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The map label for this gene is tmk

Identifier: 15835078

GI number: 15835078

Start: 558121

End: 558732

Strand: Reverse

Name: tmk

Synonym: TC0460

Alternate gene names: 15835078

Gene position: 558732-558121 (Counterclockwise)

Preceding gene: 15835079

Following gene: 15835077

Centisome position: 52.07

GC content: 41.99

Gene sequence:

>612_bases
GTGTTTATTGTAGTAGAAGGCGGAGAAGGTGCTGGGAAAACCCAATTTACACAGGCACTTTCTAAACGTTTAATGGAAGA
AGGGAAAGAGGTTGTTTTAACAAGGGAGCCAGGAGGGAGTGCTCTTGGAGAGCAGCTTCGAGATCTTGTATTGGATGTAA
CACAGGAGATATCTTCCTACGCGGAGTTATTACTGTTTCTGGCAGCGCGAGCTCAGCACATTCAAGAAAAAATATTGCCT
GCTCTTGAATCTGGAAAAACAGTTATATGTGACCGTTTTCATGATTCTACTATTGTATACCAAGGAATTGCTGGGGGGCT
AGGAGAGGCCTTCGTTACGGATTTATGTTATCGTGTTGTAGGGGATGAGCCTTTTCTTCCCGACATCACGTTTTTATTGG
ATTTGCCAGAAAAAGAGGGGTTGCTAAGAAAGACTCGTCAAAAGAATCTTGATAGGTTTGAGCAAAAACCCACATCTTTT
CACCGGGCTGCTCGAGAAGGATTTATTTCTTTAGCAGAAAGATCCCCAGACAGGTATAAAATTTTAGATGCATTATTACC
AACAGAGGTATCTGTCGATCAAGCTCTTTTACAGATTCGAGCATTGATATAG

Upstream 100 bases:

>100_bases
GATACTCTGGTTGCTATGGAAAAATTATCAGTGAATACAGAGTCTGGAGAAACAGAAGAAAGCGTTAGCATCCAAGTTGG
ACATGCGGTAGAGGAATAGA

Downstream 100 bases:

>100_bases
AAAGGGGGGGGAGAGATGGAAAGCTCTGCTTGGGACGCTCTTATACAAAGAGTGCGCGATCAGAAGGTTCCTTCTGCTAT
TATTTTGCATGGGCAAGATT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MFIVVEGGEGAGKTQFTQALSKRLMEEGKEVVLTREPGGSALGEQLRDLVLDVTQEISSYAELLLFLAARAQHIQEKILP
ALESGKTVICDRFHDSTIVYQGIAGGLGEAFVTDLCYRVVGDEPFLPDITFLLDLPEKEGLLRKTRQKNLDRFEQKPTSF
HRAAREGFISLAERSPDRYKILDALLPTEVSVDQALLQIRALI

Sequences:

>Translated_203_residues
MFIVVEGGEGAGKTQFTQALSKRLMEEGKEVVLTREPGGSALGEQLRDLVLDVTQEISSYAELLLFLAARAQHIQEKILP
ALESGKTVICDRFHDSTIVYQGIAGGLGEAFVTDLCYRVVGDEPFLPDITFLLDLPEKEGLLRKTRQKNLDRFEQKPTSF
HRAAREGFISLAERSPDRYKILDALLPTEVSVDQALLQIRALI
>Mature_203_residues
MFIVVEGGEGAGKTQFTQALSKRLMEEGKEVVLTREPGGSALGEQLRDLVLDVTQEISSYAELLLFLAARAQHIQEKILP
ALESGKTVICDRFHDSTIVYQGIAGGLGEAFVTDLCYRVVGDEPFLPDITFLLDLPEKEGLLRKTRQKNLDRFEQKPTSF
HRAAREGFISLAERSPDRYKILDALLPTEVSVDQALLQIRALI

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=197, Percent_Identity=40.1015228426396, Blast_Score=119, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_CHLMU (Q9PKK5)

Other databases:

- EMBL:   AE002160
- PIR:   G81700
- RefSeq:   NP_296837.1
- ProteinModelPortal:   Q9PKK5
- SMR:   Q9PKK5
- GeneID:   1245815
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0460
- TIGR:   TC_0460
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- PhylomeDB:   Q9PKK5
- ProtClustDB:   PRK00698
- BioCyc:   CMUR243161:TC_0460-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 22587; Mature: 22587

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIVVEGGEGAGKTQFTQALSKRLMEEGKEVVLTREPGGSALGEQLRDLVLDVTQEISSY
CEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
AELLLFLAARAQHIQEKILPALESGKTVICDRFHDSTIVYQGIAGGLGEAFVTDLCYRVV
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEHHHCCCHHHHHHHHHHHHHH
GDEPFLPDITFLLDLPEKEGLLRKTRQKNLDRFEQKPTSFHRAAREGFISLAERSPDRYK
CCCCCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHH
ILDALLPTEVSVDQALLQIRALI
HHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MFIVVEGGEGAGKTQFTQALSKRLMEEGKEVVLTREPGGSALGEQLRDLVLDVTQEISSY
CEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
AELLLFLAARAQHIQEKILPALESGKTVICDRFHDSTIVYQGIAGGLGEAFVTDLCYRVV
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEHHHCCCHHHHHHHHHHHHHH
GDEPFLPDITFLLDLPEKEGLLRKTRQKNLDRFEQKPTSFHRAAREGFISLAERSPDRYK
CCCCCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHH
ILDALLPTEVSVDQALLQIRALI
HHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935