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The map label for this gene is pyrP

Identifier: 15673585

GI number: 15673585

Start: 1646369

End: 1647661

Strand: Reverse

Name: pyrP

Synonym: L46118

Alternate gene names: 15673585

Gene position: 1647661-1646369 (Counterclockwise)

Preceding gene: 15673586

Following gene: 15673584

Centisome position: 69.65

GC content: 38.52

Gene sequence:

>1293_bases
GTGCACGATAATGATATTATCTTAAAAGTTGATGAGAAACCAGCTGCAAGTCAGTGGTTTGGTCTCTCATTTCAACATTT
GTTTGCCATGTTTGGCTCAACGGTTTTGGTGCCAATTTTAGTTGGGATTAACCCAGCCATTGCCCTCTTGAGTTCTGGAC
TTGGTACACTTGCACACATGAGTGTTACAAAATTTAAAGTGCCAGCTTACATGGGTTCAAGCTTTGCCTATATTGGTGCG
ATGACTTTACTGATGAAAAATGGTGGAATGCCAGCCATTGCTCAAGGGGCAATGACTGGTGGATTGGTTTATCTGATTGT
CGCTTTAATTGTAAAATTTGCAGGTAAAGGCTGGATTGACAAAGTTTTACCGCCAATCGTCGTTGGGCCAATCGTTATGG
TCATTGGATTATCACTTGCTCCAACAGCAATTAATGATGCCATGTACACGGACGTTGCAAATCTAAAAGGATACAGTTTA
GCTTATATCATTATTGCCCTCATCACTGTGTTATCTATTGTCATTTACAGTATCTATGGCAAAGGATTTCTGTCAGTTGT
TCCAATTTTACTTGGAATCATCACAGGATATGTTGCAGCAATGATTATTGGTAAGATTACAGGGATGAACATTGTTTCAT
TCACTGGAATCTCACATGCTAAGTGGCTGACCATTCCACCAATGGAAATTCCATTTGCCAATTACAAGTGGGCCTTCTAT
CCGTCAGCAATTTTGACAATGGCACCGATTGCTTTTGTCACAATGACTGAGCATTTTGGCCACATTATGGTTTTGAATTC
ATTAACTAAAAAAGATTACTTTAAAGAACCAGGATTAGAAAAAACATTAACTGGTGACGGTCTAGCTCAAATCATCGCCG
GATTTATTGGTGCACCGCCGGTGACCTCTTACGGTGAAAATATTGGAGTTATGGCAATTACAAAAATTCATTCGATTTAT
GTTATTGCTGGAGCTGCCGTTCTTGCTATCGTTGTCTCATTCATTGGGAAAATTACAGCACTCTTGCAATCAATTCCAGC
ACCCGTCATCGGGGGAGCATCAATTGCCCTTTTTGGAGTAATTGCAGCTTCTGGTTTGAAAATTTTAGTTGAAAATAAAG
TTAATTTTGATATCAAACGAAACTTACTAATCAGCTCAGTTGTTCTTGTTATCGGGATTGGTGGAATGATTATTAATATC
ACTCAAAATTTACAAATTTCATCAGTAGCCATTGCAACAATTCTCGGAATTGTTTTAAATCTTGTCTTGCCAAAAGATCC
TAGCGAAATTTAA

Upstream 100 bases:

>100_bases
GATTAAAAAATTTCTGTCAGTAATTTAAAGTAAAAAATATGCTGTCAGTTACTGACGAAAGAATTAACAAATATTCAACT
TAGAGTTTTAGGAGAAAAAA

Downstream 100 bases:

>100_bases
AAGATTCAAAATTACTGACAGAATCGTCAGTAATTAAAAAAAGTGAACTTATAACTGATAGAAATCCTATCGAGATTTCC
ATCAGTAGATAAAAATTTTG

Product: uracil permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MHDNDIILKVDEKPAASQWFGLSFQHLFAMFGSTVLVPILVGINPAIALLSSGLGTLAHMSVTKFKVPAYMGSSFAYIGA
MTLLMKNGGMPAIAQGAMTGGLVYLIVALIVKFAGKGWIDKVLPPIVVGPIVMVIGLSLAPTAINDAMYTDVANLKGYSL
AYIIIALITVLSIVIYSIYGKGFLSVVPILLGIITGYVAAMIIGKITGMNIVSFTGISHAKWLTIPPMEIPFANYKWAFY
PSAILTMAPIAFVTMTEHFGHIMVLNSLTKKDYFKEPGLEKTLTGDGLAQIIAGFIGAPPVTSYGENIGVMAITKIHSIY
VIAGAAVLAIVVSFIGKITALLQSIPAPVIGGASIALFGVIAASGLKILVENKVNFDIKRNLLISSVVLVIGIGGMIINI
TQNLQISSVAIATILGIVLNLVLPKDPSEI

Sequences:

>Translated_430_residues
MHDNDIILKVDEKPAASQWFGLSFQHLFAMFGSTVLVPILVGINPAIALLSSGLGTLAHMSVTKFKVPAYMGSSFAYIGA
MTLLMKNGGMPAIAQGAMTGGLVYLIVALIVKFAGKGWIDKVLPPIVVGPIVMVIGLSLAPTAINDAMYTDVANLKGYSL
AYIIIALITVLSIVIYSIYGKGFLSVVPILLGIITGYVAAMIIGKITGMNIVSFTGISHAKWLTIPPMEIPFANYKWAFY
PSAILTMAPIAFVTMTEHFGHIMVLNSLTKKDYFKEPGLEKTLTGDGLAQIIAGFIGAPPVTSYGENIGVMAITKIHSIY
VIAGAAVLAIVVSFIGKITALLQSIPAPVIGGASIALFGVIAASGLKILVENKVNFDIKRNLLISSVVLVIGIGGMIINI
TQNLQISSVAIATILGIVLNLVLPKDPSEI
>Mature_430_residues
MHDNDIILKVDEKPAASQWFGLSFQHLFAMFGSTVLVPILVGINPAIALLSSGLGTLAHMSVTKFKVPAYMGSSFAYIGA
MTLLMKNGGMPAIAQGAMTGGLVYLIVALIVKFAGKGWIDKVLPPIVVGPIVMVIGLSLAPTAINDAMYTDVANLKGYSL
AYIIIALITVLSIVIYSIYGKGFLSVVPILLGIITGYVAAMIIGKITGMNIVSFTGISHAKWLTIPPMEIPFANYKWAFY
PSAILTMAPIAFVTMTEHFGHIMVLNSLTKKDYFKEPGLEKTLTGDGLAQIIAGFIGAPPVTSYGENIGVMAITKIHSIY
VIAGAAVLAIVVSFIGKITALLQSIPAPVIGGASIALFGVIAASGLKILVENKVNFDIKRNLLISSVVLVIGIGGMIINI
TQNLQISSVAIATILGIVLNLVLPKDPSEI

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=511, Percent_Identity=24.26614481409, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI44680143, Length=515, Percent_Identity=24.0776699029126, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1788843, Length=414, Percent_Identity=43.719806763285, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI87081818, Length=426, Percent_Identity=36.3849765258216, Blast_Score=247, Evalue=9e-67,
Organism=Escherichia coli, GI87082181, Length=440, Percent_Identity=26.5909090909091, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1790087, Length=470, Percent_Identity=23.4042553191489, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87082178, Length=421, Percent_Identity=23.7529691211401, Blast_Score=83, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45313; Mature: 45313

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDNDIILKVDEKPAASQWFGLSFQHLFAMFGSTVLVPILVGINPAIALLSSGLGTLAHM
CCCCCEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHH
SVTKFKVPAYMGSSFAYIGAMTLLMKNGGMPAIAQGAMTGGLVYLIVALIVKFAGKGWID
HHHEEECCHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCHH
KVLPPIVVGPIVMVIGLSLAPTAINDAMYTDVANLKGYSLAYIIIALITVLSIVIYSIYG
HHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
KGFLSVVPILLGIITGYVAAMIIGKITGMNIVSFTGISHAKWLTIPPMEIPFANYKWAFY
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEECCCCCCCCCCCEEEEC
PSAILTMAPIAFVTMTEHFGHIMVLNSLTKKDYFKEPGLEKTLTGDGLAQIIAGFIGAPP
CHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCC
VTSYGENIGVMAITKIHSIYVIAGAAVLAIVVSFIGKITALLQSIPAPVIGGASIALFGV
CCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
IAASGLKILVENKVNFDIKRNLLISSVVLVIGIGGMIINITQNLQISSVAIATILGIVLN
HHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCEEHHHHHHHHHHHHHH
LVLPKDPSEI
HHCCCCCCCC
>Mature Secondary Structure
MHDNDIILKVDEKPAASQWFGLSFQHLFAMFGSTVLVPILVGINPAIALLSSGLGTLAHM
CCCCCEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHH
SVTKFKVPAYMGSSFAYIGAMTLLMKNGGMPAIAQGAMTGGLVYLIVALIVKFAGKGWID
HHHEEECCHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCHH
KVLPPIVVGPIVMVIGLSLAPTAINDAMYTDVANLKGYSLAYIIIALITVLSIVIYSIYG
HHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
KGFLSVVPILLGIITGYVAAMIIGKITGMNIVSFTGISHAKWLTIPPMEIPFANYKWAFY
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEECCCCCCCCCCCEEEEC
PSAILTMAPIAFVTMTEHFGHIMVLNSLTKKDYFKEPGLEKTLTGDGLAQIIAGFIGAPP
CHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCC
VTSYGENIGVMAITKIHSIYVIAGAAVLAIVVSFIGKITALLQSIPAPVIGGASIALFGV
CCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
IAASGLKILVENKVNFDIKRNLLISSVVLVIGIGGMIINITQNLQISSVAIATILGIVLN
HHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCEEHHHHHHHHHHHHHH
LVLPKDPSEI
HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8206848 [H]