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The map label for this gene is hisA

Identifier: 15673195

GI number: 15673195

Start: 1235496

End: 1236215

Strand: Direct

Name: hisA

Synonym: L0070

Alternate gene names: 15673195

Gene position: 1235496-1236215 (Clockwise)

Preceding gene: 15673194

Following gene: 15673196

Centisome position: 52.23

GC content: 34.58

Gene sequence:

>720_bases
ATGAAGATTATTCCAGCAATTGATTTGCAAAATGGTGAAGCCGTGCGTCTCTACAAAGGAGATTATGATAAGAAAACGGT
CTATTCAAAAACTCCCCTTGAAATTGCTCAAAAATTTGAAAGAATGGGAGCGACTGACCTCCATTTGGTTGATTTAGATG
ATGCTAACATAGGACAAACTCGTAATTTAGAGATTGTGCGAAAAATAAAAGAGGAAACAAGATTGAAAATCGAAATTGGT
GGTGGAATTAGAGATTTCGATACTGTTAGAATGTATCTTGAACAAATTGGTGTGGAACGAGTGATTTTAGGAACCGCAGC
GGTAGAAAAACCTGATTTTCTTAAGGAGTTATTAATTAAATATGGTCCAAGCAAAATCATTGTTGGGGTAGATATTAGAG
AGGGTTTTGTATCAACAAGTGGTTGGTTAGAAAAAACAAGTCTTCCTTACCTGTCATTTTTAAAAAAATTAGAGAGAATA
GGGGTTAAAACCACTATTATTACTGATATCTCCAAAGACGGAACACTGACAGGTCCAAATTTTAAACTTTATGATGAAAT
TTCAAAGGAAAGTTCCCTAAACGTGATTATTTCTGGAGGTGTAAAGGATAATTCTGATATTCAACGTGCAACTCGTTCTG
ACTTCTATGGAATTATCGTTGGGAAAGCTTACTATGAGAAGAAAATTAATCTTGAAAAGGAGTTCAGGAATGCTAACTAA

Upstream 100 bases:

>100_bases
AATTGTTGGAAAAAATAATGTGATAGGCTGTCAATTTCACCCTGAAAAGAGTGGAGAAATTGGCAGAAAGGTACTAAAAG
CATTCTTGGAGGAAATTTAA

Downstream 100 bases:

>100_bases
AAGAATCATCCCTTGTCTTGATATTAAAAATGGTAAGGTTGTTAAAGGAATTAATTTTGTGAGTTTAAGAGAAATAGGTG
ATTCCGTGGAATTGGCCAAA

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MKIIPAIDLQNGEAVRLYKGDYDKKTVYSKTPLEIAQKFERMGATDLHLVDLDDANIGQTRNLEIVRKIKEETRLKIEIG
GGIRDFDTVRMYLEQIGVERVILGTAAVEKPDFLKELLIKYGPSKIIVGVDIREGFVSTSGWLEKTSLPYLSFLKKLERI
GVKTTIITDISKDGTLTGPNFKLYDEISKESSLNVIISGGVKDNSDIQRATRSDFYGIIVGKAYYEKKINLEKEFRNAN

Sequences:

>Translated_239_residues
MKIIPAIDLQNGEAVRLYKGDYDKKTVYSKTPLEIAQKFERMGATDLHLVDLDDANIGQTRNLEIVRKIKEETRLKIEIG
GGIRDFDTVRMYLEQIGVERVILGTAAVEKPDFLKELLIKYGPSKIIVGVDIREGFVSTSGWLEKTSLPYLSFLKKLERI
GVKTTIITDISKDGTLTGPNFKLYDEISKESSLNVIISGGVKDNSDIQRATRSDFYGIIVGKAYYEKKINLEKEFRNAN
>Mature_239_residues
MKIIPAIDLQNGEAVRLYKGDYDKKTVYSKTPLEIAQKFERMGATDLHLVDLDDANIGQTRNLEIVRKIKEETRLKIEIG
GGIRDFDTVRMYLEQIGVERVILGTAAVEKPDFLKELLIKYGPSKIIVGVDIREGFVSTSGWLEKTSLPYLSFLKKLERI
GVKTTIITDISKDGTLTGPNFKLYDEISKESSLNVIISGGVKDNSDIQRATRSDFYGIIVGKAYYEKKINLEKEFRNAN

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=245, Percent_Identity=33.469387755102, Blast_Score=141, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26971; Mature: 26971

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIPAIDLQNGEAVRLYKGDYDKKTVYSKTPLEIAQKFERMGATDLHLVDLDDANIGQT
CCCCCEEECCCCCEEEEEECCCCCCEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCC
RNLEIVRKIKEETRLKIEIGGGIRDFDTVRMYLEQIGVERVILGTAAVEKPDFLKELLIK
CCHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHCHHEEEEEHHCCCCHHHHHHHHHH
YGPSKIIVGVDIREGFVSTSGWLEKTSLPYLSFLKKLERIGVKTTIITDISKDGTLTGPN
CCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCEECCC
FKLYDEISKESSLNVIISGGVKDNSDIQRATRSDFYGIIVGKAYYEKKINLEKEFRNAN
EEEHHHHCCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEEECHHHHHHCCHHHHCCCCC
>Mature Secondary Structure
MKIIPAIDLQNGEAVRLYKGDYDKKTVYSKTPLEIAQKFERMGATDLHLVDLDDANIGQT
CCCCCEEECCCCCEEEEEECCCCCCEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCC
RNLEIVRKIKEETRLKIEIGGGIRDFDTVRMYLEQIGVERVILGTAAVEKPDFLKELLIK
CCHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHCHHEEEEEHHCCCCHHHHHHHHHH
YGPSKIIVGVDIREGFVSTSGWLEKTSLPYLSFLKKLERIGVKTTIITDISKDGTLTGPN
CCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCEECCC
FKLYDEISKESSLNVIISGGVKDNSDIQRATRSDFYGIIVGKAYYEKKINLEKEFRNAN
EEEHHHHCCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEEECHHHHHHCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1400209; 11337471 [H]