Click here to switch to the map view.

The map label for this gene is fadA

Identifier: 15673765

GI number: 15673765

Start: 1842622

End: 1843770

Strand: Direct

Name: fadA

Synonym: L25946

Alternate gene names: 15673765

Gene position: 1842622-1843770 (Clockwise)

Preceding gene: 15673764

Following gene: 15673766

Centisome position: 77.89

GC content: 36.29

Gene sequence:

>1149_bases
ATGAGCTTTAAAAATCCCGTCGGTATCATAGCAGCAAACCGTTTACCTATAGGAAAAATCAATGGTTTTTATAAAAAAAT
TTCTCCTGAAACTTTATATCAAAATCTAATTAAACAACAATTTAATAAAAATCTACTTCTCAAAAAAGCTGATATTGACT
ATATTATTTTGGGAAATGTGACTAATCAAGGAGGAAATTTAGCTCGACGTTGTGCCTTAAAAGCAGGATTTTCTAGCCAG
GTCCCAGCTTTTACAATTGACCAGCAGTGCGGTTCTGGACTGACAGCTATGATTAGCTCTGCAAACTACATTATTTCTGG
TGAAGCTTCCGTTATTTGTACAGGAGGGGTAGAAAGCACATCTCAAGCCAATATTGTGCTTGATTCAGAGAGTTATCAGC
CGATTAACCGATTTAAAATGGCTCCTGAACCCTATGAAGATTTCGACATGGGAACAATTGCCGATATGACAGCCCTAAAA
TACAATATTCCTCGTAGTGTTCAAGACCTTTACGCTCTAAATAGTCATAAAAAAGCGACTCAAGCTATTGAAGGAAAACT
TTTAGAAAATGAAGTTTTTCCCTATCAAGATGAAGGATTTACAATAAGTAGCGATCAAACTGTTCGTCCTAAATCCTCAA
TGGAAGCTTTGAGCAAATTAACCCCTGCTTTTACCACTAACGGAACAGCCACTGCTGGAAACTCTTGCCCAATAAACGAT
GGTGCTTCTTCAATCATATTGTCATCCACTAATAATCCTTTTGATTTTCAAGGCTATTATTTAGGACAAACAACTATTGC
TTTATCTCCATCAGATTTCTTATTAGGCCCAATAAAAGCAACTGAAAAACTTTTACAGAAATTTAACCTTAAACTTAATG
ATATTGAGGCTATCGAATTAAATGAAGCCTTTGCCAGTCAGGCCATTTTATTCCAAAATTATTTTAAGCTTGATGATATA
AAATTAAATGCTTATGGTGGTTCCCTTGCATTTGGTCATCCTTACGGTGCAACTGGTGGCATTCTAATTTCTCGACTCTT
AAATCGCCTAAACCAAGTGCAAAAACCATGTCTTGGCATCGCAACTTTGTGCGTAGCTGGAGGTATGGGAATCAGTGTAC
TGATAGGTAATCAATGGTATCAAAAATGA

Upstream 100 bases:

>100_bases
CTTCCTCAAATATATTTAGAAACTCCCACTCTTAATTTTACTAAAAATCAAAAAATATCCAGAAAAGAATTAGAAAAAGA
ATATTTTAGAGGTGTCTATC

Downstream 100 bases:

>100_bases
TTTTAATCGCTCAAAAAAGTCTTCCAAGACATTTTAAATTAGAGGGCCAAAAAAATTTTCTCTCCTTACTTCCACAATTG
TGGCAAGAATTAGAAGGAAT

Product: acetyl coenzyme A acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MSFKNPVGIIAANRLPIGKINGFYKKISPETLYQNLIKQQFNKNLLLKKADIDYIILGNVTNQGGNLARRCALKAGFSSQ
VPAFTIDQQCGSGLTAMISSANYIISGEASVICTGGVESTSQANIVLDSESYQPINRFKMAPEPYEDFDMGTIADMTALK
YNIPRSVQDLYALNSHKKATQAIEGKLLENEVFPYQDEGFTISSDQTVRPKSSMEALSKLTPAFTTNGTATAGNSCPIND
GASSIILSSTNNPFDFQGYYLGQTTIALSPSDFLLGPIKATEKLLQKFNLKLNDIEAIELNEAFASQAILFQNYFKLDDI
KLNAYGGSLAFGHPYGATGGILISRLLNRLNQVQKPCLGIATLCVAGGMGISVLIGNQWYQK

Sequences:

>Translated_382_residues
MSFKNPVGIIAANRLPIGKINGFYKKISPETLYQNLIKQQFNKNLLLKKADIDYIILGNVTNQGGNLARRCALKAGFSSQ
VPAFTIDQQCGSGLTAMISSANYIISGEASVICTGGVESTSQANIVLDSESYQPINRFKMAPEPYEDFDMGTIADMTALK
YNIPRSVQDLYALNSHKKATQAIEGKLLENEVFPYQDEGFTISSDQTVRPKSSMEALSKLTPAFTTNGTATAGNSCPIND
GASSIILSSTNNPFDFQGYYLGQTTIALSPSDFLLGPIKATEKLLQKFNLKLNDIEAIELNEAFASQAILFQNYFKLDDI
KLNAYGGSLAFGHPYGATGGILISRLLNRLNQVQKPCLGIATLCVAGGMGISVLIGNQWYQK
>Mature_381_residues
SFKNPVGIIAANRLPIGKINGFYKKISPETLYQNLIKQQFNKNLLLKKADIDYIILGNVTNQGGNLARRCALKAGFSSQV
PAFTIDQQCGSGLTAMISSANYIISGEASVICTGGVESTSQANIVLDSESYQPINRFKMAPEPYEDFDMGTIADMTALKY
NIPRSVQDLYALNSHKKATQAIEGKLLENEVFPYQDEGFTISSDQTVRPKSSMEALSKLTPAFTTNGTATAGNSCPINDG
ASSIILSSTNNPFDFQGYYLGQTTIALSPSDFLLGPIKATEKLLQKFNLKLNDIEAIELNEAFASQAILFQNYFKLDDIK
LNAYGGSLAFGHPYGATGGILISRLLNRLNQVQKPCLGIATLCVAGGMGISVLIGNQWYQK

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=395, Percent_Identity=29.620253164557, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI4501853, Length=371, Percent_Identity=32.0754716981132, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI4504327, Length=422, Percent_Identity=32.4644549763033, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI148539872, Length=392, Percent_Identity=29.5918367346939, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI4557237, Length=389, Percent_Identity=29.0488431876607, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI194353979, Length=382, Percent_Identity=25.3926701570681, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI87082165, Length=388, Percent_Identity=31.701030927835, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI1788554, Length=398, Percent_Identity=35.1758793969849, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI48994986, Length=385, Percent_Identity=31.1688311688312, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1787663, Length=393, Percent_Identity=31.0432569974555, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1788683, Length=401, Percent_Identity=26.1845386533666, Blast_Score=134, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=28.9002557544757, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI25147385, Length=377, Percent_Identity=29.7082228116711, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17551802, Length=421, Percent_Identity=30.4038004750594, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17535921, Length=390, Percent_Identity=29.4871794871795, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17535917, Length=369, Percent_Identity=26.2872628726287, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6322031, Length=386, Percent_Identity=32.3834196891192, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6325229, Length=399, Percent_Identity=31.077694235589, Blast_Score=162, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24655093, Length=390, Percent_Identity=34.3589743589744, Blast_Score=207, Evalue=7e-54,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=31.025641025641, Blast_Score=168, Evalue=6e-42,
Organism=Drosophila melanogaster, GI17137578, Length=414, Percent_Identity=32.3671497584541, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24640423, Length=394, Percent_Identity=30.2030456852792, Blast_Score=155, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41427; Mature: 41296

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFKNPVGIIAANRLPIGKINGFYKKISPETLYQNLIKQQFNKNLLLKKADIDYIILGNV
CCCCCCEEEEEECCCCCHHCCCHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCEEEEECC
TNQGGNLARRCALKAGFSSQVPAFTIDQQCGSGLTAMISSANYIISGEASVICTGGVEST
CCCCCHHHHHHHHHCCCCCCCCEEEECHHHCCCHHHHHCCCCEEEECCCEEEEECCCCCC
SQANIVLDSESYQPINRFKMAPEPYEDFDMGTIADMTALKYNIPRSVQDLYALNSHKKAT
CCCEEEEECCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHEECCCHHHHHHHHHCCCHHHH
QAIEGKLLENEVFPYQDEGFTISSDQTVRPKSSMEALSKLTPAFTTNGTATAGNSCPIND
HHHHCCHHCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCEECCCCCCCCCCCCCCC
GASSIILSSTNNPFDFQGYYLGQTTIALSPSDFLLGPIKATEKLLQKFNLKLNDIEAIEL
CCCEEEEECCCCCCCCCCEEECCEEEEECCCCCEEECHHHHHHHHHHHCCCCCCEEEEEE
NEAFASQAILFQNYFKLDDIKLNAYGGSLAFGHPYGATGGILISRLLNRLNQVQKPCLGI
CHHHHHHHHHHHHCEEEEEEEEEECCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ATLCVAGGMGISVLIGNQWYQK
HHHHHHCCCCEEEEECCHHHCC
>Mature Secondary Structure 
SFKNPVGIIAANRLPIGKINGFYKKISPETLYQNLIKQQFNKNLLLKKADIDYIILGNV
CCCCCEEEEEECCCCCHHCCCHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCEEEEECC
TNQGGNLARRCALKAGFSSQVPAFTIDQQCGSGLTAMISSANYIISGEASVICTGGVEST
CCCCCHHHHHHHHHCCCCCCCCEEEECHHHCCCHHHHHCCCCEEEECCCEEEEECCCCCC
SQANIVLDSESYQPINRFKMAPEPYEDFDMGTIADMTALKYNIPRSVQDLYALNSHKKAT
CCCEEEEECCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHEECCCHHHHHHHHHCCCHHHH
QAIEGKLLENEVFPYQDEGFTISSDQTVRPKSSMEALSKLTPAFTTNGTATAGNSCPIND
HHHHCCHHCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCEECCCCCCCCCCCCCCC
GASSIILSSTNNPFDFQGYYLGQTTIALSPSDFLLGPIKATEKLLQKFNLKLNDIEAIEL
CCCEEEEECCCCCCCCCCEEECCEEEEECCCCCEEECHHHHHHHHHHHCCCCCCEEEEEE
NEAFASQAILFQNYFKLDDIKLNAYGGSLAFGHPYGATGGILISRLLNRLNQVQKPCLGI
CHHHHHHHHHHHHCEEEEEEEEEECCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ATLCVAGGMGISVLIGNQWYQK
HHHHHHCCCCEEEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]