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The map label for this gene is folD

Identifier: 15672835

GI number: 15672835

Start: 876830

End: 877714

Strand: Direct

Name: folD

Synonym: L76582

Alternate gene names: 15672835

Gene position: 876830-877714 (Clockwise)

Preceding gene: 15672834

Following gene: 15672836

Centisome position: 37.07

GC content: 39.55

Gene sequence:

>885_bases
ATGAATGTTAGCTTATGGTATAATAGTTCTATGAACTTGATAGATGGAAAAGCACTTGCTGCTAAAATGCAAGCTGAGTT
GAAAGTTAAAGTCGATAAATTAAAAGAAGCGGACAATGTTCCAGGTCTTGCCGTTATTCTTGTGGGCGAAGATCCTGCGA
GTCAAATTTATGTCCGAAATAAAGCACGACAAGCCACAGCAATTGGTTTAAATTCTAGTGTGGTTCGTCTACCAGAAACT
GTGTCGGAACAAGAACTGTTAGATTTAATTGAACAGTATAATCAGTCAGAACAATGGCATGGTATTTTGGTACAATTGCC
ATTGCCAGAACATATTTCTGAAGAAAAGGTTTTACTAGCTATTGATCCAGAAAAAGATGTGGATGGTTTTCACCCAATGA
ATATGGGACGTTTGTGGTCTGGAAATCCTTTGATGATTCCTTCAACTCCAGCCGGTATTATGGAAATGTTCCGAGAATAT
GATGTGGAACTTTCTGGTAAACGTGCAGTTGTGATTGGTCGTTCAAATATCGTCGGAAAACCAATGGCGCAATTATTAAT
GATGGCTGATGCTACTGTGACGATTGCTCATTCGAAAACAGAAAACTTGCGCGAATTGACTAAGGAAGCTGATGTTTTGG
TGGTTGCTATTGGCCGTGACCGGATGATTAAAGCTGAGGATGTCAAAGAAGGTGCAGTTGTAATTGATGTTGGGATGAAC
CGTGATGAAGATGGAAAACTTCATGGCGATGTTGATTTTGATGAAGTAAAAGATGTTGCAAGTTTGATTACCCCCGTTCC
TGGTGGAGTTGGTCCGATGACGATTACAATGCTTATGGAACAGACAGTTCGTGCAGCAAGTAGAAAAATGAATGAAAATA
AATAG

Upstream 100 bases:

>100_bases
CTTTGGAAAGAAGTTTCTTTTTAATTTGGAATTATTCCTTTATTAAAAATTACGAACAATTTAAAATAAAGAAAGAAAAA
GGAATGATGATGATTAGAGG

Downstream 100 bases:

>100_bases
TTAATTAATAAAAGAGTAACTAAGTTTATAGTAATTTCTAAGGACTTATTTTTAAGTTAGAAGTTTTTTGAAGATAAACT
TTTTACTTTTTTTCGATTTT

Product: bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MNVSLWYNSSMNLIDGKALAAKMQAELKVKVDKLKEADNVPGLAVILVGEDPASQIYVRNKARQATAIGLNSSVVRLPET
VSEQELLDLIEQYNQSEQWHGILVQLPLPEHISEEKVLLAIDPEKDVDGFHPMNMGRLWSGNPLMIPSTPAGIMEMFREY
DVELSGKRAVVIGRSNIVGKPMAQLLMMADATVTIAHSKTENLRELTKEADVLVVAIGRDRMIKAEDVKEGAVVIDVGMN
RDEDGKLHGDVDFDEVKDVASLITPVPGGVGPMTITMLMEQTVRAASRKMNENK

Sequences:

>Translated_294_residues
MNVSLWYNSSMNLIDGKALAAKMQAELKVKVDKLKEADNVPGLAVILVGEDPASQIYVRNKARQATAIGLNSSVVRLPET
VSEQELLDLIEQYNQSEQWHGILVQLPLPEHISEEKVLLAIDPEKDVDGFHPMNMGRLWSGNPLMIPSTPAGIMEMFREY
DVELSGKRAVVIGRSNIVGKPMAQLLMMADATVTIAHSKTENLRELTKEADVLVVAIGRDRMIKAEDVKEGAVVIDVGMN
RDEDGKLHGDVDFDEVKDVASLITPVPGGVGPMTITMLMEQTVRAASRKMNENK
>Mature_294_residues
MNVSLWYNSSMNLIDGKALAAKMQAELKVKVDKLKEADNVPGLAVILVGEDPASQIYVRNKARQATAIGLNSSVVRLPET
VSEQELLDLIEQYNQSEQWHGILVQLPLPEHISEEKVLLAIDPEKDVDGFHPMNMGRLWSGNPLMIPSTPAGIMEMFREY
DVELSGKRAVVIGRSNIVGKPMAQLLMMADATVTIAHSKTENLRELTKEADVLVVAIGRDRMIKAEDVKEGAVVIDVGMN
RDEDGKLHGDVDFDEVKDVASLITPVPGGVGPMTITMLMEQTVRAASRKMNENK

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate [H]

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=296, Percent_Identity=45.2702702702703, Blast_Score=240, Evalue=9e-64,
Organism=Homo sapiens, GI222418558, Length=292, Percent_Identity=45.8904109589041, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI94721354, Length=292, Percent_Identity=45.8904109589041, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI36796743, Length=199, Percent_Identity=29.1457286432161, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1786741, Length=278, Percent_Identity=49.2805755395683, Blast_Score=268, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI17568735, Length=257, Percent_Identity=42.4124513618677, Blast_Score=200, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6319558, Length=298, Percent_Identity=43.6241610738255, Blast_Score=243, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6321643, Length=301, Percent_Identity=42.5249169435216, Blast_Score=233, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6322933, Length=313, Percent_Identity=24.2811501597444, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24645718, Length=291, Percent_Identity=47.766323024055, Blast_Score=254, Evalue=5e-68,
Organism=Drosophila melanogaster, GI17137370, Length=291, Percent_Identity=47.766323024055, Blast_Score=254, Evalue=5e-68,
Organism=Drosophila melanogaster, GI62472483, Length=291, Percent_Identity=47.766323024055, Blast_Score=254, Evalue=6e-68,
Organism=Drosophila melanogaster, GI45551871, Length=291, Percent_Identity=47.766323024055, Blast_Score=254, Evalue=6e-68,
Organism=Drosophila melanogaster, GI17136816, Length=307, Percent_Identity=43.9739413680782, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI17136818, Length=299, Percent_Identity=44.4816053511706, Blast_Score=237, Evalue=8e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631 [H]

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C [H]

EC number: =1.5.1.5; =3.5.4.9 [H]

Molecular weight: Translated: 32323; Mature: 32323

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00766 THF_DHG_CYH_1 ; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVSLWYNSSMNLIDGKALAAKMQAELKVKVDKLKEADNVPGLAVILVGEDPASQIYVRN
CEEEEEECCCCCEECCHHHHHHHHHHHEEEHHHHHHHCCCCCEEEEEECCCCCCEEEEEC
KARQATAIGLNSSVVRLPETVSEQELLDLIEQYNQSEQWHGILVQLPLPEHISEEKVLLA
CCCCEEEECCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEE
IDPEKDVDGFHPMNMGRLWSGNPLMIPSTPAGIMEMFREYDVELSGKRAVVIGRSNIVGK
ECCCCCCCCCCCCCCCCEECCCEEEECCCCHHHHHHHHHCCCEECCCEEEEEECCCCCCC
PMAQLLMMADATVTIAHSKTENLRELTKEADVLVVAIGRDRMIKAEDVKEGAVVIDVGMN
HHHHHHHHHCCEEEEEECCHHHHHHHHHCCCEEEEEECCCCEEECCCCCCCEEEEEECCC
RDEDGKLHGDVDFDEVKDVASLITPVPGGVGPMTITMLMEQTVRAASRKMNENK
CCCCCCEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNVSLWYNSSMNLIDGKALAAKMQAELKVKVDKLKEADNVPGLAVILVGEDPASQIYVRN
CEEEEEECCCCCEECCHHHHHHHHHHHEEEHHHHHHHCCCCCEEEEEECCCCCCEEEEEC
KARQATAIGLNSSVVRLPETVSEQELLDLIEQYNQSEQWHGILVQLPLPEHISEEKVLLA
CCCCEEEECCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEE
IDPEKDVDGFHPMNMGRLWSGNPLMIPSTPAGIMEMFREYDVELSGKRAVVIGRSNIVGK
ECCCCCCCCCCCCCCCCEECCCEEEECCCCHHHHHHHHHCCCEECCCEEEEEECCCCCCC
PMAQLLMMADATVTIAHSKTENLRELTKEADVLVVAIGRDRMIKAEDVKEGAVVIDVGMN
HHHHHHHHHCCEEEEEECCHHHHHHHHHCCCEEEEEECCCCEEECCCCCCCEEEEEECCC
RDEDGKLHGDVDFDEVKDVASLITPVPGGVGPMTITMLMEQTVRAASRKMNENK
CCCCCCEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA