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The map label for this gene is mutY

Identifier: 15672823

GI number: 15672823

Start: 858637

End: 859800

Strand: Direct

Name: mutY

Synonym: L0296

Alternate gene names: 15672823

Gene position: 858637-859800 (Clockwise)

Preceding gene: 15672822

Following gene: 15672824

Centisome position: 36.3

GC content: 35.31

Gene sequence:

>1164_bases
ATGGACTGGTCTAAGAATCAAATAAAGGAATTTCAGCAAGATTTACTTTCTTGGTATGATGATAATAAAAAGCCACTCCC
TTGGCGAAAAACAACTGAACCTTACAAAATATGGATTTCAGAAATCATGTCCCAACAAACACAGGTTGAAACTGTCATGC
CATATTATGAACGTTTCATGAAAAAATATCCGACGATTGAAACTTTAGCTCAAGCTGATGATGCTGAACTTCTAAAACTT
TGGGAAGGCTTGGGCTATTATTCTCGCGCTCGTAATCTAAAAATCGCAGCGCAAGAAGTTGTTGATAAATATAATGGAAA
ATTTCCTGACAATCTAGCCGATATATTATCATTAAAAGGAATTGGACCTTATACAGCCGCTGCAATTGCCTCAATTTCTT
TTGGACTCGCTGAGCCAGCAATTGATGGAAATCTAATGCGCGTGACCAGCAGGCTGTTTGAATTAGATTGTGATATTTCT
AAAAGCAGTTCAAGGAAAATTTTTGATGGCTACCTAAGAAAGCTCATCAGTAAAAAAAGACCAGGTGATTTCAATCAGGC
GCTGATGGATTTAGGTTCTTTAGTTTGTAGTCCAAAGAGTCCGAAATGTGAAGCTTGTCCCTTACTAAACTATTGTGCAG
CAGCAGCGTCAGGAAAACAATTAAATTATCCAGTAAAAACAAAAAAGATAAAACAAAAAGATTTGTATTTTACAGCCTTT
GCCTTAGAAAATTCATTAGGAGAATATTATTTAGAAAAGCGTCCATCGAAAGGCTTGTTAGCAGACATGTGGACATTTCC
ACTGACAGAATTACCAGCAGCAGATTTTGAAAAAATGATTACTGACGGCTCTGTCAGTAAAAATATTGTCATTCCAGAAC
TTCCGGAAAGTATTTCAAAAATGGAATATATAGCTAATTTTACTCACATTTTTTCTCATCAAAAATGGAATTTGGCAATC
ATTAAATTAAAACCAGAAGAGACCTTTGAAGTTGCTGACGAATTATTATCAGAAGACAAAATGTGGGTTCATTTTGATTC
AAAAGTACTGACAGAAAATGGCCAACCAAAAGTAAGTCGTTCACAAATTCCACTTGCTGGGCCACAAGTGAAGATGTTTG
AGATTTTAGATAAGAAGAATAAGAAAATTGATCTGCTAAAATAG

Upstream 100 bases:

>100_bases
TACTGACAGAAATTCTGTCAGTAAAATAAACTAGTTATTGCAAATCTGTCAGTAAATATTTACTGACAAACTAGGAATTA
AGAAAGTAATTGGAGAATCG

Downstream 100 bases:

>100_bases
TGGAGTAACCATCGAAACCAAATTTTTGGTATAATAGATAAATATACTACTTCAAGGAGAAGATTATGACAACTATTGAT
TTTAAAGCCGAAGTTGAAAA

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MDWSKNQIKEFQQDLLSWYDDNKKPLPWRKTTEPYKIWISEIMSQQTQVETVMPYYERFMKKYPTIETLAQADDAELLKL
WEGLGYYSRARNLKIAAQEVVDKYNGKFPDNLADILSLKGIGPYTAAAIASISFGLAEPAIDGNLMRVTSRLFELDCDIS
KSSSRKIFDGYLRKLISKKRPGDFNQALMDLGSLVCSPKSPKCEACPLLNYCAAAASGKQLNYPVKTKKIKQKDLYFTAF
ALENSLGEYYLEKRPSKGLLADMWTFPLTELPAADFEKMITDGSVSKNIVIPELPESISKMEYIANFTHIFSHQKWNLAI
IKLKPEETFEVADELLSEDKMWVHFDSKVLTENGQPKVSRSQIPLAGPQVKMFEILDKKNKKIDLLK

Sequences:

>Translated_387_residues
MDWSKNQIKEFQQDLLSWYDDNKKPLPWRKTTEPYKIWISEIMSQQTQVETVMPYYERFMKKYPTIETLAQADDAELLKL
WEGLGYYSRARNLKIAAQEVVDKYNGKFPDNLADILSLKGIGPYTAAAIASISFGLAEPAIDGNLMRVTSRLFELDCDIS
KSSSRKIFDGYLRKLISKKRPGDFNQALMDLGSLVCSPKSPKCEACPLLNYCAAAASGKQLNYPVKTKKIKQKDLYFTAF
ALENSLGEYYLEKRPSKGLLADMWTFPLTELPAADFEKMITDGSVSKNIVIPELPESISKMEYIANFTHIFSHQKWNLAI
IKLKPEETFEVADELLSEDKMWVHFDSKVLTENGQPKVSRSQIPLAGPQVKMFEILDKKNKKIDLLK
>Mature_387_residues
MDWSKNQIKEFQQDLLSWYDDNKKPLPWRKTTEPYKIWISEIMSQQTQVETVMPYYERFMKKYPTIETLAQADDAELLKL
WEGLGYYSRARNLKIAAQEVVDKYNGKFPDNLADILSLKGIGPYTAAAIASISFGLAEPAIDGNLMRVTSRLFELDCDIS
KSSSRKIFDGYLRKLISKKRPGDFNQALMDLGSLVCSPKSPKCEACPLLNYCAAAASGKQLNYPVKTKKIKQKDLYFTAF
ALENSLGEYYLEKRPSKGLLADMWTFPLTELPAADFEKMITDGSVSKNIVIPELPESISKMEYIANFTHIFSHQKWNLAI
IKLKPEETFEVADELLSEDKMWVHFDSKVLTENGQPKVSRSQIPLAGPQVKMFEILDKKNKKIDLLK

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=399, Percent_Identity=33.0827067669173, Blast_Score=211, Evalue=9e-55,
Organism=Homo sapiens, GI190358497, Length=399, Percent_Identity=33.0827067669173, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI115298650, Length=399, Percent_Identity=33.0827067669173, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI6912520, Length=399, Percent_Identity=33.0827067669173, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI115298654, Length=399, Percent_Identity=33.0827067669173, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI115298652, Length=399, Percent_Identity=33.0827067669173, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI4505471, Length=184, Percent_Identity=25.5434782608696, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1789331, Length=314, Percent_Identity=39.4904458598726, Blast_Score=218, Evalue=7e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 44221; Mature: 44221

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDWSKNQIKEFQQDLLSWYDDNKKPLPWRKTTEPYKIWISEIMSQQTQVETVMPYYERFM
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKYPTIETLAQADDAELLKLWEGLGYYSRARNLKIAAQEVVDKYNGKFPDNLADILSLKG
HHCCCHHHHHCCCHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHCC
IGPYTAAAIASISFGLAEPAIDGNLMRVTSRLFELDCDISKSSSRKIFDGYLRKLISKKR
CCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCC
PGDFNQALMDLGSLVCSPKSPKCEACPLLNYCAAAASGKQLNYPVKTKKIKQKDLYFTAF
CCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEHH
ALENSLGEYYLEKRPSKGLLADMWTFPLTELPAADFEKMITDGSVSKNIVIPELPESISK
HHHHHHHHHHHHCCCCCCCHHHHHHCCCHHCCHHHHHHHHCCCCCCCCEECCCCHHHHHH
MEYIANFTHIFSHQKWNLAIIKLKPEETFEVADELLSEDKMWVHFDSKVLTENGQPKVSR
HHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCCCCEEEEECCEEECCCCCCCCCC
SQIPLAGPQVKMFEILDKKNKKIDLLK
CCCCCCCCCHHHHHHHCCCCCEECCCC
>Mature Secondary Structure
MDWSKNQIKEFQQDLLSWYDDNKKPLPWRKTTEPYKIWISEIMSQQTQVETVMPYYERFM
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKYPTIETLAQADDAELLKLWEGLGYYSRARNLKIAAQEVVDKYNGKFPDNLADILSLKG
HHCCCHHHHHCCCHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHCC
IGPYTAAAIASISFGLAEPAIDGNLMRVTSRLFELDCDISKSSSRKIFDGYLRKLISKKR
CCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCC
PGDFNQALMDLGSLVCSPKSPKCEACPLLNYCAAAASGKQLNYPVKTKKIKQKDLYFTAF
CCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEHH
ALENSLGEYYLEKRPSKGLLADMWTFPLTELPAADFEKMITDGSVSKNIVIPELPESISK
HHHHHHHHHHHHCCCCCCCHHHHHHCCCHHCCHHHHHHHHCCCCCCCCEECCCCHHHHHH
MEYIANFTHIFSHQKWNLAIIKLKPEETFEVADELLSEDKMWVHFDSKVLTENGQPKVSR
HHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCCCCEEEEECCEEECCCCCCCCCC
SQIPLAGPQVKMFEILDKKNKKIDLLK
CCCCCCCCCHHHHHHHCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]