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The map label for this gene is pdhA

Identifier: 15835134

GI number: 15835134

Start: 623732

End: 624754

Strand: Direct

Name: pdhA

Synonym: TC0516

Alternate gene names: 15835134

Gene position: 623732-624754 (Clockwise)

Preceding gene: 15835132

Following gene: 15835135

Centisome position: 58.13

GC content: 41.54

Gene sequence:

>1023_bases
ATGCATCCCCTGACTTATAACATAGCTTCTGAGGAGACTACAGAAGCCCAAGTTTCCTTTGTTATAGAAAACTTCGGAAA
TGATTTCTGTATTAACTTGTTAAAAAAAATGCTGCTTATTCGTGAATTTGAGATTCGCGGAGAAGAAGCTTATTTAGAAG
GACTTGTTGGGGGATTTTACCACTCCTATATTGGGCAAGAATCGGTTGCTACAGCAGCTCTCGCATGTACAGGAACAGAT
CATTGGTTTTTTTCTTCCTATCGCTGTCATGGAGTTGCTATTTTACTAGATATTCCTTTACGCCAACTAGCAGCAGAACT
ACTAGGGAAAGAAACAGGATGTGCTTTAGGACGAGGTGGATCTATGCACATGTGTGGAGATCGCCTTCCTGGAGGATTTG
GCATAGTTGGCGGACAAATTCCTTTAGCTGCTGGTGCAGCATTCTCCATGAAGTATCAAAAATTGCCCTCTATCTCTCTA
TGTTTTATTGGAGACGGAGCCGTTGCTCAAGGAGTCTTTCATGAAACATTAAATTTCGCATCTCTTCACACCCTCCCCTT
AATGCTTATTATAGAGAATAATGGGTGGGGCATGGGAACTGCTCTACACAGAGCAATTGCTAAACAACCTATAGCAGAGT
CTCAGGCCTCTTCTTACGGGTTGTCTTCCATAACTTTAAATGGTTTTGATTTATTTAATTCGCTTATAGGTTTCAAAGAA
GCCTATCAACATATGCAAAAAACAGGGGCTCCTGTTGTTGTCGAAGCTTTATGCTCTCGTTTTAGAGGACATTCTATTTC
CGATCCCAATCTGTATCGCTCTAAAGAAGAAATGCAATGTTTGCTTAAGCGAGACCCCATTCTTTTTGCAAAAGAATGGC
TTATCCGTGCTAACGTCTTATCCGAAGATGATTTTAAAGATTTACGGCAAACCAGCAAAGAGGCCGTTCTAGAAGCATTC
TCCCAAGCTCGTCTTGATCCAGAACCTGCTGTTGCCACTTTAGAAGAGGGGATCTATGCCTAA

Upstream 100 bases:

>100_bases
CAAGAGAAGCTTTTAAAAGTTTTTATTTAGACTTGATTCAAATAGAATTTTTTAAAATCTATTCTAAAATTTTTTAGAAA
CCTTTTATCCAAGAGAATCT

Downstream 100 bases:

>100_bases
TTTTGTTACTCTCGAAATTCGAGAAGCCATAAGACAAGCTATTGATGAGGAAATGACTAGGGATCCTAATGTATGCATTT
TAGGAGAAGAAGTCGCTGAA

Product: pyruvate dehydrogenase, E1 component, alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MHPLTYNIASEETTEAQVSFVIENFGNDFCINLLKKMLLIREFEIRGEEAYLEGLVGGFYHSYIGQESVATAALACTGTD
HWFFSSYRCHGVAILLDIPLRQLAAELLGKETGCALGRGGSMHMCGDRLPGGFGIVGGQIPLAAGAAFSMKYQKLPSISL
CFIGDGAVAQGVFHETLNFASLHTLPLMLIIENNGWGMGTALHRAIAKQPIAESQASSYGLSSITLNGFDLFNSLIGFKE
AYQHMQKTGAPVVVEALCSRFRGHSISDPNLYRSKEEMQCLLKRDPILFAKEWLIRANVLSEDDFKDLRQTSKEAVLEAF
SQARLDPEPAVATLEEGIYA

Sequences:

>Translated_340_residues
MHPLTYNIASEETTEAQVSFVIENFGNDFCINLLKKMLLIREFEIRGEEAYLEGLVGGFYHSYIGQESVATAALACTGTD
HWFFSSYRCHGVAILLDIPLRQLAAELLGKETGCALGRGGSMHMCGDRLPGGFGIVGGQIPLAAGAAFSMKYQKLPSISL
CFIGDGAVAQGVFHETLNFASLHTLPLMLIIENNGWGMGTALHRAIAKQPIAESQASSYGLSSITLNGFDLFNSLIGFKE
AYQHMQKTGAPVVVEALCSRFRGHSISDPNLYRSKEEMQCLLKRDPILFAKEWLIRANVLSEDDFKDLRQTSKEAVLEAF
SQARLDPEPAVATLEEGIYA
>Mature_340_residues
MHPLTYNIASEETTEAQVSFVIENFGNDFCINLLKKMLLIREFEIRGEEAYLEGLVGGFYHSYIGQESVATAALACTGTD
HWFFSSYRCHGVAILLDIPLRQLAAELLGKETGCALGRGGSMHMCGDRLPGGFGIVGGQIPLAAGAAFSMKYQKLPSISL
CFIGDGAVAQGVFHETLNFASLHTLPLMLIIENNGWGMGTALHRAIAKQPIAESQASSYGLSSITLNGFDLFNSLIGFKE
AYQHMQKTGAPVVVEALCSRFRGHSISDPNLYRSKEEMQCLLKRDPILFAKEWLIRANVLSEDDFKDLRQTSKEAVLEAF
SQARLDPEPAVATLEEGIYA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=312, Percent_Identity=34.2948717948718, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI4505685, Length=313, Percent_Identity=34.185303514377, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI291084742, Length=313, Percent_Identity=34.185303514377, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI291084744, Length=320, Percent_Identity=33.4375, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI291084757, Length=313, Percent_Identity=30.3514376996805, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI11386135, Length=314, Percent_Identity=28.9808917197452, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI258645172, Length=314, Percent_Identity=28.9808917197452, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17536047, Length=310, Percent_Identity=35.1612903225806, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI32564172, Length=310, Percent_Identity=35.1612903225806, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI86563357, Length=322, Percent_Identity=26.0869565217391, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI86563355, Length=322, Percent_Identity=26.0869565217391, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6321026, Length=313, Percent_Identity=33.2268370607029, Blast_Score=169, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24639748, Length=312, Percent_Identity=35.8974358974359, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24639744, Length=348, Percent_Identity=33.6206896551724, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI28571106, Length=348, Percent_Identity=33.6206896551724, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24639740, Length=348, Percent_Identity=33.6206896551724, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24639746, Length=306, Percent_Identity=35.9477124183007, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI21355903, Length=338, Percent_Identity=26.0355029585799, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 37211; Mature: 37211

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPLTYNIASEETTEAQVSFVIENFGNDFCINLLKKMLLIREFEIRGEEAYLEGLVGGFY
CCCEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
HSYIGQESVATAALACTGTDHWFFSSYRCHGVAILLDIPLRQLAAELLGKETGCALGRGG
HHHHCHHHHHHHHEEECCCCCHHCCCCCCCCEEEEEECCHHHHHHHHHCCCCCCCCCCCC
SMHMCGDRLPGGFGIVGGQIPLAAGAAFSMKYQKLPSISLCFIGDGAVAQGVFHETLNFA
CCCCCCCCCCCCCEEECCCCCHHCCCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHH
SLHTLPLMLIIENNGWGMGTALHRAIAKQPIAESQASSYGLSSITLNGFDLFNSLIGFKE
HHCCCEEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHCCCCEEEECHHHHHHHHHHHHH
AYQHMQKTGAPVVVEALCSRFRGHSISDPNLYRSKEEMQCLLKRDPILFAKEWLIRANVL
HHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHCCCCHHHHHHHHHHHCC
SEDDFKDLRQTSKEAVLEAFSQARLDPEPAVATLEEGIYA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCC
>Mature Secondary Structure
MHPLTYNIASEETTEAQVSFVIENFGNDFCINLLKKMLLIREFEIRGEEAYLEGLVGGFY
CCCEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
HSYIGQESVATAALACTGTDHWFFSSYRCHGVAILLDIPLRQLAAELLGKETGCALGRGG
HHHHCHHHHHHHHEEECCCCCHHCCCCCCCCEEEEEECCHHHHHHHHHCCCCCCCCCCCC
SMHMCGDRLPGGFGIVGGQIPLAAGAAFSMKYQKLPSISLCFIGDGAVAQGVFHETLNFA
CCCCCCCCCCCCCEEECCCCCHHCCCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHH
SLHTLPLMLIIENNGWGMGTALHRAIAKQPIAESQASSYGLSSITLNGFDLFNSLIGFKE
HHCCCEEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHCCCCEEEECHHHHHHHHHHHHH
AYQHMQKTGAPVVVEALCSRFRGHSISDPNLYRSKEEMQCLLKRDPILFAKEWLIRANVL
HHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHCCCCHHHHHHHHHHHCC
SEDDFKDLRQTSKEAVLEAFSQARLDPEPAVATLEEGIYA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA