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Identifier: 15835106

GI number: 15835106

Start: 593061

End: 594461

Strand: Direct

Name: Not Available

Synonym: TC0488

Alternate gene names: 15835106

Gene position: 593061-594461 (Clockwise)

Preceding gene: 15835105

Following gene: 15835107

Centisome position: 55.27

GC content: 39.9

Gene sequence:

>1401_bases
ATGCATCATCGCAAATCTTCCACCCCGTTAGGGACTTTTACTGTGGGGATGTTATCCCTCGCAGTAGTTATTAGTTTAAG
AAATCTTCCTTTAACCGCAAAACATGGCTTGTCTACCCTGTTTTTTTATGCCATTTCTGTAGCTTGTTTTATGATTCCCT
ATGCTCTTATTGCAGCAGAGTTGGCTTCTTTCAAGCCTCAGGGCATTTATGTGTGGACACGTGATGCTTTAGGGAAGCGC
TGGGGATTCTTCGCCATATGGATGCAGTGGTTCCATAATATGACTTGGTATCCAGCTATGTTAGCTTTTATTGCTAGTAC
GCTTGTTTATCAAATCAGCCCGGATCTTGCAAATAATCGTCTCTATCTGGCCTCTGTTATTCTTTTAGGTTTTTGGGGCC
TAACTTTCTTTAATTTTCTAGGAATTGGAACATCCGCTCTTTTCAGTTCTATCTGCGTAATTATAGGAACTCTCATTCCC
GGAGCCATTTTAGTCGCTTTCGCAGCTTACTGGATTCATAGTGGAAACCCCATTGCAATTACTTTTTCTTGGGGAGAGCT
CTTCCCAGACTTCTCTTCTCTTTCTTCTTTTGTTCTTCTATCCGGAATGCTTCTTGCATTATGTGGATTAGAAGCTAATG
CCAATTTAGCCTCAGATATGGAGGATCCTAAGAGAAATTATCCCAAAGCAGTTTTCATTGGAGCAGTGGCTACGCTTGCT
ATTTTAGTGCTAGGATCATTGGCAATTGCTATTGTAATCCCTAAAGAAGAAATTAGTTTAGTCTCCGGACTTATTCGAGC
ATTCTCTCTTTTCTTTGAAAAATACAATCTTTCTTGGATGACAGGGATTATCGTTGCAATGACGATAGCTGGGTCTTTAG
GAGAATTGAATGCTTGGATGTTTGCTGGCACTAAAGGGTTATTCATTTCTACTCAAAATGACTGCTTACCTAAAATTTTC
AAAAAAACTAATTCTAGGAATGTCCCCACAAATCTTATGCTTTTCCAGGCGATTGTGGTTACTTTATTCACATTCATATT
CATCTATGTGGACTCTGCAGACCTCGCTTACTGGATTTTGAGCGCTCTTAGCGTGCAGATGTACCTTGTCATGTACATTT
GCTTATTTATATCTGGCCCTGTTCTTAGAATTAAAGAGCCTAAAGCTCAAAGACTCTATTGTGTGCCTGGGAAACTTGTG
GGAATGTGTATTCTGTCTGCTTTAGGGATTCTCTCTTGCTTGTTTGCTTTAGGCATTAGCTTCCTTCCTCCTCAGGCAGT
AATTTCCTCATCAACTATGGGAGGCGGGTTTGGTTATACAGCGCTCCTGCTCTTAGCCTTTACTATTAATTGTTGCATTC
CTTTTGGAATGTACTATTCCCATAAAAAATTAATTAAATAA

Upstream 100 bases:

>100_bases
GCCTTCCAAAGACCTTTCTCTGAAGGAGTTCAGCTACTTAATTTAATTCAAGACATTTACTTAGATCCGACCATCTCCAT
ATCGTAATTTAGAGGTACTC

Downstream 100 bases:

>100_bases
TTTATTCTTTAGTGACGGCCTTCATAAAAGGAAGGCCGTTCCTTCCTTGTTCCTGGATTTCTAATCCGCAAATCTTTAAA
ATTCTTCCATGTTTACACTA

Product: amino acid antiporter

Products: L-glutamate [Cytoplasm]; 4-aminobutyrate [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MHHRKSSTPLGTFTVGMLSLAVVISLRNLPLTAKHGLSTLFFYAISVACFMIPYALIAAELASFKPQGIYVWTRDALGKR
WGFFAIWMQWFHNMTWYPAMLAFIASTLVYQISPDLANNRLYLASVILLGFWGLTFFNFLGIGTSALFSSICVIIGTLIP
GAILVAFAAYWIHSGNPIAITFSWGELFPDFSSLSSFVLLSGMLLALCGLEANANLASDMEDPKRNYPKAVFIGAVATLA
ILVLGSLAIAIVIPKEEISLVSGLIRAFSLFFEKYNLSWMTGIIVAMTIAGSLGELNAWMFAGTKGLFISTQNDCLPKIF
KKTNSRNVPTNLMLFQAIVVTLFTFIFIYVDSADLAYWILSALSVQMYLVMYICLFISGPVLRIKEPKAQRLYCVPGKLV
GMCILSALGILSCLFALGISFLPPQAVISSSTMGGGFGYTALLLLAFTINCCIPFGMYYSHKKLIK

Sequences:

>Translated_466_residues
MHHRKSSTPLGTFTVGMLSLAVVISLRNLPLTAKHGLSTLFFYAISVACFMIPYALIAAELASFKPQGIYVWTRDALGKR
WGFFAIWMQWFHNMTWYPAMLAFIASTLVYQISPDLANNRLYLASVILLGFWGLTFFNFLGIGTSALFSSICVIIGTLIP
GAILVAFAAYWIHSGNPIAITFSWGELFPDFSSLSSFVLLSGMLLALCGLEANANLASDMEDPKRNYPKAVFIGAVATLA
ILVLGSLAIAIVIPKEEISLVSGLIRAFSLFFEKYNLSWMTGIIVAMTIAGSLGELNAWMFAGTKGLFISTQNDCLPKIF
KKTNSRNVPTNLMLFQAIVVTLFTFIFIYVDSADLAYWILSALSVQMYLVMYICLFISGPVLRIKEPKAQRLYCVPGKLV
GMCILSALGILSCLFALGISFLPPQAVISSSTMGGGFGYTALLLLAFTINCCIPFGMYYSHKKLIK
>Mature_466_residues
MHHRKSSTPLGTFTVGMLSLAVVISLRNLPLTAKHGLSTLFFYAISVACFMIPYALIAAELASFKPQGIYVWTRDALGKR
WGFFAIWMQWFHNMTWYPAMLAFIASTLVYQISPDLANNRLYLASVILLGFWGLTFFNFLGIGTSALFSSICVIIGTLIP
GAILVAFAAYWIHSGNPIAITFSWGELFPDFSSLSSFVLLSGMLLALCGLEANANLASDMEDPKRNYPKAVFIGAVATLA
ILVLGSLAIAIVIPKEEISLVSGLIRAFSLFFEKYNLSWMTGIIVAMTIAGSLGELNAWMFAGTKGLFISTQNDCLPKIF
KKTNSRNVPTNLMLFQAIVVTLFTFIFIYVDSADLAYWILSALSVQMYLVMYICLFISGPVLRIKEPKAQRLYCVPGKLV
GMCILSALGILSCLFALGISFLPPQAVISSSTMGGGFGYTALLLLAFTINCCIPFGMYYSHKKLIK

Specific function: Probable Amino Acid Transporter. Involved In Extreme Acid Resistance. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1787768, Length=435, Percent_Identity=30.5747126436782, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI87081798, Length=394, Percent_Identity=23.6040609137056, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786908, Length=362, Percent_Identity=24.3093922651934, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51113; Mature: 51113

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHRKSSTPLGTFTVGMLSLAVVISLRNLPLTAKHGLSTLFFYAISVACFMIPYALIAAE
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LASFKPQGIYVWTRDALGKRWGFFAIWMQWFHNMTWYPAMLAFIASTLVYQISPDLANNR
HHCCCCCCEEEEEHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCH
LYLASVILLGFWGLTFFNFLGIGTSALFSSICVIIGTLIPGAILVAFAAYWIHSGNPIAI
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
TFSWGELFPDFSSLSSFVLLSGMLLALCGLEANANLASDMEDPKRNYPKAVFIGAVATLA
EEEHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHCCCCHHHHHHHHHHH
ILVLGSLAIAIVIPKEEISLVSGLIRAFSLFFEKYNLSWMTGIIVAMTIAGSLGELNAWM
HHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHE
FAGTKGLFISTQNDCLPKIFKKTNSRNVPTNLMLFQAIVVTLFTFIFIYVDSADLAYWIL
EECCCEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
SALSVQMYLVMYICLFISGPVLRIKEPKAQRLYCVPGKLVGMCILSALGILSCLFALGIS
HHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCC
FLPPQAVISSSTMGGGFGYTALLLLAFTINCCIPFGMYYSHKKLIK
CCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHHRKSSTPLGTFTVGMLSLAVVISLRNLPLTAKHGLSTLFFYAISVACFMIPYALIAAE
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LASFKPQGIYVWTRDALGKRWGFFAIWMQWFHNMTWYPAMLAFIASTLVYQISPDLANNR
HHCCCCCCEEEEEHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCH
LYLASVILLGFWGLTFFNFLGIGTSALFSSICVIIGTLIPGAILVAFAAYWIHSGNPIAI
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
TFSWGELFPDFSSLSSFVLLSGMLLALCGLEANANLASDMEDPKRNYPKAVFIGAVATLA
EEEHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHCCCCHHHHHHHHHHH
ILVLGSLAIAIVIPKEEISLVSGLIRAFSLFFEKYNLSWMTGIIVAMTIAGSLGELNAWM
HHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHE
FAGTKGLFISTQNDCLPKIFKKTNSRNVPTNLMLFQAIVVTLFTFIFIYVDSADLAYWIL
EECCCEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
SALSVQMYLVMYICLFISGPVLRIKEPKAQRLYCVPGKLVGMCILSALGILSCLFALGIS
HHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCC
FLPPQAVISSSTMGGGFGYTALLLLAFTINCCIPFGMYYSHKKLIK
CCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-aminobutyrate [Cytoplasm]; L-glutamate [Periplasm] [C]

Specific reaction: 4-aminobutyrate [Cytoplasm] + L-glutamate [Periplasm] = L-glutamate [Cytoplasm] + 4-aminobutyrate [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8366052 [H]