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Identifier: 15835366

GI number: 15835366

Start: 894070

End: 895128

Strand: Direct

Name: Not Available

Synonym: TC0752

Alternate gene names: 15835366

Gene position: 894070-895128 (Clockwise)

Preceding gene: 15835365

Following gene: 15835367

Centisome position: 83.33

GC content: 39.66

Gene sequence:

>1059_bases
ATGCCAAAGATCGACACCTGTGATTCTTGCGTTTCCAACGACGAGCTTTTAGCCATTCGTGCACGAGTAACCCAATCGTA
CAGCGAAGCTCAAACTATCTTAACCTCCATTCCTGATGGAATCATCCTACTTTCAGAAGTTGGAGAAATCTTAATGTGTA
ATTCTCAAGCACGCTCTATTTTGGGAATTCCTGAAGATATCCAATTAATCCATCAGAAGTTTCATGATTTTTTCCCCGAT
ACCTTTTTTGGATTCTCCGTGCAAGAAGCTCTAGAAAAAGAAATCCCTCCAAAAACGATTCGATTAACTCTATCTCAAGA
CCTTTCCCATAAAGAAGTTGAGGTATTCGTTAGAAAAAATATTTCTAATCAATTTCTATTTCTTCTTATCCGAGACCGTT
CCGACTATCGACAGCTAGAACAAGCGATTGAAAAATATCGCAGCATCTCCGAACTGGGGAAAATAGCCGCTACCCTTGCT
CATGAGATACGTAATCCTCTGACTGGAATTTCTGGATTTGCAACGATTCTTAAAGAAGAGCTCTCTTCAGAACGTCATCA
ACGTATGCTGAATGCTATCATAGAAGGATCCCGATCTTTAAATTCTCTCGTATCTTCTATGCTTGAATACACAAAAATAC
AGCCCCTGAATCTCCGCTCTATCGACATACAAGACTTTTTCTCTTCTTTAATCCCCGAGCTTTCATTAACATTTCCATCT
TGCACATTCAGAAGAACTTACTCATCCCCCATACTGCATTCTATAGACCCAGATCGCTTACGATGCGTCATATGGAATCT
CGTAAAAAATGCTGTTGAAGCATCTGATGATGAAGTTTTTCTAGAACTACATGAAAAAGGCTTGTCTGTCGTAAATACGG
GAACTCTTCCCCTACATGTTCAAGAAAAACTCTTTATTCCTTTCTTCACAACAAAACCTCAGGGGAATGGACTAGGATTA
GCAGAGGCTCATAAAATCATGCGATTGCATGGAGGAGATCTTATTGTTTCCAATCAAGACAATCTTATCACCTTTACCAT
CCTATGGACTCCTGCTTAA

Upstream 100 bases:

>100_bases
GAAATCCAGGAAGAGCTAACAGAAATACGCTCCGTTATTCAGCGCATTTTGGAAGCAGATAAAAAAAACTATTCTATAAG
AAAAAACGAACTGGGAACTT

Downstream 100 bases:

>100_bases
AAGCTGCTATTACAAAGACGATACCCATCTTGTAAAAATCCCATGTCTATAGAAAAAATTCTTATTATTGACGATGATCC
CCGTATTCTTTCTCTGCTCT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MPKIDTCDSCVSNDELLAIRARVTQSYSEAQTILTSIPDGIILLSEVGEILMCNSQARSILGIPEDIQLIHQKFHDFFPD
TFFGFSVQEALEKEIPPKTIRLTLSQDLSHKEVEVFVRKNISNQFLFLLIRDRSDYRQLEQAIEKYRSISELGKIAATLA
HEIRNPLTGISGFATILKEELSSERHQRMLNAIIEGSRSLNSLVSSMLEYTKIQPLNLRSIDIQDFFSSLIPELSLTFPS
CTFRRTYSSPILHSIDPDRLRCVIWNLVKNAVEASDDEVFLELHEKGLSVVNTGTLPLHVQEKLFIPFFTTKPQGNGLGL
AEAHKIMRLHGGDLIVSNQDNLITFTILWTPA

Sequences:

>Translated_352_residues
MPKIDTCDSCVSNDELLAIRARVTQSYSEAQTILTSIPDGIILLSEVGEILMCNSQARSILGIPEDIQLIHQKFHDFFPD
TFFGFSVQEALEKEIPPKTIRLTLSQDLSHKEVEVFVRKNISNQFLFLLIRDRSDYRQLEQAIEKYRSISELGKIAATLA
HEIRNPLTGISGFATILKEELSSERHQRMLNAIIEGSRSLNSLVSSMLEYTKIQPLNLRSIDIQDFFSSLIPELSLTFPS
CTFRRTYSSPILHSIDPDRLRCVIWNLVKNAVEASDDEVFLELHEKGLSVVNTGTLPLHVQEKLFIPFFTTKPQGNGLGL
AEAHKIMRLHGGDLIVSNQDNLITFTILWTPA
>Mature_351_residues
PKIDTCDSCVSNDELLAIRARVTQSYSEAQTILTSIPDGIILLSEVGEILMCNSQARSILGIPEDIQLIHQKFHDFFPDT
FFGFSVQEALEKEIPPKTIRLTLSQDLSHKEVEVFVRKNISNQFLFLLIRDRSDYRQLEQAIEKYRSISELGKIAATLAH
EIRNPLTGISGFATILKEELSSERHQRMLNAIIEGSRSLNSLVSSMLEYTKIQPLNLRSIDIQDFFSSLIPELSLTFPSC
TFRRTYSSPILHSIDPDRLRCVIWNLVKNAVEASDDEVFLELHEKGLSVVNTGTLPLHVQEKLFIPFFTTKPQGNGLGLA
EAHKIMRLHGGDLIVSNQDNLITFTILWTPA

Specific function: Member of the two-component regulatory system AtoS/AtoC; may activate AtoC by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=337, Percent_Identity=24.9258160237389, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1790436, Length=239, Percent_Identity=31.7991631799163, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI48994928, Length=367, Percent_Identity=24.5231607629428, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI145693157, Length=213, Percent_Identity=27.6995305164319, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 39782; Mature: 39651

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKIDTCDSCVSNDELLAIRARVTQSYSEAQTILTSIPDGIILLSEVGEILMCNSQARSI
CCCCCCCHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCEEEHHHCCCEEEECCHHHHH
LGIPEDIQLIHQKFHDFFPDTFFGFSVQEALEKEIPPKTIRLTLSQDLSHKEVEVFVRKN
CCCCHHHHHHHHHHHHHCCCHHCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHC
ISNQFLFLLIRDRSDYRQLEQAIEKYRSISELGKIAATLAHEIRNPLTGISGFATILKEE
CCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LSSERHQRMLNAIIEGSRSLNSLVSSMLEYTKIQPLNLRSIDIQDFFSSLIPELSLTFPS
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHCCHHCCCCCC
CTFRRTYSSPILHSIDPDRLRCVIWNLVKNAVEASDDEVFLELHEKGLSVVNTGTLPLHV
CEEHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEECCCCEEEE
QEKLFIPFFTTKPQGNGLGLAEAHKIMRLHGGDLIVSNQDNLITFTILWTPA
CCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEEEEEECC
>Mature Secondary Structure 
PKIDTCDSCVSNDELLAIRARVTQSYSEAQTILTSIPDGIILLSEVGEILMCNSQARSI
CCCCCCHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCEEEHHHCCCEEEECCHHHHH
LGIPEDIQLIHQKFHDFFPDTFFGFSVQEALEKEIPPKTIRLTLSQDLSHKEVEVFVRKN
CCCCHHHHHHHHHHHHHCCCHHCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHC
ISNQFLFLLIRDRSDYRQLEQAIEKYRSISELGKIAATLAHEIRNPLTGISGFATILKEE
CCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LSSERHQRMLNAIIEGSRSLNSLVSSMLEYTKIQPLNLRSIDIQDFFSSLIPELSLTFPS
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHCCHHCCCCCC
CTFRRTYSSPILHSIDPDRLRCVIWNLVKNAVEASDDEVFLELHEKGLSVVNTGTLPLHV
CEEHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEECCCCEEEE
QEKLFIPFFTTKPQGNGLGLAEAHKIMRLHGGDLIVSNQDNLITFTILWTPA
CCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8346225; 9097040; 9278503 [H]