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The map label for this gene is parE

Identifier: 15672961

GI number: 15672961

Start: 1006671

End: 1008605

Strand: Direct

Name: parE

Synonym: L0290

Alternate gene names: 15672961

Gene position: 1006671-1008605 (Clockwise)

Preceding gene: 15672955

Following gene: 15672962

Centisome position: 42.55

GC content: 38.14

Gene sequence:

>1935_bases
ATGGTAATAGATATTAATAACTATGATGACAGTGCGATTCAGGTTCTTGAAGGATTGGATGCTGTCAGAAAACGTCCAGG
AATGTATATTGGATCAACTGACGGAACTGGTTTGCACCATTTGGTTTGGGAAATTGTAGATAATGCGGTTGATGAAGCTT
TATCTGGCTTTGGTAACAGAATTTCAGTGACCATTAATGCTGATGGTTCTTTATCAGTAGAAGATGAAGGACGGGGAATG
CCAGTTGGGAAACACGCCATGGGTATTCCCACTGTGGAAGTAATTTTTACTATTTTGCACGCAGGTGGTAAATTTGGTCA
AGGGGGTTATAAAACTTCTGGTGGACTCCATGGTGTTGGATCTTCAGTCGTAAATGCCCTCTCGACTTGGTTAGAAGTTG
AAATTACTCGTGACGGGACTGTTTATCGTCAACGTTTTGAAAATGGTGGACATCCAGCGACAACTTTAGTAAAAATTGGG
AAAGCACCAAAGTCTAAAACAGGGACTAAAGTTACCTTCATGCCGGATTCTAGCATTTTTTCGACAACAGAATTTAAATA
TAATATCATTTCAGAACGACTAAATGAGTCTGCTTTTCTTTTAAAAGAAGTGACGATTAGTCTTGAAGATAAACGAACAG
ATGAAAAAGAAGAATTTCATTATGAAAATGGGGTTCAAGATTTCGTTTCTTATCTTAATGAAGATAAAGACAGTTTGACT
CCAGTTCTTTATTTTGAAGGAAAACAAGATGGTTTTGAAGTTGAAGTTGCCCTTCAATATAATGATGGCTATTCAGAAAA
CATTCTTTCATTCGTCAATAATGTCCGAACAAAAGATGGCGGAACGCACGAAGCAGGTTTGAAGACGGCAATTACGAAAG
CAATGAATGAATATGCTCGTAAAGTAAATTTACTCAAAGAGAAAGATAAAAATCTCGAAGGTTCGGATTATCGTGAAGGT
TTGACAGTCGTCTTGTCAGTTTTAATTCCTGAGGAACATCTCCAATTTGAAGGACAAACCAAAGATAAATTGGGTTCTCC
TTTAGCTCGTCCAGTTGTTGATTCTTTGGTTTCTGAGAAACTAAGTTTCTATTTGATGGAAAATGGCGAATTAGCGCAAA
ATTTGATTCGTAAAGCAATCAAAGCCCGTGAGGCTCGTGAAGCGGCTCGTAAAGCGCGTGAAGATTCACGAAATGGAAAG
AAATCTAAAAAAGACAAAGGACTTTTGTCTGGTAAATTAACCCCTGCTCAAACAAAAAATCCAAATAAAAATGAACTTTA
TTTGGTCGAAGGAGATTCTGCCGGAGGGTCCGCTAAACAAGGACGAGATCGTAAATTCCAAGCCATTTTGCCTTTGCGTG
GTAAAGTCATTAACACCGAAAAAGCTAAGATGCAAGATATTCTCAAAAATGAGGAAATCAATACAATGATTTATACCATT
GGTGCAGGCGTTGGGGCAGATTTTACCTTGGCCGACCGTAATTATGACAAAATCATTATTATGACCGATGCCGATACTGA
TGGAGCACACATTCAAACGCTCTTATTGACTTTCTTCTATCGCTATATGAAACCATTGGTTGAAGCGGGTCATGTCTATA
TTGCCCTTCCACCACTTTATAAAATGAGTGAAGGAAAAGGCAAAAAAGAAAAAATTGAGTATGCTTGGACAGATGGTGAG
TTAGCAGAACTTCGCAAGCAATTTGGTAAAAATGCTAATTTGCAACGTTATAAAGGACTTGGAGAAATGAATGCTGACCA
ACTTTGGGAAACAACAATGGACCCAGAAACTCGGACATTGATTCAAGTGACCATTGATGATGCAGCTCAAGCAGAGAAAC
GTGTTTCAGTACTGATGGGGGATAAAGTTGAACCTCGTCGTAAATGGATTGAAAATAATGTGAAATTTACAATGGAAGAA
GAAACAGTATTCTAA

Upstream 100 bases:

>100_bases
AAGGTACAATAATCAAGATGAATATTTTTTATTAGCTCATTGTGGATAAAAAAATAGTGATTTAGATAGAAGATATAGGC
TTTCGATGAGAGGAAAATAA

Downstream 100 bases:

>100_bases
GTTACTTTCTTTAATAATTAACCTCGATTTTTCGAGGTTTTTTACTTTAATTTATGATGTAAGTATCACTATTGCTCACT
TTAGGTGTAACAACAAGCCT

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MVIDINNYDDSAIQVLEGLDAVRKRPGMYIGSTDGTGLHHLVWEIVDNAVDEALSGFGNRISVTINADGSLSVEDEGRGM
PVGKHAMGIPTVEVIFTILHAGGKFGQGGYKTSGGLHGVGSSVVNALSTWLEVEITRDGTVYRQRFENGGHPATTLVKIG
KAPKSKTGTKVTFMPDSSIFSTTEFKYNIISERLNESAFLLKEVTISLEDKRTDEKEEFHYENGVQDFVSYLNEDKDSLT
PVLYFEGKQDGFEVEVALQYNDGYSENILSFVNNVRTKDGGTHEAGLKTAITKAMNEYARKVNLLKEKDKNLEGSDYREG
LTVVLSVLIPEEHLQFEGQTKDKLGSPLARPVVDSLVSEKLSFYLMENGELAQNLIRKAIKAREAREAARKAREDSRNGK
KSKKDKGLLSGKLTPAQTKNPNKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTEKAKMQDILKNEEINTMIYTI
GAGVGADFTLADRNYDKIIIMTDADTDGAHIQTLLLTFFYRYMKPLVEAGHVYIALPPLYKMSEGKGKKEKIEYAWTDGE
LAELRKQFGKNANLQRYKGLGEMNADQLWETTMDPETRTLIQVTIDDAAQAEKRVSVLMGDKVEPRRKWIENNVKFTMEE
ETVF

Sequences:

>Translated_644_residues
MVIDINNYDDSAIQVLEGLDAVRKRPGMYIGSTDGTGLHHLVWEIVDNAVDEALSGFGNRISVTINADGSLSVEDEGRGM
PVGKHAMGIPTVEVIFTILHAGGKFGQGGYKTSGGLHGVGSSVVNALSTWLEVEITRDGTVYRQRFENGGHPATTLVKIG
KAPKSKTGTKVTFMPDSSIFSTTEFKYNIISERLNESAFLLKEVTISLEDKRTDEKEEFHYENGVQDFVSYLNEDKDSLT
PVLYFEGKQDGFEVEVALQYNDGYSENILSFVNNVRTKDGGTHEAGLKTAITKAMNEYARKVNLLKEKDKNLEGSDYREG
LTVVLSVLIPEEHLQFEGQTKDKLGSPLARPVVDSLVSEKLSFYLMENGELAQNLIRKAIKAREAREAARKAREDSRNGK
KSKKDKGLLSGKLTPAQTKNPNKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTEKAKMQDILKNEEINTMIYTI
GAGVGADFTLADRNYDKIIIMTDADTDGAHIQTLLLTFFYRYMKPLVEAGHVYIALPPLYKMSEGKGKKEKIEYAWTDGE
LAELRKQFGKNANLQRYKGLGEMNADQLWETTMDPETRTLIQVTIDDAAQAEKRVSVLMGDKVEPRRKWIENNVKFTMEE
ETVF
>Mature_644_residues
MVIDINNYDDSAIQVLEGLDAVRKRPGMYIGSTDGTGLHHLVWEIVDNAVDEALSGFGNRISVTINADGSLSVEDEGRGM
PVGKHAMGIPTVEVIFTILHAGGKFGQGGYKTSGGLHGVGSSVVNALSTWLEVEITRDGTVYRQRFENGGHPATTLVKIG
KAPKSKTGTKVTFMPDSSIFSTTEFKYNIISERLNESAFLLKEVTISLEDKRTDEKEEFHYENGVQDFVSYLNEDKDSLT
PVLYFEGKQDGFEVEVALQYNDGYSENILSFVNNVRTKDGGTHEAGLKTAITKAMNEYARKVNLLKEKDKNLEGSDYREG
LTVVLSVLIPEEHLQFEGQTKDKLGSPLARPVVDSLVSEKLSFYLMENGELAQNLIRKAIKAREAREAARKAREDSRNGK
KSKKDKGLLSGKLTPAQTKNPNKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTEKAKMQDILKNEEINTMIYTI
GAGVGADFTLADRNYDKIIIMTDADTDGAHIQTLLLTFFYRYMKPLVEAGHVYIALPPLYKMSEGKGKKEKIEYAWTDGE
LAELRKQFGKNANLQRYKGLGEMNADQLWETTMDPETRTLIQVTIDDAAQAEKRVSVLMGDKVEPRRKWIENNVKFTMEE
ETVF

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=670, Percent_Identity=25.8208955223881, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI19913408, Length=669, Percent_Identity=25.8594917787743, Blast_Score=122, Evalue=1e-27,
Organism=Escherichia coli, GI48994957, Length=546, Percent_Identity=53.2967032967033, Blast_Score=526, Evalue=1e-150,
Organism=Escherichia coli, GI1789408, Length=639, Percent_Identity=41.1580594679186, Blast_Score=426, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17535065, Length=660, Percent_Identity=27.2727272727273, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI212645845, Length=589, Percent_Identity=25.1273344651952, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI212645657, Length=209, Percent_Identity=29.6650717703349, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=641, Percent_Identity=26.2090483619345, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI17136538, Length=676, Percent_Identity=26.9230769230769, Blast_Score=142, Evalue=9e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005740
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: 5.99.1.-

Molecular weight: Translated: 71719; Mature: 71719

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIDINNYDDSAIQVLEGLDAVRKRPGMYIGSTDGTGLHHLVWEIVDNAVDEALSGFGNR
CEEECCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCE
ISVTINADGSLSVEDEGRGMPVGKHAMGIPTVEVIFTILHAGGKFGQGGYKTSGGLHGVG
EEEEEECCCCEEECCCCCCCCCCCHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCH
SSVVNALSTWLEVEITRDGTVYRQRFENGGHPATTLVKIGKAPKSKTGTKVTFMPDSSIF
HHHHHHHHHHEEEEEECCCHHHHHHHHCCCCCHHHHEEECCCCCCCCCCEEEECCCCCCC
STTEFKYNIISERLNESAFLLKEVTISLEDKRTDEKEEFHYENGVQDFVSYLNEDKDSLT
CCCCHHHHHHHHHCCCHHEEEHHHEEEECCCCCCCHHHHHHHCCHHHHHHHHCCCHHHCC
PVLYFEGKQDGFEVEVALQYNDGYSENILSFVNNVRTKDGGTHEAGLKTAITKAMNEYAR
EEEEECCCCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
KVNLLKEKDKNLEGSDYREGLTVVLSVLIPEEHLQFEGQTKDKLGSPLARPVVDSLVSEK
HHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCHHHHCCCHHHHHHHHHHHHH
LSFYLMENGELAQNLIRKAIKAREAREAARKAREDSRNGKKSKKDKGLLSGKLTPAQTKN
HEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCC
PNKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTEKAKMQDILKNEEINTMIYTI
CCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCEEECCHHHHHHHHHCCCCCCEEEEEE
GAGVGADFTLADRNYDKIIIMTDADTDGAHIQTLLLTFFYRYMKPLVEAGHVYIALPPLY
CCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCE
KMSEGKGKKEKIEYAWTDGELAELRKQFGKNANLQRYKGLGEMNADQLWETTMDPETRTL
ECCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHCCCCCCCEEE
IQVTIDDAAQAEKRVSVLMGDKVEPRRKWIENNVKFTMEEETVF
EEEEECCHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEECCCCC
>Mature Secondary Structure
MVIDINNYDDSAIQVLEGLDAVRKRPGMYIGSTDGTGLHHLVWEIVDNAVDEALSGFGNR
CEEECCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCE
ISVTINADGSLSVEDEGRGMPVGKHAMGIPTVEVIFTILHAGGKFGQGGYKTSGGLHGVG
EEEEEECCCCEEECCCCCCCCCCCHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCH
SSVVNALSTWLEVEITRDGTVYRQRFENGGHPATTLVKIGKAPKSKTGTKVTFMPDSSIF
HHHHHHHHHHEEEEEECCCHHHHHHHHCCCCCHHHHEEECCCCCCCCCCEEEECCCCCCC
STTEFKYNIISERLNESAFLLKEVTISLEDKRTDEKEEFHYENGVQDFVSYLNEDKDSLT
CCCCHHHHHHHHHCCCHHEEEHHHEEEECCCCCCCHHHHHHHCCHHHHHHHHCCCHHHCC
PVLYFEGKQDGFEVEVALQYNDGYSENILSFVNNVRTKDGGTHEAGLKTAITKAMNEYAR
EEEEECCCCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
KVNLLKEKDKNLEGSDYREGLTVVLSVLIPEEHLQFEGQTKDKLGSPLARPVVDSLVSEK
HHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCHHHHCCCHHHHHHHHHHHHH
LSFYLMENGELAQNLIRKAIKAREAREAARKAREDSRNGKKSKKDKGLLSGKLTPAQTKN
HEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCC
PNKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTEKAKMQDILKNEEINTMIYTI
CCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCEEECCHHHHHHHHHCCCCCCEEEEEE
GAGVGADFTLADRNYDKIIIMTDADTDGAHIQTLLLTFFYRYMKPLVEAGHVYIALPPLY
CCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCE
KMSEGKGKKEKIEYAWTDGELAELRKQFGKNANLQRYKGLGEMNADQLWETTMDPETRTL
ECCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHCCCCCCCEEE
IQVTIDDAAQAEKRVSVLMGDKVEPRRKWIENNVKFTMEEETVF
EEEEECCHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8763932; 11463916; 8891124 [H]