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The map label for this gene is folP

Identifier: 15673137

GI number: 15673137

Start: 1167233

End: 1168306

Strand: Direct

Name: folP

Synonym: L0176

Alternate gene names: 15673137

Gene position: 1167233-1168306 (Clockwise)

Preceding gene: 15673136

Following gene: 15673138

Centisome position: 49.34

GC content: 33.15

Gene sequence:

>1074_bases
ATGAAAATCTTAGAACTTAATCAAGAATCTTTTTCTCTTAAAAATATTATCCTAAAATTTGATGAGTTAAATCACAATGA
AATGATTTCTCTTCAAAAAAAACTTTATCGAAATGGTAGTTTGACAAGACTGGCTCCAGACTCCTTGTTAGTAGTTTTAA
CAATTGATGACTTAGCAAAATTGATTAATCTTTTTGAAAATGATGAAGATAAAAAAATGCTTGAAGTGATTTATAAGCGT
CATCAAATCATTTGGTCAGGTAAAAATTTCAATTTTGATTTAACTAGAAAGTCAATTGTCTATTCAATCGTCAATGTTAC
ACCAGACTCTTTTTATGATGGAAATCCAGATAATTTAAACCTCTCTCATATTTTAAAAAGAGTAGAAGCTGATTTAGAAA
ATGGAGCTTCTGTTCTTGAGCTGGGAGGGAAATCATCGAAACCAGGATATGACGATATTAGCCCAGAAGAGGAATGGAAC
AGACTGAAAGAACCTATTCTTGAGTTGAAAAAAAACTTTCCTAAAGCGATTTTTGCTGTCGATACGGATGAAGCTTATGT
CATGGAACGAGTTTTAGACGCTGGGGTTGATATTATTAACGATATTGATGGTTTTGATACAAATGATAAATTAAAAGTGG
TAGAAAAGTATCAACCGGCTTTAGTTGCTATGAATAATGGGCGAGCTGGTTTTAGTTATGCTGATAATGTTTATGAAGAA
CTTCCATTATTTTTTGAAAATAAAAAAGAAGAGTTACTTCAACTTGGTTTAAAAGCTGAGCAAATCGTTATTGATCCTGG
AGTTGGTTTTTTTAATGGAGATTCAGGTTCAGATAGTCTTGAGCGGGTTAAAGCAACTGAAATTTTAAGCAGAATAGGTT
TACCTCTTATGATTGCAATCTCTCGTAAGTCATTTATGGGAAAACTCTTCAATGCCCAAGGAGATGAGCGGCTTTTTTCA
AGCCTTGTCCTAGAAGCGCAAATGGTTGCTGATGGGGGACGGATTTTGCGTGTTCATGATGTTAAGGAGACTAAACGTTT
ACTCGATGCAATTGAAATTTATAAGGAATTTTAA

Upstream 100 bases:

>100_bases
GTGGAGTAAAAAAAGTAAATTCTATTACTAAAACTTCTTATTTTTTAGGTGAATTTAAAGAAAATAATGAAAAAAGAATG
GAATTTTTAGAAAGTCTTTT

Downstream 100 bases:

>100_bases
AAATGAATGAAGACCTAATTGCTGAAATTCAAGCTTTATCTGCTATTGGAAGTGAAGAAAAATTTTCCGAGATTATTCGA
TTATTGAAAAATTCGACTTT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MKILELNQESFSLKNIILKFDELNHNEMISLQKKLYRNGSLTRLAPDSLLVVLTIDDLAKLINLFENDEDKKMLEVIYKR
HQIIWSGKNFNFDLTRKSIVYSIVNVTPDSFYDGNPDNLNLSHILKRVEADLENGASVLELGGKSSKPGYDDISPEEEWN
RLKEPILELKKNFPKAIFAVDTDEAYVMERVLDAGVDIINDIDGFDTNDKLKVVEKYQPALVAMNNGRAGFSYADNVYEE
LPLFFENKKEELLQLGLKAEQIVIDPGVGFFNGDSGSDSLERVKATEILSRIGLPLMIAISRKSFMGKLFNAQGDERLFS
SLVLEAQMVADGGRILRVHDVKETKRLLDAIEIYKEF

Sequences:

>Translated_357_residues
MKILELNQESFSLKNIILKFDELNHNEMISLQKKLYRNGSLTRLAPDSLLVVLTIDDLAKLINLFENDEDKKMLEVIYKR
HQIIWSGKNFNFDLTRKSIVYSIVNVTPDSFYDGNPDNLNLSHILKRVEADLENGASVLELGGKSSKPGYDDISPEEEWN
RLKEPILELKKNFPKAIFAVDTDEAYVMERVLDAGVDIINDIDGFDTNDKLKVVEKYQPALVAMNNGRAGFSYADNVYEE
LPLFFENKKEELLQLGLKAEQIVIDPGVGFFNGDSGSDSLERVKATEILSRIGLPLMIAISRKSFMGKLFNAQGDERLFS
SLVLEAQMVADGGRILRVHDVKETKRLLDAIEIYKEF
>Mature_357_residues
MKILELNQESFSLKNIILKFDELNHNEMISLQKKLYRNGSLTRLAPDSLLVVLTIDDLAKLINLFENDEDKKMLEVIYKR
HQIIWSGKNFNFDLTRKSIVYSIVNVTPDSFYDGNPDNLNLSHILKRVEADLENGASVLELGGKSSKPGYDDISPEEEWN
RLKEPILELKKNFPKAIFAVDTDEAYVMERVLDAGVDIINDIDGFDTNDKLKVVEKYQPALVAMNNGRAGFSYADNVYEE
LPLFFENKKEELLQLGLKAEQIVIDPGVGFFNGDSGSDSLERVKATEILSRIGLPLMIAISRKSFMGKLFNAQGDERLFS
SLVLEAQMVADGGRILRVHDVKETKRLLDAIEIYKEF

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=271, Percent_Identity=31.7343173431734, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 40531; Mature: 40531

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILELNQESFSLKNIILKFDELNHNEMISLQKKLYRNGSLTRLAPDSLLVVLTIDDLAK
CCEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCEEEEEEHHHHHH
LINLFENDEDKKMLEVIYKRHQIIWSGKNFNFDLTRKSIVYSIVNVTPDSFYDGNPDNLN
HHHHHCCCCHHHHHHHHHHHHHEEECCCCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCC
LSHILKRVEADLENGASVLELGGKSSKPGYDDISPEEEWNRLKEPILELKKNFPKAIFAV
HHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEE
DTDEAYVMERVLDAGVDIINDIDGFDTNDKLKVVEKYQPALVAMNNGRAGFSYADNVYEE
CCCHHHHHHHHHHHCHHHHHCCCCCCCCCHHHHHHHCCCEEEEEECCCCCCCHHHHHHHH
LPLFFENKKEELLQLGLKAEQIVIDPGVGFFNGDSGSDSLERVKATEILSRIGLPLMIAI
CCHHHCCCHHHHHHHCCCCCEEEEECCCCEECCCCCCHHHHHHHHHHHHHHCCCCEEEEE
SRKSFMGKLFNAQGDERLFSSLVLEAQMVADGGRILRVHDVKETKRLLDAIEIYKEF
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKILELNQESFSLKNIILKFDELNHNEMISLQKKLYRNGSLTRLAPDSLLVVLTIDDLAK
CCEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCEEEEEEHHHHHH
LINLFENDEDKKMLEVIYKRHQIIWSGKNFNFDLTRKSIVYSIVNVTPDSFYDGNPDNLN
HHHHHCCCCHHHHHHHHHHHHHEEECCCCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCC
LSHILKRVEADLENGASVLELGGKSSKPGYDDISPEEEWNRLKEPILELKKNFPKAIFAV
HHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEE
DTDEAYVMERVLDAGVDIINDIDGFDTNDKLKVVEKYQPALVAMNNGRAGFSYADNVYEE
CCCHHHHHHHHHHHCHHHHHCCCCCCCCCHHHHHHHCCCEEEEEECCCCCCCHHHHHHHH
LPLFFENKKEELLQLGLKAEQIVIDPGVGFFNGDSGSDSLERVKATEILSRIGLPLMIAI
CCHHHCCCHHHHHHHCCCCCEEEEECCCCEECCCCCCHHHHHHHHHHHHHHCCCCEEEEE
SRKSFMGKLFNAQGDERLFSSLVLEAQMVADGGRILRVHDVKETKRLLDAIEIYKEF
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1400191; 7642493; 10710307 [H]