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The map label for this gene is llrD

Identifier: 15672873

GI number: 15672873

Start: 912508

End: 913137

Strand: Direct

Name: llrD

Synonym: L0127

Alternate gene names: 15672873

Gene position: 912508-913137 (Clockwise)

Preceding gene: 15672872

Following gene: 15672874

Centisome position: 38.57

GC content: 34.44

Gene sequence:

>630_bases
ATGGAAAAAATTAAACTTTTAATTGTTGATGACCACCAGATGGTGCGACTAGGTTTATCAAGTTTCATGAATATTCAACC
CGATATCGAAGTGGTTGGTGAAGCTGCCGATGGCGAGTCAGGATTTTTAAAAACTGAAATGCTTGACCCTGATGTTATTC
TCATGGATTTAGTGATGGATCGACTTGATGGAATTGGAGCAACTCAAAAGATTTTAGCCAAAAATCCAGAACGAAAAATT
TTAATTCTAACGAGTTTTATTGATGACGAAAAAGTTTTTCCGGCTTTAGCTGCTGGAGCTAAAGGTTATATTCTTAAAAC
ATCACAAGCCGCTGATATTGCATCTGCAATCAGAAAAGTTGCCAATGGAGAAGATGTCCTTTCCGATGCTGTCAAGGAAA
AGATTGCTCAACAAAAACATCGAAAACATGAATTATATGATGATTTATCAAAAAGAGAATTAGAAGTATTAAAAGTACTT
GCGACGGGACTTTCTAATCAAGAAATTGCTGATGAACTTTTTATCAGTTTAAAAACAGTCAAAACTCATGTTTCTAATAT
TTTTAATAAGCTTGAAGTGTCAGACCGAACTCAAGCAACAATTTATGCCATTCAACATCACTTAGTTTAA

Upstream 100 bases:

>100_bases
CAAAGTAATCTCGGCACCAGGTGCGGGGACAACTGTTGAAATCATTATCCCTAAAGCGAAGCCGAGCCTTTAAAAATGAT
GCGTATTTAGAAAGAACAAA

Downstream 100 bases:

>100_bases
ACCTGAGGAAAAACAAGTTAGAAATATGATATAATTAAGTTTGTACAAATAAAATTAAAGTGAAAAAAAGATGGAAAAAA
TATTAGAAAAAGCCCCAAAA

Product: two-component system regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MEKIKLLIVDDHQMVRLGLSSFMNIQPDIEVVGEAADGESGFLKTEMLDPDVILMDLVMDRLDGIGATQKILAKNPERKI
LILTSFIDDEKVFPALAAGAKGYILKTSQAADIASAIRKVANGEDVLSDAVKEKIAQQKHRKHELYDDLSKRELEVLKVL
ATGLSNQEIADELFISLKTVKTHVSNIFNKLEVSDRTQATIYAIQHHLV

Sequences:

>Translated_209_residues
MEKIKLLIVDDHQMVRLGLSSFMNIQPDIEVVGEAADGESGFLKTEMLDPDVILMDLVMDRLDGIGATQKILAKNPERKI
LILTSFIDDEKVFPALAAGAKGYILKTSQAADIASAIRKVANGEDVLSDAVKEKIAQQKHRKHELYDDLSKRELEVLKVL
ATGLSNQEIADELFISLKTVKTHVSNIFNKLEVSDRTQATIYAIQHHLV
>Mature_209_residues
MEKIKLLIVDDHQMVRLGLSSFMNIQPDIEVVGEAADGESGFLKTEMLDPDVILMDLVMDRLDGIGATQKILAKNPERKI
LILTSFIDDEKVFPALAAGAKGYILKTSQAADIASAIRKVANGEDVLSDAVKEKIAQQKHRKHELYDDLSKRELEVLKVL
ATGLSNQEIADELFISLKTVKTHVSNIFNKLEVSDRTQATIYAIQHHLV

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=206, Percent_Identity=37.8640776699029, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1788222, Length=211, Percent_Identity=32.7014218009479, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1787473, Length=211, Percent_Identity=35.5450236966825, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1790102, Length=193, Percent_Identity=31.6062176165803, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1786747, Length=212, Percent_Identity=28.3018867924528, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1788712, Length=188, Percent_Identity=30.3191489361702, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI87082052, Length=119, Percent_Identity=33.6134453781513, Blast_Score=61, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23205; Mature: 23205

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIKLLIVDDHQMVRLGLSSFMNIQPDIEVVGEAADGESGFLKTEMLDPDVILMDLVMD
CCCEEEEEECCHHHHHHHHHHHCCCCCCHHEEECCCCCCCCCEEEECCCCHHHHHHHHHH
RLDGIGATQKILAKNPERKILILTSFIDDEKVFPALAAGAKGYILKTSQAADIASAIRKV
HHCCCCHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHH
ANGEDVLSDAVKEKIAQQKHRKHELYDDLSKRELEVLKVLATGLSNQEIADELFISLKTV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
KTHVSNIFNKLEVSDRTQATIYAIQHHLV
HHHHHHHHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MEKIKLLIVDDHQMVRLGLSSFMNIQPDIEVVGEAADGESGFLKTEMLDPDVILMDLVMD
CCCEEEEEECCHHHHHHHHHHHCCCCCCHHEEECCCCCCCCCEEEECCCCHHHHHHHHHH
RLDGIGATQKILAKNPERKILILTSFIDDEKVFPALAAGAKGYILKTSQAADIASAIRKV
HHCCCCHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHH
ANGEDVLSDAVKEKIAQQKHRKHELYDDLSKRELEVLKVLATGLSNQEIADELFISLKTV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
KTHVSNIFNKLEVSDRTQATIYAIQHHLV
HHHHHHHHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]