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The map label for this gene is trpF

Identifier: 15835220

GI number: 15835220

Start: 722765

End: 723391

Strand: Reverse

Name: trpF

Synonym: TC0603

Alternate gene names: 15835220

Gene position: 723391-722765 (Counterclockwise)

Preceding gene: 15835230

Following gene: 15835219

Centisome position: 67.42

GC content: 42.9

Gene sequence:

>627_bases
ATGAAGGTGAAAATTTGTGGTGTTACGCATCCTGATGATGCTTGGGAAGCTGCTAAAGCTGGAGCTGACTATGTTGGCAT
GATTTTTGCTAAAGATTCTCAAAGATGCGTTACCAAAGAGACGGCAAAGTGCATTGTAGAAGCAATACGAGATGGTGGTT
CGGAACCTGTAGGAGTGTTTTCAGAGCATTCTATAGGGGAAATTATCGCTATTTCCTCGGCAACTGGAATTACTAGTATT
CAGTTGTCTGGAAGGAACATTGATTTTAAATTTTCTCAATTACGAGAGTTGTTTTCCATTTTTTATGTTGTGTCTGTCTA
TTCTAATGGTCAGCCATCAGCAGCGATCCCTCCAATGAGTAACACGGTTACTGTGATATATGATCACATTGGAGGAGAAA
GGGGGACACCTTTTGATTGGAGAGCATTTTCTCCATTCCAACATGACAACTGGATGTTAGGAGGCGGAGTGAATCCTGGA
AATGTTGGGGAGGCAGTGAGACTTCTTAGTCCCAGGGGGATTGATGTATCTTCAGGAGTAGAGCGTCCTGGTGTTTTACG
GAAAGATGTTACCCTCATGCAGGCTTTGATAGATTCTGCCAAAGGAGTGGGGAATTTGACATCGTAA

Upstream 100 bases:

>100_bases
TTTTATTGCTTTGATATAAATCTTTTAGATACGCTAAATACCTTTCCTTATTTTTTTCTTGTTTATTTCGTTAAATAGTT
GGTCTTAGACCCTTTATTGT

Downstream 100 bases:

>100_bases
TCTTTTTATCTGAACTCCCTCACAAGGAAATCACGTTGTTCGAATCCATCTATTAATCCTATAAGTGAATAGCTTGAATG
AATACCCAGTGTCTACTGGG

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MKVKICGVTHPDDAWEAAKAGADYVGMIFAKDSQRCVTKETAKCIVEAIRDGGSEPVGVFSEHSIGEIIAISSATGITSI
QLSGRNIDFKFSQLRELFSIFYVVSVYSNGQPSAAIPPMSNTVTVIYDHIGGERGTPFDWRAFSPFQHDNWMLGGGVNPG
NVGEAVRLLSPRGIDVSSGVERPGVLRKDVTLMQALIDSAKGVGNLTS

Sequences:

>Translated_208_residues
MKVKICGVTHPDDAWEAAKAGADYVGMIFAKDSQRCVTKETAKCIVEAIRDGGSEPVGVFSEHSIGEIIAISSATGITSI
QLSGRNIDFKFSQLRELFSIFYVVSVYSNGQPSAAIPPMSNTVTVIYDHIGGERGTPFDWRAFSPFQHDNWMLGGGVNPG
NVGEAVRLLSPRGIDVSSGVERPGVLRKDVTLMQALIDSAKGVGNLTS
>Mature_208_residues
MKVKICGVTHPDDAWEAAKAGADYVGMIFAKDSQRCVTKETAKCIVEAIRDGGSEPVGVFSEHSIGEIIAISSATGITSI
QLSGRNIDFKFSQLRELFSIFYVVSVYSNGQPSAAIPPMSNTVTVIYDHIGGERGTPFDWRAFSPFQHDNWMLGGGVNPG
NVGEAVRLLSPRGIDVSSGVERPGVLRKDVTLMQALIDSAKGVGNLTS

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=202, Percent_Identity=28.7128712871287, Blast_Score=77, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6320210, Length=212, Percent_Identity=28.3018867924528, Blast_Score=72, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_CHLMU (Q9PK67)

Other databases:

- EMBL:   AE002160
- RefSeq:   NP_296979.1
- ProteinModelPortal:   Q9PK67
- SMR:   Q9PK67
- GeneID:   1245965
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0603
- TIGR:   TC_0603
- HOGENOM:   HBG554803
- OMA:   ETTGITS
- ProtClustDB:   PRK01222
- BioCyc:   CMUR243161:TC_0603-MONOMER
- BRENDA:   5.3.1.24
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 22234; Mature: 22234

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVKICGVTHPDDAWEAAKAGADYVGMIFAKDSQRCVTKETAKCIVEAIRDGGSEPVGVF
CEEEEECCCCCCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
SEHSIGEIIAISSATGITSIQLSGRNIDFKFSQLRELFSIFYVVSVYSNGQPSAAIPPMS
CCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
NTVTVIYDHIGGERGTPFDWRAFSPFQHDNWMLGGGVNPGNVGEAVRLLSPRGIDVSSGV
CEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHCCCCCCCCCCCC
ERPGVLRKDVTLMQALIDSAKGVGNLTS
CCCCCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKVKICGVTHPDDAWEAAKAGADYVGMIFAKDSQRCVTKETAKCIVEAIRDGGSEPVGVF
CEEEEECCCCCCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
SEHSIGEIIAISSATGITSIQLSGRNIDFKFSQLRELFSIFYVVSVYSNGQPSAAIPPMS
CCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
NTVTVIYDHIGGERGTPFDWRAFSPFQHDNWMLGGGVNPGNVGEAVRLLSPRGIDVSSGV
CEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHCCCCCCCCCCCC
ERPGVLRKDVTLMQALIDSAKGVGNLTS
CCCCCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935