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The map label for this gene is pepP

Identifier: 15672673

GI number: 15672673

Start: 690433

End: 691491

Strand: Direct

Name: pepP

Synonym: L90422

Alternate gene names: 15672673

Gene position: 690433-691491 (Clockwise)

Preceding gene: 15672672

Following gene: 15672674

Centisome position: 29.19

GC content: 36.73

Gene sequence:

>1059_bases
ATGAGAATTGAAAAATTAAAAGCAAAAATGCTGACAGAAAATATTGATAGTTTATTGATTACTGATATGAAGAATATCTT
TTATCTGACAGGATTTTCTGGAACCGCGGGCACAGTTTTTTTGACAGCGAAGCGAAATATTTTTATGACAGACAGCCGTT
ATAGTGAAATGGCGCGTGGATTGATTAGTGATTTTGAAATTATCGAAACAAGAGATCCAATAAGTTTACTGACAGACCTG
TCAGCAAGTGAATCAATTAAAAATATAGCTTTTGAAGAAACAGTTGACTATGCTTTCTTTAAAAGACTCTCTGACGCCAC
TCCAGGATTAGAACTTTTAGCCACAAGTAATTTTGTTTTGGAATTGCGCCAATTTAAAGATGACACAGAGATTGATTTGA
TAAAAAAAGCCTGTGCAATTGCTGATGAAGCATTTATGTCAGCTTTAAAATTCATTGAGCCGGGCCGAACTGAAATTGAA
GTTGCTAATTTTCTTGATTTCAAAATGCGTGATTTAGAGGCGAGCGGAATTTCTTTTGAAACCATTGTTGCCTCAGGCAA
GAGAAGTAGCTTGCCTCATGGCGTTGCGACCAGTAAAATGATTCAATTTGGCGACCCAGTGACCATTGATTTTGGTTGTT
ATTATGAACATTATGCTAGCGATATGACCAGAACAATTTTCGTGGGTTCTGTAGACGACAAGATGCGAACAATTTATGAA
ACCGTGCGTAAGGCTAATGAAGCACTTATCAAAGAAGTCAAAGCGGGAATGACTTATGCTGAATATGATAAGGTTCCGCG
TACCGTCATTGAAGAAGCCAATTTTGGTCAGTATTTTACGCATGGAATTGGACATGGACTTGGTTTAGATGTTCATGAAA
TTCCTTATTTTAATCAATCAATGACAGAAAATCACTTGGAAGCTGGGATGGTTATTACAGATGAGCCAGGAATTTATATT
CCTGAATTTGGTGGAGTCAGAATTGAAGATGACTTATTAGTGACAGAAAATGGCTGTGAAGTCTTAACAAAAGCCCCAAA
AGAGCTTATCGTTATTTGA

Upstream 100 bases:

>100_bases
ATTAAAAGGAAACGTTAACTCATGTTAGCGTTTTTGTGTTATCATGTAAGAAAATGAAGAAATATTTTAAAGTTTAATTC
TTAATTTAAAGGAGAATAAA

Downstream 100 bases:

>100_bases
AAAAAGCAATAACTTGTGATAAAATAAGATGTTAAATCCTGTCATTTCACTTCTTTTGTGTACAGAAAAATTGCTGACAA
AAGAAAAATGACAGAATATC

Product: aminopeptidase P

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MRIEKLKAKMLTENIDSLLITDMKNIFYLTGFSGTAGTVFLTAKRNIFMTDSRYSEMARGLISDFEIIETRDPISLLTDL
SASESIKNIAFEETVDYAFFKRLSDATPGLELLATSNFVLELRQFKDDTEIDLIKKACAIADEAFMSALKFIEPGRTEIE
VANFLDFKMRDLEASGISFETIVASGKRSSLPHGVATSKMIQFGDPVTIDFGCYYEHYASDMTRTIFVGSVDDKMRTIYE
TVRKANEALIKEVKAGMTYAEYDKVPRTVIEEANFGQYFTHGIGHGLGLDVHEIPYFNQSMTENHLEAGMVITDEPGIYI
PEFGGVRIEDDLLVTENGCEVLTKAPKELIVI

Sequences:

>Translated_352_residues
MRIEKLKAKMLTENIDSLLITDMKNIFYLTGFSGTAGTVFLTAKRNIFMTDSRYSEMARGLISDFEIIETRDPISLLTDL
SASESIKNIAFEETVDYAFFKRLSDATPGLELLATSNFVLELRQFKDDTEIDLIKKACAIADEAFMSALKFIEPGRTEIE
VANFLDFKMRDLEASGISFETIVASGKRSSLPHGVATSKMIQFGDPVTIDFGCYYEHYASDMTRTIFVGSVDDKMRTIYE
TVRKANEALIKEVKAGMTYAEYDKVPRTVIEEANFGQYFTHGIGHGLGLDVHEIPYFNQSMTENHLEAGMVITDEPGIYI
PEFGGVRIEDDLLVTENGCEVLTKAPKELIVI
>Mature_352_residues
MRIEKLKAKMLTENIDSLLITDMKNIFYLTGFSGTAGTVFLTAKRNIFMTDSRYSEMARGLISDFEIIETRDPISLLTDL
SASESIKNIAFEETVDYAFFKRLSDATPGLELLATSNFVLELRQFKDDTEIDLIKKACAIADEAFMSALKFIEPGRTEIE
VANFLDFKMRDLEASGISFETIVASGKRSSLPHGVATSKMIQFGDPVTIDFGCYYEHYASDMTRTIFVGSVDDKMRTIYE
TVRKANEALIKEVKAGMTYAEYDKVPRTVIEEANFGQYFTHGIGHGLGLDVHEIPYFNQSMTENHLEAGMVITDEPGIYI
PEFGGVRIEDDLLVTENGCEVLTKAPKELIVI

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI260593665, Length=293, Percent_Identity=28.3276450511945, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI149589008, Length=293, Percent_Identity=28.3276450511945, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI11559925, Length=265, Percent_Identity=29.4339622641509, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI260593663, Length=231, Percent_Identity=29.4372294372294, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI40385867, Length=249, Percent_Identity=25.7028112449799, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI164420681, Length=242, Percent_Identity=28.099173553719, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI264681563, Length=189, Percent_Identity=30.6878306878307, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1788728, Length=358, Percent_Identity=34.9162011173184, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1789275, Length=263, Percent_Identity=33.0798479087452, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790282, Length=288, Percent_Identity=27.4305555555556, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17508215, Length=292, Percent_Identity=28.4246575342466, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17509539, Length=362, Percent_Identity=24.3093922651934, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71996291, Length=284, Percent_Identity=24.2957746478873, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321118, Length=393, Percent_Identity=24.9363867684478, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320922, Length=259, Percent_Identity=28.1853281853282, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323273, Length=246, Percent_Identity=27.6422764227642, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322999, Length=178, Percent_Identity=33.7078651685393, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19920384, Length=267, Percent_Identity=32.9588014981273, Blast_Score=127, Evalue=8e-30,
Organism=Drosophila melanogaster, GI21357079, Length=290, Percent_Identity=27.5862068965517, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI21355531, Length=248, Percent_Identity=24.5967741935484, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 39455; Mature: 39455

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIEKLKAKMLTENIDSLLITDMKNIFYLTGFSGTAGTVFLTAKRNIFMTDSRYSEMARG
CCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCCEEEECHHHHHHHHH
LISDFEIIETRDPISLLTDLSASESIKNIAFEETVDYAFFKRLSDATPGLELLATSNFVL
HHHCHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHH
ELRQFKDDTEIDLIKKACAIADEAFMSALKFIEPGRTEIEVANFLDFKMRDLEASGISFE
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCCCCCEEE
TIVASGKRSSLPHGVATSKMIQFGDPVTIDFGCYYEHYASDMTRTIFVGSVDDKMRTIYE
HHEECCCCCCCCCCHHHHHHHCCCCCEEEEECCHHHHHHCCCEEEEEEECCCHHHHHHHH
TVRKANEALIKEVKAGMTYAEYDKVPRTVIEEANFGQYFTHGIGHGLGLDVHEIPYFNQS
HHHHHHHHHHHHHHHCCCHHHHHHCHHHHHHCCCCCHHHHHHCCCCCCCCHHHCCCCCCH
MTENHLEAGMVITDEPGIYIPEFGGVRIEDDLLVTENGCEVLTKAPKELIVI
HHHHHHHCCEEEECCCCEECCCCCCEEEECCEEEECCCCHHHHCCCCCEEEC
>Mature Secondary Structure
MRIEKLKAKMLTENIDSLLITDMKNIFYLTGFSGTAGTVFLTAKRNIFMTDSRYSEMARG
CCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCCEEEECHHHHHHHHH
LISDFEIIETRDPISLLTDLSASESIKNIAFEETVDYAFFKRLSDATPGLELLATSNFVL
HHHCHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHH
ELRQFKDDTEIDLIKKACAIADEAFMSALKFIEPGRTEIEVANFLDFKMRDLEASGISFE
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCCCCCEEE
TIVASGKRSSLPHGVATSKMIQFGDPVTIDFGCYYEHYASDMTRTIFVGSVDDKMRTIYE
HHEECCCCCCCCCCHHHHHHHCCCCCEEEEECCHHHHHHCCCEEEEEEECCCHHHHHHHH
TVRKANEALIKEVKAGMTYAEYDKVPRTVIEEANFGQYFTHGIGHGLGLDVHEIPYFNQS
HHHHHHHHHHHHHHHCCCHHHHHHCHHHHHHCCCCCHHHHHHCCCCCCCCHHHCCCCCCH
MTENHLEAGMVITDEPGIYIPEFGGVRIEDDLLVTENGCEVLTKAPKELIVI
HHHHHHHCCEEEECCCCEECCCCCCEEEECCEEEECCCCHHHHCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]