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The map label for this gene is dapA

Identifier: 15835255

GI number: 15835255

Start: 765946

End: 766806

Strand: Reverse

Name: dapA

Synonym: TC0640

Alternate gene names: 15835255

Gene position: 766806-765946 (Counterclockwise)

Preceding gene: 15835256

Following gene: 15835254

Centisome position: 71.47

GC content: 43.21

Gene sequence:

>861_bases
ATGAGCGTCGTGACGGCTTGTATTACGCCTTTTAAAGCGGATTTATCTATTGATTTCGCTGCTTTAGAGAGCGTGGTCCG
TTCGCAAGAGCATGCTGGTAATGGAGTCTTTTTATTTGGGAGCACGGGAGAGAGTTTATCTTTAGCGTATGAAGAAAAAT
TTGCAGCTCTTTCATTTGTTTCTACCTTGAAATTGAATGTCCCTCTGTTCTTAGGAGTCACGGCTACGTCTATTCAAGAA
GCGATTTCTTGGATTGAATTTGCTCAACGATGGCCTATAGATGGTTTTTTTGTTCCAACTCCTCTTTACACTAAGCCGGG
ACTTTATGGACAGAAGGTTTGGTTTGAGAAAATTTTGAGTGTGAGTAAGAAGCCGATCATTCTTTATAATAATCCTTCTC
GTACTGGAGTGGCTTTGCATCCAGAGGTAGTCAAATCCTTGGCTTCGCATCCTTTATGCATGGGGGTTAAGGATTCTGGT
GGATCAACACAAGCTTGCACGCTTTTTGCAGAATCAGGAGTACGAGTATTTTGTGGTGATGATGGGATGTGGCCAGAAAT
GCGTTTGTCTGGAGCTTCTGGATTAGTTTCTGTGTTATCTAACGTTTGGCCAGAGTTAGCCCGAGATTATGTGGCTCAAT
GTCGATCTATAGATGCGTGGAAGAAGACGTGTTCTTGGCTTGAGTTGTCTGTGAATCCTTTAGGGATTAAGGCTTTAATG
GCTGCGCAGAAAATGATCGAATGTGAATTGGTGCGCCCACCGCTATCTATACGAGATTTTCAAGAAAGAGATCAGCTTGC
GGATATCCTAGCTTGTAGAGCTATTTTGCAGGCAGAACTGCTATCGGTATGTGTGCAGTGA

Upstream 100 bases:

>100_bases
AAACAGATACAGTTATTAACTTAATTATTAATGAAGAGTCTGGAGTCGTGGTAACGAAGTTACTTCACGATTACGTATTG
GGATTAAACAGGAGTGGTTT

Downstream 100 bases:

>100_bases
TTTAAGGTAATCCCTAAATAATGTGCTTTATCACAAGCGGAGTGGGATTGAAATGAACCTACCTTAACCATGCCTCTTGT
TGCTTCCCTCCTGTAGGGGG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MSVVTACITPFKADLSIDFAALESVVRSQEHAGNGVFLFGSTGESLSLAYEEKFAALSFVSTLKLNVPLFLGVTATSIQE
AISWIEFAQRWPIDGFFVPTPLYTKPGLYGQKVWFEKILSVSKKPIILYNNPSRTGVALHPEVVKSLASHPLCMGVKDSG
GSTQACTLFAESGVRVFCGDDGMWPEMRLSGASGLVSVLSNVWPELARDYVAQCRSIDAWKKTCSWLELSVNPLGIKALM
AAQKMIECELVRPPLSIRDFQERDQLADILACRAILQAELLSVCVQ

Sequences:

>Translated_286_residues
MSVVTACITPFKADLSIDFAALESVVRSQEHAGNGVFLFGSTGESLSLAYEEKFAALSFVSTLKLNVPLFLGVTATSIQE
AISWIEFAQRWPIDGFFVPTPLYTKPGLYGQKVWFEKILSVSKKPIILYNNPSRTGVALHPEVVKSLASHPLCMGVKDSG
GSTQACTLFAESGVRVFCGDDGMWPEMRLSGASGLVSVLSNVWPELARDYVAQCRSIDAWKKTCSWLELSVNPLGIKALM
AAQKMIECELVRPPLSIRDFQERDQLADILACRAILQAELLSVCVQ
>Mature_285_residues
SVVTACITPFKADLSIDFAALESVVRSQEHAGNGVFLFGSTGESLSLAYEEKFAALSFVSTLKLNVPLFLGVTATSIQEA
ISWIEFAQRWPIDGFFVPTPLYTKPGLYGQKVWFEKILSVSKKPIILYNNPSRTGVALHPEVVKSLASHPLCMGVKDSGG
STQACTLFAESGVRVFCGDDGMWPEMRLSGASGLVSVLSNVWPELARDYVAQCRSIDAWKKTCSWLELSVNPLGIKALMA
AQKMIECELVRPPLSIRDFQERDQLADILACRAILQAELLSVCVQ

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Escherichia coli, GI1788823, Length=220, Percent_Identity=30.9090909090909, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786463, Length=229, Percent_Identity=28.82096069869, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87082415, Length=206, Percent_Identity=29.6116504854369, Blast_Score=78, Evalue=6e-16,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_CHLMU (Q9PK33)

Other databases:

- EMBL:   AE002160
- PIR:   C81681
- RefSeq:   NP_297014.1
- ProteinModelPortal:   Q9PK33
- SMR:   Q9PK33
- GeneID:   1246001
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0640
- TIGR:   TC_0640
- HOGENOM:   HBG358848
- OMA:   LAYKQDI
- ProtClustDB:   PRK03170
- BioCyc:   CMUR243161:TC_0640-MONOMER
- BRENDA:   4.2.1.52
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31286; Mature: 31154

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 157-157

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVVTACITPFKADLSIDFAALESVVRSQEHAGNGVFLFGSTGESLSLAYEEKFAALSFV
CCCHHHHHCCCCCCCEECHHHHHHHHHHHHCCCCEEEEECCCCCCEEHHHHHHHHHHHHH
STLKLNVPLFLGVTATSIQEAISWIEFAQRWPIDGFFVPTPLYTKPGLYGQKVWFEKILS
HHHEECCCEEECCHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHH
VSKKPIILYNNPSRTGVALHPEVVKSLASHPLCMGVKDSGGSTQACTLFAESGVRVFCGD
CCCCCEEEECCCCCCCEEECHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCCCEEEECC
DGMWPEMRLSGASGLVSVLSNVWPELARDYVAQCRSIDAWKKTCSWLELSVNPLGIKALM
CCCCHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEECCCHHHHHHH
AAQKMIECELVRPPLSIRDFQERDQLADILACRAILQAELLSVCVQ
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVVTACITPFKADLSIDFAALESVVRSQEHAGNGVFLFGSTGESLSLAYEEKFAALSFV
CCHHHHHCCCCCCCEECHHHHHHHHHHHHCCCCEEEEECCCCCCEEHHHHHHHHHHHHH
STLKLNVPLFLGVTATSIQEAISWIEFAQRWPIDGFFVPTPLYTKPGLYGQKVWFEKILS
HHHEECCCEEECCHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHH
VSKKPIILYNNPSRTGVALHPEVVKSLASHPLCMGVKDSGGSTQACTLFAESGVRVFCGD
CCCCCEEEECCCCCCCEEECHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCCCEEEECC
DGMWPEMRLSGASGLVSVLSNVWPELARDYVAQCRSIDAWKKTCSWLELSVNPLGIKALM
CCCCHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEECCCHHHHHHH
AAQKMIECELVRPPLSIRDFQERDQLADILACRAILQAELLSVCVQ
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935