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The map label for this gene is hisD

Identifier: 15673191

GI number: 15673191

Start: 1231329

End: 1232624

Strand: Direct

Name: hisD

Synonym: L0067

Alternate gene names: 15673191

Gene position: 1231329-1232624 (Clockwise)

Preceding gene: 15673190

Following gene: 15673192

Centisome position: 52.05

GC content: 36.65

Gene sequence:

>1296_bases
ATGCTCAAACAAATTGATTATCAAGGAAAGCTTGAAGAAATTGCTGAAAAATTTCAAGGTCGAAAAACAGAACTATCAAA
AGAAGTTAATAAAACTGTTCAACAGATTGTAGAAGACATTCAAAAAAGTGGAGATACTGCCTTATTTAACTATGCTAAAA
AGTTCGATGGTTATGATGTGAATACTAGTAATTTACTCGTCACGCCCATGGAACGTGAAACAGGACTAGAACAAATTGAT
GAGGATTATTTTAGAATTCTTAGACGCACCAAATCACAAATCGAAGAATTTCATAAGCACCAACTGGGAAATTCATGGAA
TATTTTTAAGGAAAATGGTGTTATCATGGGACAAATTGCGCGTCCTCTGGAACGTGTTGCTCTCTATGTTCCCGGAGGAA
CGGCTGCATATCCCTCAACAGTCATTATGAATGCTGTTCCAGCGCTTTTAGCAGGCGTCAAAGAAATTATTATGATTACT
CCAGTTAAAACTGATGGAAAAGTAAATCCTAATATTTTAGCAGCTGCTGAAGTTTGTGGAATAGAAACAATCTATAAAGT
GGGTGGAGCACAAGGCGTTGCTGCCGTTGCGTATGGGACAGAATCTATTCCTAAAGTTGATAAGATTGTCGGACCTGGAA
ATATTTTTGTAGCTACAGCTAAGAAAATCTGTTATGGGGTGGTAGATATTGATATGATTGCCGGTCCGTCAGAAGTTCTA
GTTATTGCTGACGAAACTGCCAATCCAAAGTATATTGCTGCTGATTTAATGGCGCAAGCAGAACATGATAAACTTGCGTC
AGCGATTTTAGTGACGACTTCTGAAAAACTTGTTCAACAAGTAGATGAGGAATTAAATAGACAAGTTCAAAATTTGGAAC
GTAGTGAAATCATTGAAAGTTACATCAGTAATTACGGTGGAGCCATTGTTGTAAAAAATATTGATGAAGCCTTTGATGTT
TCCAATCAGCTGGCTCCAGAACATTTAGAAGTTTTGACTAGTGAACCTTTAACCCAACTTCCAAAAATCAAAAATGCTGG
CTCAATTTTTATTGGAGAGTATACGCCAGAACCGTTAGGCGACTATATGTCAGGAAGCAATCATGTCTTACCAACTGGAG
GAACAGCCAAATTTTACTCTGGTTTGGGTGTTTATAATTTTATAAAATATTTGACTTATAGCTATTATCCTAAAGAAGTT
TTGGCTGCTTTTAAAGAGGATGTTGAGACATTTGCAAAATCAGAAGGATTGACGGCTCATGCTAACTCAATTTCTGTGAG
ATTTGATGAAATGTAA

Upstream 100 bases:

>100_bases
CATTGAAAAATCAGTGACATTTCAACACGGATGATTGTCAATAAATCTAGTTTCAAATTTAAAAAAGATAAAATTATAGA
AATGGTGGAGAGGTTAGAAG

Downstream 100 bases:

>100_bases
TACTTGAGACAAGATTTTCAAAATTTATTGATCAAGGCGTGAGGAGCCACATGGATTTTAAAATATTGAATAAGAAAAAT
AGTAGGGAGAAAAGCATGAC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MLKQIDYQGKLEEIAEKFQGRKTELSKEVNKTVQQIVEDIQKSGDTALFNYAKKFDGYDVNTSNLLVTPMERETGLEQID
EDYFRILRRTKSQIEEFHKHQLGNSWNIFKENGVIMGQIARPLERVALYVPGGTAAYPSTVIMNAVPALLAGVKEIIMIT
PVKTDGKVNPNILAAAEVCGIETIYKVGGAQGVAAVAYGTESIPKVDKIVGPGNIFVATAKKICYGVVDIDMIAGPSEVL
VIADETANPKYIAADLMAQAEHDKLASAILVTTSEKLVQQVDEELNRQVQNLERSEIIESYISNYGGAIVVKNIDEAFDV
SNQLAPEHLEVLTSEPLTQLPKIKNAGSIFIGEYTPEPLGDYMSGSNHVLPTGGTAKFYSGLGVYNFIKYLTYSYYPKEV
LAAFKEDVETFAKSEGLTAHANSISVRFDEM

Sequences:

>Translated_431_residues
MLKQIDYQGKLEEIAEKFQGRKTELSKEVNKTVQQIVEDIQKSGDTALFNYAKKFDGYDVNTSNLLVTPMERETGLEQID
EDYFRILRRTKSQIEEFHKHQLGNSWNIFKENGVIMGQIARPLERVALYVPGGTAAYPSTVIMNAVPALLAGVKEIIMIT
PVKTDGKVNPNILAAAEVCGIETIYKVGGAQGVAAVAYGTESIPKVDKIVGPGNIFVATAKKICYGVVDIDMIAGPSEVL
VIADETANPKYIAADLMAQAEHDKLASAILVTTSEKLVQQVDEELNRQVQNLERSEIIESYISNYGGAIVVKNIDEAFDV
SNQLAPEHLEVLTSEPLTQLPKIKNAGSIFIGEYTPEPLGDYMSGSNHVLPTGGTAKFYSGLGVYNFIKYLTYSYYPKEV
LAAFKEDVETFAKSEGLTAHANSISVRFDEM
>Mature_431_residues
MLKQIDYQGKLEEIAEKFQGRKTELSKEVNKTVQQIVEDIQKSGDTALFNYAKKFDGYDVNTSNLLVTPMERETGLEQID
EDYFRILRRTKSQIEEFHKHQLGNSWNIFKENGVIMGQIARPLERVALYVPGGTAAYPSTVIMNAVPALLAGVKEIIMIT
PVKTDGKVNPNILAAAEVCGIETIYKVGGAQGVAAVAYGTESIPKVDKIVGPGNIFVATAKKICYGVVDIDMIAGPSEVL
VIADETANPKYIAADLMAQAEHDKLASAILVTTSEKLVQQVDEELNRQVQNLERSEIIESYISNYGGAIVVKNIDEAFDV
SNQLAPEHLEVLTSEPLTQLPKIKNAGSIFIGEYTPEPLGDYMSGSNHVLPTGGTAKFYSGLGVYNFIKYLTYSYYPKEV
LAAFKEDVETFAKSEGLTAHANSISVRFDEM

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=409, Percent_Identity=39.6088019559902, Blast_Score=304, Evalue=8e-84,
Organism=Saccharomyces cerevisiae, GI6319819, Length=419, Percent_Identity=40.5727923627685, Blast_Score=297, Evalue=3e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47352; Mature: 47352

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKQIDYQGKLEEIAEKFQGRKTELSKEVNKTVQQIVEDIQKSGDTALFNYAKKFDGYDV
CCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCC
NTSNLLVTPMERETGLEQIDEDYFRILRRTKSQIEEFHKHQLGNSWNIFKENGVIMGQIA
CCCCEEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEHHHH
RPLERVALYVPGGTAAYPSTVIMNAVPALLAGVKEIIMITPVKTDGKVNPNILAAAEVCG
HHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHH
IETIYKVGGAQGVAAVAYGTESIPKVDKIVGPGNIFVATAKKICYGVVDIDMIAGPSEVL
HHHHHHHCCCCCEEEEEECCCCCCCHHHHCCCCCEEEEEHHHHHHHHHHHEEECCCCEEE
VIADETANPKYIAADLMAQAEHDKLASAILVTTSEKLVQQVDEELNRQVQNLERSEIIES
EEEECCCCCCHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHCHHHHHHHH
YISNYGGAIVVKNIDEAFDVSNQLAPEHLEVLTSEPLTQLPKIKNAGSIFIGEYTPEPLG
HHHCCCCEEEEECCHHHHCCCCCCCHHHHHHHHCCCHHHCCCCCCCCCEEEECCCCCCHH
DYMSGSNHVLPTGGTAKFYSGLGVYNFIKYLTYSYYPKEVLAAFKEDVETFAKSEGLTAH
HHHCCCCEEECCCCCHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEE
ANSISVRFDEM
CCEEEEEECCC
>Mature Secondary Structure
MLKQIDYQGKLEEIAEKFQGRKTELSKEVNKTVQQIVEDIQKSGDTALFNYAKKFDGYDV
CCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCC
NTSNLLVTPMERETGLEQIDEDYFRILRRTKSQIEEFHKHQLGNSWNIFKENGVIMGQIA
CCCCEEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEHHHH
RPLERVALYVPGGTAAYPSTVIMNAVPALLAGVKEIIMITPVKTDGKVNPNILAAAEVCG
HHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHH
IETIYKVGGAQGVAAVAYGTESIPKVDKIVGPGNIFVATAKKICYGVVDIDMIAGPSEVL
HHHHHHHCCCCCEEEEEECCCCCCCHHHHCCCCCEEEEEHHHHHHHHHHHEEECCCCEEE
VIADETANPKYIAADLMAQAEHDKLASAILVTTSEKLVQQVDEELNRQVQNLERSEIIES
EEEECCCCCCHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHCHHHHHHHH
YISNYGGAIVVKNIDEAFDVSNQLAPEHLEVLTSEPLTQLPKIKNAGSIFIGEYTPEPLG
HHHCCCCEEEEECCHHHHCCCCCCCHHHHHHHHCCCHHHCCCCCCCCCEEEECCCCCCHH
DYMSGSNHVLPTGGTAKFYSGLGVYNFIKYLTYSYYPKEVLAAFKEDVETFAKSEGLTAH
HHHCCCCEEECCCCCHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEE
ANSISVRFDEM
CCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1400209; 11337471 [H]