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The map label for this gene is lysC

Identifier: 15835256

GI number: 15835256

Start: 766803

End: 768116

Strand: Reverse

Name: lysC

Synonym: TC0641

Alternate gene names: 15835256

Gene position: 768116-766803 (Counterclockwise)

Preceding gene: 15835257

Following gene: 15835255

Centisome position: 71.59

GC content: 42.31

Gene sequence:

>1314_bases
ATGTTTAAAGAGAAAAAAGCGCCTCTTGTTTGCAAGTTCGGAGGAACGAGTGTAGGAACATCCTCCAGCATCCAACGTGT
TTGCGAGATTATCCGAAAGGAAAAGCCCTCTTTCGTAGTTGTCAGTGCAGTGGCTGGTGTTACAGATTTATTGGAAGAGT
TTTGTCGGGCACCTGTAGGACAGAAATCTCAATTCACGGCCATGATTCGGGAGAAACATGAATCTATTGCTAAAGAGTTG
GGGATAGACGTTGCTATCGAACCTTTTTTAGGGCCTTTAAAGCAATTTGAGGGCGCTGGACATCTTCAGCAAGAAGACCA
AGCAAAGATTCTAGCTATAGGAGAAGATTTATCTGCTTCCCTAATTTGTAGTTATTGCCGTGCAAATAGTCTGCAGCTTG
AGCAGCTAGAAGCTCGTCAGGTGATATTGACTGACTCACAATTTTTGCGAGCGGAACCAGATTTAGCTTTGATGCAAACT
ATGTGGGGAGAGTTGGTATTAAAAGAGAATACGATTTATCTTATGCAGGGATTCTTGGGAGCAACAGCTTCTGGGGCAAC
TACAGTTCTTGGGAGAGGGGGCAGCGATTTTTCTGCCTCTTTGGTAGGAGAACTATGTGAAGCGAGGGAGCTGCGTATTT
ACACAGATGTTCGTGGTGTACATACCGCAGATCCTAAGATTCTAAAAGATACGCAACTCATAGATTTTTTAACATTTGAG
GAGATGCAGGAGTTAGCAAGTTCTGGGTCTAAAGTGTTGCACCAGGATATGTTAAAGCCTTGTATTCGAGCAAAAGTCCC
TATTTTTGTGACTTCAACGTTTGATTTAACTAAAGAGGGAACCTGGATTTGTGCCTCATTGAATGAGGGTGTAGAAGGGC
CTGAGATAAAAGCTCTTTCGTTAAAGGCAAATCAGGCTCTTTGGTTTGTGGAATACCATTCTCCTTTGATGAGATTAGAG
AATGTTTTGAGATGTGTGCGAGGCCTAGGATCGATTCCTGGAGTTGTTATGGCTCAAAATTCTGGAGTATATTTCACCGT
GGATTGGGAAGAAAATAACCAGTCAATGACAGAAGCTCTTAGAGAATTTGGTGCGGTGAGTTGTGAAGGTCCTGTGTCTT
TGGTTGCATTAGTTGGAGCTAAGTTGACTTCTTGGAGTATGACAGGAGTTTTTGATGCTTTGCAAGGGACTCCGGTATTG
TATTGGAGCCAAACAGATACAGTTATTAACTTAATTATTAATGAAGAGTCTGGAGTCGTGGTAACGAAGTTACTTCACGA
TTACGTATTGGGATTAAACAGGAGTGGTTTATGA

Upstream 100 bases:

>100_bases
CTTCTTCATAATTTGGTTCGAGGCGCTGCAGGAGCCTTAATATCGAATATGAATTTTCTCCAGGATAGGGTGAATCTTTT
CTATCAAGAGGGGCTGGCAC

Downstream 100 bases:

>100_bases
GCGTCGTGACGGCTTGTATTACGCCTTTTAAAGCGGATTTATCTATTGATTTCGCTGCTTTAGAGAGCGTGGTCCGTTCG
CAAGAGCATGCTGGTAATGG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MFKEKKAPLVCKFGGTSVGTSSSIQRVCEIIRKEKPSFVVVSAVAGVTDLLEEFCRAPVGQKSQFTAMIREKHESIAKEL
GIDVAIEPFLGPLKQFEGAGHLQQEDQAKILAIGEDLSASLICSYCRANSLQLEQLEARQVILTDSQFLRAEPDLALMQT
MWGELVLKENTIYLMQGFLGATASGATTVLGRGGSDFSASLVGELCEARELRIYTDVRGVHTADPKILKDTQLIDFLTFE
EMQELASSGSKVLHQDMLKPCIRAKVPIFVTSTFDLTKEGTWICASLNEGVEGPEIKALSLKANQALWFVEYHSPLMRLE
NVLRCVRGLGSIPGVVMAQNSGVYFTVDWEENNQSMTEALREFGAVSCEGPVSLVALVGAKLTSWSMTGVFDALQGTPVL
YWSQTDTVINLIINEESGVVVTKLLHDYVLGLNRSGL

Sequences:

>Translated_437_residues
MFKEKKAPLVCKFGGTSVGTSSSIQRVCEIIRKEKPSFVVVSAVAGVTDLLEEFCRAPVGQKSQFTAMIREKHESIAKEL
GIDVAIEPFLGPLKQFEGAGHLQQEDQAKILAIGEDLSASLICSYCRANSLQLEQLEARQVILTDSQFLRAEPDLALMQT
MWGELVLKENTIYLMQGFLGATASGATTVLGRGGSDFSASLVGELCEARELRIYTDVRGVHTADPKILKDTQLIDFLTFE
EMQELASSGSKVLHQDMLKPCIRAKVPIFVTSTFDLTKEGTWICASLNEGVEGPEIKALSLKANQALWFVEYHSPLMRLE
NVLRCVRGLGSIPGVVMAQNSGVYFTVDWEENNQSMTEALREFGAVSCEGPVSLVALVGAKLTSWSMTGVFDALQGTPVL
YWSQTDTVINLIINEESGVVVTKLLHDYVLGLNRSGL
>Mature_437_residues
MFKEKKAPLVCKFGGTSVGTSSSIQRVCEIIRKEKPSFVVVSAVAGVTDLLEEFCRAPVGQKSQFTAMIREKHESIAKEL
GIDVAIEPFLGPLKQFEGAGHLQQEDQAKILAIGEDLSASLICSYCRANSLQLEQLEARQVILTDSQFLRAEPDLALMQT
MWGELVLKENTIYLMQGFLGATASGATTVLGRGGSDFSASLVGELCEARELRIYTDVRGVHTADPKILKDTQLIDFLTFE
EMQELASSGSKVLHQDMLKPCIRAKVPIFVTSTFDLTKEGTWICASLNEGVEGPEIKALSLKANQALWFVEYHSPLMRLE
NVLRCVRGLGSIPGVVMAQNSGVYFTVDWEENNQSMTEALREFGAVSCEGPVSLVALVGAKLTSWSMTGVFDALQGTPVL
YWSQTDTVINLIINEESGVVVTKLLHDYVLGLNRSGL

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartokinase family

Homologues:

Organism=Escherichia coli, GI1790455, Length=455, Percent_Identity=29.2307692307692, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI1786183, Length=322, Percent_Identity=27.9503105590062, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790376, Length=432, Percent_Identity=25, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320893, Length=309, Percent_Identity=26.8608414239482, Blast_Score=91, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AK_CHLMU (Q9PK32)

Other databases:

- EMBL:   AE002160
- PIR:   D81681
- RefSeq:   NP_297015.1
- ProteinModelPortal:   Q9PK32
- SMR:   Q9PK32
- GeneID:   1246002
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0641
- TIGR:   TC_0641
- HOGENOM:   HBG724395
- OMA:   GTWICAS
- PhylomeDB:   Q9PK32
- ProtClustDB:   PRK05925
- BioCyc:   CMUR243161:TC_0641-MONOMER
- BRENDA:   2.7.2.4
- InterPro:   IPR001048
- InterPro:   IPR001341
- InterPro:   IPR018042
- Gene3D:   G3DSA:3.40.1160.10
- TIGRFAMs:   TIGR00657

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.2.4

Molecular weight: Translated: 47796; Mature: 47796

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKEKKAPLVCKFGGTSVGTSSSIQRVCEIIRKEKPSFVVVSAVAGVTDLLEEFCRAPVG
CCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCCCC
QKSQFTAMIREKHESIAKELGIDVAIEPFLGPLKQFEGAGHLQQEDQAKILAIGEDLSAS
CCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCHH
LICSYCRANSLQLEQLEARQVILTDSQFLRAEPDLALMQTMWGELVLKENTIYLMQGFLG
HHHHHHCCCCCCHHHHCCCEEEEECCHHHCCCCCHHHHHHHHHHEEEECCEEEEEHHHHC
ATASGATTVLGRGGSDFSASLVGELCEARELRIYTDVRGVHTADPKILKDTQLIDFLTFE
CCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHH
EMQELASSGSKVLHQDMLKPCIRAKVPIFVTSTFDLTKEGTWICASLNEGVEGPEIKALS
HHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCEEEEE
LKANQALWFVEYHSPLMRLENVLRCVRGLGSIPGVVMAQNSGVYFTVDWEENNQSMTEAL
EECCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECCCCHHHHHHH
REFGAVSCEGPVSLVALVGAKLTSWSMTGVFDALQGTPVLYWSQTDTVINLIINEESGVV
HHHCCCCCCCHHHHHHHHHCHHCCCCHHHHHHHHCCCEEEEECCCCEEEEEEEECCCCCH
VTKLLHDYVLGLNRSGL
HHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFKEKKAPLVCKFGGTSVGTSSSIQRVCEIIRKEKPSFVVVSAVAGVTDLLEEFCRAPVG
CCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCCCC
QKSQFTAMIREKHESIAKELGIDVAIEPFLGPLKQFEGAGHLQQEDQAKILAIGEDLSAS
CCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCHH
LICSYCRANSLQLEQLEARQVILTDSQFLRAEPDLALMQTMWGELVLKENTIYLMQGFLG
HHHHHHCCCCCCHHHHCCCEEEEECCHHHCCCCCHHHHHHHHHHEEEECCEEEEEHHHHC
ATASGATTVLGRGGSDFSASLVGELCEARELRIYTDVRGVHTADPKILKDTQLIDFLTFE
CCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHH
EMQELASSGSKVLHQDMLKPCIRAKVPIFVTSTFDLTKEGTWICASLNEGVEGPEIKALS
HHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCEEEEE
LKANQALWFVEYHSPLMRLENVLRCVRGLGSIPGVVMAQNSGVYFTVDWEENNQSMTEAL
EECCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECCCCHHHHHHH
REFGAVSCEGPVSLVALVGAKLTSWSMTGVFDALQGTPVLYWSQTDTVINLIINEESGVV
HHHCCCCCCCHHHHHHHHHCHHCCCCHHHHHHHHCCCEEEEECCCCEEEEEEEECCCCCH
VTKLLHDYVLGLNRSGL
HHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935