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The map label for this gene is adk

Identifier: 15674059

GI number: 15674059

Start: 2157280

End: 2157927

Strand: Reverse

Name: adk

Synonym: L140714

Alternate gene names: 15674059

Gene position: 2157927-2157280 (Counterclockwise)

Preceding gene: 15674060

Following gene: 15674058

Centisome position: 91.22

GC content: 37.04

Gene sequence:

>648_bases
ATGAATTTATTAATCATGGGACTTCCAGGAGCTGGTAAAGGAACTCAAGCTGAGTTCATCGTTAAAAATTATGGAGTAAA
TCACATTTCAACAGGTGACATGTTCCGTGCCGCAATGAAAAACGAAACTGAAATGGGTAAACTTGCTAAATCTTTCATCG
ATAAAGGTGAACTCGTACCTGATGAAGTAACGAACGGAATTGTTAAAGAACGTTTAGCACAAGATGATATCAAAGCTTCA
GGCTTCTTGCTTGATGGATATCCACGTACGATTGACCAAGCTCATGCACTTGATACAATGCTTGAAGAACTCGGAATTAA
ACTTGATGCCGTTGTAAATATCGTTGTTAACCCAGATATTTTGGTTGACCGTTTAAGTGGCCGTTACATCTGCCGTAACT
GTGGAGCAACTTATCATAAAATCTTCAATCCAACTAAAGTTGAAGGCGTTTGTGACGTTTGTGGTAGTCATGACCTTTAT
CAACGTGCGGATGATGTTCCAGAAACAGTTAAAAATCGTTTGGATGTCAATATTAAAGAATCAGCTCCAATTATTGAACA
CTACACTGAACTTGGACTTGTTAAAAACATTGAAGGTGAACAAGAAATTAGCCAAGTAACAGAAGATATTAAAAAAGTTT
TAGGATAA

Upstream 100 bases:

>100_bases
AAAAATACGCTAAAATAGTGTAGGTAAAATCACAGAGAACATCTGCAATTTACTGACAGTTCTGTCAGTAATTTATAAAT
TAAAATCAGGAGAAAACAAA

Downstream 100 bases:

>100_bases
TAAAAATAAAAACCTCTGTCTGTAGTGACCCCCAAAATATAGACTTTTCAAATCTATATTTCGGAGGTCTTTTCTTATGG
TCAAATATTCCATAGAATTA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MNLLIMGLPGAGKGTQAEFIVKNYGVNHISTGDMFRAAMKNETEMGKLAKSFIDKGELVPDEVTNGIVKERLAQDDIKAS
GFLLDGYPRTIDQAHALDTMLEELGIKLDAVVNIVVNPDILVDRLSGRYICRNCGATYHKIFNPTKVEGVCDVCGSHDLY
QRADDVPETVKNRLDVNIKESAPIIEHYTELGLVKNIEGEQEISQVTEDIKKVLG

Sequences:

>Translated_215_residues
MNLLIMGLPGAGKGTQAEFIVKNYGVNHISTGDMFRAAMKNETEMGKLAKSFIDKGELVPDEVTNGIVKERLAQDDIKAS
GFLLDGYPRTIDQAHALDTMLEELGIKLDAVVNIVVNPDILVDRLSGRYICRNCGATYHKIFNPTKVEGVCDVCGSHDLY
QRADDVPETVKNRLDVNIKESAPIIEHYTELGLVKNIEGEQEISQVTEDIKKVLG
>Mature_215_residues
MNLLIMGLPGAGKGTQAEFIVKNYGVNHISTGDMFRAAMKNETEMGKLAKSFIDKGELVPDEVTNGIVKERLAQDDIKAS
GFLLDGYPRTIDQAHALDTMLEELGIKLDAVVNIVVNPDILVDRLSGRYICRNCGATYHKIFNPTKVEGVCDVCGSHDLY
QRADDVPETVKNRLDVNIKESAPIIEHYTELGLVKNIEGEQEISQVTEDIKKVLG

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=198, Percent_Identity=38.3838383838384, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI4502013, Length=198, Percent_Identity=38.3838383838384, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI19923437, Length=204, Percent_Identity=38.7254901960784, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI310110345, Length=201, Percent_Identity=37.8109452736318, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI53832003, Length=201, Percent_Identity=37.8109452736318, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI8051579, Length=201, Percent_Identity=37.8109452736318, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI53832001, Length=201, Percent_Identity=37.8109452736318, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI4502011, Length=208, Percent_Identity=27.8846153846154, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI28144899, Length=208, Percent_Identity=30.7692307692308, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI28144897, Length=208, Percent_Identity=30.7692307692308, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI22749187, Length=209, Percent_Identity=29.1866028708134, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI7706497, Length=216, Percent_Identity=26.3888888888889, Blast_Score=92, Evalue=3e-19,
Organism=Escherichia coli, GI1786680, Length=220, Percent_Identity=46.3636363636364, Blast_Score=184, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17552384, Length=215, Percent_Identity=35.3488372093023, Blast_Score=137, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17537943, Length=216, Percent_Identity=32.8703703703704, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17567503, Length=205, Percent_Identity=30.7317073170732, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17550688, Length=217, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17533833, Length=215, Percent_Identity=30.2325581395349, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320432, Length=215, Percent_Identity=38.1395348837209, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6321018, Length=197, Percent_Identity=36.0406091370558, Blast_Score=127, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6322828, Length=215, Percent_Identity=28.3720930232558, Blast_Score=92, Evalue=6e-20,
Organism=Drosophila melanogaster, GI22026816, Length=214, Percent_Identity=36.4485981308411, Blast_Score=148, Evalue=3e-36,
Organism=Drosophila melanogaster, GI17737899, Length=198, Percent_Identity=38.8888888888889, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24645822, Length=198, Percent_Identity=38.8888888888889, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI221459597, Length=216, Percent_Identity=27.7777777777778, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21356893, Length=216, Percent_Identity=27.7777777777778, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24663208, Length=196, Percent_Identity=24.4897959183673, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17647141, Length=196, Percent_Identity=24.4897959183673, Blast_Score=70, Evalue=9e-13,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_LACLA (P58117)

Other databases:

- EMBL:   AE005176
- PIR:   E86884
- RefSeq:   NP_268234.1
- ProteinModelPortal:   P58117
- SMR:   P58117
- GeneID:   1115754
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L140714
- NMPDR:   fig|272623.1.peg.2132
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   PRK00279
- BioCyc:   LLAC272623:L140714-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23688; Mature: 23688

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLIMGLPGAGKGTQAEFIVKNYGVNHISTGDMFRAAMKNETEMGKLAKSFIDKGELVP
CCEEEEECCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCH
DEVTNGIVKERLAQDDIKASGFLLDGYPRTIDQAHALDTMLEELGIKLDAVVNIVVNPDI
HHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCHHHEEEEECCHH
LVDRLSGRYICRNCGATYHKIFNPTKVEGVCDVCGSHDLYQRADDVPETVKNRLDVNIKE
HHHHHCCCHHHHHCCCHHHHHCCCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHCCCCCCC
SAPIIEHYTELGLVKNIEGEQEISQVTEDIKKVLG
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNLLIMGLPGAGKGTQAEFIVKNYGVNHISTGDMFRAAMKNETEMGKLAKSFIDKGELVP
CCEEEEECCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCH
DEVTNGIVKERLAQDDIKASGFLLDGYPRTIDQAHALDTMLEELGIKLDAVVNIVVNPDI
HHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCHHHEEEEECCHH
LVDRLSGRYICRNCGATYHKIFNPTKVEGVCDVCGSHDLYQRADDVPETVKNRLDVNIKE
HHHHHCCCHHHHHCCCHHHHHCCCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHCCCCCCC
SAPIIEHYTELGLVKNIEGEQEISQVTEDIKKVLG
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471