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The map label for this gene is uxuA

Identifier: 15673613

GI number: 15673613

Start: 1677084

End: 1678160

Strand: Reverse

Name: uxuA

Synonym: L0020

Alternate gene names: 15673613

Gene position: 1678160-1677084 (Counterclockwise)

Preceding gene: 15673614

Following gene: 15673612

Centisome position: 70.94

GC content: 38.72

Gene sequence:

>1077_bases
ATGGAAATGACAATGCGTTGGTTTGGTTCAAATGCAGATAAGATAAAACTTTCTGAAATTGCCCAAGTTCCAGGTGTTAA
AGGAGTCGTTGGAATGATTATGGACATTCCAGCGGGAGAAATTTGGCCAAAGGAGAGAATCAAAGCACTTAAAGAGGAAA
TCGAAGCCGCAGGTTTAACTTTAAAAGTAATTGAATCTGTCAATATTCATGATGATATCAAAATTGGCTTGCCAACTCGT
GATAAATATATTGAGAATTATAAAGAAACGATTCGAAATCTTGCTGAGTTTGGGATTGAAGTGATTTGCTATAATTTTAT
GCCTGTATTTGACTGGTTGAAATCAGATTTGGATTATCGTTTAGCTGATAATTCACAAACTATGGCTTTTGTTGCTAGAG
ATATTCCAGCAAACCCTCAGGAGATAATTGACCGCGTTCAAGCAGCGGATGGTTGCTTTTCACTCCCAGGTTGGGAACCT
GAAAGATTATCAGAAGTCAGAGGACTCTTTGAGGCATACAAAAATGTCGATGAGCATAAATTGCGTGAAAATTTTGCTTA
TTTTTTAAAAGCAATCATTCCTACATGTGAAGAAGTTGGGATTAAAATGGCGGTTCACCCTGATGACCCTCCTTATCCTA
TGTTTGGGCTTCCTCGGGTGGTGAAAAATCGGGAAGATTTAGATTGGATATGTAATGTTGTAGATAGTCCGTCAAACGCG
ATTACGCTTTGTACGGGGTCGATTGCTGAAGATCCAGCTAATAATGTCTATGAAATTATGGCTGAATTTGTCAAAAGAGA
CCGAATTCCTTTTGCACATGTGCGGAATATTAAATTTTTGCCAAGTGGTAAAAAAGATTTTTACGAAGCTCCTCATATGT
CGAAGTATGGTTCGCTTGATATGTATAAAATAATGAAAGCCATGTATGATAATGGTTTTGATGGCTATATTCGTCCAGAC
CATGGTCGAATGATTTGGGGAGAAACAGGACGCCCAGGCTACGGTTTATATGACCGAGCACTTGGAGCAAGTTATCTTAA
TGGGCTTTGGGAGGCGCTTGAGAAAACGAATCAGTAA

Upstream 100 bases:

>100_bases
ACGAAATCATTGACGTACAACTTTCAGCTGGTCTTACCGCTTGGTGGGAAGCTACAGCACGCTATTTGATTTTATATAAA
TAAGATAAAGGAATAAAAAA

Downstream 100 bases:

>100_bases
ATAAAAATGATATGAAGAAATCTATTTTAAAGAACTTTTTGTGAAAAAAATGTGCGGAGAATACTCTCCGCTAAAATTAA
AACGTTGGAGTAAGCGTTTC

Product: mannonate dehydratase

Products: NA

Alternate protein names: D-mannonate hydrolase

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MEMTMRWFGSNADKIKLSEIAQVPGVKGVVGMIMDIPAGEIWPKERIKALKEEIEAAGLTLKVIESVNIHDDIKIGLPTR
DKYIENYKETIRNLAEFGIEVICYNFMPVFDWLKSDLDYRLADNSQTMAFVARDIPANPQEIIDRVQAADGCFSLPGWEP
ERLSEVRGLFEAYKNVDEHKLRENFAYFLKAIIPTCEEVGIKMAVHPDDPPYPMFGLPRVVKNREDLDWICNVVDSPSNA
ITLCTGSIAEDPANNVYEIMAEFVKRDRIPFAHVRNIKFLPSGKKDFYEAPHMSKYGSLDMYKIMKAMYDNGFDGYIRPD
HGRMIWGETGRPGYGLYDRALGASYLNGLWEALEKTNQ

Sequences:

>Translated_358_residues
MEMTMRWFGSNADKIKLSEIAQVPGVKGVVGMIMDIPAGEIWPKERIKALKEEIEAAGLTLKVIESVNIHDDIKIGLPTR
DKYIENYKETIRNLAEFGIEVICYNFMPVFDWLKSDLDYRLADNSQTMAFVARDIPANPQEIIDRVQAADGCFSLPGWEP
ERLSEVRGLFEAYKNVDEHKLRENFAYFLKAIIPTCEEVGIKMAVHPDDPPYPMFGLPRVVKNREDLDWICNVVDSPSNA
ITLCTGSIAEDPANNVYEIMAEFVKRDRIPFAHVRNIKFLPSGKKDFYEAPHMSKYGSLDMYKIMKAMYDNGFDGYIRPD
HGRMIWGETGRPGYGLYDRALGASYLNGLWEALEKTNQ
>Mature_358_residues
MEMTMRWFGSNADKIKLSEIAQVPGVKGVVGMIMDIPAGEIWPKERIKALKEEIEAAGLTLKVIESVNIHDDIKIGLPTR
DKYIENYKETIRNLAEFGIEVICYNFMPVFDWLKSDLDYRLADNSQTMAFVARDIPANPQEIIDRVQAADGCFSLPGWEP
ERLSEVRGLFEAYKNVDEHKLRENFAYFLKAIIPTCEEVGIKMAVHPDDPPYPMFGLPRVVKNREDLDWICNVVDSPSNA
ITLCTGSIAEDPANNVYEIMAEFVKRDRIPFAHVRNIKFLPSGKKDFYEAPHMSKYGSLDMYKIMKAMYDNGFDGYIRPD
HGRMIWGETGRPGYGLYDRALGASYLNGLWEALEKTNQ

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG1312

COG function: function code G; D-mannonate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannonate dehydratase family

Homologues:

Organism=Escherichia coli, GI1790778, Length=396, Percent_Identity=38.8888888888889, Blast_Score=259, Evalue=3e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UXUA_LACLA (Q9CF50)

Other databases:

- EMBL:   AE005176
- PIR:   G86828
- RefSeq:   NP_267787.1
- ProteinModelPortal:   Q9CF50
- GeneID:   1115291
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0020
- NMPDR:   fig|272623.1.peg.1673
- HOGENOM:   HBG585927
- OMA:   DIKLGKP
- ProtClustDB:   PRK03906
- BioCyc:   LLAC272623:L0020-MONOMER
- BRENDA:   4.2.1.8
- HAMAP:   MF_00106
- InterPro:   IPR004628
- InterPro:   IPR013022
- Gene3D:   G3DSA:3.20.20.150
- PIRSF:   PIRSF016049
- TIGRFAMs:   TIGR00695

Pfam domain/function: PF03786 UxuA; SSF51658 Xyl_isomerase-like_TIM-brl

EC number: =4.2.1.8

Molecular weight: Translated: 40826; Mature: 40826

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMTMRWFGSNADKIKLSEIAQVPGVKGVVGMIMDIPAGEIWPKERIKALKEEIEAAGLT
CCCEEEECCCCCCEEEHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCE
LKVIESVNIHDDIKIGLPTRDKYIENYKETIRNLAEFGIEVICYNFMPVFDWLKSDLDYR
EEEHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEE
LADNSQTMAFVARDIPANPQEIIDRVQAADGCFSLPGWEPERLSEVRGLFEAYKNVDEHK
ECCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHH
LRENFAYFLKAIIPTCEEVGIKMAVHPDDPPYPMFGLPRVVKNREDLDWICNVVDSPSNA
HHHHHHHHHHHHHCCHHHCCCEEEECCCCCCCCCCCCCHHHCCCCCHHHHHHHHCCCCCE
ITLCTGSIAEDPANNVYEIMAEFVKRDRIPFAHVRNIKFLPSGKKDFYEAPHMSKYGSLD
EEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCEEECCCCCHHHHCCCCCCCCCCCH
MYKIMKAMYDNGFDGYIRPDHGRMIWGETGRPGYGLYDRALGASYLNGLWEALEKTNQ
HHHHHHHHHCCCCCCCEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEMTMRWFGSNADKIKLSEIAQVPGVKGVVGMIMDIPAGEIWPKERIKALKEEIEAAGLT
CCCEEEECCCCCCEEEHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCE
LKVIESVNIHDDIKIGLPTRDKYIENYKETIRNLAEFGIEVICYNFMPVFDWLKSDLDYR
EEEHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEE
LADNSQTMAFVARDIPANPQEIIDRVQAADGCFSLPGWEPERLSEVRGLFEAYKNVDEHK
ECCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHH
LRENFAYFLKAIIPTCEEVGIKMAVHPDDPPYPMFGLPRVVKNREDLDWICNVVDSPSNA
HHHHHHHHHHHHHCCHHHCCCEEEECCCCCCCCCCCCCHHHCCCCCHHHHHHHHCCCCCE
ITLCTGSIAEDPANNVYEIMAEFVKRDRIPFAHVRNIKFLPSGKKDFYEAPHMSKYGSLD
EEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCEEECCCCCHHHHCCCCCCCCCCCH
MYKIMKAMYDNGFDGYIRPDHGRMIWGETGRPGYGLYDRALGASYLNGLWEALEKTNQ
HHHHHHHHHCCCCCCCEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471