Click here to switch to the map view.

The map label for this gene is atpB

Identifier: 15835198

GI number: 15835198

Start: 693838

End: 695154

Strand: Reverse

Name: atpB

Synonym: TC0581

Alternate gene names: 15835198

Gene position: 695154-693838 (Counterclockwise)

Preceding gene: 15835199

Following gene: 15835197

Centisome position: 64.79

GC content: 39.79

Gene sequence:

>1317_bases
ATGCAAACAATATATACAAGAATTACGGATATCAAGGGGAACTTGATTACTGTAGAGGCCGAAGGAGCCTCTTTAGGTGA
ATTAGTGCAGATTGAGCGAGCTGATGGGCGCTCGTCTTATGCTTCTGTTTTGCGTTTCGATGCGAAGAAAGTGACTCTAC
AAGTGTTTGGAGGCACTTCTGGATTGTCGACAGGAGACAAAGTAGTCTTTTTGGGAAGACCTATGGAGGTTGTATACGGG
GATTCTCTATTAGGAAGACGTTTCAATGGTACAGGGAAACCTATTGACAATGAAGAGATTTGTTTTGGAGAGCCGATACC
TATTACAACTCCTTCTTTTAATCCTGTTTGTCGGATTGTTCCAAGAGAAATGGTACGCACGAACATACCAATGATTGATA
TGTTCAATTGTTTAGTGAAGTCCCAAAAGATTCCTATTTTTTCTTCTTCAGGAGAAAATCATAACGCATTGTTAATGCGT
ATTGCCGCTCAAACAGATGCAGATATTGTAATCATTGGAGGGATGGGATTAACGTTTGTTGATTACAGCTTTTTTGTCGA
AGAATCTCAACGTTTAGGATTCGCTGATAAATGCGTTATGTTCATTCATAAAGCTGTAGATGCCCCAGTTGAATGTGTGT
TAATTCCTGATATGGCTTTAGCTTGTGCTGAGCGTTTTGCTTTAGAGCAAAAGAAAAATGTTCTGGTTTTGTTAACAGAT
ATGACAGCTTTTGCTGATGCCTTGAAAGAGATCGCTATCACAATGGATCAAATTCCAGCAAACAGGGGGTATCCAGGATC
TTTGTATTCTGATCTTGCTGTACGTTATGAGAAAGCTGTAGATATAGCGCAAGGTGGATCCATTACTTTGATTAGTGTGA
CTACGATGCCAGGGGATGATATCACGCACCCAGTTCCTGATAATACAGGCTTCATTACAGAAGGACAGTTTTATCTGAAA
GATAATCGAATAGATCCTTTTGGGTCGTTATCTCGGTTGAAACAACTAGTCATTGGTAAAAGGACTCGAGAAGATCATGG
GGATTTAGCAAATGCGCTGATTCGTCTTTACGCGGACTCTAGAAAGTCTGCAGAACGGATGTCCATGGGTTTCAAACTTT
CCAATTGGGATAAAAAATTATTAGCTTTTGCAGAGCTGTTTGAGACGCGATTAATGAGTCTGGAGGTGAATATTCCTCTT
GAAGAAGCTTTAGATATCGGATGGAAAATTTTGGCACAAAGTTTTCATTCTGAGGAAGTTGGAATTAAAGAGCAGTTGAT
TCAGAAATATTGGCCGAAAGCATGTCTTCACAAATAA

Upstream 100 bases:

>100_bases
AAACGCTGAATGGTCAAAAATTCCTTTCTGAAGACTATCAGAAGGGGCTAGAAGTGATCTATAAACTATTAGAAAGCAAA
ATGGTGCAGACGGCGTAGGT

Downstream 100 bases:

>100_bases
AATTAACGAAAAATTCTTATCGAGCTGAGAAACAAAAGCTTAATCTATTGGGGATGTATCTTCCTACATTGAAGTTGAAG
AAGGCTTTATTGCAGGCTGA

Product: V-type ATP synthase subunit B

Products: ADP; phosphate; H+

Alternate protein names: V-ATPase subunit B [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MQTIYTRITDIKGNLITVEAEGASLGELVQIERADGRSSYASVLRFDAKKVTLQVFGGTSGLSTGDKVVFLGRPMEVVYG
DSLLGRRFNGTGKPIDNEEICFGEPIPITTPSFNPVCRIVPREMVRTNIPMIDMFNCLVKSQKIPIFSSSGENHNALLMR
IAAQTDADIVIIGGMGLTFVDYSFFVEESQRLGFADKCVMFIHKAVDAPVECVLIPDMALACAERFALEQKKNVLVLLTD
MTAFADALKEIAITMDQIPANRGYPGSLYSDLAVRYEKAVDIAQGGSITLISVTTMPGDDITHPVPDNTGFITEGQFYLK
DNRIDPFGSLSRLKQLVIGKRTREDHGDLANALIRLYADSRKSAERMSMGFKLSNWDKKLLAFAELFETRLMSLEVNIPL
EEALDIGWKILAQSFHSEEVGIKEQLIQKYWPKACLHK

Sequences:

>Translated_438_residues
MQTIYTRITDIKGNLITVEAEGASLGELVQIERADGRSSYASVLRFDAKKVTLQVFGGTSGLSTGDKVVFLGRPMEVVYG
DSLLGRRFNGTGKPIDNEEICFGEPIPITTPSFNPVCRIVPREMVRTNIPMIDMFNCLVKSQKIPIFSSSGENHNALLMR
IAAQTDADIVIIGGMGLTFVDYSFFVEESQRLGFADKCVMFIHKAVDAPVECVLIPDMALACAERFALEQKKNVLVLLTD
MTAFADALKEIAITMDQIPANRGYPGSLYSDLAVRYEKAVDIAQGGSITLISVTTMPGDDITHPVPDNTGFITEGQFYLK
DNRIDPFGSLSRLKQLVIGKRTREDHGDLANALIRLYADSRKSAERMSMGFKLSNWDKKLLAFAELFETRLMSLEVNIPL
EEALDIGWKILAQSFHSEEVGIKEQLIQKYWPKACLHK
>Mature_438_residues
MQTIYTRITDIKGNLITVEAEGASLGELVQIERADGRSSYASVLRFDAKKVTLQVFGGTSGLSTGDKVVFLGRPMEVVYG
DSLLGRRFNGTGKPIDNEEICFGEPIPITTPSFNPVCRIVPREMVRTNIPMIDMFNCLVKSQKIPIFSSSGENHNALLMR
IAAQTDADIVIIGGMGLTFVDYSFFVEESQRLGFADKCVMFIHKAVDAPVECVLIPDMALACAERFALEQKKNVLVLLTD
MTAFADALKEIAITMDQIPANRGYPGSLYSDLAVRYEKAVDIAQGGSITLISVTTMPGDDITHPVPDNTGFITEGQFYLK
DNRIDPFGSLSRLKQLVIGKRTREDHGDLANALIRLYADSRKSAERMSMGFKLSNWDKKLLAFAELFETRLMSLEVNIPL
EEALDIGWKILAQSFHSEEVGIKEQLIQKYWPKACLHK

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit [H]

COG id: COG1156

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit B

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI19913426, Length=438, Percent_Identity=36.3013698630137, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI19913428, Length=461, Percent_Identity=35.1409978308026, Blast_Score=254, Evalue=9e-68,
Organism=Homo sapiens, GI32189394, Length=399, Percent_Identity=24.3107769423559, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1788251, Length=333, Percent_Identity=26.4264264264264, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1790170, Length=347, Percent_Identity=25.3602305475504, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790172, Length=346, Percent_Identity=23.6994219653179, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17570191, Length=462, Percent_Identity=36.7965367965368, Blast_Score=261, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI17510931, Length=459, Percent_Identity=35.7298474945534, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI25144756, Length=330, Percent_Identity=24.8484848484848, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71988080, Length=293, Percent_Identity=25.2559726962457, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71988063, Length=293, Percent_Identity=25.2559726962457, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319603, Length=438, Percent_Identity=35.1598173515982, Blast_Score=253, Evalue=6e-68,
Organism=Saccharomyces cerevisiae, GI6322581, Length=371, Percent_Identity=23.989218328841, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI281361666, Length=466, Percent_Identity=35.4077253218884, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24646341, Length=466, Percent_Identity=35.4077253218884, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI17136796, Length=466, Percent_Identity=35.4077253218884, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24638766, Length=411, Percent_Identity=24.330900243309, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28574560, Length=321, Percent_Identity=26.4797507788162, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24658560, Length=296, Percent_Identity=25.6756756756757, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: 10-20 (rich media) [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000194
- InterPro:   IPR004100
- InterPro:   IPR022879 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF02874 ATP-synt_ab_N [H]

EC number: 3.6.3.14

Molecular weight: Translated: 48595; Mature: 48595

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTIYTRITDIKGNLITVEAEGASLGELVQIERADGRSSYASVLRFDAKKVTLQVFGGTS
CCCCEEEHEECCCCEEEEEECCCCCCCEEEEECCCCCHHHHHHHHCCCEEEEEEEECCCC
GLSTGDKVVFLGRPMEVVYGDSLLGRRFNGTGKPIDNEEICFGEPIPITTPSFNPVCRIV
CCCCCCEEEEECCCEEEEECCHHHCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCHHHHC
PREMVRTNIPMIDMFNCLVKSQKIPIFSSSGENHNALLMRIAAQTDADIVIIGGMGLTFV
CHHHHHCCCCHHHHHHHHHHCCCCCEEECCCCCCCEEEEEEEECCCCCEEEECCCCCCHH
DYSFFVEESQRLGFADKCVMFIHKAVDAPVECVLIPDMALACAERFALEQKKNVLVLLTD
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHCCCCEEEEEEC
MTAFADALKEIAITMDQIPANRGYPGSLYSDLAVRYEKAVDIAQGGSITLISVTTMPGDD
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCC
ITHPVPDNTGFITEGQFYLKDNRIDPFGSLSRLKQLVIGKRTREDHGDLANALIRLYADS
CCCCCCCCCCEEECCEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHC
RKSAERMSMGFKLSNWDKKLLAFAELFETRLMSLEVNIPLEEALDIGWKILAQSFHSEEV
HHHHHHHHCCCEECCHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHCCCCC
GIKEQLIQKYWPKACLHK
CHHHHHHHHHCCHHHCCC
>Mature Secondary Structure
MQTIYTRITDIKGNLITVEAEGASLGELVQIERADGRSSYASVLRFDAKKVTLQVFGGTS
CCCCEEEHEECCCCEEEEEECCCCCCCEEEEECCCCCHHHHHHHHCCCEEEEEEEECCCC
GLSTGDKVVFLGRPMEVVYGDSLLGRRFNGTGKPIDNEEICFGEPIPITTPSFNPVCRIV
CCCCCCEEEEECCCEEEEECCHHHCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCHHHHC
PREMVRTNIPMIDMFNCLVKSQKIPIFSSSGENHNALLMRIAAQTDADIVIIGGMGLTFV
CHHHHHCCCCHHHHHHHHHHCCCCCEEECCCCCCCEEEEEEEECCCCCEEEECCCCCCHH
DYSFFVEESQRLGFADKCVMFIHKAVDAPVECVLIPDMALACAERFALEQKKNVLVLLTD
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHCCCCEEEEEEC
MTAFADALKEIAITMDQIPANRGYPGSLYSDLAVRYEKAVDIAQGGSITLISVTTMPGDD
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCC
ITHPVPDNTGFITEGQFYLKDNRIDPFGSLSRLKQLVIGKRTREDHGDLANALIRLYADS
CCCCCCCCCCEEECCEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHC
RKSAERMSMGFKLSNWDKKLLAFAELFETRLMSLEVNIPLEEALDIGWKILAQSFHSEEV
HHHHHHHHCCCEECCHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHCCCCC
GIKEQLIQKYWPKACLHK
CHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Borate; Diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines various reactions catalyzed by ATPase, analogs; Oligomycin; Quercetin; Trialkyl tinderivatives; Venturicidin [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA