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The map label for this gene is hisC

Identifier: 15673188

GI number: 15673188

Start: 1228672

End: 1229754

Strand: Direct

Name: hisC

Synonym: L0065

Alternate gene names: 15673188

Gene position: 1228672-1229754 (Clockwise)

Preceding gene: 15673187

Following gene: 15673189

Centisome position: 51.94

GC content: 31.95

Gene sequence:

>1083_bases
ATGAGTTGGCAAAATAACCTTCGGTCAGTAAGTCCCTATATTGCAGGTGAACAACCTGAACTTACTGACATAATCAAATT
AAACACTAACGAAAATCCATATCCGCCCACTAGTGTAGCTCAATTATTTAATGAACGTTATAAGACAAAAAATTTGCGTC
TTTACCCAAGTACTGACGCGAAAAGTTTAAGAAAAAAATTGGCCGACTATCATCATTTAGAAGTTGAACAGGTTATTATT
GGAAATGGCTCTGACGAAGTTTTGTCACTTAGTTTTCTGACCTTTTTTAATAGTCAAAGCCCTTTATTAATGCCTGACAT
TACTTATTCTTTTTACCCTATTTATTGCGAACTCTATCGAATTCCTTTTCAAAAAGTCCCTGTGGATGATGATTTTAAAG
TTTTAATAAAAGATTATTGTATTGAAAATGGCGGAATTGTGATTGCAAATCCTGATGCTCCAACGGCTTTGGCACTAAAT
CTTAAAGATATAGAAGAAATTCTGAAAAAAAATCAAAACTCAATTGTCTTGATTAATGAAGCCTATATTGATTTTGGTGG
TGAAACATGTCTTCCTTTGCTTAAAAAATACGATAATTTAGTAGTGGTTCAAACTTTTTCTAAATCACGGAGTTTGGCAG
GAATTCGTTTGGGTGTAGCTTATGGCTCTGCTGAAGCAATTTCTCATTTGTATGATGTGAAAAATTCATTTAATTCCTAT
CCAATTGATAGTTTGGCACAAATTATTGGAGAAGCAAGTTTAATGGATGAACATTATTTTCAAAAAAACATTCAGAAAAT
CATTAAGACAAGAGAAGTTTTTAAAGATAATCTGGTTAATTTAGGATTTGAAGTGACTGATTCAAAGGCTAACTTTGTTT
TTGTTCATCATCCAAAAGTAAAAGCGGAAGAACTTTTTAAGGCGCTTTATGAGGCAAAAATTATTGTCAGGCATTGGAAT
CAACCACGGATTGATGATTGGTTACGGATAACTATTGGAACTAATAAAGAAATGAACAAAGTGATTGAATTTTTAAAAGG
CTATTTAAAAAAGAATGAGGAAATTGACGAATGGAAAAAATAA

Upstream 100 bases:

>100_bases
AGTGATAAATTAAGGTGGAACCACGATTAAACCGTCCTTTAAGTCAAGTACTTTTAGGCGTTTTTTTATATTATCTTTCT
ATTCTCGAAAGGAGAAATCT

Downstream 100 bases:

>100_bases
ATTATCTGCTTCCTGAAGAATCGGCAGAAATGACCTTGAATCAAGTTAAAAGTCTACGGCAGATAGAAGGGCGTTTAAGA
AAATTATTTAGCTTGAAAAT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MSWQNNLRSVSPYIAGEQPELTDIIKLNTNENPYPPTSVAQLFNERYKTKNLRLYPSTDAKSLRKKLADYHHLEVEQVII
GNGSDEVLSLSFLTFFNSQSPLLMPDITYSFYPIYCELYRIPFQKVPVDDDFKVLIKDYCIENGGIVIANPDAPTALALN
LKDIEEILKKNQNSIVLINEAYIDFGGETCLPLLKKYDNLVVVQTFSKSRSLAGIRLGVAYGSAEAISHLYDVKNSFNSY
PIDSLAQIIGEASLMDEHYFQKNIQKIIKTREVFKDNLVNLGFEVTDSKANFVFVHHPKVKAEELFKALYEAKIIVRHWN
QPRIDDWLRITIGTNKEMNKVIEFLKGYLKKNEEIDEWKK

Sequences:

>Translated_360_residues
MSWQNNLRSVSPYIAGEQPELTDIIKLNTNENPYPPTSVAQLFNERYKTKNLRLYPSTDAKSLRKKLADYHHLEVEQVII
GNGSDEVLSLSFLTFFNSQSPLLMPDITYSFYPIYCELYRIPFQKVPVDDDFKVLIKDYCIENGGIVIANPDAPTALALN
LKDIEEILKKNQNSIVLINEAYIDFGGETCLPLLKKYDNLVVVQTFSKSRSLAGIRLGVAYGSAEAISHLYDVKNSFNSY
PIDSLAQIIGEASLMDEHYFQKNIQKIIKTREVFKDNLVNLGFEVTDSKANFVFVHHPKVKAEELFKALYEAKIIVRHWN
QPRIDDWLRITIGTNKEMNKVIEFLKGYLKKNEEIDEWKK
>Mature_359_residues
SWQNNLRSVSPYIAGEQPELTDIIKLNTNENPYPPTSVAQLFNERYKTKNLRLYPSTDAKSLRKKLADYHHLEVEQVIIG
NGSDEVLSLSFLTFFNSQSPLLMPDITYSFYPIYCELYRIPFQKVPVDDDFKVLIKDYCIENGGIVIANPDAPTALALNL
KDIEEILKKNQNSIVLINEAYIDFGGETCLPLLKKYDNLVVVQTFSKSRSLAGIRLGVAYGSAEAISHLYDVKNSFNSYP
IDSLAQIIGEASLMDEHYFQKNIQKIIKTREVFKDNLVNLGFEVTDSKANFVFVHHPKVKAEELFKALYEAKIIVRHWNQ
PRIDDWLRITIGTNKEMNKVIEFLKGYLKKNEEIDEWKK

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=355, Percent_Identity=27.3239436619718, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322075, Length=392, Percent_Identity=29.5918367346939, Blast_Score=114, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_LACLA (Q02135)

Other databases:

- EMBL:   U92974
- EMBL:   AE005176
- PIR:   B45734
- PIR:   F86775
- RefSeq:   NP_267362.1
- ProteinModelPortal:   Q02135
- SMR:   Q02135
- GeneID:   1114853
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0065
- NMPDR:   fig|272623.1.peg.1241
- HOGENOM:   HBG646350
- OMA:   SSHEIIN
- ProtClustDB:   PRK05387
- BioCyc:   LLAC272623:L0065-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 41401; Mature: 41270

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWQNNLRSVSPYIAGEQPELTDIIKLNTNENPYPPTSVAQLFNERYKTKNLRLYPSTDA
CCCCCCCHHCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCH
KSLRKKLADYHHLEVEQVIIGNGSDEVLSLSFLTFFNSQSPLLMPDITYSFYPIYCELYR
HHHHHHHHHHHCCEEEEEEEECCCCHHEEEHHHHHHCCCCCEEECCCCCHHHHEEHEEEE
IPFQKVPVDDDFKVLIKDYCIENGGIVIANPDAPTALALNLKDIEEILKKNQNSIVLINE
CCHHCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCEEEEEHHHHHHHHHCCCCCEEEEEE
AYIDFGGETCLPLLKKYDNLVVVQTFSKSRSLAGIRLGVAYGSAEAISHLYDVKNSFNSY
EEEECCCCHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCC
PIDSLAQIIGEASLMDEHYFQKNIQKIIKTREVFKDNLVNLGFEVTDSKANFVFVHHPKV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEECCCC
KAEELFKALYEAKIIVRHWNQPRIDDWLRITIGTNKEMNKVIEFLKGYLKKNEEIDEWKK
CHHHHHHHHHHHHHEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure 
SWQNNLRSVSPYIAGEQPELTDIIKLNTNENPYPPTSVAQLFNERYKTKNLRLYPSTDA
CCCCCCHHCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCH
KSLRKKLADYHHLEVEQVIIGNGSDEVLSLSFLTFFNSQSPLLMPDITYSFYPIYCELYR
HHHHHHHHHHHCCEEEEEEEECCCCHHEEEHHHHHHCCCCCEEECCCCCHHHHEEHEEEE
IPFQKVPVDDDFKVLIKDYCIENGGIVIANPDAPTALALNLKDIEEILKKNQNSIVLINE
CCHHCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCEEEEEHHHHHHHHHCCCCCEEEEEE
AYIDFGGETCLPLLKKYDNLVVVQTFSKSRSLAGIRLGVAYGSAEAISHLYDVKNSFNSY
EEEECCCCHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCC
PIDSLAQIIGEASLMDEHYFQKNIQKIIKTREVFKDNLVNLGFEVTDSKANFVFVHHPKV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEECCCC
KAEELFKALYEAKIIVRHWNQPRIDDWLRITIGTNKEMNKVIEFLKGYLKKNEEIDEWKK
CHHHHHHHHHHHHHEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1400209; 11337471