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Identifier: 15835160

GI number: 15835160

Start: 651954

End: 653924

Strand: Reverse

Name: Not Available

Synonym: TC0542

Alternate gene names: 15835160

Gene position: 653924-651954 (Counterclockwise)

Preceding gene: 15835161

Following gene: 15835158

Centisome position: 60.95

GC content: 40.44

Gene sequence:

>1971_bases
GTGAGGAGAAAATCAGCGTTTTATCTTATGAATTACCGTAGACAATTAACTCTAATCGTTGTTGGGGTTTTGTCTCTATA
CGCACTTTTAATAGTTCGTTATTACAAAATTCAAATTTGTGATGGAGAGCGTTGGGCTATGGAGGCGGCAAATCAACATG
AATTTCGTGTTGAGGACCCTTTTCAAAGGGGAACTTTTTTTGCTAATACAAGTTTGCGTAAAGGCGAAAAAGAGCAGTTT
CAACCGCTAGCCATTGATGTTACTAAGTTTCATTTGTGTTTGGATGCGGTTGTTGTCCCTGAAGAATACCGTGATGAGAT
CGCTCATATGGTTGTCGTCATGGTAGGAGAAGGAGATTATCAAAGTATCCGTAATGAGTTTGATAGGAAATCGCGTTACC
GTAAGCTATATGTTTCTTTAGACTCTTCCATCAGAGATCGTATTTTATCTTGGTGGAAGCCATTCGCTATCAAGCATAAA
ATCCCTACTAACGCGCTATTTTTTATTAGTGACTACCAGCGTTCTTATCCTTTTGGACAGCTATTGGGACAAGTTTTACA
TACTCTCCGAGAAGTGAAAGATGAAAAATCAGGCGAAGCTTTCCCTACAGGAGGATTGGAAGCTTATTTTAATCATCTGT
TGAAAGGAGAAAACGGTGAGCGTAAGCTATTGCGATCTCCTTTAAACCGTTTGGATGTCGATAAAGTAACAAAAATTCCT
AGAGATGGGAGTGATGTTTATTTAACAATAGATGCCAACATTCAAACAATTGCAGAACAAGAAATAGCTATAGGAGTATT
AGAGGCAAAGGCTCGCAGTGGGCGAGTTGTTGTGCTTAATTCACATACGGGAGAGATTCTTGCTTTAGCACAGTATCCTT
TCTTTAATCCAGTAGGGTATCGAGAGTTTTTTAATTGTGAGGACCGGATAGAAGATACCAAGGTCAAAGCAGTTAGTGAT
GTTTTTGAGCCTGGGTCTATTATGAAGCCGCTGACTATCGCTATTGCCTTATTGGCAAATGAAGAGTCGCAAAAACGTTA
TGGAGAAGTTCTTTTTGATCCTTATGCGCCGATAGATGTTAGCCGACGTTTGTTTCCTGGGCGTCAAAAAATGCCTCTCC
GAGACATTGTGAATAATCGATACTTAAATATGTACATGGCGATTCAAAAATCTTCCAATGTATATATGGCTCAACTTGCA
GATCGTATTGTGCAAAAGTTGGGGGCAGATTGGTATGAGCAGCGTTTACAGGATTTTGGTTTTGGAAAGAAAACCGGGAT
AGAATTGCCTGCAGAGGCTGTAGGTTTGGTTCCTTCAAGAAAGCGTTTTCATAGAAATGGGTCCCCAGAGTGGTCTTTAT
CAACTCCGTATTCTTTAGCTATGGGCTATAATTTATTGGCTACAAGTATGCAAATGGTGCAAGCATATGCGGTTTTTGGT
AATGGCGGGTTTTTAGTGCGTCCCACATTAGTAAAAAGAGTTGTTTCTCCTTCTGGAGAAGAAATAATCTTTTCCGAAAA
GCCGGAAAAAATTCGTTTGCTTTCTGAAACAATTGTTTCAGATGTTGTGCGTGCCATGCGCTTTACAACTTGTTTAGGAG
GGACAGGATTTCGTGCAGCTCCTAAAGGCTATTCTAGTGCTGGGAAAACAGGTACAACTGAAAAGCTTGTTAATGGGCGA
TATGATAAGAAACGGCATATCGCCTCATTCATCGGACTTGCGCCTATAACTGCTTTGTCGGAAACAGCTGTTCCTTTGGT
GATTCTTGTTTCTATTGATGATCCTGCCCACGGGGTAAGAGAAGATGGTACTAAAAATTACATGGGCGGGCGATGTGCTG
CCCCAGTTTTTTCTAGAATAGCGTCTCGAATATTGCCGTATCTAGGTGTGCCGGAAGATCAACAACAAAACGATTGGAAA
GAAGAAATTACTCAGTTGAAAATTTTGTATAACGATTGGAATGGCAAATAG

Upstream 100 bases:

>100_bases
GAGAATGTTGCACTCAGTTTCCTGCTGGAGAAACTAGAAAGCCCTGAACACTTGTTACAGATAGCTTCTCTTCCGGAGTA
CCAGTATCTAGAGTATCCTA

Downstream 100 bases:

>100_bases
TAATTTATTTCGATGAAAGAGAATGTGTTAAAGCTTGTTGTTGAGGAATGAGCGTGCATCCTGGAATGAGTAATACTGGA
GAAGAGAAGAGCAACACAGA

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 656; Mature: 656

Protein sequence:

>656_residues
MRRKSAFYLMNYRRQLTLIVVGVLSLYALLIVRYYKIQICDGERWAMEAANQHEFRVEDPFQRGTFFANTSLRKGEKEQF
QPLAIDVTKFHLCLDAVVVPEEYRDEIAHMVVVMVGEGDYQSIRNEFDRKSRYRKLYVSLDSSIRDRILSWWKPFAIKHK
IPTNALFFISDYQRSYPFGQLLGQVLHTLREVKDEKSGEAFPTGGLEAYFNHLLKGENGERKLLRSPLNRLDVDKVTKIP
RDGSDVYLTIDANIQTIAEQEIAIGVLEAKARSGRVVVLNSHTGEILALAQYPFFNPVGYREFFNCEDRIEDTKVKAVSD
VFEPGSIMKPLTIAIALLANEESQKRYGEVLFDPYAPIDVSRRLFPGRQKMPLRDIVNNRYLNMYMAIQKSSNVYMAQLA
DRIVQKLGADWYEQRLQDFGFGKKTGIELPAEAVGLVPSRKRFHRNGSPEWSLSTPYSLAMGYNLLATSMQMVQAYAVFG
NGGFLVRPTLVKRVVSPSGEEIIFSEKPEKIRLLSETIVSDVVRAMRFTTCLGGTGFRAAPKGYSSAGKTGTTEKLVNGR
YDKKRHIASFIGLAPITALSETAVPLVILVSIDDPAHGVREDGTKNYMGGRCAAPVFSRIASRILPYLGVPEDQQQNDWK
EEITQLKILYNDWNGK

Sequences:

>Translated_656_residues
MRRKSAFYLMNYRRQLTLIVVGVLSLYALLIVRYYKIQICDGERWAMEAANQHEFRVEDPFQRGTFFANTSLRKGEKEQF
QPLAIDVTKFHLCLDAVVVPEEYRDEIAHMVVVMVGEGDYQSIRNEFDRKSRYRKLYVSLDSSIRDRILSWWKPFAIKHK
IPTNALFFISDYQRSYPFGQLLGQVLHTLREVKDEKSGEAFPTGGLEAYFNHLLKGENGERKLLRSPLNRLDVDKVTKIP
RDGSDVYLTIDANIQTIAEQEIAIGVLEAKARSGRVVVLNSHTGEILALAQYPFFNPVGYREFFNCEDRIEDTKVKAVSD
VFEPGSIMKPLTIAIALLANEESQKRYGEVLFDPYAPIDVSRRLFPGRQKMPLRDIVNNRYLNMYMAIQKSSNVYMAQLA
DRIVQKLGADWYEQRLQDFGFGKKTGIELPAEAVGLVPSRKRFHRNGSPEWSLSTPYSLAMGYNLLATSMQMVQAYAVFG
NGGFLVRPTLVKRVVSPSGEEIIFSEKPEKIRLLSETIVSDVVRAMRFTTCLGGTGFRAAPKGYSSAGKTGTTEKLVNGR
YDKKRHIASFIGLAPITALSETAVPLVILVSIDDPAHGVREDGTKNYMGGRCAAPVFSRIASRILPYLGVPEDQQQNDWK
EEITQLKILYNDWNGK
>Mature_656_residues
MRRKSAFYLMNYRRQLTLIVVGVLSLYALLIVRYYKIQICDGERWAMEAANQHEFRVEDPFQRGTFFANTSLRKGEKEQF
QPLAIDVTKFHLCLDAVVVPEEYRDEIAHMVVVMVGEGDYQSIRNEFDRKSRYRKLYVSLDSSIRDRILSWWKPFAIKHK
IPTNALFFISDYQRSYPFGQLLGQVLHTLREVKDEKSGEAFPTGGLEAYFNHLLKGENGERKLLRSPLNRLDVDKVTKIP
RDGSDVYLTIDANIQTIAEQEIAIGVLEAKARSGRVVVLNSHTGEILALAQYPFFNPVGYREFFNCEDRIEDTKVKAVSD
VFEPGSIMKPLTIAIALLANEESQKRYGEVLFDPYAPIDVSRRLFPGRQKMPLRDIVNNRYLNMYMAIQKSSNVYMAQLA
DRIVQKLGADWYEQRLQDFGFGKKTGIELPAEAVGLVPSRKRFHRNGSPEWSLSTPYSLAMGYNLLATSMQMVQAYAVFG
NGGFLVRPTLVKRVVSPSGEEIIFSEKPEKIRLLSETIVSDVVRAMRFTTCLGGTGFRAAPKGYSSAGKTGTTEKLVNGR
YDKKRHIASFIGLAPITALSETAVPLVILVSIDDPAHGVREDGTKNYMGGRCAAPVFSRIASRILPYLGVPEDQQQNDWK
EEITQLKILYNDWNGK

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=526, Percent_Identity=29.0874524714829, Blast_Score=156, Evalue=4e-39,
Organism=Escherichia coli, GI1786854, Length=505, Percent_Identity=23.3663366336634, Blast_Score=90, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 74447; Mature: 74447

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRKSAFYLMNYRRQLTLIVVGVLSLYALLIVRYYKIQICDGERWAMEAANQHEFRVEDP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHCCCCCCEECCCC
FQRGTFFANTSLRKGEKEQFQPLAIDVTKFHLCLDAVVVPEEYRDEIAHMVVVMVGEGDY
HHCCCEEECCCCCCCCHHHCCCEEEEHHHHHHHHHHHCCCHHHHHHHHHEEEEEECCCCH
QSIRNEFDRKSRYRKLYVSLDSSIRDRILSWWKPFAIKHKIPTNALFFISDYQRSYPFGQ
HHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHCCCEEEECCCCCEEEEEECCCCCCCHHH
LLGQVLHTLREVKDEKSGEAFPTGGLEAYFNHLLKGENGERKLLRSPLNRLDVDKVTKIP
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHCCC
RDGSDVYLTIDANIQTIAEQEIAIGVLEAKARSGRVVVLNSHTGEILALAQYPFFNPVGY
CCCCEEEEEEECCHHHHHHHHHHEEEEECCCCCCCEEEEECCCCCEEEEECCCCCCCCCH
REFFNCEDRIEDTKVKAVSDVFEPGSIMKPLTIAIALLANEESQKRYGEVLFDPYAPIDV
HHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHCCEEECCCCCCCC
SRRLFPGRQKMPLRDIVNNRYLNMYMAIQKSSNVYMAQLADRIVQKLGADWYEQRLQDFG
HHHCCCCCCCCCHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHCC
FGKKTGIELPAEAVGLVPSRKRFHRNGSPEWSLSTPYSLAMGYNLLATSMQMVQAYAVFG
CCCCCCCCCCHHHHCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEC
NGGFLVRPTLVKRVVSPSGEEIIFSEKPEKIRLLSETIVSDVVRAMRFTTCLGGTGFRAA
CCCEEECHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PKGYSSAGKTGTTEKLVNGRYDKKRHIASFIGLAPITALSETAVPLVILVSIDDPAHGVR
CCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCC
EDGTKNYMGGRCAAPVFSRIASRILPYLGVPEDQQQNDWKEEITQLKILYNDWNGK
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHEEEEEECCCCC
>Mature Secondary Structure
MRRKSAFYLMNYRRQLTLIVVGVLSLYALLIVRYYKIQICDGERWAMEAANQHEFRVEDP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHCCCCCCEECCCC
FQRGTFFANTSLRKGEKEQFQPLAIDVTKFHLCLDAVVVPEEYRDEIAHMVVVMVGEGDY
HHCCCEEECCCCCCCCHHHCCCEEEEHHHHHHHHHHHCCCHHHHHHHHHEEEEEECCCCH
QSIRNEFDRKSRYRKLYVSLDSSIRDRILSWWKPFAIKHKIPTNALFFISDYQRSYPFGQ
HHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHCCCEEEECCCCCEEEEEECCCCCCCHHH
LLGQVLHTLREVKDEKSGEAFPTGGLEAYFNHLLKGENGERKLLRSPLNRLDVDKVTKIP
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHCCC
RDGSDVYLTIDANIQTIAEQEIAIGVLEAKARSGRVVVLNSHTGEILALAQYPFFNPVGY
CCCCEEEEEEECCHHHHHHHHHHEEEEECCCCCCCEEEEECCCCCEEEEECCCCCCCCCH
REFFNCEDRIEDTKVKAVSDVFEPGSIMKPLTIAIALLANEESQKRYGEVLFDPYAPIDV
HHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHCCEEECCCCCCCC
SRRLFPGRQKMPLRDIVNNRYLNMYMAIQKSSNVYMAQLADRIVQKLGADWYEQRLQDFG
HHHCCCCCCCCCHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHCC
FGKKTGIELPAEAVGLVPSRKRFHRNGSPEWSLSTPYSLAMGYNLLATSMQMVQAYAVFG
CCCCCCCCCCHHHHCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEC
NGGFLVRPTLVKRVVSPSGEEIIFSEKPEKIRLLSETIVSDVVRAMRFTTCLGGTGFRAA
CCCEEECHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PKGYSSAGKTGTTEKLVNGRYDKKRHIASFIGLAPITALSETAVPLVILVSIDDPAHGVR
CCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCC
EDGTKNYMGGRCAAPVFSRIASRILPYLGVPEDQQQNDWKEEITQLKILYNDWNGK
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]