Click here to switch to the map view.

The map label for this gene is lpxD

Identifier: 15835132

GI number: 15835132

Start: 621234

End: 622298

Strand: Direct

Name: lpxD

Synonym: TC0514

Alternate gene names: 15835132

Gene position: 621234-622298 (Clockwise)

Preceding gene: 15835131

Following gene: 15835134

Centisome position: 57.9

GC content: 42.25

Gene sequence:

>1065_bases
ATGTCTCAACCCGTTTATTCTCTTAAACAATTAGCTGATTTTTTAAATGTCGAGTTTCAAGGAAATGGAGCCACACTTCT
TTCCGGTGTTGAGGAGATAGGAGAAGCAAAAGCGGCACACGTTACTTTCTTGGACAATGAAAAATATGCTAAACATTTAA
AATCATCTGAAGCTGGCGCCATCATTCTTTCTCGAACGCAGTTTCAAAAATATCGAGAATTGAACAAAAATTTCCTTATA
GTTTCAGAATCCCCCTCCCTAGTTTTCCAAAAATGCTTAGAACTATTCATAGCTCCTGTCGACTCTGGATTTCCAGGCAT
TCATCCTACTGCAGTTATTCATCCAACAGCAATTATTGAAGAACATGTGTGTATCGAGCCTTATGTTGTGATTTGTCAAC
ATGCTCGTATTGGAGCGGCTTGTCATATTGGAACAGGAAGTGTCATCGGAGCCCATTCTTCTATTGGAGAACATTCTTAT
ATTTATCCTCGCGTTGTTGTTAGAGAAAGGGTTTCTATCGGCAAACGCGTTATCATCCAACCGGGAGCAATCATAGGGTC
TTGCGGGTTCGGTTATGTTACCAGTGCTTTTGGGCAGCACAAACATTTGAAGCACCTAGGAACAGTAATCATTGAAGATG
ATGTAGAGATCGGTGCTAACACGACTATTGATAGAGGAAGATTTAAGCATAGCATTGTACGTGAAGGCTCTAAAATTGAT
AATCTTGTACAAATCGCACATCAAGTCGAGGTTGGTCAGCACAGTATGGTAGTAGCGCAGGCTGGGATTGCAGGGTCAAC
TAAGATAGGCAACCACGTGATTATCGGCGGACAAGCTGGTGTAACAGGACATATTTGCATTGCTGATCATGTTATCATGA
TGGCGCAAACTGGTGTCACAAAATCCATTACCTCTCCAGGGATCTATGGAGGAGCTCCCGCTCGTCCATATCAAGAGGTT
CATCGTCAAGTCGCCAAAATACGCAATCTTCCTCGCCTTGAGGAGCGTATCGCATCGCTTGAAAAATTGGTACAGAAGCT
AGAAGCTCTTTCTGAACAACATTAA

Upstream 100 bases:

>100_bases
AGCTATTGATACCTCTTCAGACAAAACGGATGCTGTTATTAAAATTCTTGATGATTCTTTTCAAAATAATTAACATGCGA
AGCTAGCCTAGGAGTGCCGT

Downstream 100 bases:

>100_bases
TTTACTTGAGTTATCAGACGAAGCTTTTGCATTCACAACAAAGGACTCTTGAAAGCTCTTTTTTTTAAGAGCAAAACTTT
GATAAGCTTTTTACGAATGA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MSQPVYSLKQLADFLNVEFQGNGATLLSGVEEIGEAKAAHVTFLDNEKYAKHLKSSEAGAIILSRTQFQKYRELNKNFLI
VSESPSLVFQKCLELFIAPVDSGFPGIHPTAVIHPTAIIEEHVCIEPYVVICQHARIGAACHIGTGSVIGAHSSIGEHSY
IYPRVVVRERVSIGKRVIIQPGAIIGSCGFGYVTSAFGQHKHLKHLGTVIIEDDVEIGANTTIDRGRFKHSIVREGSKID
NLVQIAHQVEVGQHSMVVAQAGIAGSTKIGNHVIIGGQAGVTGHICIADHVIMMAQTGVTKSITSPGIYGGAPARPYQEV
HRQVAKIRNLPRLEERIASLEKLVQKLEALSEQH

Sequences:

>Translated_354_residues
MSQPVYSLKQLADFLNVEFQGNGATLLSGVEEIGEAKAAHVTFLDNEKYAKHLKSSEAGAIILSRTQFQKYRELNKNFLI
VSESPSLVFQKCLELFIAPVDSGFPGIHPTAVIHPTAIIEEHVCIEPYVVICQHARIGAACHIGTGSVIGAHSSIGEHSY
IYPRVVVRERVSIGKRVIIQPGAIIGSCGFGYVTSAFGQHKHLKHLGTVIIEDDVEIGANTTIDRGRFKHSIVREGSKID
NLVQIAHQVEVGQHSMVVAQAGIAGSTKIGNHVIIGGQAGVTGHICIADHVIMMAQTGVTKSITSPGIYGGAPARPYQEV
HRQVAKIRNLPRLEERIASLEKLVQKLEALSEQH
>Mature_353_residues
SQPVYSLKQLADFLNVEFQGNGATLLSGVEEIGEAKAAHVTFLDNEKYAKHLKSSEAGAIILSRTQFQKYRELNKNFLIV
SESPSLVFQKCLELFIAPVDSGFPGIHPTAVIHPTAIIEEHVCIEPYVVICQHARIGAACHIGTGSVIGAHSSIGEHSYI
YPRVVVRERVSIGKRVIIQPGAIIGSCGFGYVTSAFGQHKHLKHLGTVIIEDDVEIGANTTIDRGRFKHSIVREGSKIDN
LVQIAHQVEVGQHSMVVAQAGIAGSTKIGNHVIIGGQAGVTGHICIADHVIMMAQTGVTKSITSPGIYGGAPARPYQEVH
RQVAKIRNLPRLEERIASLEKLVQKLEALSEQH

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=346, Percent_Identity=33.2369942196532, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1786378, Length=267, Percent_Identity=28.8389513108614, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_CHLMU (Q9PKF1)

Other databases:

- EMBL:   AE002160
- PIR:   B81694
- RefSeq:   NP_296891.1
- ProteinModelPortal:   Q9PKF1
- SMR:   Q9PKF1
- GeneID:   1245874
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0514
- TIGR:   TC_0514
- HOGENOM:   HBG469615
- OMA:   AKIMKSA
- PhylomeDB:   Q9PKF1
- ProtClustDB:   PRK00892
- BioCyc:   CMUR243161:TC_0514-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 38326; Mature: 38194

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPVYSLKQLADFLNVEFQGNGATLLSGVEEIGEAKAAHVTFLDNEKYAKHLKSSEAGA
CCCHHHHHHHHHHHHCEEECCCCHHHHHHHHHHCCCCEEEEEEECCHHHHHHHCCCCCCE
IILSRTQFQKYRELNKNFLIVSESPSLVFQKCLELFIAPVDSGFPGIHPTAVIHPTAIIE
EEEEHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCEEECHHHHHH
EHVCIEPYVVICQHARIGAACHIGTGSVIGAHSSIGEHSYIYPRVVVRERVSIGKRVIIQ
CCCCCCCHHEEECCCCCCCEEECCCCCEEECCCCCCCCCEECHHHHHHHHHHCCCEEEEE
PGAIIGSCGFGYVTSAFGQHKHLKHLGTVIIEDDVEIGANTTIDRGRFKHSIVREGSKID
CCCEEECCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCHHH
NLVQIAHQVEVGQHSMVVAQAGIAGSTKIGNHVIIGGQAGVTGHICIADHVIMMAQTGVT
HHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEECCCCCCEEEEHHHHHHHHHHCCCCC
KSITSPGIYGGAPARPYQEVHRQVAKIRNLPRLEERIASLEKLVQKLEALSEQH
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SQPVYSLKQLADFLNVEFQGNGATLLSGVEEIGEAKAAHVTFLDNEKYAKHLKSSEAGA
CCHHHHHHHHHHHHCEEECCCCHHHHHHHHHHCCCCEEEEEEECCHHHHHHHCCCCCCE
IILSRTQFQKYRELNKNFLIVSESPSLVFQKCLELFIAPVDSGFPGIHPTAVIHPTAIIE
EEEEHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCEEECHHHHHH
EHVCIEPYVVICQHARIGAACHIGTGSVIGAHSSIGEHSYIYPRVVVRERVSIGKRVIIQ
CCCCCCCHHEEECCCCCCCEEECCCCCEEECCCCCCCCCEECHHHHHHHHHHCCCEEEEE
PGAIIGSCGFGYVTSAFGQHKHLKHLGTVIIEDDVEIGANTTIDRGRFKHSIVREGSKID
CCCEEECCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCHHH
NLVQIAHQVEVGQHSMVVAQAGIAGSTKIGNHVIIGGQAGVTGHICIADHVIMMAQTGVT
HHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEECCCCCCEEEEHHHHHHHHHHCCCCC
KSITSPGIYGGAPARPYQEVHRQVAKIRNLPRLEERIASLEKLVQKLEALSEQH
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935