAEVLHHTVI
PAAEMQKEVEKYLGLK

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=444, Percent_Identity=42.1171171171171, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI149193323, Length=437, Percent_Identity=32.0366132723112, Blast_Score=216, Evalue=3e-56,
Organism=Escherichia coli, GI1786185, Length=426, Percent_Identity=31.2206572769953, Blast_Score=187, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6319901, Length=473, Percent_Identity=35.3065539112051, Blast_Score=271, Evalue=1e-73,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 55222; Mature: 55222

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTFYQSTRDKSNKKTASQAILQGLAEDGGLFVPVDFPKVDLDFEKLKNASYQEIAELVL
CCEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCCCHHHHHHHHH
KAFFDDFSADEIKSMVTKAYGEKFDSPEIAPLKRLGNHYILELFHGETIAFKDMALSILP
HHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEECCCEEEHHHHHHHHHH
HLMTQAAKKNGVTNEIVILTATSGDTGKAAMAGFADVPQTKIIVFYPKGGVSHIQEQQML
HHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHH
TQKGENVHVVGIDGNFDQAQTAVKEMFNNKVLHDQLLKNNKQFSSANSMNIGRLIPQVAY
HHCCCEEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
YIYAYAQLVKTGQITDGEEINFSVPTGNFGNILAAYYAKKLGLPVHQLICASNKNNVLTD
HHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHH
FFKTGLYDKNREFYVTSSPSMDILVSSNLERLIFELTDENDKVTSDLLTALSVEGHYQIS
HHHCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHH
KEMITKLQGFVADWASEDEISKEIQETFENEKYVLDPHTAVANYVYHQIQPKEKTVVVST
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHCCCCCCEEEEEC
ASPYKFPKVVLEGLENDKTELSVNRDDFAAVKSLEKLSGIPLPKAVIGLEEAEVLHHTVI
CCCCCHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHC
PAAEMQKEVEKYLGLK
CHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVTFYQSTRDKSNKKTASQAILQGLAEDGGLFVPVDFPKVDLDFEKLKNASYQEIAELVL
CCEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCCCHHHHHHHHH
KAFFDDFSADEIKSMVTKAYGEKFDSPEIAPLKRLGNHYILELFHGETIAFKDMALSILP
HHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEECCCEEEHHHHHHHHHH
HLMTQAAKKNGVTNEIVILTATSGDTGKAAMAGFADVPQTKIIVFYPKGGVSHIQEQQML
HHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHH
TQKGENVHVVGIDGNFDQAQTAVKEMFNNKVLHDQLLKNNKQFSSANSMNIGRLIPQVAY
HHCCCEEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
YIYAYAQLVKTGQITDGEEINFSVPTGNFGNILAAYYAKKLGLPVHQLICASNKNNVLTD
HHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHH
FFKTGLYDKNREFYVTSSPSMDILVSSNLERLIFELTDENDKVTSDLLTALSVEGHYQIS
HHHCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHH
KEMITKLQGFVADWASEDEISKEIQETFENEKYVLDPHTAVANYVYHQIQPKEKTVVVST
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHCCCCCCEEEEEC
ASPYKFPKVVLEGLENDKTELSVNRDDFAAVKSLEKLSGIPLPKAVIGLEEAEVLHHTVI
CCCCCHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHC
PAAEMQKEVEKYLGLK
CHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]