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The map label for this gene is pyrC

Identifier: 15673051

GI number: 15673051

Start: 1081430

End: 1082755

Strand: Direct

Name: pyrC

Synonym: L81189

Alternate gene names: 15673051

Gene position: 1081430-1082755 (Clockwise)

Preceding gene: 15673050

Following gene: 15673052

Centisome position: 45.72

GC content: 38.61

Gene sequence:

>1326_bases
ATGAACAAGTCGGCAAAGCTGATTGTTCTGTCAGTAATTTATGAAAGGAAGAAAATGACTTTATTAATTAAAAATGGACG
ACTTGTTGACCCCAAATCAAATCGAGATGAAGTGTTAGATATTCTGATTGAAAATGACAAGATAGTAAAAATCGGCTTAA
ATTTGTCAGTAGAAAATGCAGAAATTGTTGATGCAAGGGGATTAGTCGTTGCCCCTGGTTTAATTGATGTTCATGTTCAT
TTTCGTGAACCAGGACAAACACATAAAGAAACGATTCATAGCGGTGCAAAATCAGCTGCGGCTGGTGGTTTTACAAGAGT
AGTTATGATGGCAAATACAAAACCTATTTTATCTACGCCAAAAGTACTGACAGAAACTTTAGAAATTGCTGACAAAGAAG
ATATTAAGATTGATGCAGTTGGGTCAATTACGCAAGATTTTGATGGAGAGCATTTAACAGATTTTGATGAACTCATTAAA
GCAGGAGCAATCGGCTTTTCTGATGATGGTATTCCACTGACAGATGCTGGCGTTTTACGTAAAGCTCTGCAAAAAGCGAA
ATTAACTGACAGCCTGATTTCAATTCATGAAGAAGATCCAAATTTGATTGGAACTTTAGGAGTGAATGATGGCGAAGTGG
CTCATAAATGTGGCTTCACAGGGGCACCGACTGTTTCAGAATACAGCATGATGGCGCGTGATAGTATGATTGCTTACGAA
ACAGGAGCTCGCTTGCACATTCAACATTTATCAGCTGGAGAATCTGTTGAAGTGGTGCGATTTGCCAAAAATTTAGGAGC
AAAAATCACAGCAGAAGTGACTCCACAACATTTTTCGATTACAGAACAAATGATTTTTGAGCAAGGGACCAATGCTAAAC
TCAACCCACCATTGCGTAGCACTACTGATATCGGTAAAATAATTGAGGGATTGAAAGATGGAACGATTGATGTCATCGCC
ACAGACCATGCCCCTCATACTCGTGAAGAGAAAAATGTCAGCCTTGATAAGGCGCCTTCAGGAATGATTGGATTAGAAAC
TTCATTGCAACTTGGCTTGACAAACTTAGTCGCAAAAGGCCATTTGACACTCAGTGAATTACTGACAAAAATGACAGTTA
ATCCAGCTAAACTTTATAATTTTGATGCAGGTTACCTCGCAGAAAATGGACCAGCTGACCTCGTCATTTTTGACGCTGAA
AATGACTATCAGGTCGGTGAAACATTTGACTCCAAAGCGACCAATTCTCCATTTATCAAACAGAAAGTTCAAGGGCAAGT
CAAATATACAATATGTGATGGAAAAATAGTCTATCAAGCGAAATAA

Upstream 100 bases:

>100_bases
TTTACTGACAGAAATTCAAGGAGCCTGTCAGTAAATAATTAGGTTCTGGAATAGCTGTCAGTTCAATGCGACCAAAGGGA
GACATTGAATCGGAGGATAA

Downstream 100 bases:

>100_bases
TAAAAAAAGGACCATAAGAAATTAATTTTCATAGGTCCTTTTTTTGTGTTACTTTACATCAGTATAAAGAACCGTTGTAG
AGTAAGTCATTAAGTGAGTG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MNKSAKLIVLSVIYERKKMTLLIKNGRLVDPKSNRDEVLDILIENDKIVKIGLNLSVENAEIVDARGLVVAPGLIDVHVH
FREPGQTHKETIHSGAKSAAAGGFTRVVMMANTKPILSTPKVLTETLEIADKEDIKIDAVGSITQDFDGEHLTDFDELIK
AGAIGFSDDGIPLTDAGVLRKALQKAKLTDSLISIHEEDPNLIGTLGVNDGEVAHKCGFTGAPTVSEYSMMARDSMIAYE
TGARLHIQHLSAGESVEVVRFAKNLGAKITAEVTPQHFSITEQMIFEQGTNAKLNPPLRSTTDIGKIIEGLKDGTIDVIA
TDHAPHTREEKNVSLDKAPSGMIGLETSLQLGLTNLVAKGHLTLSELLTKMTVNPAKLYNFDAGYLAENGPADLVIFDAE
NDYQVGETFDSKATNSPFIKQKVQGQVKYTICDGKIVYQAK

Sequences:

>Translated_441_residues
MNKSAKLIVLSVIYERKKMTLLIKNGRLVDPKSNRDEVLDILIENDKIVKIGLNLSVENAEIVDARGLVVAPGLIDVHVH
FREPGQTHKETIHSGAKSAAAGGFTRVVMMANTKPILSTPKVLTETLEIADKEDIKIDAVGSITQDFDGEHLTDFDELIK
AGAIGFSDDGIPLTDAGVLRKALQKAKLTDSLISIHEEDPNLIGTLGVNDGEVAHKCGFTGAPTVSEYSMMARDSMIAYE
TGARLHIQHLSAGESVEVVRFAKNLGAKITAEVTPQHFSITEQMIFEQGTNAKLNPPLRSTTDIGKIIEGLKDGTIDVIA
TDHAPHTREEKNVSLDKAPSGMIGLETSLQLGLTNLVAKGHLTLSELLTKMTVNPAKLYNFDAGYLAENGPADLVIFDAE
NDYQVGETFDSKATNSPFIKQKVQGQVKYTICDGKIVYQAK
>Mature_441_residues
MNKSAKLIVLSVIYERKKMTLLIKNGRLVDPKSNRDEVLDILIENDKIVKIGLNLSVENAEIVDARGLVVAPGLIDVHVH
FREPGQTHKETIHSGAKSAAAGGFTRVVMMANTKPILSTPKVLTETLEIADKEDIKIDAVGSITQDFDGEHLTDFDELIK
AGAIGFSDDGIPLTDAGVLRKALQKAKLTDSLISIHEEDPNLIGTLGVNDGEVAHKCGFTGAPTVSEYSMMARDSMIAYE
TGARLHIQHLSAGESVEVVRFAKNLGAKITAEVTPQHFSITEQMIFEQGTNAKLNPPLRSTTDIGKIIEGLKDGTIDVIA
TDHAPHTREEKNVSLDKAPSGMIGLETSLQLGLTNLVAKGHLTLSELLTKMTVNPAKLYNFDAGYLAENGPADLVIFDAE
NDYQVGETFDSKATNSPFIKQKVQGQVKYTICDGKIVYQAK

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=387, Percent_Identity=31.7829457364341, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI4503377, Length=451, Percent_Identity=24.390243902439, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI4503379, Length=452, Percent_Identity=23.2300884955752, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1786722, Length=437, Percent_Identity=28.3752860411899, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI87082175, Length=439, Percent_Identity=26.879271070615, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI193204318, Length=378, Percent_Identity=28.8359788359788, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI86575075, Length=445, Percent_Identity=26.5168539325843, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322218, Length=404, Percent_Identity=26.7326732673267, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24642586, Length=394, Percent_Identity=29.9492385786802, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI18859883, Length=417, Percent_Identity=26.378896882494, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 47779; Mature: 47779

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKSAKLIVLSVIYERKKMTLLIKNGRLVDPKSNRDEVLDILIENDKIVKIGLNLSVENA
CCCCCCEEEEEEECCCCEEEEEEECCEEECCCCCCCCEEEEEECCCEEEEEEEEEEECCC
EIVDARGLVVAPGLIDVHVHFREPGQTHKETIHSGAKSAAAGGFTRVVMMANTKPILSTP
EEEECCCEEEECCEEEEEEEECCCCCHHHHHHHCCCCHHCCCCEEEEEEEECCCCCCCCH
KVLTETLEIADKEDIKIDAVGSITQDFDGEHLTDFDELIKAGAIGFSDDGIPLTDAGVLR
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHH
KALQKAKLTDSLISIHEEDPNLIGTLGVNDGEVAHKCGFTGAPTVSEYSMMARDSMIAYE
HHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHCCCCCCCCHHHHHHHHHCCEEEEE
TGARLHIQHLSAGESVEVVRFAKNLGAKITAEVTPQHFSITEQMIFEQGTNAKLNPPLRS
CCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCC
TTDIGKIIEGLKDGTIDVIATDHAPHTREEKNVSLDKAPSGMIGLETSLQLGLTNLVAKG
HHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHCC
HLTLSELLTKMTVNPAKLYNFDAGYLAENGPADLVIFDAENDYQVGETFDSKATNSPFIK
CCCHHHHHHHHCCCHHHEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHH
QKVQGQVKYTICDGKIVYQAK
HHCCCEEEEEEECCEEEEEEC
>Mature Secondary Structure
MNKSAKLIVLSVIYERKKMTLLIKNGRLVDPKSNRDEVLDILIENDKIVKIGLNLSVENA
CCCCCCEEEEEEECCCCEEEEEEECCEEECCCCCCCCEEEEEECCCEEEEEEEEEEECCC
EIVDARGLVVAPGLIDVHVHFREPGQTHKETIHSGAKSAAAGGFTRVVMMANTKPILSTP
EEEECCCEEEECCEEEEEEEECCCCCHHHHHHHCCCCHHCCCCEEEEEEEECCCCCCCCH
KVLTETLEIADKEDIKIDAVGSITQDFDGEHLTDFDELIKAGAIGFSDDGIPLTDAGVLR
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHH
KALQKAKLTDSLISIHEEDPNLIGTLGVNDGEVAHKCGFTGAPTVSEYSMMARDSMIAYE
HHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHCCCCCCCCHHHHHHHHHCCEEEEE
TGARLHIQHLSAGESVEVVRFAKNLGAKITAEVTPQHFSITEQMIFEQGTNAKLNPPLRS
CCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCC
TTDIGKIIEGLKDGTIDVIATDHAPHTREEKNVSLDKAPSGMIGLETSLQLGLTNLVAKG
HHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHCC
HLTLSELLTKMTVNPAKLYNFDAGYLAENGPADLVIFDAENDYQVGETFDSKATNSPFIK
CCCHHHHHHHHCCCHHHEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHH
QKVQGQVKYTICDGKIVYQAK
HHCCCEEEEEEECCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]