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The map label for this gene is yugC

Identifier: 15673970

GI number: 15673970

Start: 2067601

End: 2068578

Strand: Reverse

Name: yugC

Synonym: L51032

Alternate gene names: 15673970

Gene position: 2068578-2067601 (Counterclockwise)

Preceding gene: 15673971

Following gene: 15673969

Centisome position: 87.44

GC content: 35.48

Gene sequence:

>978_bases
ATGATAAAAGCAATTGCCTTAGAAAATGTTTGGTTAAATTTTTCAGATGAAACAAAAGCGGCTTTCAAGAAAAATAAAGC
TTACCAGTTTCAATTTAAAAAAGAAGAAGAGCTGACAGAATCAGATTTTCTGGAAACAGAAGTATTAGTTGGTCTGCCAA
AGCCTGATTTATTAGCAAAATATAAAAATTTAAAATGGCTCCAACTTTTATCAGCTGGGACCAATGGTTATACTCAAGGA
GCAAATTTTCCTCAAGAGGTAGTTTTGACAAATGCAACAGGAACTTATGGACTTACGATTTCTGAGCATTTACTAACAAT
GGCTTTCGTTCTTCTAAGAAAATTTGACCTTTATCAAAAACAACAAGAAAAAGAAATCTGGGAAAATATTGGTCAGATTC
AATCTATTTATGGCTCAACAGTATTGGTTCATGGTTTAGGTGATATTGGAAGTCACTTTGCACAAAAGATTCAAGCTTTG
GGAGGTCATGTCATTGCAGTCAAACGAACTGTTTATGGTGATGAAGAATTTGCTGATGAAGTCTATGCCGAAACTGACCT
AGACAAAGTTTTACCGAGAGCTGATATTATTGCTTCAAGTGTCCCTGGGACCCATGAAACTTATAAATTATTTAATCAAG
AAAAATTTGATTTAATGAAAGAAAATGCTATTTTCCTAAATGTTGGTCGGGGAACAAATGTCGATTTAGAAGCCTTGTGT
GATGCTCTTGAGTCTAAAAAAATTGCTGGGGCAGGAATTGACGTGACCGACCCAGAACCATTGCCTAAAGGTCACCGGGC
TTGGCATACAGAAAGACTATTAATCACTCCTCATGCTTCTGGCGGTTATACTCTTCCTGAAACATGGCGTCGCTTTATGA
AAATATTGGAAAAAAATCTCGATGCCTATGCAAATGGTAAGGAATTGACAAATATTGTTGATATGAAAACAGGATATAAA
CGAAATGCTCACAAATAA

Upstream 100 bases:

>100_bases
GGCAAAGTGCTATAATCAAAGAAAGAAGATAAAGAAAACAAGGCTTGACTTTATTCTCTTTAAGTAGTCTTTAAAATTCA
TTTTATACAAAGGAGTCCCA

Downstream 100 bases:

>100_bases
TATTTCAAAATCAAAATTAAGTGGAAAAAATATCGGTATTTATTTTGGAACTTTTGCTCCTCTACATACGGGGCATCAGC
AACAAATCTATAAATGTGCG

Product: dehydrogenase

Products: NADPH; glyoxylate; glycerate [C]

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MIKAIALENVWLNFSDETKAAFKKNKAYQFQFKKEEELTESDFLETEVLVGLPKPDLLAKYKNLKWLQLLSAGTNGYTQG
ANFPQEVVLTNATGTYGLTISEHLLTMAFVLLRKFDLYQKQQEKEIWENIGQIQSIYGSTVLVHGLGDIGSHFAQKIQAL
GGHVIAVKRTVYGDEEFADEVYAETDLDKVLPRADIIASSVPGTHETYKLFNQEKFDLMKENAIFLNVGRGTNVDLEALC
DALESKKIAGAGIDVTDPEPLPKGHRAWHTERLLITPHASGGYTLPETWRRFMKILEKNLDAYANGKELTNIVDMKTGYK
RNAHK

Sequences:

>Translated_325_residues
MIKAIALENVWLNFSDETKAAFKKNKAYQFQFKKEEELTESDFLETEVLVGLPKPDLLAKYKNLKWLQLLSAGTNGYTQG
ANFPQEVVLTNATGTYGLTISEHLLTMAFVLLRKFDLYQKQQEKEIWENIGQIQSIYGSTVLVHGLGDIGSHFAQKIQAL
GGHVIAVKRTVYGDEEFADEVYAETDLDKVLPRADIIASSVPGTHETYKLFNQEKFDLMKENAIFLNVGRGTNVDLEALC
DALESKKIAGAGIDVTDPEPLPKGHRAWHTERLLITPHASGGYTLPETWRRFMKILEKNLDAYANGKELTNIVDMKTGYK
RNAHK
>Mature_325_residues
MIKAIALENVWLNFSDETKAAFKKNKAYQFQFKKEEELTESDFLETEVLVGLPKPDLLAKYKNLKWLQLLSAGTNGYTQG
ANFPQEVVLTNATGTYGLTISEHLLTMAFVLLRKFDLYQKQQEKEIWENIGQIQSIYGSTVLVHGLGDIGSHFAQKIQAL
GGHVIAVKRTVYGDEEFADEVYAETDLDKVLPRADIIASSVPGTHETYKLFNQEKFDLMKENAIFLNVGRGTNVDLEALC
DALESKKIAGAGIDVTDPEPLPKGHRAWHTERLLITPHASGGYTLPETWRRFMKILEKNLDAYANGKELTNIVDMKTGYK
RNAHK

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=145, Percent_Identity=36.551724137931, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI23308577, Length=236, Percent_Identity=26.271186440678, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI87081824, Length=226, Percent_Identity=26.9911504424779, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87082289, Length=281, Percent_Identity=27.4021352313167, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1789279, Length=294, Percent_Identity=25.8503401360544, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787645, Length=161, Percent_Identity=27.3291925465839, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=280, Percent_Identity=26.4285714285714, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320925, Length=303, Percent_Identity=26.0726072607261, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322116, Length=297, Percent_Identity=25.9259259259259, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324055, Length=195, Percent_Identity=29.7435897435897, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324964, Length=276, Percent_Identity=24.6376811594203, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28574286, Length=235, Percent_Identity=28.0851063829787, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28571528, Length=182, Percent_Identity=32.967032967033, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45552429, Length=224, Percent_Identity=27.2321428571429, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24585514, Length=224, Percent_Identity=27.2321428571429, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28574282, Length=224, Percent_Identity=27.2321428571429, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28574284, Length=224, Percent_Identity=27.2321428571429, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45551003, Length=224, Percent_Identity=27.2321428571429, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24585516, Length=173, Percent_Identity=32.9479768786127, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI19921140, Length=226, Percent_Identity=28.7610619469027, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: NA

Molecular weight: Translated: 36569; Mature: 36569

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKAIALENVWLNFSDETKAAFKKNKAYQFQFKKEEELTESDFLETEVLVGLPKPDLLAK
CCEEEEEEEEEECCCCHHHHHHHCCCCEEEEECCHHHCCHHHHHHHHHEEECCCHHHHHH
YKNLKWLQLLSAGTNGYTQGANFPQEVVLTNATGTYGLTISEHLLTMAFVLLRKFDLYQK
HCCCHHHHHHHCCCCCCCCCCCCCHHEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHH
QQEKEIWENIGQIQSIYGSTVLVHGLGDIGSHFAQKIQALGGHVIAVKRTVYGDEEFADE
HHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHH
VYAETDLDKVLPRADIIASSVPGTHETYKLFNQEKFDLMKENAIFLNVGRGTNVDLEALC
HHHHCCHHHHCCHHHHHHCCCCCCHHHHHHHCHHHHHHHHCCEEEEECCCCCCCCHHHHH
DALESKKIAGAGIDVTDPEPLPKGHRAWHTERLLITPHASGGYTLPETWRRFMKILEKNL
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHH
DAYANGKELTNIVDMKTGYKRNAHK
HHHCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MIKAIALENVWLNFSDETKAAFKKNKAYQFQFKKEEELTESDFLETEVLVGLPKPDLLAK
CCEEEEEEEEEECCCCHHHHHHHCCCCEEEEECCHHHCCHHHHHHHHHEEECCCHHHHHH
YKNLKWLQLLSAGTNGYTQGANFPQEVVLTNATGTYGLTISEHLLTMAFVLLRKFDLYQK
HCCCHHHHHHHCCCCCCCCCCCCCHHEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHH
QQEKEIWENIGQIQSIYGSTVLVHGLGDIGSHFAQKIQALGGHVIAVKRTVYGDEEFADE
HHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHH
VYAETDLDKVLPRADIIASSVPGTHETYKLFNQEKFDLMKENAIFLNVGRGTNVDLEALC
HHHHCCHHHHCCHHHHHHCCCCCCHHHHHHHCHHHHHHHHCCEEEEECCCCCCCCHHHHH
DALESKKIAGAGIDVTDPEPLPKGHRAWHTERLLITPHASGGYTLPETWRRFMKILEKNL
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHH
DAYANGKELTNIVDMKTGYKRNAHK
HHHCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycolate; NADP; hydroxypyruvate; NADPH [C]

Specific reaction: glycolate + NADP = NADPH + glyoxylate hydroxypyruvate + NADPH = glycerate + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]