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The map label for this gene is dxsB

Identifier: 15673655

GI number: 15673655

Start: 1723616

End: 1725358

Strand: Reverse

Name: dxsB

Synonym: L123365

Alternate gene names: 15673655

Gene position: 1725358-1723616 (Counterclockwise)

Preceding gene: 15673656

Following gene: 15673654

Centisome position: 72.94

GC content: 36.89

Gene sequence:

>1743_bases
ATGTCAGTGTTAGAAAAAATAGACAGCCCAGCGGATTTAAAAAAAGTATCAAATCAAGAACTAGAAGAATTAGCTTCAGA
AATTAGAACAGCAGTTCTTCATAAAGTATCAAACATCGGTGGACACGTTGGCCCAAACTTGGGTGTGACTGAATTAACAA
TTGCCCTTCATAAAGTTTTCAATTCACCAATTGATAAGTTTATTTGGGATGTTTCTCACCAAACTTATCCACATAAAATT
TTAACTGGACGTAAAAATGGATTTACTGATGGACATTTCCATGACATCACACCTTACACCAGTCAAAGAGAATCAGAACA
CGACTTTTTCACAGTTGGCCATACCTCGACTTCAATTGCTAATGCCTTAGGTTATGCCAAAGCGCGTGATTTGACAAATG
ACAAAGGCAACATTGTTGCGGTCATTGGTGACGGTTCACTTTCTGGGGGACTTGCTATGGAAGCCCTCAATAATGCCGGA
GATTTCAAAGGAAACCTCATTATTTTAGTTAATGATAATCAAATGTCAATTGCTGAAAATCATGGAGGACTTTACCGTAA
CCTTGCCGAACTTCGGGCGACAAATGGTCAAGCCGAAAATAACTTCTTTAAAACTTTTGGTTTAGATTATAAATATCTTG
AAAATGGAAATGATATTGAATCTTTAATTCACCTATTTGAAGAAGTAAAAGATATCGACCATCCAATTGTCCTTCATATT
CATACTGAAAAAGGACGTGGTTATCAACCAGCTCTTGAAAATAAAGAAGCTTTTCACTGGCACATGCCTTTCGATTTAGA
AACTGGTCAATCAAAAGTGATTGATTCTGGTAAATCTTATAGTTCAGTTATGTTGGATTACATGGATAAAAAGGTTTCAG
AAGGCCTTCCTCTTGTTGCCATCAATGCAGCAATTCCAGGAATCTTTGGACTGAAACAATTTGCAGCTAAATATCCTGAC
CGTTATATTGATGCAGGAATTGCTGAGCAATTTACCATTACTTTTGGTGGTGCAATGGCTGCGGCTGGTGCTCGTCCAAT
TATTTTCCACAATTCTACTTTTGTTCAACGTGCTTATGATCAATTTTGGCATGACTTAGCAATTAATGAAGAACCAGCAA
TTGTTATTGTTAAAGGTGGAGTTATTTCAGGTTCAGATGAAACACACCAAGGCTCATCAGCCATGACTTGGATTTCAAAC
ATTCCAAATATCAAATATCTTGCTCCAACTTCTGAAGAAGAATTTATTTCAATTCTTGATTGGGCACTTGAGCAACATGA
AGAACCAGTTGTGATTCAAATGCCAGAACACGGCTTAGAATCACGTCCGACAGTTCTCACAGATTATTCAACCCCTTCAT
ATCAAATGACAAAATCAGGCGAAAAAGTTGCCCTATTGGCACTTGGCGGTCTTTATTCACATGGTGAAAAAGTAGCTAAA
GTTTTGGCTGAAAATGGAATTAATGCAACCCTAATAAATCCACTTTTCATCAACGATTTGGACCAAGCTTTCCTTGAAAA
CCTAGTTGAAAATCATCAAGTTATTGCAACGATCGAAGATGGAATTCTTGACGGAGGATTTGGTCAAAAAGTTGCTTCCT
TCCTTGGTAAGTATGATGTTAAAGTTTTGAACTTTGGTGCGAAACGTGAATTTAATGATTCTGTTCCAGTGACAGAACTT
TATAATCGTTATCATTTGACACCAGAACTTATGGTTGCTGATATTCTTAGTCTTTTGAAATAA

Upstream 100 bases:

>100_bases
ACATTCAAATTATGACAATTTTGTCAGTCGATTTACTAGTTTTTAAAGACAATTTCTGTTAGTAAATAACTAAGTAAATC
TAAAAAGGAGAAAATCAGAG

Downstream 100 bases:

>100_bases
AAATTTACTGACAGATGTTCCAAAATATTTCTGTCAGTAAAAATAAAGAACTGGTAATGTCTGTCAGTAAAACTAGCAAG
AATGATGATAAGTTCTTACT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 580; Mature: 579

Protein sequence:

>580_residues
MSVLEKIDSPADLKKVSNQELEELASEIRTAVLHKVSNIGGHVGPNLGVTELTIALHKVFNSPIDKFIWDVSHQTYPHKI
LTGRKNGFTDGHFHDITPYTSQRESEHDFFTVGHTSTSIANALGYAKARDLTNDKGNIVAVIGDGSLSGGLAMEALNNAG
DFKGNLIILVNDNQMSIAENHGGLYRNLAELRATNGQAENNFFKTFGLDYKYLENGNDIESLIHLFEEVKDIDHPIVLHI
HTEKGRGYQPALENKEAFHWHMPFDLETGQSKVIDSGKSYSSVMLDYMDKKVSEGLPLVAINAAIPGIFGLKQFAAKYPD
RYIDAGIAEQFTITFGGAMAAAGARPIIFHNSTFVQRAYDQFWHDLAINEEPAIVIVKGGVISGSDETHQGSSAMTWISN
IPNIKYLAPTSEEEFISILDWALEQHEEPVVIQMPEHGLESRPTVLTDYSTPSYQMTKSGEKVALLALGGLYSHGEKVAK
VLAENGINATLINPLFINDLDQAFLENLVENHQVIATIEDGILDGGFGQKVASFLGKYDVKVLNFGAKREFNDSVPVTEL
YNRYHLTPELMVADILSLLK

Sequences:

>Translated_580_residues
MSVLEKIDSPADLKKVSNQELEELASEIRTAVLHKVSNIGGHVGPNLGVTELTIALHKVFNSPIDKFIWDVSHQTYPHKI
LTGRKNGFTDGHFHDITPYTSQRESEHDFFTVGHTSTSIANALGYAKARDLTNDKGNIVAVIGDGSLSGGLAMEALNNAG
DFKGNLIILVNDNQMSIAENHGGLYRNLAELRATNGQAENNFFKTFGLDYKYLENGNDIESLIHLFEEVKDIDHPIVLHI
HTEKGRGYQPALENKEAFHWHMPFDLETGQSKVIDSGKSYSSVMLDYMDKKVSEGLPLVAINAAIPGIFGLKQFAAKYPD
RYIDAGIAEQFTITFGGAMAAAGARPIIFHNSTFVQRAYDQFWHDLAINEEPAIVIVKGGVISGSDETHQGSSAMTWISN
IPNIKYLAPTSEEEFISILDWALEQHEEPVVIQMPEHGLESRPTVLTDYSTPSYQMTKSGEKVALLALGGLYSHGEKVAK
VLAENGINATLINPLFINDLDQAFLENLVENHQVIATIEDGILDGGFGQKVASFLGKYDVKVLNFGAKREFNDSVPVTEL
YNRYHLTPELMVADILSLLK
>Mature_579_residues
SVLEKIDSPADLKKVSNQELEELASEIRTAVLHKVSNIGGHVGPNLGVTELTIALHKVFNSPIDKFIWDVSHQTYPHKIL
TGRKNGFTDGHFHDITPYTSQRESEHDFFTVGHTSTSIANALGYAKARDLTNDKGNIVAVIGDGSLSGGLAMEALNNAGD
FKGNLIILVNDNQMSIAENHGGLYRNLAELRATNGQAENNFFKTFGLDYKYLENGNDIESLIHLFEEVKDIDHPIVLHIH
TEKGRGYQPALENKEAFHWHMPFDLETGQSKVIDSGKSYSSVMLDYMDKKVSEGLPLVAINAAIPGIFGLKQFAAKYPDR
YIDAGIAEQFTITFGGAMAAAGARPIIFHNSTFVQRAYDQFWHDLAINEEPAIVIVKGGVISGSDETHQGSSAMTWISNI
PNIKYLAPTSEEEFISILDWALEQHEEPVVIQMPEHGLESRPTVLTDYSTPSYQMTKSGEKVALLALGGLYSHGEKVAKV
LAENGINATLINPLFINDLDQAFLENLVENHQVIATIEDGILDGGFGQKVASFLGKYDVKVLNFGAKREFNDSVPVTELY
NRYHLTPELMVADILSLLK

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786622, Length=586, Percent_Identity=34.3003412969283, Blast_Score=338, Evalue=5e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 63939; Mature: 63808

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLEKIDSPADLKKVSNQELEELASEIRTAVLHKVSNIGGHVGPNLGVTELTIALHKVF
CCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
NSPIDKFIWDVSHQTYPHKILTGRKNGFTDGHFHDITPYTSQRESEHDFFTVGHTSTSIA
CCHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHH
NALGYAKARDLTNDKGNIVAVIGDGSLSGGLAMEALNNAGDFKGNLIILVNDNQMSIAEN
HHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCCEEEEECCCCEEEECC
HGGLYRNLAELRATNGQAENNFFKTFGLDYKYLENGNDIESLIHLFEEVKDIDHPIVLHI
CCHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEE
HTEKGRGYQPALENKEAFHWHMPFDLETGQSKVIDSGKSYSSVMLDYMDKKVSEGLPLVA
ECCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCEEE
INAAIPGIFGLKQFAAKYPDRYIDAGIAEQFTITFGGAMAAAGARPIIFHNSTFVQRAYD
ECCCCCCHHHHHHHHHHCCHHHHCCCCCCEEEEEECCHHHHCCCCEEEEECCHHHHHHHH
QFWHDLAINEEPAIVIVKGGVISGSDETHQGSSAMTWISNIPNIKYLAPTSEEEFISILD
HHHHHHCCCCCCCEEEEECCEECCCCCCCCCCHHHHHHHCCCCEEEECCCCHHHHHHHHH
WALEQHEEPVVIQMPEHGLESRPTVLTDYSTPSYQMTKSGEKVALLALGGLYSHGEKVAK
HHHHHCCCCEEEECCCCCCCCCCEEEEECCCCCEEEECCCCEEEEEEECCHHHHHHHHHH
VLAENGINATLINPLFINDLDQAFLENLVENHQVIATIEDGILDGGFGQKVASFLGKYDV
HHHHCCCCEEEECHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCCE
KVLNFGAKREFNDSVPVTELYNRYHLTPELMVADILSLLK
EEEECCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHC
>Mature Secondary Structure 
SVLEKIDSPADLKKVSNQELEELASEIRTAVLHKVSNIGGHVGPNLGVTELTIALHKVF
CHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
NSPIDKFIWDVSHQTYPHKILTGRKNGFTDGHFHDITPYTSQRESEHDFFTVGHTSTSIA
CCHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHH
NALGYAKARDLTNDKGNIVAVIGDGSLSGGLAMEALNNAGDFKGNLIILVNDNQMSIAEN
HHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCCEEEEECCCCEEEECC
HGGLYRNLAELRATNGQAENNFFKTFGLDYKYLENGNDIESLIHLFEEVKDIDHPIVLHI
CCHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEE
HTEKGRGYQPALENKEAFHWHMPFDLETGQSKVIDSGKSYSSVMLDYMDKKVSEGLPLVA
ECCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCEEE
INAAIPGIFGLKQFAAKYPDRYIDAGIAEQFTITFGGAMAAAGARPIIFHNSTFVQRAYD
ECCCCCCHHHHHHHHHHCCHHHHCCCCCCEEEEEECCHHHHCCCCEEEEECCHHHHHHHH
QFWHDLAINEEPAIVIVKGGVISGSDETHQGSSAMTWISNIPNIKYLAPTSEEEFISILD
HHHHHHCCCCCCCEEEEECCEECCCCCCCCCCHHHHHHHCCCCEEEECCCCHHHHHHHHH
WALEQHEEPVVIQMPEHGLESRPTVLTDYSTPSYQMTKSGEKVALLALGGLYSHGEKVAK
HHHHHCCCCEEEECCCCCCCCCCEEEEECCCCCEEEECCCCEEEEEEECCHHHHHHHHHH
VLAENGINATLINPLFINDLDQAFLENLVENHQVIATIEDGILDGGFGQKVASFLGKYDV
HHHHCCCCEEEECHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCCE
KVLNFGAKREFNDSVPVTELYNRYHLTPELMVADILSLLK
EEEECCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA