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The map label for this gene is mutS

Identifier: 15673627

GI number: 15673627

Start: 1691732

End: 1694062

Strand: Reverse

Name: mutS

Synonym: L0293

Alternate gene names: 15673627

Gene position: 1694062-1691732 (Counterclockwise)

Preceding gene: 15673628

Following gene: 15673626

Centisome position: 71.61

GC content: 35.35

Gene sequence:

>2331_bases
ATGAATAAAAAAATTCTCCAAATATTGGAATATGATAAAGTCAAAGAACAGTTTATGAATGCTTTGACGACAGCGCAGGG
TCAACAAGAATTAAAAGATTTAAAACCTTTGACAGATAAGGAAAAAATTCAGCTCCTTTTTGATGAAGTTGCTGATTTTC
GCTTATTGACCCAAGAAAATGGCCTATTAAATTTAGGAAAAACAAATGATTTAACAGAAATACTCAGACGTCTAGAGCTT
GAAGCCAGTCTTTCAGGCAAGGAATTCGTTGAAATAAAAAAAGTGATTCAATTAGGGATTAATATTCAACGCTTTTTTGA
TGAAGCTGAAAATGTTGAAACACCTTCACTAGCTATTACTTTGGAAAAATTGGTTGATTTATCAGCATTAGTCAAAAAAT
TAGAAATTTTTGATAATGCGGGAAGTCTTTATGATAATGCCAGTCTCGAATTGATGCATATCCGTGCTTCAATCAAGAGT
CATCAATCAGAAATTCGGAAAATCATGCAGGAAATGCTGACCAAAAATCTCTCATCTTTGAGTGAAAATGTCATCACTAT
CCGAAATGACCGACAAGTGCTTCCTGTAAAAGCAGAAAACAAAAATAAAATTGCTGGTGTAGTTCATGATATGTCTGCTT
CAGGTCAAACGCTTTATATTGAACCAAATGCGGTTGTTTCATTAAATAATAAACTTAATCAAAAGAGAATTGAAGAACGC
CAAGAAATCACAAGAATTTATCGTGAGCTTGCTAGTCAATTAAAACCTTATAGCTTTGATATAAGACAAAATGCTTGGCT
GATTGGTCATATTGATTTTGTTCGTGCCAAGTATCTTTATTTAGCAGCGAATAAAGCGACACTTCCAGAATTAACAACCG
ATAAAGATATTACCCTTTTTGCAGCTCGCCATCCTTTGATTGAAGCAAAAATAGTTGTGACAAATGATATTAAATTTGAT
GCAGGGCTCAATACGATTGTTATTACCGGTCCAAATACGGGTGGGAAGACCATTACTTTGAAAACAGTTGGTTTGTTGAC
AATATTGGCTCAATCAGGTCTGCCAATTTTAGCCGCTGATGGCAGTCGAATTCATCTTTTTGATGATATTTTTGCCGATA
TCGGTGATGAGCAATCCATTGAGCAAAGTTTATCAACTTTCTCAAGTCATATGACTAATATTGTTCATATTTTAGCTCAA
GCAGATGAAAATAGTTTGGTCTTGTTTGATGAACTTGGGGCAGGAACTGATCCAAAAGAAGGAGCGGCTCTTGCTATTGC
CATACTGGAAAATTTACGTGAACGAAATGTGAAAACCATGGCAAGTACTCATTATCCTGAGTTAAAAGCTTATGGGGTCG
AAACGCAACGAGTAATCAATGCAAGTATGGAATTTAACATTGATAAAATGCAACCCACTTATCATTTGCAACTGGGAGTG
CCTGGGCGTTCAAATGCCTTGGAGATTTCTAGAAGATTAGGTTTGCCAGAAACCATTATTTCAGTAGCCAGTCAACAAAT
TTCTGACAGTGAGCATGATGTCAATCAGATGATTGAAAAGTTGGAAGAAAAAACGCGTGAAGTGATTGAAAGTTCAAGAA
ATATTAAAAAAATTGAACGAGAAAATCAAAGTTTACATAAAGATTTGACGAAAGTCTATAATCAAATTAATCGCGAGCGC
GAGTTTGAATTAGAAAAAGCACAAAAAGAAGCTCAAGAAGTAGTTAAAAAAGCGAGTCTTGAAGCGCAAGAAATTTTGAA
GAATCTCAATGATAAAGCAGCGTTGAAACCACATGAAATTATTGCTGCTAGAAAAGAACTTGAAGGTTTGGCTCCAACCA
TTGATTTTTCTAAAAATAAGGTTTTGAAAAAAGCGAAAGCACAAAGAGGACTTAAGCAAGGGGCTGAAGTTAATGTCACT
TCTTATGGTCAGCGTGGTAAATTGATTCGTTTAGAAAAAGATGGACGTTGGACGGTTCAGATGGGTTCAATCACGACTCG
TTTAAATGAAGATGAATTTGAAGTGATTGAAAGTCCAGAACAAATTCAAGCCAAAACTAAAAATGTCAGCAAGAAGGTGA
CTTCTAAAGTCAAAGCTCAACTTGATTTACGCGGGATGCGTTATGAAGAAGCAGAACTGGAATTGGATAATTATATTGAC
CAAGCTCTACTTGCAAATTTGATTCAAATTACGATTGTTCATGGGATTGGAACGGGTGTTATTCGAGAAATGGTACAGAA
AAAACTTCAAAAACACCGTCATATTAAATCTTATGAATATGCACCAATTAATGCTGGTGGCTCTGGAGCAACGATTGCTA
TTTTGAAGTAA

Upstream 100 bases:

>100_bases
GAATCTTGCAAAACCTTTTTATTGAAAATATTGTCCACATTAATCCTCTAGGATAGTGCTAGGGGAGAAATCTACAGATA
CAACTTGAAATTTAAATAGA

Downstream 100 bases:

>100_bases
AATAATAAATTTCTCAAAATCTATTTTCTTGAAATTTTAAGTGAATTACACTAGAATAGTCTTACTGAAGAAAATTATTT
CAATGAAGGAGATAAAATGG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 776; Mature: 776

Protein sequence:

>776_residues
MNKKILQILEYDKVKEQFMNALTTAQGQQELKDLKPLTDKEKIQLLFDEVADFRLLTQENGLLNLGKTNDLTEILRRLEL
EASLSGKEFVEIKKVIQLGINIQRFFDEAENVETPSLAITLEKLVDLSALVKKLEIFDNAGSLYDNASLELMHIRASIKS
HQSEIRKIMQEMLTKNLSSLSENVITIRNDRQVLPVKAENKNKIAGVVHDMSASGQTLYIEPNAVVSLNNKLNQKRIEER
QEITRIYRELASQLKPYSFDIRQNAWLIGHIDFVRAKYLYLAANKATLPELTTDKDITLFAARHPLIEAKIVVTNDIKFD
AGLNTIVITGPNTGGKTITLKTVGLLTILAQSGLPILAADGSRIHLFDDIFADIGDEQSIEQSLSTFSSHMTNIVHILAQ
ADENSLVLFDELGAGTDPKEGAALAIAILENLRERNVKTMASTHYPELKAYGVETQRVINASMEFNIDKMQPTYHLQLGV
PGRSNALEISRRLGLPETIISVASQQISDSEHDVNQMIEKLEEKTREVIESSRNIKKIERENQSLHKDLTKVYNQINRER
EFELEKAQKEAQEVVKKASLEAQEILKNLNDKAALKPHEIIAARKELEGLAPTIDFSKNKVLKKAKAQRGLKQGAEVNVT
SYGQRGKLIRLEKDGRWTVQMGSITTRLNEDEFEVIESPEQIQAKTKNVSKKVTSKVKAQLDLRGMRYEEAELELDNYID
QALLANLIQITIVHGIGTGVIREMVQKKLQKHRHIKSYEYAPINAGGSGATIAILK

Sequences:

>Translated_776_residues
MNKKILQILEYDKVKEQFMNALTTAQGQQELKDLKPLTDKEKIQLLFDEVADFRLLTQENGLLNLGKTNDLTEILRRLEL
EASLSGKEFVEIKKVIQLGINIQRFFDEAENVETPSLAITLEKLVDLSALVKKLEIFDNAGSLYDNASLELMHIRASIKS
HQSEIRKIMQEMLTKNLSSLSENVITIRNDRQVLPVKAENKNKIAGVVHDMSASGQTLYIEPNAVVSLNNKLNQKRIEER
QEITRIYRELASQLKPYSFDIRQNAWLIGHIDFVRAKYLYLAANKATLPELTTDKDITLFAARHPLIEAKIVVTNDIKFD
AGLNTIVITGPNTGGKTITLKTVGLLTILAQSGLPILAADGSRIHLFDDIFADIGDEQSIEQSLSTFSSHMTNIVHILAQ
ADENSLVLFDELGAGTDPKEGAALAIAILENLRERNVKTMASTHYPELKAYGVETQRVINASMEFNIDKMQPTYHLQLGV
PGRSNALEISRRLGLPETIISVASQQISDSEHDVNQMIEKLEEKTREVIESSRNIKKIERENQSLHKDLTKVYNQINRER
EFELEKAQKEAQEVVKKASLEAQEILKNLNDKAALKPHEIIAARKELEGLAPTIDFSKNKVLKKAKAQRGLKQGAEVNVT
SYGQRGKLIRLEKDGRWTVQMGSITTRLNEDEFEVIESPEQIQAKTKNVSKKVTSKVKAQLDLRGMRYEEAELELDNYID
QALLANLIQITIVHGIGTGVIREMVQKKLQKHRHIKSYEYAPINAGGSGATIAILK
>Mature_776_residues
MNKKILQILEYDKVKEQFMNALTTAQGQQELKDLKPLTDKEKIQLLFDEVADFRLLTQENGLLNLGKTNDLTEILRRLEL
EASLSGKEFVEIKKVIQLGINIQRFFDEAENVETPSLAITLEKLVDLSALVKKLEIFDNAGSLYDNASLELMHIRASIKS
HQSEIRKIMQEMLTKNLSSLSENVITIRNDRQVLPVKAENKNKIAGVVHDMSASGQTLYIEPNAVVSLNNKLNQKRIEER
QEITRIYRELASQLKPYSFDIRQNAWLIGHIDFVRAKYLYLAANKATLPELTTDKDITLFAARHPLIEAKIVVTNDIKFD
AGLNTIVITGPNTGGKTITLKTVGLLTILAQSGLPILAADGSRIHLFDDIFADIGDEQSIEQSLSTFSSHMTNIVHILAQ
ADENSLVLFDELGAGTDPKEGAALAIAILENLRERNVKTMASTHYPELKAYGVETQRVINASMEFNIDKMQPTYHLQLGV
PGRSNALEISRRLGLPETIISVASQQISDSEHDVNQMIEKLEEKTREVIESSRNIKKIERENQSLHKDLTKVYNQINRER
EFELEKAQKEAQEVVKKASLEAQEILKNLNDKAALKPHEIIAARKELEGLAPTIDFSKNKVLKKAKAQRGLKQGAEVNVT
SYGQRGKLIRLEKDGRWTVQMGSITTRLNEDEFEVIESPEQIQAKTKNVSKKVTSKVKAQLDLRGMRYEEAELELDNYID
QALLANLIQITIVHGIGTGVIREMVQKKLQKHRHIKSYEYAPINAGGSGATIAILK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain

Homologues:

Organism=Homo sapiens, GI36949366, Length=257, Percent_Identity=30.3501945525292, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI284813531, Length=262, Percent_Identity=30.1526717557252, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI4557761, Length=530, Percent_Identity=23.9622641509434, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI4504191, Length=174, Percent_Identity=33.9080459770115, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI26638666, Length=218, Percent_Identity=32.1100917431193, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI4505253, Length=218, Percent_Identity=32.1100917431193, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI26638664, Length=222, Percent_Identity=32.8828828828829, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI262231786, Length=142, Percent_Identity=39.4366197183099, Blast_Score=77, Evalue=9e-14,
Organism=Escherichia coli, GI1789089, Length=313, Percent_Identity=27.7955271565495, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17508445, Length=250, Percent_Identity=29.2, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17534743, Length=250, Percent_Identity=26.8, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17508447, Length=270, Percent_Identity=28.1481481481481, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17539736, Length=252, Percent_Identity=25, Blast_Score=77, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324482, Length=355, Percent_Identity=23.0985915492958, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321912, Length=315, Percent_Identity=24.7619047619048, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319935, Length=152, Percent_Identity=37.5, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321109, Length=239, Percent_Identity=26.7782426778243, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320047, Length=291, Percent_Identity=26.1168384879725, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24664545, Length=234, Percent_Identity=33.7606837606838, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24584320, Length=224, Percent_Identity=29.0178571428571, Blast_Score=100, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTS2_LACLA (Q9CF36)

Other databases:

- EMBL:   AE005176
- PIR:   E86830
- RefSeq:   NP_267801.1
- HSSP:   P23909
- ProteinModelPortal:   Q9CF36
- SMR:   Q9CF36
- GeneID:   1115305
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0293
- NMPDR:   fig|272623.1.peg.1687
- HOGENOM:   HBG486560
- OMA:   PGLVHDQ
- ProtClustDB:   CLSK876903
- BioCyc:   LLAC272623:L0293-MONOMER
- HAMAP:   MF_00092
- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625
- PANTHER:   PTHR11361
- PIRSF:   PIRSF005814
- SMART:   SM00534
- SMART:   SM00533
- SMART:   SM00463
- TIGRFAMs:   TIGR01069

Pfam domain/function: PF00488 MutS_V; PF01713 Smr; SSF48334 DNA_repair_MutS_domIII

EC number: NA

Molecular weight: Translated: 87298; Mature: 87298

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2; PS50828 SMR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKILQILEYDKVKEQFMNALTTAQGQQELKDLKPLTDKEKIQLLFDEVADFRLLTQEN
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHEEEECCC
GLLNLGKTNDLTEILRRLELEASLSGKEFVEIKKVIQLGINIQRFFDEAENVETPSLAIT
CEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHEEE
LEKLVDLSALVKKLEIFDNAGSLYDNASLELMHIRASIKSHQSEIRKIMQEMLTKNLSSL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
SENVITIRNDRQVLPVKAENKNKIAGVVHDMSASGQTLYIEPNAVVSLNNKLNQKRIEER
HCCEEEEECCCEEEEEECCCCCCHHHEEEECCCCCCEEEECCCEEEEECCHHHHHHHHHH
QEITRIYRELASQLKPYSFDIRQNAWLIGHIDFVRAKYLYLAANKATLPELTTDKDITLF
HHHHHHHHHHHHHCCCCEEEECCCCEEEEEHHHHHHEEEEEEECCCCCCCCCCCCCEEEE
AARHPLIEAKIVVTNDIKFDAGLNTIVITGPNTGGKTITLKTVGLLTILAQSGLPILAAD
EECCCCEEEEEEEEECEEECCCCCEEEEECCCCCCCEEEEEHHHHHHHHHHCCCEEEEEC
GSRIHLFDDIFADIGDEQSIEQSLSTFSSHMTNIVHILAQADENSLVLFDELGAGTDPKE
CCEEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCC
GAALAIAILENLRERNVKTMASTHYPELKAYGVETQRVINASMEFNIDKMQPTYHLQLGV
CHHHHHHHHHHHHHCCHHHHHHCCCCCHHHCCCCHHHHHCCHHEECEECCCCEEEEEECC
PGRSNALEISRRLGLPETIISVASQQISDSEHDVNQMIEKLEEKTREVIESSRNIKKIER
CCCCCHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ENQSLHKDLTKVYNQINREREFELEKAQKEAQEVVKKASLEAQEILKNLNDKAALKPHEI
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHH
IAARKELEGLAPTIDFSKNKVLKKAKAQRGLKQGAEVNVTSYGQRGKLIRLEKDGRWTVQ
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCEEEE
MGSITTRLNEDEFEVIESPEQIQAKTKNVSKKVTSKVKAQLDLRGMRYEEAELELDNYID
ECCEEECCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
QALLANLIQITIVHGIGTGVIREMVQKKLQKHRHIKSYEYAPINAGGSGATIAILK
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MNKKILQILEYDKVKEQFMNALTTAQGQQELKDLKPLTDKEKIQLLFDEVADFRLLTQEN
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHEEEECCC
GLLNLGKTNDLTEILRRLELEASLSGKEFVEIKKVIQLGINIQRFFDEAENVETPSLAIT
CEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHEEE
LEKLVDLSALVKKLEIFDNAGSLYDNASLELMHIRASIKSHQSEIRKIMQEMLTKNLSSL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
SENVITIRNDRQVLPVKAENKNKIAGVVHDMSASGQTLYIEPNAVVSLNNKLNQKRIEER
HCCEEEEECCCEEEEEECCCCCCHHHEEEECCCCCCEEEECCCEEEEECCHHHHHHHHHH
QEITRIYRELASQLKPYSFDIRQNAWLIGHIDFVRAKYLYLAANKATLPELTTDKDITLF
HHHHHHHHHHHHHCCCCEEEECCCCEEEEEHHHHHHEEEEEEECCCCCCCCCCCCCEEEE
AARHPLIEAKIVVTNDIKFDAGLNTIVITGPNTGGKTITLKTVGLLTILAQSGLPILAAD
EECCCCEEEEEEEEECEEECCCCCEEEEECCCCCCCEEEEEHHHHHHHHHHCCCEEEEEC
GSRIHLFDDIFADIGDEQSIEQSLSTFSSHMTNIVHILAQADENSLVLFDELGAGTDPKE
CCEEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCC
GAALAIAILENLRERNVKTMASTHYPELKAYGVETQRVINASMEFNIDKMQPTYHLQLGV
CHHHHHHHHHHHHHCCHHHHHHCCCCCHHHCCCCHHHHHCCHHEECEECCCCEEEEEECC
PGRSNALEISRRLGLPETIISVASQQISDSEHDVNQMIEKLEEKTREVIESSRNIKKIER
CCCCCHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ENQSLHKDLTKVYNQINREREFELEKAQKEAQEVVKKASLEAQEILKNLNDKAALKPHEI
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHH
IAARKELEGLAPTIDFSKNKVLKKAKAQRGLKQGAEVNVTSYGQRGKLIRLEKDGRWTVQ
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCEEEE
MGSITTRLNEDEFEVIESPEQIQAKTKNVSKKVTSKVKAQLDLRGMRYEEAELELDNYID
ECCEEECCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
QALLANLIQITIVHGIGTGVIREMVQKKLQKHRHIKSYEYAPINAGGSGATIAILK
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471