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The map label for this gene is pyrR

Identifier: 15673586

GI number: 15673586

Start: 1647756

End: 1648277

Strand: Reverse

Name: pyrR

Synonym: L0227

Alternate gene names: 15673586

Gene position: 1648277-1647756 (Counterclockwise)

Preceding gene: 15673587

Following gene: 15673585

Centisome position: 69.68

GC content: 38.7

Gene sequence:

>522_bases
ATGGCTAGAAAAGAAATTATTGACGAAATCACAATGAAACGTGCAATTACACGTATCACTTACGAGATTATTGAACGTAA
TAAAGAGCTGGACAAATTGGTTTTGATTGGGATTAAAACACGTGGTGTTTATTTAGCAAAAAGAATCCAAGAACGTTTGC
AACAATTAGAAGGTTTGGAAATTCCTTTTGGTGAGTTGGATACACGTCCATTCCGTGATGACAAACAAGCTCAAGAAGAC
ACGACAGAAATTGACATCGATATTACAGGAAAAGATGTCATTCTTGTCGATGATGTGCTCTACACAGGTCGGACAATCCG
TGCGGCAATTGATGGAATTGTAAAACTCGGTCGTCCAGCTCGTGTTCAATTGGCTGTATTAGTTGACCGTGGACATCGTG
AATTGCCAATTCGTGCAGACTACGTTGGGAAAAATATTCCAACGGGTCGTGATGAAGAAATCATTGTTCAAATGTCTGAA
CACGATGGCAATGACAGTATTTTAATTAAACGTGAAGATTAA

Upstream 100 bases:

>100_bases
TTGTATGTTAATGGACAACTTAGAAATGGAAGCTAAATCGCTAAATGAAAGATTTGTTAGTTTACTGACCAATTGATCAT
CAAGAATGAAAGGAGCCACA

Downstream 100 bases:

>100_bases
AAAATTTCTGTCAGTAATTTAAAGTAAAAAATATGCTGTCAGTTACTGACGAAAGAATTAACAAATATTCAACTTAGAGT
TTTAGGAGAAAAAAGTGCAC

Product: bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase

Products: uracil; 5-phospho-alpha-D-ribose 1-diphosphate

Alternate protein names: NA

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MARKEIIDEITMKRAITRITYEIIERNKELDKLVLIGIKTRGVYLAKRIQERLQQLEGLEIPFGELDTRPFRDDKQAQED
TTEIDIDITGKDVILVDDVLYTGRTIRAAIDGIVKLGRPARVQLAVLVDRGHRELPIRADYVGKNIPTGRDEEIIVQMSE
HDGNDSILIKRED

Sequences:

>Translated_173_residues
MARKEIIDEITMKRAITRITYEIIERNKELDKLVLIGIKTRGVYLAKRIQERLQQLEGLEIPFGELDTRPFRDDKQAQED
TTEIDIDITGKDVILVDDVLYTGRTIRAAIDGIVKLGRPARVQLAVLVDRGHRELPIRADYVGKNIPTGRDEEIIVQMSE
HDGNDSILIKRED
>Mature_172_residues
ARKEIIDEITMKRAITRITYEIIERNKELDKLVLIGIKTRGVYLAKRIQERLQQLEGLEIPFGELDTRPFRDDKQAQEDT
TEIDIDITGKDVILVDDVLYTGRTIRAAIDGIVKLGRPARVQLAVLVDRGHRELPIRADYVGKNIPTGRDEEIIVQMSEH
DGNDSILIKRED

Specific function: Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines, probably by binding to specific sites on pyr mRNA. This probably disrupts an antiterminator hairpin in the RNA and favors formation of a

COG id: COG2065

COG function: function code F; Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRR_LACLA (Q9CF77)

Other databases:

- EMBL:   AE005176
- PIR:   D86825
- RefSeq:   NP_267760.1
- ProteinModelPortal:   Q9CF77
- SMR:   Q9CF77
- GeneID:   1115264
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0227
- NMPDR:   fig|272623.1.peg.1646
- HOGENOM:   HBG641958
- OMA:   ILDITLY
- ProtClustDB:   PRK05205
- BioCyc:   LLAC272623:L0227-MONOMER
- HAMAP:   MF_01219
- InterPro:   IPR000836
- InterPro:   IPR023050

Pfam domain/function: PF00156 Pribosyltran

EC number: 2.4.2.9

Molecular weight: Translated: 19831; Mature: 19700

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 130-130

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKEIIDEITMKRAITRITYEIIERNKELDKLVLIGIKTRGVYLAKRIQERLQQLEGLE
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCC
IPFGELDTRPFRDDKQAQEDTTEIDIDITGKDVILVDDVLYTGRTIRAAIDGIVKLGRPA
CCCCCCCCCCCCCCCHHCCCCCEEEEEECCCCEEEEECHHHCCCHHHHHHHHHHHCCCCC
RVQLAVLVDRGHRELPIRADYVGKNIPTGRDEEIIVQMSEHDGNDSILIKRED
EEEEEEEEECCCCCCCEEHHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEECC
>Mature Secondary Structure 
ARKEIIDEITMKRAITRITYEIIERNKELDKLVLIGIKTRGVYLAKRIQERLQQLEGLE
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCC
IPFGELDTRPFRDDKQAQEDTTEIDIDITGKDVILVDDVLYTGRTIRAAIDGIVKLGRPA
CCCCCCCCCCCCCCCHHCCCCCEEEEEECCCCEEEEECHHHCCCHHHHHHHHHHHCCCCC
RVQLAVLVDRGHRELPIRADYVGKNIPTGRDEEIIVQMSEHDGNDSILIKRED
EEEEEEEEECCCCCCCEEHHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UMP; diphosphate

Specific reaction: UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471