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The map label for this gene is hisB

Identifier: 15673192

GI number: 15673192

Start: 1233461

End: 1234063

Strand: Direct

Name: hisB

Synonym: L0068

Alternate gene names: 15673192

Gene position: 1233461-1234063 (Clockwise)

Preceding gene: 15673191

Following gene: 15673193

Centisome position: 52.14

GC content: 39.8

Gene sequence:

>603_bases
ATGACACGCATATCACACATCACGCGTAATACCAAAGAAACACAAATCGAACTTTCCATCAATCTTGACGGCACAGGTCA
AGCGGACATTAGTACAGGTATTGGTTTTCTCGACCACATGCTGACACTTCTCACCTTTCACAGCGATTTTGACTTAAAAA
TCATAGGACATGGGGATCATGAAACAGTAGGGATGGACCCGCACCATCTCATTGAAGATGTTGCGATTGCTCTTGGCAAA
TGTATCAGCGAAGCATTAGGTAATAAGCTCGGTATTCGACGTTATGGAAGTTTTACCATTCCAATGGATGAAGCTTTGGT
GACTTGTGATTTAGATATTAGTGGACGACCTTATTTGGTATTTCATGCTGATTTATCAGGAAATCAAAAACTTGGTGGCT
ATGATACAGAAATGACTGAAGAATTTTTTCGTGTTCTTGCTTTTAATGCTGGGATTACGTTACATCTGAACGAAAATTAT
GGGCAAAATACGCATCATATTATTGAAGGCATGTTTAAATCTACAGCGAGGGCGCTAAAACAAGCTGTAAGTATTGATGA
AGCGAAAGTTGGAGAAATACCGAGCAGTAAGGGAGTGTTATGA

Upstream 100 bases:

>100_bases
CCATGCTTAAGTTAGAGCAAAAAGTAGCGAAAGACCAAACGCTGTATCCAGTCGCACGATTACATCATTTGATATTTAAA
AAAACTAAGGAGAACCTGTT

Downstream 100 bases:

>100_bases
CTAATCTAAAAGAATTAAGAATTAATATTGAGAAATTTCCTGAAGCACTTCACAATACGCTAAAAGATGCAAAAATATAT
GATAGCAGTTCCTCTCCTGA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MTRISHITRNTKETQIELSINLDGTGQADISTGIGFLDHMLTLLTFHSDFDLKIIGHGDHETVGMDPHHLIEDVAIALGK
CISEALGNKLGIRRYGSFTIPMDEALVTCDLDISGRPYLVFHADLSGNQKLGGYDTEMTEEFFRVLAFNAGITLHLNENY
GQNTHHIIEGMFKSTARALKQAVSIDEAKVGEIPSSKGVL

Sequences:

>Translated_200_residues
MTRISHITRNTKETQIELSINLDGTGQADISTGIGFLDHMLTLLTFHSDFDLKIIGHGDHETVGMDPHHLIEDVAIALGK
CISEALGNKLGIRRYGSFTIPMDEALVTCDLDISGRPYLVFHADLSGNQKLGGYDTEMTEEFFRVLAFNAGITLHLNENY
GQNTHHIIEGMFKSTARALKQAVSIDEAKVGEIPSSKGVL
>Mature_199_residues
TRISHITRNTKETQIELSINLDGTGQADISTGIGFLDHMLTLLTFHSDFDLKIIGHGDHETVGMDPHHLIEDVAIALGKC
ISEALGNKLGIRRYGSFTIPMDEALVTCDLDISGRPYLVFHADLSGNQKLGGYDTEMTEEFFRVLAFNAGITLHLNENYG
QNTHHIIEGMFKSTARALKQAVSIDEAKVGEIPSSKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=198, Percent_Identity=46.4646464646465, Blast_Score=175, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=36.697247706422, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21952; Mature: 21821

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRISHITRNTKETQIELSINLDGTGQADISTGIGFLDHMLTLLTFHSDFDLKIIGHGDH
CCCCHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
ETVGMDPHHLIEDVAIALGKCISEALGNKLGIRRYGSFTIPMDEALVTCDLDISGRPYLV
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCEECCCCCEEEEEEECCCCCEEEE
FHADLSGNQKLGGYDTEMTEEFFRVLAFNAGITLHLNENYGQNTHHIIEGMFKSTARALK
EEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
QAVSIDEAKVGEIPSSKGVL
HHHCCCCHHCCCCCCCCCCC
>Mature Secondary Structure 
TRISHITRNTKETQIELSINLDGTGQADISTGIGFLDHMLTLLTFHSDFDLKIIGHGDH
CCCHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
ETVGMDPHHLIEDVAIALGKCISEALGNKLGIRRYGSFTIPMDEALVTCDLDISGRPYLV
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCEECCCCCEEEEEEECCCCCEEEE
FHADLSGNQKLGGYDTEMTEEFFRVLAFNAGITLHLNENYGQNTHHIIEGMFKSTARALK
EEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
QAVSIDEAKVGEIPSSKGVL
HHHCCCCHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1400209; 11337471 [H]