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The map label for this gene is lspA

Identifier: 15672979

GI number: 15672979

Start: 1025566

End: 1026018

Strand: Direct

Name: lspA

Synonym: L0335

Alternate gene names: 15672979

Gene position: 1025566-1026018 (Clockwise)

Preceding gene: 15672978

Following gene: 15672980

Centisome position: 43.35

GC content: 30.68

Gene sequence:

>453_bases
ATGAAAAAACTACTGTCACTTGTTATTATCGTTGTCGGAATTGTTGCTGACCAAATTTTTAAAAATTGGATTGTTGCTAA
TATTCAGCTTGGAGATACAGAAAAAATTTGGCCTAATGTTCTTAGTTTAACTTATATCAAAAATGATGGAGCAGCTTGGT
CTTCATTTTCAGGTCAACAATGGTTTTTCCTTATCTTAACACCGATCGTCTTAGTTGTTGCCCTTTGGTTTTTATGGAAA
AAAATGGCACAAAACTGGTATTTTATTGGATTAACTTTAATTATTGCGGGTGCTTTGGGAAATTTTATTGACCGAATTCG
TCAAGGATTTGTTGTTGATATGTTCCAAACTGAATTTATTAATTTTCCAATTTTTAATATTGCGGATATCTTATTATCTG
TTGGTTTTGTTCTTCTTTTCATTGCAATTTTGACAGACAAAGAAACAAAATAA

Upstream 100 bases:

>100_bases
TATCTATAAGTGCATTTATTTAAATGCGCTTTTTATTTTGAAATAGGATAAAAACTGTTCTAGCGAGCTATCAGATTGCG
AAATATGCTATAATTAAAGC

Downstream 100 bases:

>100_bases
ATTGATTAAAAAATCACTGACAGAAAGTTTTATTTAACATTTATAAAAAGGAAAACACACTTGCCTATCATAAAAATTAA
CGAAGAAAACAAAGGCTTAC

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 150; Mature: 150

Protein sequence:

>150_residues
MKKLLSLVIIVVGIVADQIFKNWIVANIQLGDTEKIWPNVLSLTYIKNDGAAWSSFSGQQWFFLILTPIVLVVALWFLWK
KMAQNWYFIGLTLIIAGALGNFIDRIRQGFVVDMFQTEFINFPIFNIADILLSVGFVLLFIAILTDKETK

Sequences:

>Translated_150_residues
MKKLLSLVIIVVGIVADQIFKNWIVANIQLGDTEKIWPNVLSLTYIKNDGAAWSSFSGQQWFFLILTPIVLVVALWFLWK
KMAQNWYFIGLTLIIAGALGNFIDRIRQGFVVDMFQTEFINFPIFNIADILLSVGFVLLFIAILTDKETK
>Mature_150_residues
MKKLLSLVIIVVGIVADQIFKNWIVANIQLGDTEKIWPNVLSLTYIKNDGAAWSSFSGQQWFFLILTPIVLVVALWFLWK
KMAQNWYFIGLTLIIAGALGNFIDRIRQGFVVDMFQTEFINFPIFNIADILLSVGFVLLFIAILTDKETK

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=149, Percent_Identity=38.255033557047, Blast_Score=73, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_LACLA (Q9CGU5)

Other databases:

- EMBL:   AE005176
- PIR:   E86749
- RefSeq:   NP_267153.1
- GeneID:   1114628
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0335
- NMPDR:   fig|272623.1.peg.1020
- HOGENOM:   HBG724422
- OMA:   SYVVDMI
- ProtClustDB:   PRK00376
- BioCyc:   LLAC272623:L0335-MONOMER
- BRENDA:   3.4.23.36
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 17132; Mature: 17132

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 104-104 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

HASH(0xd0c885c)-; HASH(0xe08dc68)-; HASH(0xe148c90)-; HASH(0xe0595f8)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLLSLVIIVVGIVADQIFKNWIVANIQLGDTEKIWPNVLSLTYIKNDGAAWSSFSGQQ
CHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHEEEEEECCCCCCCCCCCCH
WFFLILTPIVLVVALWFLWKKMAQNWYFIGLTLIIAGALGNFIDRIRQGFVVDMFQTEFI
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
NFPIFNIADILLSVGFVLLFIAILTDKETK
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure
MKKLLSLVIIVVGIVADQIFKNWIVANIQLGDTEKIWPNVLSLTYIKNDGAAWSSFSGQQ
CHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHEEEEEECCCCCCCCCCCCH
WFFLILTPIVLVVALWFLWKKMAQNWYFIGLTLIIAGALGNFIDRIRQGFVVDMFQTEFI
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
NFPIFNIADILLSVGFVLLFIAILTDKETK
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11337471