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Identifier: 15835367

GI number: 15835367

Start: 895171

End: 896334

Strand: Direct

Name: Not Available

Synonym: TC0753

Alternate gene names: 15835367

Gene position: 895171-896334 (Clockwise)

Preceding gene: 15835366

Following gene: 15835368

Centisome position: 83.43

GC content: 40.29

Gene sequence:

>1164_bases
ATGTCTATAGAAAAAATTCTTATTATTGACGATGATCCCCGTATTCTTTCTCTGCTCTCTGAGCTATTGCATGCTAAGGG
GTTTTCTGTTTCCTCCGCAACAGGAGTCAAGCAAGCTCTCAAACACATCCTGTCCCAAACGTTTGATCTGATCATTTCCG
ATATGAATATGCCTGACGGGTCAGGACTGGATGTCATCAAATACACAAAACAGAATTGCCCGCAAACCCCAATCTTAGTG
ATTACTGCTTTTGGCACCATTGAAAATGCCGTTAAAGCTATGCGTTTTGGAGCTTTTAACTATCTAACCAAACCTTTTTC
TCCAGAGGCTCTTTTCACCTTAATTTCTAAAGCAGCAGAACTCCAATCTCTGCAACAAGAAAACCTATTCCTCCAATCAC
AAGGCTCGTCCTTATCTCATCCATTGATTGCAGAAAGCCTTTCTATGAAACAACTTCTCGATAAAGCCCGAAGAGCCGCA
AATAGTTCCGCAAATATTTTTGTTCATGGAGAATCTGGATGCGGAAAAGAAAACCTCTCATTTTTTATACACAAACATTC
TCCCCGATCCACGAAACCTTATATCAAAGTTAACTGTGCAGCCATCCCTGACACCCTCCTGGAGTCCGAATTCTTTGGTC
ATGAAAAAGGAGCCTTTACAGGAGCTACTACAAAAAAAGTCGGAAGATTCGAATTAGCCCATCAAGGGACTCTTTTACTA
GATGAGATCACAGAAATTCCCATTCACCTGCAAGCAAAACTCTTACGAGCAATCCAAGAGCAAGAATTTGAGCACATCGG
AGGAACCAAAACTCTCCCCGTAAATATTCGTTTTCTCGCCACCTCAAATCGTGATCTTCAAGAAGCTATGGAAACAAAGG
TTCTTCGACAGGATCTCTACTATCGACTCAGTGTTATCTCTCTACACATCCCGCCTCTTCGCGATAGAAAAGAGGATATT
CTACCTTTATCCCAGTACTATTTAGAAAAATTTTGTAAACTCAATAATAAACCTACTAAAACATTATCTTTAGAAGCCCA
ACAAAATTTTTTAGACTACCCATGGCCTGGGAATGTTCGAGAACTTTCTAATGTTCTTGAACGCACGGTCATTTTAGAAA
ATGACCCTATTATCACTCCTTCCATGCTATCCCTTCTTAATTAA

Upstream 100 bases:

>100_bases
TATTGTTTCCAATCAAGACAATCTTATCACCTTTACCATCCTATGGACTCCTGCTTAAAAGCTGCTATTACAAAGACGAT
ACCCATCTTGTAAAAATCCC

Downstream 100 bases:

>100_bases
GGAGTTTTTCTTGTATTTCAGACTCAATTCTGGTAACCTGGGTCCTTTCATTTAGAAAATTTGTGCACCGATAGCTCAAC
TGGATAGAGTACCTGGCTTC

Product: sigma-54 dependent response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MSIEKILIIDDDPRILSLLSELLHAKGFSVSSATGVKQALKHILSQTFDLIISDMNMPDGSGLDVIKYTKQNCPQTPILV
ITAFGTIENAVKAMRFGAFNYLTKPFSPEALFTLISKAAELQSLQQENLFLQSQGSSLSHPLIAESLSMKQLLDKARRAA
NSSANIFVHGESGCGKENLSFFIHKHSPRSTKPYIKVNCAAIPDTLLESEFFGHEKGAFTGATTKKVGRFELAHQGTLLL
DEITEIPIHLQAKLLRAIQEQEFEHIGGTKTLPVNIRFLATSNRDLQEAMETKVLRQDLYYRLSVISLHIPPLRDRKEDI
LPLSQYYLEKFCKLNNKPTKTLSLEAQQNFLDYPWPGNVRELSNVLERTVILENDPIITPSMLSLLN

Sequences:

>Translated_387_residues
MSIEKILIIDDDPRILSLLSELLHAKGFSVSSATGVKQALKHILSQTFDLIISDMNMPDGSGLDVIKYTKQNCPQTPILV
ITAFGTIENAVKAMRFGAFNYLTKPFSPEALFTLISKAAELQSLQQENLFLQSQGSSLSHPLIAESLSMKQLLDKARRAA
NSSANIFVHGESGCGKENLSFFIHKHSPRSTKPYIKVNCAAIPDTLLESEFFGHEKGAFTGATTKKVGRFELAHQGTLLL
DEITEIPIHLQAKLLRAIQEQEFEHIGGTKTLPVNIRFLATSNRDLQEAMETKVLRQDLYYRLSVISLHIPPLRDRKEDI
LPLSQYYLEKFCKLNNKPTKTLSLEAQQNFLDYPWPGNVRELSNVLERTVILENDPIITPSMLSLLN
>Mature_386_residues
SIEKILIIDDDPRILSLLSELLHAKGFSVSSATGVKQALKHILSQTFDLIISDMNMPDGSGLDVIKYTKQNCPQTPILVI
TAFGTIENAVKAMRFGAFNYLTKPFSPEALFTLISKAAELQSLQQENLFLQSQGSSLSHPLIAESLSMKQLLDKARRAAN
SSANIFVHGESGCGKENLSFFIHKHSPRSTKPYIKVNCAAIPDTLLESEFFGHEKGAFTGATTKKVGRFELAHQGTLLLD
EITEIPIHLQAKLLRAIQEQEFEHIGGTKTLPVNIRFLATSNRDLQEAMETKVLRQDLYYRLSVISLHIPPLRDRKEDIL
PLSQYYLEKFCKLNNKPTKTLSLEAQQNFLDYPWPGNVRELSNVLERTVILENDPIITPSMLSLLN

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=381, Percent_Identity=43.5695538057743, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI1790437, Length=381, Percent_Identity=39.8950131233596, Blast_Score=303, Evalue=1e-83,
Organism=Escherichia coli, GI1788905, Length=378, Percent_Identity=37.8306878306878, Blast_Score=284, Evalue=5e-78,
Organism=Escherichia coli, GI1790299, Length=367, Percent_Identity=36.7847411444142, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI87082117, Length=253, Percent_Identity=49.0118577075099, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI1789087, Length=264, Percent_Identity=40.9090909090909, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI87082152, Length=232, Percent_Identity=43.5344827586207, Blast_Score=207, Evalue=7e-55,
Organism=Escherichia coli, GI1786524, Length=261, Percent_Identity=40.2298850574713, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1789233, Length=250, Percent_Identity=42.8, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI87081872, Length=230, Percent_Identity=40.4347826086956, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1787583, Length=238, Percent_Identity=36.9747899159664, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI87081858, Length=266, Percent_Identity=31.203007518797, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1789828, Length=230, Percent_Identity=33.0434782608696, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1789809, Length=119, Percent_Identity=30.2521008403361, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1786784, Length=119, Percent_Identity=34.453781512605, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786599, Length=152, Percent_Identity=31.5789473684211, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1789402, Length=122, Percent_Identity=31.9672131147541, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787375, Length=148, Percent_Identity=30.4054054054054, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1790552, Length=111, Percent_Identity=30.6306306306306, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI2367329, Length=113, Percent_Identity=38.0530973451327, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082012, Length=148, Percent_Identity=27.7027027027027, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 43347; Mature: 43215

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIEKILIIDDDPRILSLLSELLHAKGFSVSSATGVKQALKHILSQTFDLIISDMNMPDG
CCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SGLDVIKYTKQNCPQTPILVITAFGTIENAVKAMRFGAFNYLTKPFSPEALFTLISKAAE
CCCHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LQSLQQENLFLQSQGSSLSHPLIAESLSMKQLLDKARRAANSSANIFVHGESGCGKENLS
HHHHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCE
FFIHKHSPRSTKPYIKVNCAAIPDTLLESEFFGHEKGAFTGATTKKVGRFELAHQGTLLL
EEEEECCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCHHHHCCEEHHCCCCEEE
DEITEIPIHLQAKLLRAIQEQEFEHIGGTKTLPVNIRFLATSNRDLQEAMETKVLRQDLY
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHHH
YRLSVISLHIPPLRDRKEDILPLSQYYLEKFCKLNNKPTKTLSLEAQQNFLDYPWPGNVR
HEEEEEEEECCCCCCCHHHCCCHHHHHHHHHHHCCCCCCCEEEEEHHHCCCCCCCCCCHH
ELSNVLERTVILENDPIITPSMLSLLN
HHHHHHHHHEEECCCCCCCHHHHHHCC
>Mature Secondary Structure 
SIEKILIIDDDPRILSLLSELLHAKGFSVSSATGVKQALKHILSQTFDLIISDMNMPDG
CCCEEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SGLDVIKYTKQNCPQTPILVITAFGTIENAVKAMRFGAFNYLTKPFSPEALFTLISKAAE
CCCHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LQSLQQENLFLQSQGSSLSHPLIAESLSMKQLLDKARRAANSSANIFVHGESGCGKENLS
HHHHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCE
FFIHKHSPRSTKPYIKVNCAAIPDTLLESEFFGHEKGAFTGATTKKVGRFELAHQGTLLL
EEEEECCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCHHHHCCEEHHCCCCEEE
DEITEIPIHLQAKLLRAIQEQEFEHIGGTKTLPVNIRFLATSNRDLQEAMETKVLRQDLY
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHHH
YRLSVISLHIPPLRDRKEDILPLSQYYLEKFCKLNNKPTKTLSLEAQQNFLDYPWPGNVR
HEEEEEEEECCCCCCCHHHCCCHHHHHHHHHHHCCCCCCCEEEEEHHHCCCCCCCCCCHH
ELSNVLERTVILENDPIITPSMLSLLN
HHHHHHHHHEEECCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]