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The map label for this gene is kinF

Identifier: 15673656

GI number: 15673656

Start: 1725506

End: 1726876

Strand: Reverse

Name: kinF

Synonym: L0134

Alternate gene names: 15673656

Gene position: 1726876-1725506 (Counterclockwise)

Preceding gene: 15673657

Following gene: 15673655

Centisome position: 73.0

GC content: 33.55

Gene sequence:

>1371_bases
TTGAAGAAAATAATTAAAAAAGTTAAATCTTCAGCTATTGTAAAAAATGATGGGAAAAATTTCCTTCATTTTTTTCTAGC
TTTTACAGTCATTTTTGTTGCTTTAGCCGTGATTATTATTCAAGTCATGCAATTAGGAATGTATCGAGCGACTGACCAAA
ATTTACACAATTTGGCTCAAAACCGAGTCTTTTTGATAGAAGCAGCGAATAATCAATTAGGAATGAATAATTCGCAAGAT
AGTGGCTATTACGGTCCCAATAATAGTGTAATTTTTTATGATTCAGAGGGTAAAAGTTTCATACCTTCAGCGGGTTCAAA
TGCAAATATAAGTACAAATTTTGGCATGAGCCTTCTGCAAAAAACAATGAAATTTAACGAAAATCAAATTAACACTATTC
AAACTGTTTCTGTAAAAAATCCTTATGGAGATAATTGGCACTATCGTTATCTGACAACATCACAATTTATTATTACAAAT
ACTGATGGAACAGTAACTCCGGTTTATGCACAAATTTTTTCAAATGTTGACCAAATTCAAGATGCCATGAGCCGAGCCAT
GTGGGTCATTGTGACAACAATGATTACTTTCTGGCTTCTGTCAGTAATTATTAGTCTATATCTTGCAAACTGGACATTAA
AACCAATTTTGGCCGCTTATGAAAAACAAAAAGAATTTGTTGAAAATGCTTCACATGAATTGAGAACACCTCTGGCAATC
TTGCAAAATCGTCTAGAATTACTTTTCCAAAAGCCAACAGCAACAATTATTGATGAATCAGAAAATATTTCTGAAAGTTT
ATCAGAAGTTCGTAATATGCGTTTATTAACAAGTAACTTACTGAACTTAGCTCGTCGAGATTCTGGAATCAGAATTGAGC
CAGAGGCGACTACGGCAACTTATTTTGAGAATATTTTTAATAGCTATGAAATGCTTGCTGAAAACGCAGGTAAAAAGTTT
TCAGGCGATTTGAAATTAGATGGAACGATTAATTTGGACCAAGCCCTGATTAAACAATTGCTAACCATCTTATTTGATAA
TGCTCTTAAATACACGGGTGATGAGGGTGAAATCTCTGTAGATGTTCAAAAAAATGGGGGATTCTTAGTTTTTGCTGTCG
CCGATAATGGTGAAGGAATTTCTGATGAAGATAAGAAAAAAATCTTTGACCGCTTTTTCCGAGTAGATAAAGCAAGAACG
CGTCAAAAAGGTGGCTTAGGTTTGGGTCTTTCTCTGGCCAAACAAATTGTTGAAGCTTACAATGGGAAGATTACAGTTGA
AGATAATAAACCTAAAGGTACAAAATTCATTGTTAGAATTCGTGTGGATAGCACAATTTCAAATCCTGCAAAAATTTTCC
AAAAGTTGTAA

Upstream 100 bases:

>100_bases
TGAGATAAAATTTTACTGACAGCTTGTTGTATAGAGATGAAAGTCATCTATAAATTAACAAAAAGTTCTGTCAGTAAATC
TATCTAGAAATGAGACCTCT

Downstream 100 bases:

>100_bases
AATATGATAGGAAAAAATTACTGACAAATTATGATAAGATAATAGTAACATTCAAATTATGACAATTTTGTCAGTCGATT
TACTAGTTTTTAAAGACAAT

Product: sensor protein kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MKKIIKKVKSSAIVKNDGKNFLHFFLAFTVIFVALAVIIIQVMQLGMYRATDQNLHNLAQNRVFLIEAANNQLGMNNSQD
SGYYGPNNSVIFYDSEGKSFIPSAGSNANISTNFGMSLLQKTMKFNENQINTIQTVSVKNPYGDNWHYRYLTTSQFIITN
TDGTVTPVYAQIFSNVDQIQDAMSRAMWVIVTTMITFWLLSVIISLYLANWTLKPILAAYEKQKEFVENASHELRTPLAI
LQNRLELLFQKPTATIIDESENISESLSEVRNMRLLTSNLLNLARRDSGIRIEPEATTATYFENIFNSYEMLAENAGKKF
SGDLKLDGTINLDQALIKQLLTILFDNALKYTGDEGEISVDVQKNGGFLVFAVADNGEGISDEDKKKIFDRFFRVDKART
RQKGGLGLGLSLAKQIVEAYNGKITVEDNKPKGTKFIVRIRVDSTISNPAKIFQKL

Sequences:

>Translated_456_residues
MKKIIKKVKSSAIVKNDGKNFLHFFLAFTVIFVALAVIIIQVMQLGMYRATDQNLHNLAQNRVFLIEAANNQLGMNNSQD
SGYYGPNNSVIFYDSEGKSFIPSAGSNANISTNFGMSLLQKTMKFNENQINTIQTVSVKNPYGDNWHYRYLTTSQFIITN
TDGTVTPVYAQIFSNVDQIQDAMSRAMWVIVTTMITFWLLSVIISLYLANWTLKPILAAYEKQKEFVENASHELRTPLAI
LQNRLELLFQKPTATIIDESENISESLSEVRNMRLLTSNLLNLARRDSGIRIEPEATTATYFENIFNSYEMLAENAGKKF
SGDLKLDGTINLDQALIKQLLTILFDNALKYTGDEGEISVDVQKNGGFLVFAVADNGEGISDEDKKKIFDRFFRVDKART
RQKGGLGLGLSLAKQIVEAYNGKITVEDNKPKGTKFIVRIRVDSTISNPAKIFQKL
>Mature_456_residues
MKKIIKKVKSSAIVKNDGKNFLHFFLAFTVIFVALAVIIIQVMQLGMYRATDQNLHNLAQNRVFLIEAANNQLGMNNSQD
SGYYGPNNSVIFYDSEGKSFIPSAGSNANISTNFGMSLLQKTMKFNENQINTIQTVSVKNPYGDNWHYRYLTTSQFIITN
TDGTVTPVYAQIFSNVDQIQDAMSRAMWVIVTTMITFWLLSVIISLYLANWTLKPILAAYEKQKEFVENASHELRTPLAI
LQNRLELLFQKPTATIIDESENISESLSEVRNMRLLTSNLLNLARRDSGIRIEPEATTATYFENIFNSYEMLAENAGKKF
SGDLKLDGTINLDQALIKQLLTILFDNALKYTGDEGEISVDVQKNGGFLVFAVADNGEGISDEDKKKIFDRFFRVDKART
RQKGGLGLGLSLAKQIVEAYNGKITVEDNKPKGTKFIVRIRVDSTISNPAKIFQKL

Specific function: Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility. Probably phosphorylates CiaR [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=229, Percent_Identity=31.8777292576419, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786783, Length=277, Percent_Identity=29.2418772563177, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1788393, Length=228, Percent_Identity=28.0701754385965, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1786912, Length=246, Percent_Identity=32.1138211382114, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790346, Length=222, Percent_Identity=27.9279279279279, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI145693157, Length=229, Percent_Identity=29.6943231441048, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI87082128, Length=234, Percent_Identity=28.2051282051282, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1787894, Length=231, Percent_Identity=29.4372294372294, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788713, Length=230, Percent_Identity=25.6521739130435, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788279, Length=211, Percent_Identity=29.3838862559242, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790551, Length=239, Percent_Identity=27.1966527196653, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790861, Length=223, Percent_Identity=26.9058295964126, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787374, Length=220, Percent_Identity=27.2727272727273, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788549, Length=219, Percent_Identity=29.2237442922374, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1789149, Length=237, Percent_Identity=27.4261603375527, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=25.2136752136752, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI48994928, Length=224, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081816, Length=232, Percent_Identity=24.5689655172414, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51279; Mature: 51279

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIIKKVKSSAIVKNDGKNFLHFFLAFTVIFVALAVIIIQVMQLGMYRATDQNLHNLAQ
CHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
NRVFLIEAANNQLGMNNSQDSGYYGPNNSVIFYDSEGKSFIPSAGSNANISTNFGMSLLQ
CCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCEECCCCCCCCCCCCHHHHHHHH
KTMKFNENQINTIQTVSVKNPYGDNWHYRYLTTSQFIITNTDGTVTPVYAQIFSNVDQIQ
HHHHCCCCCCCEEEEEEECCCCCCCCEEEEEEECEEEEECCCCCCHHHHHHHHCCHHHHH
DAMSRAMWVIVTTMITFWLLSVIISLYLANWTLKPILAAYEKQKEFVENASHELRTPLAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHCHHHH
LQNRLELLFQKPTATIIDESENISESLSEVRNMRLLTSNLLNLARRDSGIRIEPEATTAT
HHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHH
YFENIFNSYEMLAENAGKKFSGDLKLDGTINLDQALIKQLLTILFDNALKYTGDEGEISV
HHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
DVQKNGGFLVFAVADNGEGISDEDKKKIFDRFFRVDKARTRQKGGLGLGLSLAKQIVEAY
EEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
NGKITVEDNKPKGTKFIVRIRVDSTISNPAKIFQKL
CCEEEEECCCCCCCEEEEEEEECCCCCCHHHHHHCC
>Mature Secondary Structure
MKKIIKKVKSSAIVKNDGKNFLHFFLAFTVIFVALAVIIIQVMQLGMYRATDQNLHNLAQ
CHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
NRVFLIEAANNQLGMNNSQDSGYYGPNNSVIFYDSEGKSFIPSAGSNANISTNFGMSLLQ
CCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCEECCCCCCCCCCCCHHHHHHHH
KTMKFNENQINTIQTVSVKNPYGDNWHYRYLTTSQFIITNTDGTVTPVYAQIFSNVDQIQ
HHHHCCCCCCCEEEEEEECCCCCCCCEEEEEEECEEEEECCCCCCHHHHHHHHCCHHHHH
DAMSRAMWVIVTTMITFWLLSVIISLYLANWTLKPILAAYEKQKEFVENASHELRTPLAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHCHHHH
LQNRLELLFQKPTATIIDESENISESLSEVRNMRLLTSNLLNLARRDSGIRIEPEATTAT
HHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHH
YFENIFNSYEMLAENAGKKFSGDLKLDGTINLDQALIKQLLTILFDNALKYTGDEGEISV
HHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
DVQKNGGFLVFAVADNGEGISDEDKKKIFDRFFRVDKARTRQKGGLGLGLSLAKQIVEAY
EEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
NGKITVEDNKPKGTKFIVRIRVDSTISNPAKIFQKL
CCEEEEECCCCCCCEEEEEEEECCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]