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The map label for this gene is ribA

Identifier: 15672977

GI number: 15672977

Start: 1023775

End: 1024971

Strand: Direct

Name: ribA

Synonym: L0165

Alternate gene names: 15672977

Gene position: 1023775-1024971 (Clockwise)

Preceding gene: 15672976

Following gene: 15672978

Centisome position: 43.28

GC content: 36.34

Gene sequence:

>1197_bases
ATGTTCCAATATAATAAAGTAGAAGAAGCACTTGCTGCACTTAAAGCAGGGGAAATGATTATCGTTAGTGACGATGAAAA
TAGAGAAAATGAGGGCGACCTTATCTGTGCGGCCGAATTTATCAGTCCAGAAATAATTAATTTTATGGCAAGTGAGGCCA
AAGGATTGATATGCGCACCACTCAGTGAAACTTATGCTAAGAATTTACAATTAGAAGCAATGGTAGAGAAAAATACAGAT
AATCATGGAACAGCTTTTACAGTTTCGGTTGATCATATTGAAACTAGCACAGGAATTTCGGCTTTTGAACGGGCCTTAAC
CATAAAAAAACTTGTTGATGCCGAGAGTTTACCAAGTGATTTTCGTAGACCAGGTCATGTATTTCCACTTATTGCCAAGA
AAAATGGTCTTTTTGAGCGAAATGGTCATACTGAGGCTACGGTTGACTTGTTGCGTCTGGCTGGTTTAAAAGAAGTAGGT
GTCTGCGTTGAAATAATGGACGAAGATGGAACAATGATGCATAAGGAGAAACTGAAGGAAAAAGCGCAAGAGTGGGGCTT
GAAATATATCACAATTAAAGCTATTCAAGAGTATCTTAAGCAAAATGAACTACAAGTAGAACAGGTGACTAGAGCTAAAC
TACCGACGAAATATGGTATGTTTGATATTTTAGGATTTGTCAATAAAATAAATGGTGAGCACCATGTTGCTTTAGTTAAA
GGAGATATTGGTGACGGTCAAGCTATTCTTTGCCGCGTTCACTCAGAATGCTTAACTAGTGATGCTTTTGGTTCTTTGAA
ATGTGACTGCGGTGGACAATTAGAAGAAGCATTAAAAAAAATAAATGATGAGGGGCGTGGCGTGCTTTTATATCTTCGAC
AAGAAGGACGTGGAATTGGTTTGATTAATAAACTTCGTGCCTACTCACTTCAAGATGAAGGACTTGATACGGTTGAAGCT
AATTTAGCTTTGGGGTTTGAAGAAGATGAGCGAGAATATTCTATTGGAGCACAAATTTTAAAAATAATTGGGGTGAAATC
ATTGAAATTAATGACTAATAATCCGCAAAAGATTAATGATTTTCAAAAATATGGTCTAGTAGTTGAAGAAAGAGTAGCTC
TCCAAATCAAAGATAACCCCTTTGACCTTGATTATTTAAAAGTAAAACAAAATAAAATGGGACATTTGTTTGACTAA

Upstream 100 bases:

>100_bases
AATATATAGAAAAATTATGGGGCGATAGTAGTTCTTCGATGAAAGAATCTTCAGTAACTAAAGAAAAGCTATTTAACAAC
GGATTTTTATAGGAGATAAA

Downstream 100 bases:

>100_bases
AGTAAAATAGAAAGTAAGGATAGAAATATGACAATTATTGAAGGAAATTTAAGAACAGAGAATGCAAAATATGGGATTGT
AGTTGCTCAATTTAATGAAT

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MFQYNKVEEALAALKAGEMIIVSDDENRENEGDLICAAEFISPEIINFMASEAKGLICAPLSETYAKNLQLEAMVEKNTD
NHGTAFTVSVDHIETSTGISAFERALTIKKLVDAESLPSDFRRPGHVFPLIAKKNGLFERNGHTEATVDLLRLAGLKEVG
VCVEIMDEDGTMMHKEKLKEKAQEWGLKYITIKAIQEYLKQNELQVEQVTRAKLPTKYGMFDILGFVNKINGEHHVALVK
GDIGDGQAILCRVHSECLTSDAFGSLKCDCGGQLEEALKKINDEGRGVLLYLRQEGRGIGLINKLRAYSLQDEGLDTVEA
NLALGFEEDEREYSIGAQILKIIGVKSLKLMTNNPQKINDFQKYGLVVEERVALQIKDNPFDLDYLKVKQNKMGHLFD

Sequences:

>Translated_398_residues
MFQYNKVEEALAALKAGEMIIVSDDENRENEGDLICAAEFISPEIINFMASEAKGLICAPLSETYAKNLQLEAMVEKNTD
NHGTAFTVSVDHIETSTGISAFERALTIKKLVDAESLPSDFRRPGHVFPLIAKKNGLFERNGHTEATVDLLRLAGLKEVG
VCVEIMDEDGTMMHKEKLKEKAQEWGLKYITIKAIQEYLKQNELQVEQVTRAKLPTKYGMFDILGFVNKINGEHHVALVK
GDIGDGQAILCRVHSECLTSDAFGSLKCDCGGQLEEALKKINDEGRGVLLYLRQEGRGIGLINKLRAYSLQDEGLDTVEA
NLALGFEEDEREYSIGAQILKIIGVKSLKLMTNNPQKINDFQKYGLVVEERVALQIKDNPFDLDYLKVKQNKMGHLFD
>Mature_398_residues
MFQYNKVEEALAALKAGEMIIVSDDENRENEGDLICAAEFISPEIINFMASEAKGLICAPLSETYAKNLQLEAMVEKNTD
NHGTAFTVSVDHIETSTGISAFERALTIKKLVDAESLPSDFRRPGHVFPLIAKKNGLFERNGHTEATVDLLRLAGLKEVG
VCVEIMDEDGTMMHKEKLKEKAQEWGLKYITIKAIQEYLKQNELQVEQVTRAKLPTKYGMFDILGFVNKINGEHHVALVK
GDIGDGQAILCRVHSECLTSDAFGSLKCDCGGQLEEALKKINDEGRGVLLYLRQEGRGIGLINKLRAYSLQDEGLDTVEA
NLALGFEEDEREYSIGAQILKIIGVKSLKLMTNNPQKINDFQKYGLVVEERVALQIKDNPFDLDYLKVKQNKMGHLFD

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=195, Percent_Identity=53.3333333333333, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI1789420, Length=201, Percent_Identity=41.7910447761194, Blast_Score=166, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6320695, Length=207, Percent_Identity=41.0628019323672, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319438, Length=169, Percent_Identity=42.0118343195266, Blast_Score=120, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 44414; Mature: 44414

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQYNKVEEALAALKAGEMIIVSDDENRENEGDLICAAEFISPEIINFMASEAKGLICAP
CCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEHHCCHHHHHHHHHHCCCEEEEC
LSETYAKNLQLEAMVEKNTDNHGTAFTVSVDHIETSTGISAFERALTIKKLVDAESLPSD
CHHHHHHCCEEEEEEECCCCCCCEEEEEEECCEECCCCHHHHHHHHHHHHHHCHHCCCHH
FRRPGHVFPLIAKKNGLFERNGHTEATVDLLRLAGLKEVGVCVEIMDEDGTMMHKEKLKE
HCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCHHHCEEEEEECCCCCHHHHHHHHH
KAQEWGLKYITIKAIQEYLKQNELQVEQVTRAKLPTKYGMFDILGFVNKINGEHHVALVK
HHHHCCCEEEEHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEEE
GDIGDGQAILCRVHSECLTSDAFGSLKCDCGGQLEEALKKINDEGRGVLLYLRQEGRGIG
CCCCCCCEEEEEEHHHHHCCCCCCCEEECCCCHHHHHHHHHCCCCCEEEEEEEECCCCCC
LINKLRAYSLQDEGLDTVEANLALGFEEDEREYSIGAQILKIIGVKSLKLMTNNPQKIND
HHHHHHHCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHH
FQKYGLVVEERVALQIKDNPFDLDYLKVKQNKMGHLFD
HHHHCCEEEEEEEEEECCCCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MFQYNKVEEALAALKAGEMIIVSDDENRENEGDLICAAEFISPEIINFMASEAKGLICAP
CCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEHHCCHHHHHHHHHHCCCEEEEC
LSETYAKNLQLEAMVEKNTDNHGTAFTVSVDHIETSTGISAFERALTIKKLVDAESLPSD
CHHHHHHCCEEEEEEECCCCCCCEEEEEEECCEECCCCHHHHHHHHHHHHHHCHHCCCHH
FRRPGHVFPLIAKKNGLFERNGHTEATVDLLRLAGLKEVGVCVEIMDEDGTMMHKEKLKE
HCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCHHHCEEEEEECCCCCHHHHHHHHH
KAQEWGLKYITIKAIQEYLKQNELQVEQVTRAKLPTKYGMFDILGFVNKINGEHHVALVK
HHHHCCCEEEEHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEEE
GDIGDGQAILCRVHSECLTSDAFGSLKCDCGGQLEEALKKINDEGRGVLLYLRQEGRGIG
CCCCCCCEEEEEEHHHHHCCCCCCCEEECCCCHHHHHHHHHCCCCCEEEEEEEECCCCCC
LINKLRAYSLQDEGLDTVEANLALGFEEDEREYSIGAQILKIIGVKSLKLMTNNPQKIND
HHHHHHHCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHH
FQKYGLVVEERVALQIKDNPFDLDYLKVKQNKMGHLFD
HHHHCCEEEEEEEEEECCCCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA