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The map label for this gene is yrbD

Identifier: 15673646

GI number: 15673646

Start: 1713651

End: 1715189

Strand: Reverse

Name: yrbD

Synonym: L113400

Alternate gene names: 15673646

Gene position: 1715189-1713651 (Counterclockwise)

Preceding gene: 15673647

Following gene: 15673644

Centisome position: 72.51

GC content: 37.1

Gene sequence:

>1539_bases
ATGAAATTAAAAGATATAGAGAAATCAACAAATAAAAATCTTTATCTGCTTTTTCTAAGTGTACTCGTGGGCTTGACTGC
GGGTTTTTTGGCCAGTCTTTATCGGTTGGCACTGGAAAAAGCTGAAACTTGGGGCTTGAGTATTTATCGCTTCGTTAGCT
CACACCTTATTTTTATTCCCCTCCTTATTTTGGGTTTGGCTTTCTTAGCTTTTGTGGTTACTTTCTTTATGAAGAAATAT
CCGATGAGTTCAGGTTCTGGGATACCACAAGTTAAAGGGCAATTACAGGGTTATTTTAAAAATAATTGGTTCACGACTGC
TTTTGCTAAATTTATCGCTGGGACTTTAGCAATGTTTGCAGGTCTATCACTGGGGCGTGAGGGTCCCTCAGTCCAACTTG
GGGCTTCAATGGGTCAGATGGTTTCTAGTCGTTTGGCTGAAACTGAACGTCATAAAAGAATTCTAATTGCTTCTGGAGCA
TCTGCTGGTTTATCTGCTGCTTTCAATGCACCTTTGTCAGGTGTCATGTTTACTTTGGAAGAAGTATTTAAATACTTTTC
TCCATTGATTTTATTAACTTGTATGACCTCAGCAATGGTTGCTGATATGGTTGCACGAATAATGTTTGGGAGTGGTCCAG
TTTTTCATTTCCAAATTGTTGGTTCAATTGAACTCTCAAATTATTGGCTACTTATTATTTTAGGAATTATTTTAGGATTT
TTCGGTGCTTTTTATAACTGGACACTCCTCACGAGTCAAAATTTGATGAAGAAAATAAAGAGTCCATTTCTTCGTGTTTT
ACTTACTTTTTTAGTGGTTGGGGCAACTGGTTTATTGTTTCCTAATATAATTGGGAGTGGCCATCGTTTAATGGATTCCT
TTAGTTTAGGAATGGGATTAGCCTTTCTATGTTTGATTCTCATTGGGAAATACCTGATTTCAATGGTATCTTATGCTTCG
GGTGTGCCAGGAGGAATTTTCTTTCCCCTGTTAGTTTTGGGTGCTAGTCTTGGAGCTGTTTTTGCGACAATTGTTATTTC
ACTTTTTCATCTTCCAAGTCATTTATTTGCCAATCTAGTAATTTTAGCGATGGCTGGGACTTTTACAGCAATTGTTCGAG
CACCGATGACTGGAATCCTTCTTTTGGTGGAAATGACTGGTTCATTTGACCATTTACTTCCTCTGGCTCTTGTCTCTTTA
ATTGCTTATGTCGTTGCTGATTTATTACAATCTGAGCCAATTTATGATTCCTTATTAGACAACATGTTGAAAGAAAAAGA
AATTGATGTTGATGATTCGGATAAGCAGATGATGTTTGAAACAATTGTTCAATTTGATTCAGTTGCGGATCGTAAGAAGT
TGTCAGAGATACATTTACCAGAAGGATGTTTGCTAGTTTCGGTTCATCGTTCAGGTAAGGATATCATTCCACACGGGAAT
ACTGAATTACAAGCAGGAGATTATTTGACCTTTTTGATTAGACGAGAAGATGAAGTGATTGCTAGAGAACAGCTTCGTCA
GGTTTTAAATGAAAAATAA

Upstream 100 bases:

>100_bases
TGTGTATATTATTAAAAGTACAAAACATAAGGAATCTATTTTATGGTATAATAATCTTGCTTAAAAATTTATTAAAATAA
GCGTTAGTAGGGAAGTAGTA

Downstream 100 bases:

>100_bases
AAAAGTGATATTCTATCACTTTTTTTATTTGCTTAAATATTGCCAAAGGATTGATAAAAACAGACTCACAGCATAAGCGC
TGTTAAATAGAACCATATTT

Product: hypothetical protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MKLKDIEKSTNKNLYLLFLSVLVGLTAGFLASLYRLALEKAETWGLSIYRFVSSHLIFIPLLILGLAFLAFVVTFFMKKY
PMSSGSGIPQVKGQLQGYFKNNWFTTAFAKFIAGTLAMFAGLSLGREGPSVQLGASMGQMVSSRLAETERHKRILIASGA
SAGLSAAFNAPLSGVMFTLEEVFKYFSPLILLTCMTSAMVADMVARIMFGSGPVFHFQIVGSIELSNYWLLIILGIILGF
FGAFYNWTLLTSQNLMKKIKSPFLRVLLTFLVVGATGLLFPNIIGSGHRLMDSFSLGMGLAFLCLILIGKYLISMVSYAS
GVPGGIFFPLLVLGASLGAVFATIVISLFHLPSHLFANLVILAMAGTFTAIVRAPMTGILLLVEMTGSFDHLLPLALVSL
IAYVVADLLQSEPIYDSLLDNMLKEKEIDVDDSDKQMMFETIVQFDSVADRKKLSEIHLPEGCLLVSVHRSGKDIIPHGN
TELQAGDYLTFLIRREDEVIAREQLRQVLNEK

Sequences:

>Translated_512_residues
MKLKDIEKSTNKNLYLLFLSVLVGLTAGFLASLYRLALEKAETWGLSIYRFVSSHLIFIPLLILGLAFLAFVVTFFMKKY
PMSSGSGIPQVKGQLQGYFKNNWFTTAFAKFIAGTLAMFAGLSLGREGPSVQLGASMGQMVSSRLAETERHKRILIASGA
SAGLSAAFNAPLSGVMFTLEEVFKYFSPLILLTCMTSAMVADMVARIMFGSGPVFHFQIVGSIELSNYWLLIILGIILGF
FGAFYNWTLLTSQNLMKKIKSPFLRVLLTFLVVGATGLLFPNIIGSGHRLMDSFSLGMGLAFLCLILIGKYLISMVSYAS
GVPGGIFFPLLVLGASLGAVFATIVISLFHLPSHLFANLVILAMAGTFTAIVRAPMTGILLLVEMTGSFDHLLPLALVSL
IAYVVADLLQSEPIYDSLLDNMLKEKEIDVDDSDKQMMFETIVQFDSVADRKKLSEIHLPEGCLLVSVHRSGKDIIPHGN
TELQAGDYLTFLIRREDEVIAREQLRQVLNEK
>Mature_512_residues
MKLKDIEKSTNKNLYLLFLSVLVGLTAGFLASLYRLALEKAETWGLSIYRFVSSHLIFIPLLILGLAFLAFVVTFFMKKY
PMSSGSGIPQVKGQLQGYFKNNWFTTAFAKFIAGTLAMFAGLSLGREGPSVQLGASMGQMVSSRLAETERHKRILIASGA
SAGLSAAFNAPLSGVMFTLEEVFKYFSPLILLTCMTSAMVADMVARIMFGSGPVFHFQIVGSIELSNYWLLIILGIILGF
FGAFYNWTLLTSQNLMKKIKSPFLRVLLTFLVVGATGLLFPNIIGSGHRLMDSFSLGMGLAFLCLILIGKYLISMVSYAS
GVPGGIFFPLLVLGASLGAVFATIVISLFHLPSHLFANLVILAMAGTFTAIVRAPMTGILLLVEMTGSFDHLLPLALVSL
IAYVVADLLQSEPIYDSLLDNMLKEKEIDVDDSDKQMMFETIVQFDSVADRKKLSEIHLPEGCLLVSVHRSGKDIIPHGN
TELQAGDYLTFLIRREDEVIAREQLRQVLNEK

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI55770838, Length=437, Percent_Identity=25.629290617849, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI55770840, Length=437, Percent_Identity=25.629290617849, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI4557473, Length=428, Percent_Identity=26.4018691588785, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI189217923, Length=428, Percent_Identity=26.4018691588785, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI189217921, Length=428, Percent_Identity=26.4018691588785, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI153252026, Length=435, Percent_Identity=24.5977011494253, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI283806618, Length=452, Percent_Identity=22.3451327433628, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI156104869, Length=406, Percent_Identity=22.6600985221675, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI283806622, Length=406, Percent_Identity=22.6600985221675, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1786350, Length=446, Percent_Identity=31.8385650224215, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI87081943, Length=332, Percent_Identity=28.6144578313253, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17532615, Length=449, Percent_Identity=26.5033407572383, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71980824, Length=576, Percent_Identity=24.3055555555556, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71980828, Length=576, Percent_Identity=24.3055555555556, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71980820, Length=579, Percent_Identity=24.1796200345423, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17559050, Length=453, Percent_Identity=24.2825607064018, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71985148, Length=148, Percent_Identity=29.0540540540541, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71985141, Length=148, Percent_Identity=29.0540540540541, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71996455, Length=135, Percent_Identity=31.8518518518519, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71996452, Length=135, Percent_Identity=31.8518518518519, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322500, Length=415, Percent_Identity=26.7469879518072, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24665008, Length=406, Percent_Identity=25.8620689655172, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45551566, Length=392, Percent_Identity=26.530612244898, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI161078208, Length=454, Percent_Identity=23.7885462555066, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI28573075, Length=453, Percent_Identity=23.841059602649, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI28573071, Length=453, Percent_Identity=23.841059602649, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI281361606, Length=454, Percent_Identity=23.7885462555066, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI28573073, Length=453, Percent_Identity=23.841059602649, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI281361608, Length=453, Percent_Identity=23.841059602649, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 56185; Mature: 56185

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKDIEKSTNKNLYLLFLSVLVGLTAGFLASLYRLALEKAETWGLSIYRFVSSHLIFIP
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLILGLAFLAFVVTFFMKKYPMSSGSGIPQVKGQLQGYFKNNWFTTAFAKFIAGTLAMFA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
GLSLGREGPSVQLGASMGQMVSSRLAETERHKRILIASGASAGLSAAFNAPLSGVMFTLE
HHHCCCCCCCEEECHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHCCCHHHHHHHHH
EVFKYFSPLILLTCMTSAMVADMVARIMFGSGPVFHFQIVGSIELSNYWLLIILGIILGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEHHHHHHHHHHHHHHH
FGAFYNWTLLTSQNLMKKIKSPFLRVLLTFLVVGATGLLFPNIIGSGHRLMDSFSLGMGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
AFLCLILIGKYLISMVSYASGVPGGIFFPLLVLGASLGAVFATIVISLFHLPSHLFANLV
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILAMAGTFTAIVRAPMTGILLLVEMTGSFDHLLPLALVSLIAYVVADLLQSEPIYDSLLD
HHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
NMLKEKEIDVDDSDKQMMFETIVQFDSVADRKKLSEIHLPEGCLLVSVHRSGKDIIPHGN
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCC
TELQAGDYLTFLIRREDEVIAREQLRQVLNEK
CCCCCCCCEEEEEECCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLKDIEKSTNKNLYLLFLSVLVGLTAGFLASLYRLALEKAETWGLSIYRFVSSHLIFIP
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLILGLAFLAFVVTFFMKKYPMSSGSGIPQVKGQLQGYFKNNWFTTAFAKFIAGTLAMFA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
GLSLGREGPSVQLGASMGQMVSSRLAETERHKRILIASGASAGLSAAFNAPLSGVMFTLE
HHHCCCCCCCEEECHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHCCCHHHHHHHHH
EVFKYFSPLILLTCMTSAMVADMVARIMFGSGPVFHFQIVGSIELSNYWLLIILGIILGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEHHHHHHHHHHHHHHH
FGAFYNWTLLTSQNLMKKIKSPFLRVLLTFLVVGATGLLFPNIIGSGHRLMDSFSLGMGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
AFLCLILIGKYLISMVSYASGVPGGIFFPLLVLGASLGAVFATIVISLFHLPSHLFANLV
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILAMAGTFTAIVRAPMTGILLLVEMTGSFDHLLPLALVSLIAYVVADLLQSEPIYDSLLD
HHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
NMLKEKEIDVDDSDKQMMFETIVQFDSVADRKKLSEIHLPEGCLLVSVHRSGKDIIPHGN
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCC
TELQAGDYLTFLIRREDEVIAREQLRQVLNEK
CCCCCCCCEEEEEECCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA