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The map label for this gene is kinB

Identifier: 15673418

GI number: 15673418

Start: 1458873

End: 1460426

Strand: Direct

Name: kinB

Synonym: L0122

Alternate gene names: 15673418

Gene position: 1458873-1460426 (Clockwise)

Preceding gene: 15673417

Following gene: 30024044

Centisome position: 61.67

GC content: 33.59

Gene sequence:

>1554_bases
ATGAAACTTAAACACATCATGCTTATGACGGTCCTATATATTATTGCGACCTTAAGTCTGGTGATTCTATCGAACCAAAA
TATCTTAGAAAATGATACAAATCGAGTATTAAAAACAATAGATAAAATACAACTCTTTTTAGAAAAACATCCTGATAATC
CTCTGCCAGATAATTTTGAACATCTTCCAAAGAATACAGTAAATTCGGATACTAAAAAAATTAAAAAGGGTGCGACTTAC
GCACGTAGTTTAGATTCTCAAGAAATAACCGTGACCAGTCCCATATTTAGCGAGGGTCAAATTAACGGTTATCTAAAGGT
TACAGAAAATCGTACCTCTACTTTCTTTACAGATTTTGCCATTATCATTTTTGCAATTTTATTTTACTTGGCTGTCGCCA
TCCAAGTTTTACGTTCTGCTCAGAGAGCTTATGTTTTTCGAGAAAATACCGTTGCTAAAATTAAAAATATCGAGCGCAGC
CCATTGACTCAAAGCTATTTGATGAATGAGAACGACGATAAAATTACAACTGAGCTCAATAAATTGGGCGAAAAAATTCA
GAAACAAGCGCTCTCTCATACTGAAAAGAAAGAAAATCTCTACGAATTTATTGAATTTTTCCAATTTCCGATTTTCATTT
ATAATAATAAAGGAAAAATTCGTCGGACCAATGCTTCTTTCAAAAATGAATTTTCAGATACTGAAAATCTAGATATTTTC
AGCCCCTATGCTGATTTCTTAAATTTTCTTGTTGATAAAATTTTACATCCTGATATTCAAGAAAAACTTTTCTATTTTGA
AAAACTTGGGGCTTATTATCAAGTCCGTATCACTCCTTTACCTGATTTGGACAGTCGATTTATGGTGACTATGATGGATG
TTAGCTCTTATCGTCGAACAGTGGATGCCCACAATGCTTTTATTGCTAACGTTTCTCATGAATTAAAAACTCCCCTTACT
TCTATCAAAGGCTTCGCTGAACTTCTGGAAACAGATTCAATTTCAAGTTCTGACACAAAAAATTTCGCATCTATTATCAA
TAAAGAAAGTTCACGCCTGATGAATTTAGTTCAGGATACACTGCTTTTGACCAAACAAAATCATCGAATTGATAAAAAGA
AAATTAATCTTACAACTTTGATACAAAATATTCTCCAAAGCTCAGGACCACAAATTAATGAAAAATCACTTCATTTCGAA
TCCCAAATTGAAGAAATCACTTTTAAAACCAACGAACCAATGGTTCACAGCATTTTTGAGAATTTGATTGAAAATGCAAT
TAAATACACTCCAGCAAATGGACAAATTTTTGTCAGCTTACATCTTGAACAAAATAAAGTTATCTTCAGTGTAACTGACA
ATGGTCCTGGTCTTAGTGAAATTCAAAAAGAGCGAATTTTCGACCGCTTCTACCGGGTTGATGAAAGTCGTGCAGAAGTT
AGTGGAACAGGCTTAGGACTTGCTATCGTTGAGAAAAATGTTCAAGAGCTTCACGGAACAATTGACGTTGTATCCATTCT
TGGAAAAGGGACAACTTTCACCGTCAATCTTTAA

Upstream 100 bases:

>100_bases
GAAACCCGCACCATTGATGTGCTCATTTCTAAAATTCGTAAAAAATTAAATAATCATTATATCAAAACAAAACGAGGATT
CGGATACTATTTTGAAGAAA

Downstream 100 bases:

>100_bases
TCGAAGCCTTCAACAAATTTACTTATCAAATTAAAAAAATCTTATAACCAAAACTCTCCAATTAAGATAAAATCAATTTA
TCAAGATTGGAGAGTTTTTA

Product: sensor protein kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MKLKHIMLMTVLYIIATLSLVILSNQNILENDTNRVLKTIDKIQLFLEKHPDNPLPDNFEHLPKNTVNSDTKKIKKGATY
ARSLDSQEITVTSPIFSEGQINGYLKVTENRTSTFFTDFAIIIFAILFYLAVAIQVLRSAQRAYVFRENTVAKIKNIERS
PLTQSYLMNENDDKITTELNKLGEKIQKQALSHTEKKENLYEFIEFFQFPIFIYNNKGKIRRTNASFKNEFSDTENLDIF
SPYADFLNFLVDKILHPDIQEKLFYFEKLGAYYQVRITPLPDLDSRFMVTMMDVSSYRRTVDAHNAFIANVSHELKTPLT
SIKGFAELLETDSISSSDTKNFASIINKESSRLMNLVQDTLLLTKQNHRIDKKKINLTTLIQNILQSSGPQINEKSLHFE
SQIEEITFKTNEPMVHSIFENLIENAIKYTPANGQIFVSLHLEQNKVIFSVTDNGPGLSEIQKERIFDRFYRVDESRAEV
SGTGLGLAIVEKNVQELHGTIDVVSILGKGTTFTVNL

Sequences:

>Translated_517_residues
MKLKHIMLMTVLYIIATLSLVILSNQNILENDTNRVLKTIDKIQLFLEKHPDNPLPDNFEHLPKNTVNSDTKKIKKGATY
ARSLDSQEITVTSPIFSEGQINGYLKVTENRTSTFFTDFAIIIFAILFYLAVAIQVLRSAQRAYVFRENTVAKIKNIERS
PLTQSYLMNENDDKITTELNKLGEKIQKQALSHTEKKENLYEFIEFFQFPIFIYNNKGKIRRTNASFKNEFSDTENLDIF
SPYADFLNFLVDKILHPDIQEKLFYFEKLGAYYQVRITPLPDLDSRFMVTMMDVSSYRRTVDAHNAFIANVSHELKTPLT
SIKGFAELLETDSISSSDTKNFASIINKESSRLMNLVQDTLLLTKQNHRIDKKKINLTTLIQNILQSSGPQINEKSLHFE
SQIEEITFKTNEPMVHSIFENLIENAIKYTPANGQIFVSLHLEQNKVIFSVTDNGPGLSEIQKERIFDRFYRVDESRAEV
SGTGLGLAIVEKNVQELHGTIDVVSILGKGTTFTVNL
>Mature_517_residues
MKLKHIMLMTVLYIIATLSLVILSNQNILENDTNRVLKTIDKIQLFLEKHPDNPLPDNFEHLPKNTVNSDTKKIKKGATY
ARSLDSQEITVTSPIFSEGQINGYLKVTENRTSTFFTDFAIIIFAILFYLAVAIQVLRSAQRAYVFRENTVAKIKNIERS
PLTQSYLMNENDDKITTELNKLGEKIQKQALSHTEKKENLYEFIEFFQFPIFIYNNKGKIRRTNASFKNEFSDTENLDIF
SPYADFLNFLVDKILHPDIQEKLFYFEKLGAYYQVRITPLPDLDSRFMVTMMDVSSYRRTVDAHNAFIANVSHELKTPLT
SIKGFAELLETDSISSSDTKNFASIINKESSRLMNLVQDTLLLTKQNHRIDKKKINLTTLIQNILQSSGPQINEKSLHFE
SQIEEITFKTNEPMVHSIFENLIENAIKYTPANGQIFVSLHLEQNKVIFSVTDNGPGLSEIQKERIFDRFYRVDESRAEV
SGTGLGLAIVEKNVQELHGTIDVVSILGKGTTFTVNL

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=278, Percent_Identity=28.0575539568345, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1788713, Length=246, Percent_Identity=27.6422764227642, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786912, Length=218, Percent_Identity=33.4862385321101, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI48994928, Length=311, Percent_Identity=26.3665594855305, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790436, Length=213, Percent_Identity=33.8028169014084, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790346, Length=213, Percent_Identity=30.0469483568075, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1790861, Length=245, Percent_Identity=26.1224489795918, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI145693157, Length=218, Percent_Identity=31.651376146789, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1788393, Length=216, Percent_Identity=29.6296296296296, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1789808, Length=212, Percent_Identity=30.6603773584906, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082128, Length=217, Percent_Identity=25.8064516129032, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788549, Length=217, Percent_Identity=27.1889400921659, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786783, Length=215, Percent_Identity=27.906976744186, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790551, Length=212, Percent_Identity=25.9433962264151, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787894, Length=239, Percent_Identity=27.6150627615063, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788279, Length=216, Percent_Identity=29.6296296296296, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789149, Length=225, Percent_Identity=29.3333333333333, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87081816, Length=261, Percent_Identity=22.9885057471264, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787374, Length=219, Percent_Identity=26.4840182648402, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789403, Length=200, Percent_Identity=27.5, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 59226; Mature: 59226

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKHIMLMTVLYIIATLSLVILSNQNILENDTNRVLKTIDKIQLFLEKHPDNPLPDNFE
CCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
HLPKNTVNSDTKKIKKGATYARSLDSQEITVTSPIFSEGQINGYLKVTENRTSTFFTDFA
HCCCCCCCHHHHHHHHCCHHHHCCCCCCEEEECCCCCCCCCCEEEEEECCCCHHHHHHHH
IIIFAILFYLAVAIQVLRSAQRAYVFRENTVAKIKNIERSPLTQSYLMNENDDKITTELN
HHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHH
KLGEKIQKQALSHTEKKENLYEFIEFFQFPIFIYNNKGKIRRTNASFKNEFSDTENLDIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEECCCCHHHCCCCCCCCCEE
SPYADFLNFLVDKILHPDIQEKLFYFEKLGAYYQVRITPLPDLDSRFMVTMMDVSSYRRT
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCEEHHHHHHHHHHH
VDAHNAFIANVSHELKTPLTSIKGFAELLETDSISSSDTKNFASIINKESSRLMNLVQDT
HHHHHHHHHHCHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LLLTKQNHRIDKKKINLTTLIQNILQSSGPQINEKSLHFESQIEEITFKTNEPMVHSIFE
HHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHCCHHHHHHHHEECCCCCHHHHHHH
NLIENAIKYTPANGQIFVSLHLEQNKVIFSVTDNGPGLSEIQKERIFDRFYRVDESRAEV
HHHHHHHEECCCCCEEEEEEEEECCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHH
SGTGLGLAIVEKNVQELHGTIDVVSILGKGTTFTVNL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
>Mature Secondary Structure
MKLKHIMLMTVLYIIATLSLVILSNQNILENDTNRVLKTIDKIQLFLEKHPDNPLPDNFE
CCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
HLPKNTVNSDTKKIKKGATYARSLDSQEITVTSPIFSEGQINGYLKVTENRTSTFFTDFA
HCCCCCCCHHHHHHHHCCHHHHCCCCCCEEEECCCCCCCCCCEEEEEECCCCHHHHHHHH
IIIFAILFYLAVAIQVLRSAQRAYVFRENTVAKIKNIERSPLTQSYLMNENDDKITTELN
HHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHH
KLGEKIQKQALSHTEKKENLYEFIEFFQFPIFIYNNKGKIRRTNASFKNEFSDTENLDIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEECCCCHHHCCCCCCCCCEE
SPYADFLNFLVDKILHPDIQEKLFYFEKLGAYYQVRITPLPDLDSRFMVTMMDVSSYRRT
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCEEHHHHHHHHHHH
VDAHNAFIANVSHELKTPLTSIKGFAELLETDSISSSDTKNFASIINKESSRLMNLVQDT
HHHHHHHHHHCHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LLLTKQNHRIDKKKINLTTLIQNILQSSGPQINEKSLHFESQIEEITFKTNEPMVHSIFE
HHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHCCHHHHHHHHEECCCCCHHHHHHH
NLIENAIKYTPANGQIFVSLHLEQNKVIFSVTDNGPGLSEIQKERIFDRFYRVDESRAEV
HHHHHHHEECCCCCEEEEEEEEECCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHH
SGTGLGLAIVEKNVQELHGTIDVVSILGKGTTFTVNL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]