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The map label for this gene is ilvC

Identifier: 15673208

GI number: 15673208

Start: 1249736

End: 1250758

Strand: Direct

Name: ilvC

Synonym: L0080

Alternate gene names: 15673208

Gene position: 1249736-1250758 (Clockwise)

Preceding gene: 15673207

Following gene: 15673209

Centisome position: 52.83

GC content: 40.18

Gene sequence:

>1023_bases
ATGGCAGTTACAATGTATTATGAAGATGATGTAGAAGTATCAGCACTTGCTGGAAAGCAAATTGCAGTAATCGGTTATGG
TTCACAAGGACATGCTCACGCACAGAATTTGCGTGATTCTGGTCACAACGTTATCATTGGTGTGCGCCACGGAAAATCTT
TTGATAAAGCAAAAGAAGATGGCTTTGAAACATTTGAAGTAGGAGAAGCGGTAGCTAAAGCTGATGTTATTATGGTTTTG
GCGCCAGATGAACTTCAACAATCCATTTATGAAGAGGACATCAAACCAAACTTGAAAGCAGGTTCAGCACTTGGTTTTGC
TCACGGATTTAATATCCATTTTGGCTATATTAAAGTACCAGAAGACGTTGACGTCTTTATGGTTGCACCTAAGGCTCCAG
GTCACCTTGTCCGTCGGACTTATACTGAAGGTTTTGGTACACCAGCTTTGTTTGTTTCACACCAAAATGCAAGTGGTCAT
GCGCGTGAAATCGCAATGGATTGGGCCAAAGGAATTGGTTGTGCTCGAGTGGGAATTATTGAAACAACCTTTAAAGAAGA
AACAGAAGAAGATTTGTTTGGAGAACAAGCTGTTCTATGTGGAGGTTTGACAGCACTTGTTGAAGCCGGTTTTGAAACAC
TGACAGAAGCTGGATACGCTGGCGAATTGGCTTACTTTGAAGTTTTGCACGAAATGAAATTGATTGTTGACCTCATGTAT
GAAGGTGGTTTTACTAAAATGCGTCAATCCATCTCAAATACTGCTGAGTTTGGCGATTATGTGACTGGTCCAAGGATTAT
TACTGACGCAGTTAAAAAGAATATGAAGCTTGTTTTGGCTGATATTCAATCTGGAAAATTTGCTCAAGATTTCGTTGATG
ACTTCAAAGCGGGGCGTCCAAAATTAACAGCCTATCGCGAAGCTGCTAAAAATCTTGAAATTGAAAAAATTGGGGCAGAA
TTACGTAAAGCAATGCCATTCACACAATCTGGTGATGACGATGCCTTTAAAATCTATCAGTAA

Upstream 100 bases:

>100_bases
TTATGGCATTCTAAATATGGCTCGGACAGGTAGTGCAGGTTTTGAGCGTGGCTAAATTTAAATAAGTTAACAAATAAATA
GAAAAATAGAGGAAACAAAA

Downstream 100 bases:

>100_bases
TTTCTCTTATTGATTGAACAAAAACATAAAAGCATTTTATGGAGGAATGACATAAATGATAAGTGCCAAAGAGGTTGAAG
ATGCCTATGATTTGTTAAAA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MAVTMYYEDDVEVSALAGKQIAVIGYGSQGHAHAQNLRDSGHNVIIGVRHGKSFDKAKEDGFETFEVGEAVAKADVIMVL
APDELQQSIYEEDIKPNLKAGSALGFAHGFNIHFGYIKVPEDVDVFMVAPKAPGHLVRRTYTEGFGTPALFVSHQNASGH
AREIAMDWAKGIGCARVGIIETTFKEETEEDLFGEQAVLCGGLTALVEAGFETLTEAGYAGELAYFEVLHEMKLIVDLMY
EGGFTKMRQSISNTAEFGDYVTGPRIITDAVKKNMKLVLADIQSGKFAQDFVDDFKAGRPKLTAYREAAKNLEIEKIGAE
LRKAMPFTQSGDDDAFKIYQ

Sequences:

>Translated_340_residues
MAVTMYYEDDVEVSALAGKQIAVIGYGSQGHAHAQNLRDSGHNVIIGVRHGKSFDKAKEDGFETFEVGEAVAKADVIMVL
APDELQQSIYEEDIKPNLKAGSALGFAHGFNIHFGYIKVPEDVDVFMVAPKAPGHLVRRTYTEGFGTPALFVSHQNASGH
AREIAMDWAKGIGCARVGIIETTFKEETEEDLFGEQAVLCGGLTALVEAGFETLTEAGYAGELAYFEVLHEMKLIVDLMY
EGGFTKMRQSISNTAEFGDYVTGPRIITDAVKKNMKLVLADIQSGKFAQDFVDDFKAGRPKLTAYREAAKNLEIEKIGAE
LRKAMPFTQSGDDDAFKIYQ
>Mature_339_residues
AVTMYYEDDVEVSALAGKQIAVIGYGSQGHAHAQNLRDSGHNVIIGVRHGKSFDKAKEDGFETFEVGEAVAKADVIMVLA
PDELQQSIYEEDIKPNLKAGSALGFAHGFNIHFGYIKVPEDVDVFMVAPKAPGHLVRRTYTEGFGTPALFVSHQNASGHA
REIAMDWAKGIGCARVGIIETTFKEETEEDLFGEQAVLCGGLTALVEAGFETLTEAGYAGELAYFEVLHEMKLIVDLMYE
GGFTKMRQSISNTAEFGDYVTGPRIITDAVKKNMKLVLADIQSGKFAQDFVDDFKAGRPKLTAYREAAKNLEIEKIGAEL
RKAMPFTQSGDDDAFKIYQ

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=307, Percent_Identity=35.1791530944625, Blast_Score=157, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6323387, Length=320, Percent_Identity=34.375, Blast_Score=136, Evalue=6e-33,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_LACLA (Q02138)

Other databases:

- EMBL:   U92974
- EMBL:   AE005176
- PIR:   B86778
- PIR:   S35140
- RefSeq:   NP_267382.1
- ProteinModelPortal:   Q02138
- SMR:   Q02138
- GeneID:   1114875
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0080
- NMPDR:   fig|272623.1.peg.1261
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- BioCyc:   LLAC272623:L0080-MONOMER
- BRENDA:   1.1.1.86
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 37212; Mature: 37080

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTMYYEDDVEVSALAGKQIAVIGYGSQGHAHAQNLRDSGHNVIIGVRHGKSFDKAKED
CEEEEEECCCCEEEEECCCEEEEEEECCCCCHHHHHHHCCCCEEEEEEECCCCHHHHHHC
GFETFEVGEAVAKADVIMVLAPDELQQSIYEEDIKPNLKAGSALGFAHGFNIHFGYIKVP
CCCHHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCCCCCCCCEEEEEECCEEEEEEEECC
EDVDVFMVAPKAPGHLVRRTYTEGFGTPALFVSHQNASGHAREIAMDWAKGIGCARVGII
CCCCEEEECCCCCCHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEE
ETTFKEETEEDLFGEQAVLCGGLTALVEAGFETLTEAGYAGELAYFEVLHEMKLIVDLMY
EHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGFTKMRQSISNTAEFGDYVTGPRIITDAVKKNMKLVLADIQSGKFAQDFVDDFKAGRP
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCC
KLTAYREAAKNLEIEKIGAELRKAMPFTQSGDDDAFKIYQ
CHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCEEECC
>Mature Secondary Structure 
AVTMYYEDDVEVSALAGKQIAVIGYGSQGHAHAQNLRDSGHNVIIGVRHGKSFDKAKED
EEEEEECCCCEEEEECCCEEEEEEECCCCCHHHHHHHCCCCEEEEEEECCCCHHHHHHC
GFETFEVGEAVAKADVIMVLAPDELQQSIYEEDIKPNLKAGSALGFAHGFNIHFGYIKVP
CCCHHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCCCCCCCCEEEEEECCEEEEEEEECC
EDVDVFMVAPKAPGHLVRRTYTEGFGTPALFVSHQNASGHAREIAMDWAKGIGCARVGII
CCCCEEEECCCCCCHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEE
ETTFKEETEEDLFGEQAVLCGGLTALVEAGFETLTEAGYAGELAYFEVLHEMKLIVDLMY
EHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGFTKMRQSISNTAEFGDYVTGPRIITDAVKKNMKLVLADIQSGKFAQDFVDDFKAGRP
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCC
KLTAYREAAKNLEIEKIGAELRKAMPFTQSGDDDAFKIYQ
CHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1400210; 11337471