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The map label for this gene is uvrC

Identifier: 15672822

GI number: 15672822

Start: 856467

End: 858473

Strand: Direct

Name: uvrC

Synonym: L0258

Alternate gene names: 15672822

Gene position: 856467-858473 (Clockwise)

Preceding gene: 15672821

Following gene: 15672823

Centisome position: 36.21

GC content: 34.78

Gene sequence:

>2007_bases
ATGAATCAAACGATAAAAGCAAAGTTAGAACTATTACCAGATAGTCCTGGCTGTTATTTACATAAAGATAAAAATGGGAC
AGTTATTTATGTCGGAAAGGCAAAGAATCTTAAAAATCGAGTGCGCTCTTATTTTCATGGTTCTCATAATACCAAGACAG
AATTACTAGTTTCTGAAATTGAAGATTTGGAATGGATTGTTGTAGGTTCAAATATTGAATCCTTAGTTTTGGAAATCAAT
CTCATTCAACGTTATAAGCCTAAATATAATATTATGCTTAAGGATGATAAATATTATCCTTTCCTAAAAATAACAAATGA
AAAATATCCTCGTTTGTTGGTCGTCCGTAAAGTTCAAAAAGATGGTGCGACTTATTTTGGACCTTATCCAGATGTCAAAG
CTGCCAATGAAGTTAAACGCCTTTTAGACCGAATTTTTCCATTTAGAAAATGTGGCTTACACGAGAAAAAAGTATGTTTC
TATTTTCATATTCATCAGTGCTTATGCCCAGTGGTTAATCATGTTGATCCTCAAGTTTTTAAGGATATGACTCAAGAAGT
GAAAGAGTTTTTGACAGGTTCGGATAAAAAAATTGTTAATGAACTCGAAGCGAAAATGATGGTTTCTTCTGATAATATGG
AATTTGAGCAAGCTGCTGAGTATCGGGATGTGATTAAGGCAATTGGAACTTTAAGAACAAAACAACGGGTCATGAATCAA
GATTTGAAAGACCGCGATGTTTTTGGATATTATGTTGATAAAGGATGGATGTGTGTCCAAGTATTTTTTGTGCGCCAAGG
AAAATTGATTCAGCGTGATGTGAATATGTTTCCTTACTACAATGATGCTGAAGAGGATTTTTTAACTTACATTGGACAAT
TTTATCAAGATAATAATCATATGATGCCAAGGGAAATTTTTATTCCGCAAGACATCGATAAGGAATCTGTGGAAGCAGTA
GTTGCAGCTAGCCAAGAGGGAAATTTATTAACTAAAGCTCAAGCTAAAGAAGTGGATGCAAAAGTTTTTACGGCCAAGAC
GCTTAAATTTTCTGATCAAAAAGATGTTGAGCAATCAATTGTTAAACTTGATAAAGAATTATCAGCCGAAAAACGTTTAT
CATCACTTTTAGCTAAAACACAGATTGTTCAACCAAGCCGTGGTGAGAAAAAACAATTGGTTAATATGGCAACTAAGAAT
GCTCAAAGTCAATTACAATTGAAATTTGATGTGGCTGAGCGTGATATTTTGAAAACGACTAAAGCGGTTGAAAACTTGGG
TAAAATTTTGGGAATACCAAAACCTGTAAGAATTGAATCTTTTGATAATTCAAATATTATGGGGACTTCACCAGTATCTG
CAATGGTTGTTTTTATTGATGGAAAACCTTCAAAAAAAGATTATCGGAAATATAAAATTAAAACAGTGGTTGGTGCGGAT
GACTATGCTTCAATGCGCGAGGTGATGACGAGACGTTATTCGCGAGCTTTAAAAGAAGAAACGGCTCTTCCTGATTTGAT
TGCAATGGATGGTGGAGCTGGTCAAGTTAACATTACCAAGCAAGTTTTAAAAGAGCTTGGGCTATCGATTCCGGTTGCTG
GGATGCAAAAAAATGATAAGCACCAAACGTCAGAATTACTTTTTGGTGATCCTTTAGACGTGGTTCCCTTGTCAAGACAA
TCTCAAGAATTCTTTTTGCTGACCAGAATTCAAGATGAGGTTCACCGTTTTGCGATTACATTCCATAGACAACTACGTGG
TAAAAATACATTTTCAAGTAAATTGGACGGTATTGTTGGACTTGGTCCAAAACGAAAACAAAAGTTACTGACAACTTTCA
AAAATTTGAAAGCAATTGAAGAGGCAAGTGTACAAGAAGTGGCAGAAGCTGACATTCCTTATGAAGTAGCAGAACGTGTG
AAAACAACTTTGTCTGGACCAATTCAAGAAAATGAAAATTGGGAATCACTCAAGGATAATGTTCCTCTTTTAGAAGGTAA
AAAATAA

Upstream 100 bases:

>100_bases
AAATAACAAGTGAAAATGACTCAAGTAAATGGGTCATTTTTTGTTTTATAAACGTCCAAAAGAAGAGCAGCTCCTACATT
TTTTTGCTATAATAAACAAT

Downstream 100 bases:

>100_bases
AGTAATCAAAAGAATTGTCAGTAAATCTGTCAGTTCTTTTGATTCTTGAAAAAATATAAAAATTACTGACAGAAATTCTG
TCAGTAAAATAAACTAGTTA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MNQTIKAKLELLPDSPGCYLHKDKNGTVIYVGKAKNLKNRVRSYFHGSHNTKTELLVSEIEDLEWIVVGSNIESLVLEIN
LIQRYKPKYNIMLKDDKYYPFLKITNEKYPRLLVVRKVQKDGATYFGPYPDVKAANEVKRLLDRIFPFRKCGLHEKKVCF
YFHIHQCLCPVVNHVDPQVFKDMTQEVKEFLTGSDKKIVNELEAKMMVSSDNMEFEQAAEYRDVIKAIGTLRTKQRVMNQ
DLKDRDVFGYYVDKGWMCVQVFFVRQGKLIQRDVNMFPYYNDAEEDFLTYIGQFYQDNNHMMPREIFIPQDIDKESVEAV
VAASQEGNLLTKAQAKEVDAKVFTAKTLKFSDQKDVEQSIVKLDKELSAEKRLSSLLAKTQIVQPSRGEKKQLVNMATKN
AQSQLQLKFDVAERDILKTTKAVENLGKILGIPKPVRIESFDNSNIMGTSPVSAMVVFIDGKPSKKDYRKYKIKTVVGAD
DYASMREVMTRRYSRALKEETALPDLIAMDGGAGQVNITKQVLKELGLSIPVAGMQKNDKHQTSELLFGDPLDVVPLSRQ
SQEFFLLTRIQDEVHRFAITFHRQLRGKNTFSSKLDGIVGLGPKRKQKLLTTFKNLKAIEEASVQEVAEADIPYEVAERV
KTTLSGPIQENENWESLKDNVPLLEGKK

Sequences:

>Translated_668_residues
MNQTIKAKLELLPDSPGCYLHKDKNGTVIYVGKAKNLKNRVRSYFHGSHNTKTELLVSEIEDLEWIVVGSNIESLVLEIN
LIQRYKPKYNIMLKDDKYYPFLKITNEKYPRLLVVRKVQKDGATYFGPYPDVKAANEVKRLLDRIFPFRKCGLHEKKVCF
YFHIHQCLCPVVNHVDPQVFKDMTQEVKEFLTGSDKKIVNELEAKMMVSSDNMEFEQAAEYRDVIKAIGTLRTKQRVMNQ
DLKDRDVFGYYVDKGWMCVQVFFVRQGKLIQRDVNMFPYYNDAEEDFLTYIGQFYQDNNHMMPREIFIPQDIDKESVEAV
VAASQEGNLLTKAQAKEVDAKVFTAKTLKFSDQKDVEQSIVKLDKELSAEKRLSSLLAKTQIVQPSRGEKKQLVNMATKN
AQSQLQLKFDVAERDILKTTKAVENLGKILGIPKPVRIESFDNSNIMGTSPVSAMVVFIDGKPSKKDYRKYKIKTVVGAD
DYASMREVMTRRYSRALKEETALPDLIAMDGGAGQVNITKQVLKELGLSIPVAGMQKNDKHQTSELLFGDPLDVVPLSRQ
SQEFFLLTRIQDEVHRFAITFHRQLRGKNTFSSKLDGIVGLGPKRKQKLLTTFKNLKAIEEASVQEVAEADIPYEVAERV
KTTLSGPIQENENWESLKDNVPLLEGKK
>Mature_668_residues
MNQTIKAKLELLPDSPGCYLHKDKNGTVIYVGKAKNLKNRVRSYFHGSHNTKTELLVSEIEDLEWIVVGSNIESLVLEIN
LIQRYKPKYNIMLKDDKYYPFLKITNEKYPRLLVVRKVQKDGATYFGPYPDVKAANEVKRLLDRIFPFRKCGLHEKKVCF
YFHIHQCLCPVVNHVDPQVFKDMTQEVKEFLTGSDKKIVNELEAKMMVSSDNMEFEQAAEYRDVIKAIGTLRTKQRVMNQ
DLKDRDVFGYYVDKGWMCVQVFFVRQGKLIQRDVNMFPYYNDAEEDFLTYIGQFYQDNNHMMPREIFIPQDIDKESVEAV
VAASQEGNLLTKAQAKEVDAKVFTAKTLKFSDQKDVEQSIVKLDKELSAEKRLSSLLAKTQIVQPSRGEKKQLVNMATKN
AQSQLQLKFDVAERDILKTTKAVENLGKILGIPKPVRIESFDNSNIMGTSPVSAMVVFIDGKPSKKDYRKYKIKTVVGAD
DYASMREVMTRRYSRALKEETALPDLIAMDGGAGQVNITKQVLKELGLSIPVAGMQKNDKHQTSELLFGDPLDVVPLSRQ
SQEFFLLTRIQDEVHRFAITFHRQLRGKNTFSSKLDGIVGLGPKRKQKLLTTFKNLKAIEEASVQEVAEADIPYEVAERV
KTTLSGPIQENENWESLKDNVPLLEGKK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=660, Percent_Identity=32.4242424242424, Blast_Score=321, Evalue=8e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 76426; Mature: 76426

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQTIKAKLELLPDSPGCYLHKDKNGTVIYVGKAKNLKNRVRSYFHGSHNTKTELLVSEI
CCCCEEEHEEECCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHH
EDLEWIVVGSNIESLVLEINLIQRYKPKYNIMLKDDKYYPFLKITNEKYPRLLVVRKVQK
CCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCCEEEEEEHHHH
DGATYFGPYPDVKAANEVKRLLDRIFPFRKCGLHEKKVCFYFHIHQCLCPVVNHVDPQVF
CCCEECCCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCEEEEEEHHHHHHHHHHCCCHHHH
KDMTQEVKEFLTGSDKKIVNELEAKMMVSSDNMEFEQAAEYRDVIKAIGTLRTKQRVMNQ
HHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
DLKDRDVFGYYVDKGWMCVQVFFVRQGKLIQRDVNMFPYYNDAEEDFLTYIGQFYQDNNH
CCCCCCEEEEEECCCEEEEEEEHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCC
MMPREIFIPQDIDKESVEAVVAASQEGNLLTKAQAKEVDAKVFTAKTLKFSDQKDVEQSI
CCCCEEECCCCCCHHHHHHHHEECCCCCEEEHHHHHHCCHHEEEEEEECCCCHHHHHHHH
VKLDKELSAEKRLSSLLAKTQIVQPSRGEKKQLVNMATKNAQSQLQLKFDVAERDILKTT
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHH
KAVENLGKILGIPKPVRIESFDNSNIMGTSPVSAMVVFIDGKPSKKDYRKYKIKTVVGAD
HHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCCCHHHEEEEEEEECCC
DYASMREVMTRRYSRALKEETALPDLIAMDGGAGQVNITKQVLKELGLSIPVAGMQKNDK
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEHHHHHHHHCCCCCCCCCCCCCCC
HQTSELLFGDPLDVVPLSRQSQEFFLLTRIQDEVHRFAITFHRQLRGKNTFSSKLDGIVG
HHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCEEC
LGPKRKQKLLTTFKNLKAIEEASVQEVAEADIPYEVAERVKTTLSGPIQENENWESLKDN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCC
VPLLEGKK
CCCCCCCC
>Mature Secondary Structure
MNQTIKAKLELLPDSPGCYLHKDKNGTVIYVGKAKNLKNRVRSYFHGSHNTKTELLVSEI
CCCCEEEHEEECCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHH
EDLEWIVVGSNIESLVLEINLIQRYKPKYNIMLKDDKYYPFLKITNEKYPRLLVVRKVQK
CCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCCEEEEEEHHHH
DGATYFGPYPDVKAANEVKRLLDRIFPFRKCGLHEKKVCFYFHIHQCLCPVVNHVDPQVF
CCCEECCCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCEEEEEEHHHHHHHHHHCCCHHHH
KDMTQEVKEFLTGSDKKIVNELEAKMMVSSDNMEFEQAAEYRDVIKAIGTLRTKQRVMNQ
HHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
DLKDRDVFGYYVDKGWMCVQVFFVRQGKLIQRDVNMFPYYNDAEEDFLTYIGQFYQDNNH
CCCCCCEEEEEECCCEEEEEEEHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCC
MMPREIFIPQDIDKESVEAVVAASQEGNLLTKAQAKEVDAKVFTAKTLKFSDQKDVEQSI
CCCCEEECCCCCCHHHHHHHHEECCCCCEEEHHHHHHCCHHEEEEEEECCCCHHHHHHHH
VKLDKELSAEKRLSSLLAKTQIVQPSRGEKKQLVNMATKNAQSQLQLKFDVAERDILKTT
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHH
KAVENLGKILGIPKPVRIESFDNSNIMGTSPVSAMVVFIDGKPSKKDYRKYKIKTVVGAD
HHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCCCHHHEEEEEEEECCC
DYASMREVMTRRYSRALKEETALPDLIAMDGGAGQVNITKQVLKELGLSIPVAGMQKNDK
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEHHHHHHHHCCCCCCCCCCCCCCC
HQTSELLFGDPLDVVPLSRQSQEFFLLTRIQDEVHRFAITFHRQLRGKNTFSSKLDGIVG
HHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCEEC
LGPKRKQKLLTTFKNLKAIEEASVQEVAEADIPYEVAERVKTTLSGPIQENENWESLKDN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCC
VPLLEGKK
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA