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The map label for this gene is rnc

Identifier: 15835187

GI number: 15835187

Start: 680743

End: 681441

Strand: Direct

Name: rnc

Synonym: TC0570

Alternate gene names: 15835187

Gene position: 680743-681441 (Clockwise)

Preceding gene: 15835178

Following gene: 15835188

Centisome position: 63.45

GC content: 42.2

Gene sequence:

>699_bases
ATGCAGCGTACCGTAAATATTCAGGCCGTAGAGTCTAAATTAAAATTTACATTTTCTCAGCCACGGCTTCTCGTCACAGC
TCTTACCCATCCCTCGTATCGGAATGAGTTTCCTTCTGACGGGGAAGATAGTGAGCGTTTAGAATTTCTTGGGGATGCTG
TCTTAGGATTAGTCGTCACTGAACACCTTTTCCTCCTCTTCCCCTCTTTGAATGAAGGGCTTTTGTCAACAACAAGATCA
GCTTTGGTGAATGCTGAAGCATGTTTTAACTATACGCAAAAATTATCTCTGGGCGAACACCTCTTGATCGGTCGCGGTGA
AAAAATGCAAAGTCATCGAGGAAAAATTTCTGCCTATGCCAACCTATTCGAGGCCATTTTAGGCGCTGTGTACTTAGATG
GTGGACTAGCTCCCGCAAGACAAATTATCGTTCCTTTACTTCCCAATAAAGAGGCTATACTACCTCTAATGCTAGTTAAT
CCTAAAAATCGCTTACAACAATTCACTCAGCAGACATTAAAGGTTCTTCCTACATATATCGCTCTTCCTTGGTCATCCGA
AGATGGCACTCCTGGATACCATGTACAAGTCTTCGTTAATGAAAAACTTTGGGGAGAGGGCTTTGCTGGATCAAAAAAGG
AAGCAGAAAAACTTGCAGCTAAACAGGCGTTATCAACACATGACGACAACAAAAATTAA

Upstream 100 bases:

>100_bases
ATTTAAGCGACCAAACTCGAAAGTACTATAGACTTTAAGAGTATTTCCGCCTATAAAAACCCGGTTGACATTTTAGATTT
TGTATTCTTAAAAAATAGTT

Downstream 100 bases:

>100_bases
AACACAATGGGCATGTTCAGAATGCGGCTCCTATTCTCCAAAATGGTTAGGACAATGCCCTGGATGCTTTCAATGGAATA
CTTTAGTTGAAGAAATACAT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MQRTVNIQAVESKLKFTFSQPRLLVTALTHPSYRNEFPSDGEDSERLEFLGDAVLGLVVTEHLFLLFPSLNEGLLSTTRS
ALVNAEACFNYTQKLSLGEHLLIGRGEKMQSHRGKISAYANLFEAILGAVYLDGGLAPARQIIVPLLPNKEAILPLMLVN
PKNRLQQFTQQTLKVLPTYIALPWSSEDGTPGYHVQVFVNEKLWGEGFAGSKKEAEKLAAKQALSTHDDNKN

Sequences:

>Translated_232_residues
MQRTVNIQAVESKLKFTFSQPRLLVTALTHPSYRNEFPSDGEDSERLEFLGDAVLGLVVTEHLFLLFPSLNEGLLSTTRS
ALVNAEACFNYTQKLSLGEHLLIGRGEKMQSHRGKISAYANLFEAILGAVYLDGGLAPARQIIVPLLPNKEAILPLMLVN
PKNRLQQFTQQTLKVLPTYIALPWSSEDGTPGYHVQVFVNEKLWGEGFAGSKKEAEKLAAKQALSTHDDNKN
>Mature_232_residues
MQRTVNIQAVESKLKFTFSQPRLLVTALTHPSYRNEFPSDGEDSERLEFLGDAVLGLVVTEHLFLLFPSLNEGLLSTTRS
ALVNAEACFNYTQKLSLGEHLLIGRGEKMQSHRGKISAYANLFEAILGAVYLDGGLAPARQIIVPLLPNKEAILPLMLVN
PKNRLQQFTQQTLKVLPTYIALPWSSEDGTPGYHVQVFVNEKLWGEGFAGSKKEAEKLAAKQALSTHDDNKN

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030236, Length=129, Percent_Identity=41.0852713178295, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI155030234, Length=129, Percent_Identity=41.0852713178295, Blast_Score=89, Evalue=3e-18,
Organism=Escherichia coli, GI1788920, Length=213, Percent_Identity=31.924882629108, Blast_Score=92, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17506883, Length=111, Percent_Identity=36.9369369369369, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193202651, Length=111, Percent_Identity=36.9369369369369, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17137682, Length=231, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_CHLMU (Q9PK97)

Other databases:

- EMBL:   AE002160
- PIR:   C81688
- RefSeq:   NP_296946.1
- ProteinModelPortal:   Q9PK97
- SMR:   Q9PK97
- GeneID:   1245929
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0570
- TIGR:   TC_0570
- HOGENOM:   HBG744556
- OMA:   RTESEIS
- ProtClustDB:   PRK00102
- BioCyc:   CMUR243161:TC_0570-MONOMER
- BRENDA:   3.1.26.3
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 25719; Mature: 25719

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRTVNIQAVESKLKFTFSQPRLLVTALTHPSYRNEFPSDGEDSERLEFLGDAVLGLVVT
CCCEEEHHHHHHHHHEEECCCEEEEEEECCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
EHLFLLFPSLNEGLLSTTRSALVNAEACFNYTQKLSLGEHLLIGRGEKMQSHRGKISAYA
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCHHHHHH
NLFEAILGAVYLDGGLAPARQIIVPLLPNKEAILPLMLVNPKNRLQQFTQQTLKVLPTYI
HHHHHHHHHHHHCCCCCCHHHEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHE
ALPWSSEDGTPGYHVQVFVNEKLWGEGFAGSKKEAEKLAAKQALSTHDDNKN
EEEECCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQRTVNIQAVESKLKFTFSQPRLLVTALTHPSYRNEFPSDGEDSERLEFLGDAVLGLVVT
CCCEEEHHHHHHHHHEEECCCEEEEEEECCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
EHLFLLFPSLNEGLLSTTRSALVNAEACFNYTQKLSLGEHLLIGRGEKMQSHRGKISAYA
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCHHHHHH
NLFEAILGAVYLDGGLAPARQIIVPLLPNKEAILPLMLVNPKNRLQQFTQQTLKVLPTYI
HHHHHHHHHHHHCCCCCCHHHEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHE
ALPWSSEDGTPGYHVQVFVNEKLWGEGFAGSKKEAEKLAAKQALSTHDDNKN
EEEECCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935