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The map label for this gene is recQ

Identifier: 15673790

GI number: 15673790

Start: 1873622

End: 1875400

Strand: Direct

Name: recQ

Synonym: L0268

Alternate gene names: 15673790

Gene position: 1873622-1875400 (Clockwise)

Preceding gene: 15673788

Following gene: 15673798

Centisome position: 79.2

GC content: 37.16

Gene sequence:

>1779_bases
ATGAATTTAGAAGCTAAATTAAAAGAAATTTTTGGTTATGACAATTTCCGAAATGGTCAGAAACAAATTATTGAACAAGT
CCTAGATGGACAAGCCACTCTTGGTATTTTACCCACAGGAGCTGGAAAATCAATCTGCTATCAGTTACCAGCTCTTATTC
AACCAGGGCTTACTCTCGTAATCTCCCCACTTATTAGCTTGATGAAAGATCAAGTCGACCAGCTGAATATTGCCGGAATT
CCAGCAACATTTATTAACTCTACCTTAGAGGATTCCGAATCTTATCAAAGAATGCGACAGGTTGAAAATGGCGAAATCAA
GCTTCTTTTTGTAGCACCAGAGCGTTTTTCATTAGACTATTTCAATGCCTTTTTACAAAAACTTCCAATTGATTTAGTTG
CCATAGACGAAGCACACTGCATTTCACAATGGGGGCACGATTTCAGACCCAGTTATGTCGATTTTGCCTCTCATCTCCAA
TATTTACCAACAAATCCTACCGTCTTAGCCCTTACGGCTACTGCGACACCAAAAGTTGCAGATGATATTCAAAAACTTCT
TTCAATTTCCCCCAGTCATACTATTAAAACCGGTTTTCTTAGAGAAAACTTACGTTTTGAAGTAGTCAAAGGGATGGATA
AGAGAACTTTTCTTAAAAATTATCTTAAAAATCAAGAAAGTGAGGCTGCTGGAATTATCTATGCAAGCACTCGTAAAGAA
GTTGAAGAAATTTGTGAATGGCTCAACCATAATCATTTCAAATCCGTTCGTTACCATGCTGGACTGAGCGAACAGGAACG
TCAAATAAATCAAGAACTTTTTCTCTTTGACGAAGTACCGATAATGGTTGCCACTAATGCTTTTGGCATGGGAATCAATA
AACCAAATGTTCGATTTGTGATTCATTATGCCCTTCCCGCAACAATTGAAAGTTATTATCAAGAAGCTGGGCGAGCAGGA
CGGGACGGGCTTGAATCTGATGCTAACCTCCTTTTTTCACCAAATGATTTACGAATTCGTAATTTCTTGATTGAGCAAAG
TGAAGGTGATGAAGCGCACAAGGAACATGAATACGAAAAGCTTCGACAAATGCAAGCATACACAAGTGCCGAAACCTGTT
TACAACGCTATATCTTGCAATATTTTGGTGATGAAGGTGAAGATTGTAAAAAATGTAGTAATTGTCTTGATGAAAGAGAG
CTTCTCGATATTACAATTGATGCTCAAAAAGTCCTATCTTGTGTCGTCCGAATGGGTGAACGTTTTGGTAAGACGGCCGT
AGCACAAGTTTTGATTGGTTCTAAAAATAAAAATATTGCCAAATGGAATTTTGAATCTCTATCGACTTTTGGAATTATGA
AAAACCATTCCCAAAAGACCGTGGGTGAATTAATCGATTTTCTATCTGCTGAAAGTTATTTAAACATTACATCAGGTAAA
TTCCCACTTCTCCTTCTTTCAGCCCAAGGATTAAAAGTCCTCAAAGGACAAATCAAAGTTTATCGCAAAGCTAGCCTAAT
TATTGAATCGAAAACAAAAATTTCTCATCATTTTGATGAAGAATGTTTTGCAAGTATTCGTGCACTTCGACTTGAACTAG
CCAAGGAAGAAGGCGTCCCTCCTTTCATGATTTTTTCTGATAGTGCCCTTAAAGAAATGGCTCAAGTTCTGCCGGATAGT
CAAAGTCAATTTTTACAAATTTCTGGTGTCGGACCTGTTAAACTCAAAAAATATGGAAGGCTTTTTATCGACAAAATATC
TGAATATAAAAAAAGCTGA

Upstream 100 bases:

>100_bases
AACATCTTGGTTCTTTTAATGTAATCTTTGAACCATTCGTTATCAATTTTTATGAGTCATTTGTGATTTTTTTTCTTCTT
TTACGTATAATATAGTAAGA

Downstream 100 bases:

>100_bases
GCAAACTCAGCTTTTATTTTTTTAAAATAATTTTATTACAAGTTATTTTTCTTTCTATAGTTGCGCATCATGAAGTAGGC
AATTACACCAAAGATAAGTG

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MNLEAKLKEIFGYDNFRNGQKQIIEQVLDGQATLGILPTGAGKSICYQLPALIQPGLTLVISPLISLMKDQVDQLNIAGI
PATFINSTLEDSESYQRMRQVENGEIKLLFVAPERFSLDYFNAFLQKLPIDLVAIDEAHCISQWGHDFRPSYVDFASHLQ
YLPTNPTVLALTATATPKVADDIQKLLSISPSHTIKTGFLRENLRFEVVKGMDKRTFLKNYLKNQESEAAGIIYASTRKE
VEEICEWLNHNHFKSVRYHAGLSEQERQINQELFLFDEVPIMVATNAFGMGINKPNVRFVIHYALPATIESYYQEAGRAG
RDGLESDANLLFSPNDLRIRNFLIEQSEGDEAHKEHEYEKLRQMQAYTSAETCLQRYILQYFGDEGEDCKKCSNCLDERE
LLDITIDAQKVLSCVVRMGERFGKTAVAQVLIGSKNKNIAKWNFESLSTFGIMKNHSQKTVGELIDFLSAESYLNITSGK
FPLLLLSAQGLKVLKGQIKVYRKASLIIESKTKISHHFDEECFASIRALRLELAKEEGVPPFMIFSDSALKEMAQVLPDS
QSQFLQISGVGPVKLKKYGRLFIDKISEYKKS

Sequences:

>Translated_592_residues
MNLEAKLKEIFGYDNFRNGQKQIIEQVLDGQATLGILPTGAGKSICYQLPALIQPGLTLVISPLISLMKDQVDQLNIAGI
PATFINSTLEDSESYQRMRQVENGEIKLLFVAPERFSLDYFNAFLQKLPIDLVAIDEAHCISQWGHDFRPSYVDFASHLQ
YLPTNPTVLALTATATPKVADDIQKLLSISPSHTIKTGFLRENLRFEVVKGMDKRTFLKNYLKNQESEAAGIIYASTRKE
VEEICEWLNHNHFKSVRYHAGLSEQERQINQELFLFDEVPIMVATNAFGMGINKPNVRFVIHYALPATIESYYQEAGRAG
RDGLESDANLLFSPNDLRIRNFLIEQSEGDEAHKEHEYEKLRQMQAYTSAETCLQRYILQYFGDEGEDCKKCSNCLDERE
LLDITIDAQKVLSCVVRMGERFGKTAVAQVLIGSKNKNIAKWNFESLSTFGIMKNHSQKTVGELIDFLSAESYLNITSGK
FPLLLLSAQGLKVLKGQIKVYRKASLIIESKTKISHHFDEECFASIRALRLELAKEEGVPPFMIFSDSALKEMAQVLPDS
QSQFLQISGVGPVKLKKYGRLFIDKISEYKKS
>Mature_592_residues
MNLEAKLKEIFGYDNFRNGQKQIIEQVLDGQATLGILPTGAGKSICYQLPALIQPGLTLVISPLISLMKDQVDQLNIAGI
PATFINSTLEDSESYQRMRQVENGEIKLLFVAPERFSLDYFNAFLQKLPIDLVAIDEAHCISQWGHDFRPSYVDFASHLQ
YLPTNPTVLALTATATPKVADDIQKLLSISPSHTIKTGFLRENLRFEVVKGMDKRTFLKNYLKNQESEAAGIIYASTRKE
VEEICEWLNHNHFKSVRYHAGLSEQERQINQELFLFDEVPIMVATNAFGMGINKPNVRFVIHYALPATIESYYQEAGRAG
RDGLESDANLLFSPNDLRIRNFLIEQSEGDEAHKEHEYEKLRQMQAYTSAETCLQRYILQYFGDEGEDCKKCSNCLDERE
LLDITIDAQKVLSCVVRMGERFGKTAVAQVLIGSKNKNIAKWNFESLSTFGIMKNHSQKTVGELIDFLSAESYLNITSGK
FPLLLLSAQGLKVLKGQIKVYRKASLIIESKTKISHHFDEECFASIRALRLELAKEEGVPPFMIFSDSALKEMAQVLPDS
QSQFLQISGVGPVKLKKYGRLFIDKISEYKKS

Specific function: Probable DNA helicase. Required for DNA repair and intramolecular recombination; probably has overlapping function with recS (AC P50729). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm, nucleoid. Note=Localized throughout the nucleoid in the presence or absence of DNA double- strand breaks [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=627, Percent_Identity=33.652312599681, Blast_Score=309, Evalue=4e-84,
Organism=Homo sapiens, GI110735439, Length=484, Percent_Identity=35.5371900826446, Blast_Score=270, Evalue=3e-72,
Organism=Homo sapiens, GI169218196, Length=484, Percent_Identity=35.5371900826446, Blast_Score=269, Evalue=4e-72,
Organism=Homo sapiens, GI14591902, Length=412, Percent_Identity=36.4077669902913, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI14591904, Length=412, Percent_Identity=36.4077669902913, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI148612816, Length=420, Percent_Identity=36.4285714285714, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI51242943, Length=363, Percent_Identity=38.8429752066116, Blast_Score=241, Evalue=2e-63,
Organism=Homo sapiens, GI51242947, Length=363, Percent_Identity=38.8429752066116, Blast_Score=241, Evalue=2e-63,
Organism=Homo sapiens, GI284005309, Length=354, Percent_Identity=35.3107344632768, Blast_Score=207, Evalue=3e-53,
Organism=Homo sapiens, GI4758138, Length=370, Percent_Identity=24.5945945945946, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI169881239, Length=152, Percent_Identity=29.6052631578947, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI13514809, Length=152, Percent_Identity=29.6052631578947, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI31542656, Length=345, Percent_Identity=23.1884057971014, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI301171475, Length=152, Percent_Identity=28.2894736842105, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI87196351, Length=152, Percent_Identity=28.2894736842105, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI301171467, Length=152, Percent_Identity=28.2894736842105, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI48994977, Length=600, Percent_Identity=40, Blast_Score=431, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI25145561, Length=648, Percent_Identity=31.9444444444444, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI32564293, Length=499, Percent_Identity=34.4689378757515, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17552866, Length=428, Percent_Identity=35.2803738317757, Blast_Score=255, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI71987997, Length=404, Percent_Identity=36.8811881188119, Blast_Score=251, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI71987993, Length=404, Percent_Identity=36.6336633663366, Blast_Score=250, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17510309, Length=159, Percent_Identity=33.3333333333333, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17510307, Length=159, Percent_Identity=33.3333333333333, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71995514, Length=159, Percent_Identity=33.3333333333333, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71995718, Length=152, Percent_Identity=27.6315789473684, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17537549, Length=378, Percent_Identity=22.2222222222222, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115533224, Length=334, Percent_Identity=24.251497005988, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17507945, Length=334, Percent_Identity=22.7544910179641, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=525, Percent_Identity=34.0952380952381, Blast_Score=274, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6324217, Length=351, Percent_Identity=26.2108262108262, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320224, Length=348, Percent_Identity=22.1264367816092, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6325138, Length=262, Percent_Identity=28.2442748091603, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321856, Length=359, Percent_Identity=26.1838440111421, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321360, Length=348, Percent_Identity=24.7126436781609, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324778, Length=250, Percent_Identity=24.8, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24646066, Length=628, Percent_Identity=32.9617834394904, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI24664226, Length=422, Percent_Identity=34.5971563981043, Blast_Score=243, Evalue=3e-64,
Organism=Drosophila melanogaster, GI62472181, Length=422, Percent_Identity=34.8341232227488, Blast_Score=243, Evalue=3e-64,
Organism=Drosophila melanogaster, GI24664230, Length=422, Percent_Identity=34.8341232227488, Blast_Score=243, Evalue=3e-64,
Organism=Drosophila melanogaster, GI21358123, Length=358, Percent_Identity=39.9441340782123, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI28574962, Length=356, Percent_Identity=25.561797752809, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24644479, Length=343, Percent_Identity=22.7405247813411, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24644487, Length=343, Percent_Identity=22.7405247813411, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI45551833, Length=343, Percent_Identity=22.7405247813411, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24644485, Length=343, Percent_Identity=22.7405247813411, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI281361218, Length=343, Percent_Identity=22.7405247813411, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24644481, Length=343, Percent_Identity=22.7405247813411, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24644483, Length=343, Percent_Identity=22.7405247813411, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17985987, Length=369, Percent_Identity=23.3062330623306, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 66960; Mature: 66960

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLEAKLKEIFGYDNFRNGQKQIIEQVLDGQATLGILPTGAGKSICYQLPALIQPGLTLV
CCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHH
ISPLISLMKDQVDQLNIAGIPATFINSTLEDSESYQRMRQVENGEIKLLFVAPERFSLDY
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHH
FNAFLQKLPIDLVAIDEAHCISQWGHDFRPSYVDFASHLQYLPTNPTVLALTATATPKVA
HHHHHHHCCCCEEEECHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCEEEEEEECCCCHHH
DDIQKLLSISPSHTIKTGFLRENLRFEVVKGMDKRTFLKNYLKNQESEAAGIIYASTRKE
HHHHHHHCCCCCCCEEHHHHHCCCHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEHHHHH
VEEICEWLNHNHFKSVRYHAGLSEQERQINQELFLFDEVPIMVATNAFGMGINKPNVRFV
HHHHHHHHCCCCHHHHHHHCCCCHHHHHHCCCEEEEECCCEEEEECCCCCCCCCCCEEEE
IHYALPATIESYYQEAGRAGRDGLESDANLLFSPNDLRIRNFLIEQSEGDEAHKEHEYEK
EEEECHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCEEHHHHEECCCCCHHHHHHHHHH
LRQMQAYTSAETCLQRYILQYFGDEGEDCKKCSNCLDERELLDITIDAQKVLSCVVRMGE
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHEEEEECHHHHHHHHHHHHH
RFGKTAVAQVLIGSKNKNIAKWNFESLSTFGIMKNHSQKTVGELIDFLSAESYLNITSGK
HHCHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCC
FPLLLLSAQGLKVLKGQIKVYRKASLIIESKTKISHHFDEECFASIRALRLELAKEEGVP
CCEEEEECCCHHHHHHHHHHHHHHHHEEECCHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
PFMIFSDSALKEMAQVLPDSQSQFLQISGVGPVKLKKYGRLFIDKISEYKKS
CEEEECCHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLEAKLKEIFGYDNFRNGQKQIIEQVLDGQATLGILPTGAGKSICYQLPALIQPGLTLV
CCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHH
ISPLISLMKDQVDQLNIAGIPATFINSTLEDSESYQRMRQVENGEIKLLFVAPERFSLDY
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHH
FNAFLQKLPIDLVAIDEAHCISQWGHDFRPSYVDFASHLQYLPTNPTVLALTATATPKVA
HHHHHHHCCCCEEEECHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCEEEEEEECCCCHHH
DDIQKLLSISPSHTIKTGFLRENLRFEVVKGMDKRTFLKNYLKNQESEAAGIIYASTRKE
HHHHHHHCCCCCCCEEHHHHHCCCHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEHHHHH
VEEICEWLNHNHFKSVRYHAGLSEQERQINQELFLFDEVPIMVATNAFGMGINKPNVRFV
HHHHHHHHCCCCHHHHHHHCCCCHHHHHHCCCEEEEECCCEEEEECCCCCCCCCCCEEEE
IHYALPATIESYYQEAGRAGRDGLESDANLLFSPNDLRIRNFLIEQSEGDEAHKEHEYEK
EEEECHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCEEHHHHEECCCCCHHHHHHHHHH
LRQMQAYTSAETCLQRYILQYFGDEGEDCKKCSNCLDERELLDITIDAQKVLSCVVRMGE
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHEEEEECHHHHHHHHHHHHH
RFGKTAVAQVLIGSKNKNIAKWNFESLSTFGIMKNHSQKTVGELIDFLSAESYLNITSGK
HHCHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCC
FPLLLLSAQGLKVLKGQIKVYRKASLIIESKTKISHHFDEECFASIRALRLELAKEEGVP
CCEEEEECCCHHHHHHHHHHHHHHHHEEECCHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
PFMIFSDSALKEMAQVLPDSQSQFLQISGVGPVKLKKYGRLFIDKISEYKKS
CEEEECCHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9642195 [H]