Click here to switch to the map view.

The map label for this gene is yjdE

Identifier: 15672891

GI number: 15672891

Start: 932527

End: 934071

Strand: Direct

Name: yjdE

Synonym: L132251

Alternate gene names: 15672891

Gene position: 932527-934071 (Clockwise)

Preceding gene: 15672890

Following gene: 15672892

Centisome position: 39.42

GC content: 39.87

Gene sequence:

>1545_bases
ATGCCTGATACATACGAAAAAGATTACCATTTAGATATACATGGTAAACATTATAGCCGAATCGGAATGCTTATTTTGAT
TCTGGTTGGTACATTTGGAGCCATGTTGATGCAAACATCACTCGGGACAGCAATTCCAACATTGATGAATGACTTCAACA
TCTCCATGTCAACAGCACAACAAGCAACAACATGGTTTTTATTAGCCAATGGGATTATGGTTCCTATTTCAGCATATTTA
GCAACAAAATTCCCTACACGTTGGCTTTACGTAACAGCATACGCAACTTTATTTATCGGAATGTTTGTTGCTTACTCGGC
TCCAACATCAAGCTGGTGGGTTTTCCTAGCAGGTCGGATTCTGCAAGCTATTGCAGTTGGGATTACAATGCCTTTGATGC
AAGTTGCCCTTGTTAATATGTTTCCAGCTAAACAAATGGGAGCAATCATGGGGGTTGCCGGAGTTGTTCTTGTCCTTGCG
CCAGCCTTAGGTCCAACATTTGCAGGTTGGTTAATTACTCATAAATTTAACCTTATCTTTTGGACATTTGCAGCAAGTTG
GAGAACAATTTTCCTTATTCCAATGATTGTTGTCGGAGTTGTTTTCCTTATTTCAATCTTTGCAATGCGTGATGTTATTC
CGAACCGTCCAATGAAATTAGACTTCTTGTCAGTTTTACTTTCAGTTGTTGGTTTTGGTGCTTTCCTATGGGGATTCACT
AATGTTGCAACTGACGGATGGGGTAAATTCAACACCGTTATCGCCCCAATTGTTGGAGGGTTGATTATTATCTTCCTCTT
TGGTTTACGTCAACTTAAAATGGACGATCCATTCCTTGATATTCGCGTCTTTAAAATTAGACAGTTTACTTTGGTAACTC
TTGCACTTGCTTTAAGTACAATGGCAATGATGGGTGTTGAAATGATGCTTCCTCTTTACCTTCAAGATGTTCATGGACTT
TCTGCCTTTAATTCAGGTTTGGTTCTCTTACCTGGGTCATTAATGATGGCTGTTGTTGCCCCACTTGCTGGTGGAGTTTA
TGACCGAATTGGTTCAAAACGTCTTGCGGTGATTGGTTTCCTCGTTTTAGCACTGGGAACTATACCATTTATGTTCTTTA
CAGCTACGACTCCTGATCACTTTGATACTCTTCTTTATGGATTACGTATGGTTGGTGTTGGTATGGTAATGATGCCATTA
ACAACTAGTGCCATGAATGCAGTTCCAGTTAATGAAGTCGCTCAAGCAACAGCTTCAAACAATACAGCGCGTCAAGTCGC
GTCATCAGTTGTTGTTGCCCTCCTTTCTTCAGTCGCTCAAAATGTAATTACTAACAATATGCCTGCTTCATCATTAAAAT
CAACAAATCCATTGCAATTTGCAAATAAAGCAATCGAAGCAATGTTACAAGGTTACCACGCTTCATTCGCAATTGGACTC
GTCTTTGCCATTATTGGTATCGGAGTTGCTCTCTTCTTGAAGAGTGGTCGAATGATTTCTGGTGTCCCTGTTGAAGAACA
AGACTTGAAAGGAGAAAATAAATAA

Upstream 100 bases:

>100_bases
GGTGAAGAACGAACAGAAAGTTTCATTGAAAATTTCAAATTATTTTTAGAAATTGGAATGAAGCTAGCTAAAGAAGACAA
AGAAAAAGAGGAGGAAAAAA

Downstream 100 bases:

>100_bases
TGCTAATTATATTATTATTGGTAGTGTTTATGATTGGAACTTTCTTTGGTTTCATGTTTATAAAAAACACAATCGCTCAT
TGGTTAGTTGGTGGAATTTC

Product: multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MPDTYEKDYHLDIHGKHYSRIGMLILILVGTFGAMLMQTSLGTAIPTLMNDFNISMSTAQQATTWFLLANGIMVPISAYL
ATKFPTRWLYVTAYATLFIGMFVAYSAPTSSWWVFLAGRILQAIAVGITMPLMQVALVNMFPAKQMGAIMGVAGVVLVLA
PALGPTFAGWLITHKFNLIFWTFAASWRTIFLIPMIVVGVVFLISIFAMRDVIPNRPMKLDFLSVLLSVVGFGAFLWGFT
NVATDGWGKFNTVIAPIVGGLIIIFLFGLRQLKMDDPFLDIRVFKIRQFTLVTLALALSTMAMMGVEMMLPLYLQDVHGL
SAFNSGLVLLPGSLMMAVVAPLAGGVYDRIGSKRLAVIGFLVLALGTIPFMFFTATTPDHFDTLLYGLRMVGVGMVMMPL
TTSAMNAVPVNEVAQATASNNTARQVASSVVVALLSSVAQNVITNNMPASSLKSTNPLQFANKAIEAMLQGYHASFAIGL
VFAIIGIGVALFLKSGRMISGVPVEEQDLKGENK

Sequences:

>Translated_514_residues
MPDTYEKDYHLDIHGKHYSRIGMLILILVGTFGAMLMQTSLGTAIPTLMNDFNISMSTAQQATTWFLLANGIMVPISAYL
ATKFPTRWLYVTAYATLFIGMFVAYSAPTSSWWVFLAGRILQAIAVGITMPLMQVALVNMFPAKQMGAIMGVAGVVLVLA
PALGPTFAGWLITHKFNLIFWTFAASWRTIFLIPMIVVGVVFLISIFAMRDVIPNRPMKLDFLSVLLSVVGFGAFLWGFT
NVATDGWGKFNTVIAPIVGGLIIIFLFGLRQLKMDDPFLDIRVFKIRQFTLVTLALALSTMAMMGVEMMLPLYLQDVHGL
SAFNSGLVLLPGSLMMAVVAPLAGGVYDRIGSKRLAVIGFLVLALGTIPFMFFTATTPDHFDTLLYGLRMVGVGMVMMPL
TTSAMNAVPVNEVAQATASNNTARQVASSVVVALLSSVAQNVITNNMPASSLKSTNPLQFANKAIEAMLQGYHASFAIGL
VFAIIGIGVALFLKSGRMISGVPVEEQDLKGENK
>Mature_513_residues
PDTYEKDYHLDIHGKHYSRIGMLILILVGTFGAMLMQTSLGTAIPTLMNDFNISMSTAQQATTWFLLANGIMVPISAYLA
TKFPTRWLYVTAYATLFIGMFVAYSAPTSSWWVFLAGRILQAIAVGITMPLMQVALVNMFPAKQMGAIMGVAGVVLVLAP
ALGPTFAGWLITHKFNLIFWTFAASWRTIFLIPMIVVGVVFLISIFAMRDVIPNRPMKLDFLSVLLSVVGFGAFLWGFTN
VATDGWGKFNTVIAPIVGGLIIIFLFGLRQLKMDDPFLDIRVFKIRQFTLVTLALALSTMAMMGVEMMLPLYLQDVHGLS
AFNSGLVLLPGSLMMAVVAPLAGGVYDRIGSKRLAVIGFLVLALGTIPFMFFTATTPDHFDTLLYGLRMVGVGMVMMPLT
TSAMNAVPVNEVAQATASNNTARQVASSVVVALLSSVAQNVITNNMPASSLKSTNPLQFANKAIEAMLQGYHASFAIGLV
FAIIGIGVALFLKSGRMISGVPVEEQDLKGENK

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=458, Percent_Identity=24.6724890829694, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1788710, Length=415, Percent_Identity=24.0963855421687, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI87081983, Length=431, Percent_Identity=25.2900232018561, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1790195, Length=324, Percent_Identity=24.6913580246914, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 55675; Mature: 55544

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHCCCEECCCCCCHHCCCCCCC
>Mature Secondary Structure 
PDTYEKDYHLDIHGKHYSRIGMLILILVGTFGAMLMQTSLGTAIPTLMNDFNISMSTAQ
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH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HHHHHHHHHHHHHHCCCEECCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]