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The map label for this gene is glmS

Identifier: 15672988

GI number: 15672988

Start: 1033815

End: 1035632

Strand: Direct

Name: glmS

Synonym: L33556

Alternate gene names: 15672988

Gene position: 1033815-1035632 (Clockwise)

Preceding gene: 15672987

Following gene: 15672989

Centisome position: 43.7

GC content: 37.29

Gene sequence:

>1818_bases
ATGTGTGGGATTGTTGGTGTTGTAGGTAGTAAAAATGCAACTGATATTTTGATGCAAGGACTAGAAAAACTTGAATATCG
TGGTTATGATTCAGCAGGTATTTTTGTAAATGGTCAAGAAACAGCAGCAAAATTAGTTAAATCTGTCGGACGTATTGCAG
ACTTAAGAGGAAAGTTAGGGATTGATGTTTCAGGAACAGCCGGCATTGGTCACACACGTTGGGCTACTCATGGTAAACCA
ACGGAAGACAATGCTCATCCACATACTTCAACATCAGGTCGCTTTATTTTAGTACATAATGGTGTGATTGAAAATTTTGT
TGAACTTAAAAACGAATTTTTGATGAATGATACTTTTAAAGGACAAACCGATACTGAAATTGCGGTTCATTTAATTGCTA
AATTTGCTGAAGAAGAAGGACTATCAACACTTGAAGCATTCAAAAAAGCTCTAAGCTTAATTCAAGGTTCTTATGCCTTT
GCTCTTATGGATAGCGAAGATGCAGAAGTGATTTATGTTGCCAAAAATAAATCACCATTATTAATCGGCCTTGGCGAAGG
CTACAACATGGTCTGCTCAGATGCTATGGCGATGATTCGTGAAACGTCTGAATTTATGGAAATTCACGATAAAGAGCTTG
TTGTGTTAACAAAAGATAATGTTACAGTTATGGATTACGAAGGTAATGTACTTTCACGTGAGTCATACACAGCTGAACTT
GATTTATCTGACATTGGAAAAGGAACTTATCCTTTCTACATGCTCAAAGAAATTGATGAGCAACCCGCAGTTATGCGTAA
ACTCATTGCGACTTATGCAAATGAAGATGGAACAATGAAAGTCGATCAAGACATTATCAAAGGAATTCAAGAGGCTGATC
GTATTTATATTATTGCCGCCGGAACGTCTTATCATGCAGGTTTTGGGGCAAAAATGATGCTTGAATCTTTGACAAATACA
CCGGTTGAACTTGGTCTTGCTTCAGAATGGGGCTATGATATGCCTTTGCTGAGCCAAAAACCATTCTTTATTTTCCTTTC
ACAGTCTGGTGAAACGGCTGACAGCCGTCAGGTTTTAGTAAAAGTAAATGAATTAGGACTTCCAAGCTTAACAGTTACAA
ATGTTCCCGGTTCTACTTTGTCACGCGAAGCAACTTATACAATGTTAATCGGTGCTGGACCAGAAATTGCAGTTGCTTCA
ACCAAAGCATATACAGGACAAATTGCAACTTTGGCTTTTCTTGCAAAGGCAGTTGGTGAGGCTGAAGGGGAAGTTAAAGC
AAAAGAATTTGATTTAGTTAAAGAATTGTCTTTAGTTGCTCAATCAATTGAAGCCACTTTATCTGAAAAGGATGAAATTG
CAGCAATTGTAGCTGACTTATTGCCAACTACTCGCAATGCCTTCTATATTGGTCGAAAACAAGATTATTATGTAGCAATG
GAAGCTTCTCTCAAATTAAAAGAAATTTCTTATATTCAATGTGAAGGATTTGCTGCTGGAGAATTAAAACATGGAACGAT
TTCATTGATTGAAAAAGGAACTCCAGTACTTGCTTTAATTTCTAATAATGAAGAAGTAGCAGCTCATACTCGTGGAAATG
TAATGGAAACAGTGGCTCGTGGAGCCTCAGCTATCACAATTGTTGAAGAAGGAGTGGCTCGTGAAGATGATACAATTGTT
GTCAACCAAGTTCATCCTTATTTGTCAGCAATTTCAATGGTTATTCCAACACAATTAATTGCTTATTATGCGTCAATGCA
GCGTGGACTTGATGTTGATAAACCACGTAACTTAGCTAAAGCAGTAACAGTTGAATAA

Upstream 100 bases:

>100_bases
GACAATGATAAATAAGTGTAATATAATGCTATTTATAAATAAATATTAGAAAAATAATTAACTATACCAATTTTAAGGGT
GAGTTAAATGGAGCTTTATT

Downstream 100 bases:

>100_bases
AAGTTACTGACAGAAATCTCTGTCAGTAAAATGATAACTAAAAATAAAAAGTTCTGAGATTCATCAGAACTTTTTTGGTT
AATTAATCTTTTGTCAGTGA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MCGIVGVVGSKNATDILMQGLEKLEYRGYDSAGIFVNGQETAAKLVKSVGRIADLRGKLGIDVSGTAGIGHTRWATHGKP
TEDNAHPHTSTSGRFILVHNGVIENFVELKNEFLMNDTFKGQTDTEIAVHLIAKFAEEEGLSTLEAFKKALSLIQGSYAF
ALMDSEDAEVIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVVLTKDNVTVMDYEGNVLSRESYTAEL
DLSDIGKGTYPFYMLKEIDEQPAVMRKLIATYANEDGTMKVDQDIIKGIQEADRIYIIAAGTSYHAGFGAKMMLESLTNT
PVELGLASEWGYDMPLLSQKPFFIFLSQSGETADSRQVLVKVNELGLPSLTVTNVPGSTLSREATYTMLIGAGPEIAVAS
TKAYTGQIATLAFLAKAVGEAEGEVKAKEFDLVKELSLVAQSIEATLSEKDEIAAIVADLLPTTRNAFYIGRKQDYYVAM
EASLKLKEISYIQCEGFAAGELKHGTISLIEKGTPVLALISNNEEVAAHTRGNVMETVARGASAITIVEEGVAREDDTIV
VNQVHPYLSAISMVIPTQLIAYYASMQRGLDVDKPRNLAKAVTVE

Sequences:

>Translated_605_residues
MCGIVGVVGSKNATDILMQGLEKLEYRGYDSAGIFVNGQETAAKLVKSVGRIADLRGKLGIDVSGTAGIGHTRWATHGKP
TEDNAHPHTSTSGRFILVHNGVIENFVELKNEFLMNDTFKGQTDTEIAVHLIAKFAEEEGLSTLEAFKKALSLIQGSYAF
ALMDSEDAEVIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVVLTKDNVTVMDYEGNVLSRESYTAEL
DLSDIGKGTYPFYMLKEIDEQPAVMRKLIATYANEDGTMKVDQDIIKGIQEADRIYIIAAGTSYHAGFGAKMMLESLTNT
PVELGLASEWGYDMPLLSQKPFFIFLSQSGETADSRQVLVKVNELGLPSLTVTNVPGSTLSREATYTMLIGAGPEIAVAS
TKAYTGQIATLAFLAKAVGEAEGEVKAKEFDLVKELSLVAQSIEATLSEKDEIAAIVADLLPTTRNAFYIGRKQDYYVAM
EASLKLKEISYIQCEGFAAGELKHGTISLIEKGTPVLALISNNEEVAAHTRGNVMETVARGASAITIVEEGVAREDDTIV
VNQVHPYLSAISMVIPTQLIAYYASMQRGLDVDKPRNLAKAVTVE
>Mature_605_residues
MCGIVGVVGSKNATDILMQGLEKLEYRGYDSAGIFVNGQETAAKLVKSVGRIADLRGKLGIDVSGTAGIGHTRWATHGKP
TEDNAHPHTSTSGRFILVHNGVIENFVELKNEFLMNDTFKGQTDTEIAVHLIAKFAEEEGLSTLEAFKKALSLIQGSYAF
ALMDSEDAEVIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVVLTKDNVTVMDYEGNVLSRESYTAEL
DLSDIGKGTYPFYMLKEIDEQPAVMRKLIATYANEDGTMKVDQDIIKGIQEADRIYIIAAGTSYHAGFGAKMMLESLTNT
PVELGLASEWGYDMPLLSQKPFFIFLSQSGETADSRQVLVKVNELGLPSLTVTNVPGSTLSREATYTMLIGAGPEIAVAS
TKAYTGQIATLAFLAKAVGEAEGEVKAKEFDLVKELSLVAQSIEATLSEKDEIAAIVADLLPTTRNAFYIGRKQDYYVAM
EASLKLKEISYIQCEGFAAGELKHGTISLIEKGTPVLALISNNEEVAAHTRGNVMETVARGASAITIVEEGVAREDDTIV
VNQVHPYLSAISMVIPTQLIAYYASMQRGLDVDKPRNLAKAVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI205277386, Length=685, Percent_Identity=32.1167883211679, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI4826742, Length=688, Percent_Identity=31.3953488372093, Blast_Score=300, Evalue=3e-81,
Organism=Escherichia coli, GI1790167, Length=615, Percent_Identity=37.0731707317073, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1788651, Length=194, Percent_Identity=28.3505154639175, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17539970, Length=432, Percent_Identity=31.25, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17532899, Length=459, Percent_Identity=30.5010893246187, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17532897, Length=459, Percent_Identity=30.5010893246187, Blast_Score=202, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6322745, Length=436, Percent_Identity=31.8807339449541, Blast_Score=209, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6323731, Length=373, Percent_Identity=27.6139410187668, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6323730, Length=206, Percent_Identity=33.9805825242718, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21357745, Length=693, Percent_Identity=30.7359307359307, Blast_Score=306, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_LACLA (Q9CGT6)

Other databases:

- EMBL:   AE005176
- PIR:   F86750
- RefSeq:   NP_267162.1
- ProteinModelPortal:   Q9CGT6
- SMR:   Q9CGT6
- MEROPS:   C44.971
- GeneID:   1114637
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L33556
- NMPDR:   fig|272623.1.peg.1029
- HOGENOM:   HBG645312
- OMA:   KNHSFVS
- ProtClustDB:   PRK00331
- BioCyc:   LLAC272623:L33556-MONOMER
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 65613; Mature: 65613

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 600-600

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGVVGSKNATDILMQGLEKLEYRGYDSAGIFVNGQETAAKLVKSVGRIADLRGKLG
CCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCC
IDVSGTAGIGHTRWATHGKPTEDNAHPHTSTSGRFILVHNGVIENFVELKNEFLMNDTFK
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCC
GQTDTEIAVHLIAKFAEEEGLSTLEAFKKALSLIQGSYAFALMDSEDAEVIYVAKNKSPL
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCE
LIGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVVLTKDNVTVMDYEGNVLSRESYTAEL
EEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEEEEECCCEECCCCCEEEE
DLSDIGKGTYPFYMLKEIDEQPAVMRKLIATYANEDGTMKVDQDIIKGIQEADRIYIIAA
CHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCEEECHHHHHHHHCCCEEEEEEE
GTSYHAGFGAKMMLESLTNTPVELGLASEWGYDMPLLSQKPFFIFLSQSGETADSRQVLV
CCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEE
KVNELGLPSLTVTNVPGSTLSREATYTMLIGAGPEIAVASTKAYTGQIATLAFLAKAVGE
EEECCCCCEEEEECCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHCC
AEGEVKAKEFDLVKELSLVAQSIEATLSEKDEIAAIVADLLPTTRNAFYIGRKQDYYVAM
CCCCEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCCEEEEE
EASLKLKEISYIQCEGFAAGELKHGTISLIEKGTPVLALISNNEEVAAHTRGNVMETVAR
ECCEEEEEEEEEEECCEECCCCCCCEEEEEECCCCEEEEEECCCEEEEECCCHHHHHHHC
GASAITIVEEGVAREDDTIVVNQVHPYLSAISMVIPTQLIAYYASMQRGLDVDKPRNLAK
CCCEEEEEECCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
AVTVE
EEECC
>Mature Secondary Structure
MCGIVGVVGSKNATDILMQGLEKLEYRGYDSAGIFVNGQETAAKLVKSVGRIADLRGKLG
CCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCC
IDVSGTAGIGHTRWATHGKPTEDNAHPHTSTSGRFILVHNGVIENFVELKNEFLMNDTFK
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCC
GQTDTEIAVHLIAKFAEEEGLSTLEAFKKALSLIQGSYAFALMDSEDAEVIYVAKNKSPL
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCE
LIGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVVLTKDNVTVMDYEGNVLSRESYTAEL
EEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEEEEECCCEECCCCCEEEE
DLSDIGKGTYPFYMLKEIDEQPAVMRKLIATYANEDGTMKVDQDIIKGIQEADRIYIIAA
CHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCEEECHHHHHHHHCCCEEEEEEE
GTSYHAGFGAKMMLESLTNTPVELGLASEWGYDMPLLSQKPFFIFLSQSGETADSRQVLV
CCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEE
KVNELGLPSLTVTNVPGSTLSREATYTMLIGAGPEIAVASTKAYTGQIATLAFLAKAVGE
EEECCCCCEEEEECCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHCC
AEGEVKAKEFDLVKELSLVAQSIEATLSEKDEIAAIVADLLPTTRNAFYIGRKQDYYVAM
CCCCEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCCEEEEE
EASLKLKEISYIQCEGFAAGELKHGTISLIEKGTPVLALISNNEEVAAHTRGNVMETVAR
ECCEEEEEEEEEEECCEECCCCCCCEEEEEECCCCEEEEEECCCEEEEECCCHHHHHHHC
GASAITIVEEGVAREDDTIVVNQVHPYLSAISMVIPTQLIAYYASMQRGLDVDKPRNLAK
CCCEEEEEECCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
AVTVE
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471